TW201431559A - 抗-her3抗體之組合療法 - Google Patents
抗-her3抗體之組合療法 Download PDFInfo
- Publication number
- TW201431559A TW201431559A TW103101044A TW103101044A TW201431559A TW 201431559 A TW201431559 A TW 201431559A TW 103101044 A TW103101044 A TW 103101044A TW 103101044 A TW103101044 A TW 103101044A TW 201431559 A TW201431559 A TW 201431559A
- Authority
- TW
- Taiwan
- Prior art keywords
- antibody
- seq
- cancer
- human
- her3
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13151076 | 2013-01-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW201431559A true TW201431559A (zh) | 2014-08-16 |
Family
ID=47504772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW103101044A TW201431559A (zh) | 2013-01-11 | 2014-01-10 | 抗-her3抗體之組合療法 |
Country Status (19)
Country | Link |
---|---|
US (2) | US9180185B2 (fr) |
EP (1) | EP2943508B1 (fr) |
JP (1) | JP6257646B2 (fr) |
KR (1) | KR20150093231A (fr) |
CN (1) | CN104797602A (fr) |
AR (1) | AR094403A1 (fr) |
AU (1) | AU2014204795A1 (fr) |
CA (1) | CA2887508A1 (fr) |
CL (1) | CL2015001049A1 (fr) |
CR (1) | CR20150284A (fr) |
EA (1) | EA201500744A1 (fr) |
HK (1) | HK1211950A1 (fr) |
IL (1) | IL238393A0 (fr) |
MA (1) | MA38273A1 (fr) |
MX (1) | MX2015008313A (fr) |
PH (1) | PH12015501071A1 (fr) |
SG (1) | SG11201503802UA (fr) |
TW (1) | TW201431559A (fr) |
WO (1) | WO2014108484A2 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至her2結構域ii之抗體及其酸性變異體的組合物 |
BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
AR094403A1 (es) * | 2013-01-11 | 2015-07-29 | Hoffmann La Roche | Terapia de combinación de anticuerpos anti-her3 |
MX368259B (es) | 2013-04-16 | 2019-09-25 | Genentech Inc | Variantes de pertuzumab y su evaluacion. |
CN106255705B (zh) | 2014-05-14 | 2021-01-08 | 豪夫迈·罗氏有限公司 | 结合HER3β-发夹和HER2域II的HER3/HER2双特异性抗体 |
EP3091033A1 (fr) * | 2015-05-06 | 2016-11-09 | Gamamabs Pharma | Anticorps anti-her3 humains et leurs utilisations |
AU2016366521A1 (en) | 2015-12-11 | 2018-06-21 | Regeneron Pharmaceuticals, Inc. | Methods for reducing or preventing growth of tumors resistant to EGFR and/or ErbB3 blockade |
WO2017102789A1 (fr) * | 2015-12-17 | 2017-06-22 | F. Hoffmann-La Roche Ag | Polythérapie à base d'anticorps anti-her3 et d'anticorps anti-her2 |
CR20190376A (es) | 2017-01-17 | 2019-11-20 | Genentech Inc | Formulaciones de anticuerpos de her2 subcutáneas |
JP7181181B2 (ja) | 2017-02-28 | 2022-11-30 | 第一三共株式会社 | 抗her3抗体-薬物コンジュゲート投与によるegfr-tki抵抗性の非小細胞肺癌の治療方法 |
CN116531511A (zh) | 2017-03-02 | 2023-08-04 | 豪夫迈·罗氏有限公司 | Her2阳性乳腺癌的辅助治疗 |
KR20200021987A (ko) | 2017-06-27 | 2020-03-02 | 리제너론 파마슈티칼스 인코포레이티드 | 유전 물질을 인간 세포 내로 표적화하여 도입하기 위한 향성-변형 재조합 바이러스 입자 및 이의 용도 |
EP3820496A4 (fr) * | 2018-07-09 | 2022-04-20 | Precigen, Inc. | Constructions de fusion et leurs méthodes d'utilisation |
TW202024133A (zh) | 2018-09-20 | 2020-07-01 | 日商第一三共股份有限公司 | 利用投予抗her3抗體-藥物結合物之her3突變癌之治療 |
TW202328191A (zh) * | 2021-09-03 | 2023-07-16 | 英商癌症研究科技有限公司 | 使用her3抗原結合分子的癌症之治療及預防 |
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-
2014
- 2014-01-09 AR ARP140100081A patent/AR094403A1/es unknown
- 2014-01-09 US US14/151,626 patent/US9180185B2/en active Active
- 2014-01-10 EP EP14700281.0A patent/EP2943508B1/fr active Active
- 2014-01-10 AU AU2014204795A patent/AU2014204795A1/en not_active Abandoned
- 2014-01-10 SG SG11201503802UA patent/SG11201503802UA/en unknown
- 2014-01-10 JP JP2015552051A patent/JP6257646B2/ja active Active
- 2014-01-10 EA EA201500744A patent/EA201500744A1/ru unknown
- 2014-01-10 TW TW103101044A patent/TW201431559A/zh unknown
- 2014-01-10 CA CA 2887508 patent/CA2887508A1/fr not_active Abandoned
- 2014-01-10 CN CN201480003140.2A patent/CN104797602A/zh active Pending
- 2014-01-10 KR KR1020157018413A patent/KR20150093231A/ko not_active Application Discontinuation
- 2014-01-10 MA MA38273A patent/MA38273A1/fr unknown
- 2014-01-10 MX MX2015008313A patent/MX2015008313A/es unknown
- 2014-01-10 WO PCT/EP2014/050344 patent/WO2014108484A2/fr active Application Filing
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2015
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- 2015-04-23 CL CL2015001049A patent/CL2015001049A1/es unknown
- 2015-05-14 PH PH12015501071A patent/PH12015501071A1/en unknown
- 2015-05-28 CR CR20150284A patent/CR20150284A/es unknown
- 2015-10-07 US US14/877,569 patent/US20160159912A1/en not_active Abandoned
- 2015-12-24 HK HK15112676.9A patent/HK1211950A1/xx unknown
Also Published As
Publication number | Publication date |
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CA2887508A1 (fr) | 2014-07-17 |
AU2014204795A1 (en) | 2015-04-30 |
CN104797602A (zh) | 2015-07-22 |
WO2014108484A3 (fr) | 2014-09-04 |
MA38273A1 (fr) | 2017-05-31 |
SG11201503802UA (en) | 2015-08-28 |
HK1211950A1 (en) | 2016-06-03 |
EA201500744A1 (ru) | 2015-12-30 |
CR20150284A (es) | 2015-06-30 |
US9180185B2 (en) | 2015-11-10 |
IL238393A0 (en) | 2015-06-30 |
EP2943508A2 (fr) | 2015-11-18 |
US20160159912A1 (en) | 2016-06-09 |
CL2015001049A1 (es) | 2015-10-16 |
KR20150093231A (ko) | 2015-08-17 |
AR094403A1 (es) | 2015-07-29 |
PH12015501071A1 (en) | 2015-08-03 |
EP2943508B1 (fr) | 2020-07-15 |
WO2014108484A2 (fr) | 2014-07-17 |
MX2015008313A (es) | 2015-11-11 |
US20140227255A1 (en) | 2014-08-14 |
JP2016504399A (ja) | 2016-02-12 |
JP6257646B2 (ja) | 2018-01-10 |
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