TW201605791A - Ｎｒ２ｂ之選擇性八氫-環戊二烯并［ｃ］吡咯負向調節劑 - Google Patents

Ｎｒ２ｂ之選擇性八氫-環戊二烯并［ｃ］吡咯負向調節劑 Download PDF

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TW201605791A
TW201605791A TW103133682A TW103133682A TW201605791A TW 201605791 A TW201605791 A TW 201605791A TW 103133682 A TW103133682 A TW 103133682A TW 103133682 A TW103133682 A TW 103133682A TW 201605791 A TW201605791 A TW 201605791A
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pyrrole
octahydrocyclopenta
hydroxy
benzyl
racemic
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TW103133682A
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English (en)
Chinese (zh)
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大衛Ｒ 安德森
羅伯特Ａ 沃克曼
法蘭克Ｓ 曼奈迪
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美涅莫辛製藥公司
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Publication of TW201605791A publication Critical patent/TW201605791A/zh

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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TW103133682A 2013-09-26 2014-09-26 Ｎｒ２ｂ之選擇性八氫-環戊二烯并［ｃ］吡咯負向調節劑 TW201605791A (zh)

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AU2016303558B2 (en) * 2015-08-05 2020-08-06 Indivior Uk Limited Dopamine D3 receptor antagonists having a bicyclo moiety
WO2018232158A1 (en) * 2017-06-15 2018-12-20 Belite Bio, Inc. Methods of treating metabolic diseases with fused bicyclic pyrroles
US11452881B2 (en) 2019-01-03 2022-09-27 Avive Solutions, Inc. Defibrillator communications architecture
IL303357A (en) * 2020-12-04 2023-08-01 Novartis Ag Dosage regimen for a nr2b-nmda receptor nam for the treatment of depression
WO2022204337A1 (en) * 2021-03-26 2022-09-29 Novartis Ag Novel cyclopenta[c]pyrrol negative allosteric modulators of nr2b
IL305601A (en) * 2021-03-26 2023-11-01 Novartis Ag Novel cyclopental[C]pyro-type negative allosteric modulators of NR2B

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