TW201410706A - 抗－ｐｃｓｋ９抗體、調配物、劑量及使用方法 - Google Patents

抗－ｐｃｓｋ９抗體、調配物、劑量及使用方法 Download PDF

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Publication number
TW201410706A
TW201410706A TW102121268A TW102121268A TW201410706A TW 201410706 A TW201410706 A TW 201410706A TW 102121268 A TW102121268 A TW 102121268A TW 102121268 A TW102121268 A TW 102121268A TW 201410706 A TW201410706 A TW 201410706A
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TW
Taiwan
Prior art keywords
seq
antibody
hvr
pcsk9
amino acid
Prior art date
Application number
TW102121268A
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English (en)
Chinese (zh)
Inventor
Yan Wu
Cecilia Pui Chi Chiu
Daniel K Kirchhofer
Andrew Peterson
Ganesh A Kolumam
Monica Kong Beltran
Paul Moran
Wei Li
Xanthe Lam
Lin Luis
Ada Hui
Whittemore Tingley
John Douglas Davis
Nageshwar R Budha
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Genentech Inc
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Application filed by Genentech Inc filed Critical Genentech Inc
Publication of TW201410706A publication Critical patent/TW201410706A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW102121268A 2012-06-15 2013-06-14 抗－ｐｃｓｋ９抗體、調配物、劑量及使用方法 TW201410706A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261660605P 2012-06-15 2012-06-15
US201361786280P 2013-03-14 2013-03-14

Publications (1)

Publication Number Publication Date
TW201410706A true TW201410706A (zh) 2014-03-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW102121268A TW201410706A (zh) 2012-06-15 2013-06-14 抗－ｐｃｓｋ９抗體、調配物、劑量及使用方法

Country Status (13)

Country Link
US (2) US9266961B2 (enExample)
EP (1) EP2861624A1 (enExample)
JP (1) JP2015530867A (enExample)
KR (1) KR20150023711A (enExample)
CN (1) CN104364266A (enExample)
AR (1) AR091462A1 (enExample)
BR (1) BR112014031310A2 (enExample)
CA (1) CA2875096A1 (enExample)
HK (1) HK1205141A1 (enExample)
MX (1) MX2014014830A (enExample)
RU (1) RU2015101113A (enExample)
TW (1) TW201410706A (enExample)
WO (1) WO2013188855A1 (enExample)

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JOP20200043A1 (ar) 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
EA039663B1 (ru) 2012-05-03 2022-02-24 Амген Инк. Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств
US9255154B2 (en) 2012-05-08 2016-02-09 Alderbio Holdings, Llc Anti-PCSK9 antibodies and use thereof
EP3169710A1 (en) * 2014-07-14 2017-05-24 Amgen Inc. Crystalline antibody formulations
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CN106810609A (zh) * 2015-11-27 2017-06-09 苏州君盟生物医药科技有限公司 抗pcsk9抗体及其应用
CN107406511B (zh) * 2015-12-31 2021-01-19 江苏恒瑞医药股份有限公司 Pcsk9抗体、其抗原结合片段及其医药用途
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CN107474140B (zh) * 2016-06-08 2022-06-03 常州博嘉生物医药科技有限公司 Pcsk9特异性的结合蛋白mv072及其应用
CA3026823A1 (en) * 2016-06-24 2017-12-28 F. Hoffmann-La Roche Ag Compositions and methods for treating cardiovascular disease
WO2018054240A1 (en) * 2016-09-20 2018-03-29 Wuxi Biologics (Shanghai) Co. Ltd. Novel anti-pcsk9 antibodies
CN107698680B (zh) * 2017-01-22 2019-03-01 北京东方百泰生物科技有限公司 抗pcsk9单克隆抗体
BR112019020148A2 (pt) 2017-04-13 2020-05-05 Cadila Healthcare Limited peptídeo
CN107177003A (zh) * 2017-06-27 2017-09-19 上海海玫生物科技有限公司 一种特异性抗人pcsk9的抗体及其应用
AU2018291702A1 (en) 2017-06-30 2020-02-06 Jiangsu Hengrui Medicine Co., Ltd. Pharmaceutical composition comprising PCSK-9 antibody and use thereof
GB201820687D0 (en) * 2018-12-19 2019-01-30 Kymab Ltd Antagonists
US11248001B2 (en) 2019-01-18 2022-02-15 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof
CN109776680B (zh) * 2019-01-25 2020-05-12 浙江蓝盾药业有限公司 抗人pcsk9单克隆抗体及其用途
WO2020236670A1 (en) 2019-05-17 2020-11-26 Regeneron Pharmaceuticals, Inc. Genome-based methods for reducing cardiovascular risk
KR20230034367A (ko) * 2020-07-02 2023-03-09 바이오로직 디자인 리미티드 항-종양 괴사 인자 수용체 (tnfr2) 항체 및 그 용도

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US20160355606A1 (en) 2016-12-08
KR20150023711A (ko) 2015-03-05
CN104364266A (zh) 2015-02-18
US9266961B2 (en) 2016-02-23
HK1205141A1 (en) 2015-12-11
BR112014031310A2 (pt) 2017-07-25
EP2861624A1 (en) 2015-04-22
RU2015101113A (ru) 2016-08-10
AR091462A1 (es) 2015-02-04
CA2875096A1 (en) 2013-12-19
US20130344085A1 (en) 2013-12-26
MX2014014830A (es) 2015-05-11

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