TW201619159A - 吡咯并［２，３－ｄ］嘧啶衍生物 - Google Patents

吡咯并［２，３－ｄ］嘧啶衍生物 Download PDF

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Publication number
TW201619159A
TW201619159A TW104125949A TW104125949A TW201619159A TW 201619159 A TW201619159 A TW 201619159A TW 104125949 A TW104125949 A TW 104125949A TW 104125949 A TW104125949 A TW 104125949A TW 201619159 A TW201619159 A TW 201619159A
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Taiwan
Prior art keywords
methyl
cis
pyrrolo
cyclobutyl
pyrimidin
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TW104125949A
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English (en)
Chinese (zh)
Inventor
凱倫 考夫曼
詹姆士 杜爾
尼路 凱拉
米海爾 派瑞克
馬修 瑞斯
泰瑞克 薩瑪德
西蒙 夏波拉
傑明森 塔爾特
麥可 凡奎茲
派崔克 佛赫斯特
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輝瑞股份有限公司
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
TW104125949A 2014-08-12 2015-08-10 吡咯并［２，３－ｄ］嘧啶衍生物 TW201619159A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462036276P 2014-08-12 2014-08-12
US201562189347P 2015-07-07 2015-07-07

Publications (1)

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TW201619159A true TW201619159A (zh) 2016-06-01

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Country Link
US (1) US10966980B2 (en:Method)
EP (1) EP3180344B1 (en:Method)
JP (1) JP6585158B2 (en:Method)
CA (1) CA2899888A1 (en:Method)
ES (1) ES2750655T3 (en:Method)
TW (1) TW201619159A (en:Method)
UY (1) UY36265A (en:Method)
WO (1) WO2016024185A1 (en:Method)

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TWI771342B (zh) * 2016-11-23 2022-07-21 大陸商江蘇恆瑞醫藥股份有限公司 吡咯并六員雜芳環類衍生物的製備方法及中間體

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TW201822764A (zh) 2016-09-14 2018-07-01 美商基利科學股份有限公司 Syk抑制劑
WO2018053190A1 (en) 2016-09-14 2018-03-22 Gilead Sciences, Inc. Syk inhibitors
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US12274703B2 (en) * 2017-12-21 2025-04-15 Gliapharm Sa Compositions and methods of treatment for neurological disorders comprising a dementia
US12310967B2 (en) 2017-12-21 2025-05-27 Gliapharm Sa Compositions and methods of treatment for neurological disorders comprising motor neuron diseases
JP7462951B2 (ja) * 2018-03-21 2024-04-08 リャオ，シビン Ｊａｋ阻害剤
CN112384282B (zh) 2018-07-06 2024-07-02 辉瑞公司 吡咯并[2,3-d]嘧啶化合物的制造方法与中间体及其用途
CA3118488A1 (en) * 2018-11-05 2020-05-14 Avista Pharma Solutions, Inc. Chemical compounds
WO2020132378A2 (en) 2018-12-22 2020-06-25 Gliapharm Sa Compositions and methods of treatment for neurological disorders comprising depression
EP3947388A4 (en) 2019-04-02 2022-12-21 Aligos Therapeutics, Inc. PRMT5 TARGETING COMPOUNDS
EP3969458A4 (en) 2019-05-13 2023-05-17 Borah, Inc. CHEMICAL COMPOUNDS
CN110483338A (zh) * 2019-08-14 2019-11-22 苏州汉德创宏生化科技有限公司 一种大环类抑制剂中间体环庚烷基磺酰氯的合成方法
CN115667263A (zh) * 2020-05-28 2023-01-31 辉瑞公司 吡咯并[2,3-d]嘧啶衍生物
CA3191598A1 (en) * 2020-09-11 2022-03-17 Gilles Ouvry Novel jak inhibitor compounds, method for synthesizing same and use thereof
CN112697912B (zh) * 2020-12-14 2021-09-21 上海博悦生物科技有限公司 一种检测枸橼酸托法替布中间体及其相关杂质的方法
CA3206106A1 (en) 2021-02-10 2022-08-18 Bhaskar Chaudhuri Methods for ophthalmic delivery of roflumilast
IL311534A (en) 2021-09-22 2024-05-01 Iolyx Therapeutics Inc Methods of treating ocular inflammatory diseases
TW202342458A (zh) 2022-02-14 2023-11-01 美商雅瑞斯醫療公司 Ｐａｒｇ抑制劑
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