TW201609747A - Ｐｉ３激酶抑制劑及其用途 - Google Patents

Ｐｉ３激酶抑制劑及其用途 Download PDF

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Publication number
TW201609747A
TW201609747A TW104118050A TW104118050A TW201609747A TW 201609747 A TW201609747 A TW 201609747A TW 104118050 A TW104118050 A TW 104118050A TW 104118050 A TW104118050 A TW 104118050A TW 201609747 A TW201609747 A TW 201609747A
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Taiwan
Prior art keywords
ring
nitrogen
certain embodiments
group
oxygen
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TW104118050A
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English (en)
Chinese (zh)
Inventor
牛德強
拉塞爾Ｃ 彼得
尤斯溫德 辛格
亞瑟Ｆ 克魯格
賀孟茲 馬茲迪亞斯尼
朱振東
喬立新
凱文 剛茲
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阿維拉製藥公司
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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TW104118050A 2009-09-09 2010-09-09 Ｐｉ３激酶抑制劑及其用途 TW201609747A (zh)

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US24094709P 2009-09-09 2009-09-09
US37139610P 2010-08-06 2010-08-06

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TW201609747A true TW201609747A (zh) 2016-03-16

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TW099130780A TWI499592B (zh) 2009-09-09 2010-09-09 Ｐｉ３激酶抑制劑及其用途

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US (1) US20110230476A1 (enExample)
EP (1) EP2475375A4 (enExample)
JP (1) JP2013504325A (enExample)
KR (1) KR20120063515A (enExample)
CN (1) CN102625708A (enExample)
AU (1) AU2010292198A1 (enExample)
BR (1) BR112012008385A2 (enExample)
CA (1) CA2773848A1 (enExample)
IL (1) IL218555A0 (enExample)
MX (1) MX339584B (enExample)
NZ (2) NZ598808A (enExample)
PH (1) PH12012500491A1 (enExample)
RU (1) RU2595718C2 (enExample)
SG (2) SG10201405598QA (enExample)
TW (2) TW201609747A (enExample)
WO (1) WO2011031896A2 (enExample)

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