TW201444847A - 作爲鉀離子通道抑制劑之吡咯并三嗪 - Google Patents

作爲鉀離子通道抑制劑之吡咯并三嗪 Download PDF

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Publication number
TW201444847A
TW201444847A TW103108204A TW103108204A TW201444847A TW 201444847 A TW201444847 A TW 201444847A TW 103108204 A TW103108204 A TW 103108204A TW 103108204 A TW103108204 A TW 103108204A TW 201444847 A TW201444847 A TW 201444847A
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TW
Taiwan
Prior art keywords
group
alkyl
cycloalkyl
phenyl
substituted
Prior art date
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TW103108204A
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English (en)
Chinese (zh)
Inventor
海瑟 芬雷
艾索 庫瑪 艾迪森漢
卡維塔 葛文卓裘盧
普拉珊沙 古納卡
約翰 洛伊德
波瑟肯努瑞 斯林瓦舒
Original Assignee
必治妥美雅史谷比公司
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Application filed by 必治妥美雅史谷比公司 filed Critical 必治妥美雅史谷比公司
Publication of TW201444847A publication Critical patent/TW201444847A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW103108204A 2013-03-11 2014-03-10 作爲鉀離子通道抑制劑之吡咯并三嗪 TW201444847A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361775731P 2013-03-11 2013-03-11
US14/200,055 US9050345B2 (en) 2013-03-11 2014-03-07 Pyrrolotriazines as potassium ion channel inhibitors

Publications (1)

Publication Number Publication Date
TW201444847A true TW201444847A (zh) 2014-12-01

Family

ID=51488539

Family Applications (1)

Application Number Title Priority Date Filing Date
TW103108204A TW201444847A (zh) 2013-03-11 2014-03-10 作爲鉀離子通道抑制劑之吡咯并三嗪

Country Status (8)

Country Link
US (1) US9050345B2 (OSRAM)
EP (1) EP2970296B1 (OSRAM)
JP (1) JP6427551B2 (OSRAM)
CN (1) CN105008367B (OSRAM)
AR (1) AR095208A1 (OSRAM)
TW (1) TW201444847A (OSRAM)
UY (1) UY35381A (OSRAM)
WO (1) WO2014143610A1 (OSRAM)

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WO2017004134A1 (en) * 2015-06-29 2017-01-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof
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KR102431405B1 (ko) * 2016-04-28 2022-08-10 다케다 야쿠힌 고교 가부시키가이샤 축합 헤테로시클릭 화합물
WO2018204721A1 (en) 2017-05-05 2018-11-08 Nino Sorgente Methods and compositions for improving eye health
US11382881B2 (en) 2017-05-05 2022-07-12 Nino Sorgente Methods and compositions for diagnosing and treating glaucoma
JP7514005B2 (ja) 2017-06-21 2024-07-10 シャイ・セラピューティクス・エルエルシー がん、炎症性疾患、ラソパシー、及び線維性疾患の治療のためのｒａｓスーパーファミリーと相互作用する化合物
EP3898609A1 (en) 2018-12-19 2021-10-27 Shy Therapeutics LLC Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
CN111825675B (zh) * 2019-04-15 2023-08-01 武汉朗来科技发展有限公司 Rock抑制剂及其制备方法和用途
JP7675182B2 (ja) * 2020-11-10 2025-05-12 フォグホーン セラピューティクス インコーポレイテッド 化合物及びその使用
KR20250007533A (ko) 2022-04-08 2025-01-14 샤이 테라퓨틱스 엘엘씨 암, 염증성 질환, ras질환 및 섬유성 질환의 치료를 위한 ras 슈퍼패밀리 단백질과 상호작용하는 화합물
CN119677738A (zh) 2022-05-11 2025-03-21 福宏治疗公司 化合物及其用途
CN116063183B (zh) * 2023-01-28 2023-06-27 山东国邦药业有限公司 一种环丙胺的合成方法
WO2025077671A1 (zh) * 2023-10-09 2025-04-17 浙江海正药业股份有限公司 多取代芳基类衍生物及其制备方法和用途

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Also Published As

Publication number Publication date
WO2014143610A1 (en) 2014-09-18
EP2970296A1 (en) 2016-01-20
US9050345B2 (en) 2015-06-09
JP2016512505A (ja) 2016-04-28
CN105008367B (zh) 2017-08-29
JP6427551B2 (ja) 2018-11-21
AR095208A1 (es) 2015-09-30
US20140256719A1 (en) 2014-09-11
CN105008367A (zh) 2015-10-28
EP2970296B1 (en) 2016-12-21
UY35381A (es) 2014-09-30

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