JP6546596B2 - Ｎｒ２ｂの選択的オクタヒドロ−シクロペンタ［ｃ］ピロール負調節因子 - Google Patents

Ｎｒ２ｂの選択的オクタヒドロ−シクロペンタ［ｃ］ピロール負調節因子 Download PDF

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JP6546596B2
JP6546596B2 JP2016545243A JP2016545243A JP6546596B2 JP 6546596 B2 JP6546596 B2 JP 6546596B2 JP 2016545243 A JP2016545243 A JP 2016545243A JP 2016545243 A JP2016545243 A JP 2016545243A JP 6546596 B2 JP6546596 B2 JP 6546596B2
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pyrrol
octahydrocyclopenta
hydroxy
benzyl
pyrrole
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JP2016536348A5 (enExample
JP2016536348A (ja
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アンダーソン，デーヴィッド・アール
ヴォルクマン，ロバート・エイ
メンニティ，フランク・エス
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カデント セラピューティクス，インコーポレーテッド
カデント セラピューティクス，インコーポレーテッド
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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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  • Indole Compounds (AREA)
JP2016545243A 2013-09-26 2014-09-26 Ｎｒ２ｂの選択的オクタヒドロ−シクロペンタ［ｃ］ピロール負調節因子 Active JP6546596B2 (ja)

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US201361883050P 2013-09-26 2013-09-26
US61/883,050 2013-09-26
PCT/US2014/057800 WO2015048507A1 (en) 2013-09-26 2014-09-26 Selective octahydro-cyclopenta[c] pyrrole negative modulators of nr2b

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JP2016536348A5 JP2016536348A5 (enExample) 2017-11-24
JP6546596B2 true JP6546596B2 (ja) 2019-07-17

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AR (1) AR097794A1 (enExample)
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AR097794A1 (es) 2013-09-26 2016-04-13 Mnemosyne Pharmaceuticals Inc Moduladores octahidro-ciclopenta[c]pirrol negativos de nr2b
JO3579B1 (ar) * 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
AU2016303558B2 (en) * 2015-08-05 2020-08-06 Indivior Uk Limited Dopamine D3 receptor antagonists having a bicyclo moiety
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US20230012073A1 (en) 2023-01-12
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