MX2014014830A - Anticuerpos anti-pcsk9, formulaciones, dosificacion y metodos de uso. - Google Patents
Anticuerpos anti-pcsk9, formulaciones, dosificacion y metodos de uso.Info
- Publication number
- MX2014014830A MX2014014830A MX2014014830A MX2014014830A MX2014014830A MX 2014014830 A MX2014014830 A MX 2014014830A MX 2014014830 A MX2014014830 A MX 2014014830A MX 2014014830 A MX2014014830 A MX 2014014830A MX 2014014830 A MX2014014830 A MX 2014014830A
- Authority
- MX
- Mexico
- Prior art keywords
- seq
- antibody
- hvr
- amino acid
- pcsk9
- Prior art date
Links
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Classifications
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
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- Biophysics (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660605P | 2012-06-15 | 2012-06-15 | |
| US201361786280P | 2013-03-14 | 2013-03-14 | |
| PCT/US2013/046032 WO2013188855A1 (en) | 2012-06-15 | 2013-06-14 | Anti-pcsk9 antibodies, formulations, dosing, and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2014014830A true MX2014014830A (es) | 2015-05-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014014830A MX2014014830A (es) | 2012-06-15 | 2013-06-14 | Anticuerpos anti-pcsk9, formulaciones, dosificacion y metodos de uso. |
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| Country | Link |
|---|---|
| US (2) | US9266961B2 (enExample) |
| EP (1) | EP2861624A1 (enExample) |
| JP (1) | JP2015530867A (enExample) |
| KR (1) | KR20150023711A (enExample) |
| CN (1) | CN104364266A (enExample) |
| AR (1) | AR091462A1 (enExample) |
| BR (1) | BR112014031310A2 (enExample) |
| CA (1) | CA2875096A1 (enExample) |
| HK (1) | HK1205141A1 (enExample) |
| MX (1) | MX2014014830A (enExample) |
| RU (1) | RU2015101113A (enExample) |
| TW (1) | TW201410706A (enExample) |
| WO (1) | WO2013188855A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20080381B1 (ar) | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| WO2016010927A1 (en) * | 2014-07-14 | 2016-01-21 | Amgen Inc. | Crystalline antibody formulations |
| CN105461809B (zh) * | 2015-02-11 | 2018-10-12 | 康融东方(广东)医药有限公司 | Pcsk9抗体、其药物组合物及其用途 |
| CN106810609A (zh) | 2015-11-27 | 2017-06-09 | 苏州君盟生物医药科技有限公司 | 抗pcsk9抗体及其应用 |
| US10793643B2 (en) | 2015-12-31 | 2020-10-06 | Jiangsu Hengrui Medicine Co., Ltd. | PCSK9 antibody, antigen-binding fragment thereof, and medical application thereof |
| US20200270365A1 (en) * | 2016-01-05 | 2020-08-27 | Jiangsu Hengrui Medicine Co., Ltd. | Pcsk9 antibody, antigen-binding fragment thereof, and medical uses thereof |
| CN107266575B (zh) | 2016-04-07 | 2021-12-24 | 天士力生物医药股份有限公司 | 前蛋白转化酶枯草溶菌素kexin 9型的结合蛋白及其应用 |
| CN107474140B (zh) * | 2016-06-08 | 2022-06-03 | 常州博嘉生物医药科技有限公司 | Pcsk9特异性的结合蛋白mv072及其应用 |
| AU2017281332A1 (en) * | 2016-06-24 | 2018-12-20 | F. Hoffmann-La Roche Ag | Compositions and methods for treating cardiovascular disease |
| WO2018054240A1 (en) * | 2016-09-20 | 2018-03-29 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel anti-pcsk9 antibodies |
| CN107698679B (zh) * | 2017-01-22 | 2019-03-01 | 北京东方百泰生物科技有限公司 | 抗pcsk9单克隆抗体 |
| CA3058567A1 (en) | 2017-04-13 | 2018-10-18 | Cadila Healthcare Limited | Novel peptide based pcsk9 vaccine |
| CN107177003A (zh) * | 2017-06-27 | 2017-09-19 | 上海海玫生物科技有限公司 | 一种特异性抗人pcsk9的抗体及其应用 |
| AU2018291702A1 (en) | 2017-06-30 | 2020-02-06 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition comprising PCSK-9 antibody and use thereof |
| GB201820687D0 (en) * | 2018-12-19 | 2019-01-30 | Kymab Ltd | Antagonists |
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-
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- 2013-06-14 EP EP13733479.3A patent/EP2861624A1/en not_active Withdrawn
- 2013-06-14 TW TW102121268A patent/TW201410706A/zh unknown
- 2013-06-14 US US13/918,755 patent/US9266961B2/en not_active Expired - Fee Related
- 2013-06-14 RU RU2015101113A patent/RU2015101113A/ru not_active Application Discontinuation
- 2013-06-14 JP JP2015517471A patent/JP2015530867A/ja active Pending
- 2013-06-14 KR KR20157000680A patent/KR20150023711A/ko not_active Withdrawn
- 2013-06-14 HK HK15105650.3A patent/HK1205141A1/xx unknown
- 2013-06-14 AR ARP130102123 patent/AR091462A1/es unknown
- 2013-06-14 WO PCT/US2013/046032 patent/WO2013188855A1/en not_active Ceased
- 2013-06-14 CN CN201380031599.9A patent/CN104364266A/zh active Pending
- 2013-06-14 BR BR112014031310A patent/BR112014031310A2/pt active Search and Examination
- 2013-06-14 MX MX2014014830A patent/MX2014014830A/es unknown
- 2013-06-14 CA CA2875096A patent/CA2875096A1/en not_active Abandoned
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2015
- 2015-12-28 US US14/981,853 patent/US20160355606A1/en not_active Abandoned
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| AR091462A1 (es) | 2015-02-04 |
| CA2875096A1 (en) | 2013-12-19 |
| US20160355606A1 (en) | 2016-12-08 |
| RU2015101113A (ru) | 2016-08-10 |
| KR20150023711A (ko) | 2015-03-05 |
| US20130344085A1 (en) | 2013-12-26 |
| EP2861624A1 (en) | 2015-04-22 |
| CN104364266A (zh) | 2015-02-18 |
| US9266961B2 (en) | 2016-02-23 |
| WO2013188855A1 (en) | 2013-12-19 |
| JP2015530867A (ja) | 2015-10-29 |
| BR112014031310A2 (pt) | 2017-07-25 |
| TW201410706A (zh) | 2014-03-16 |
| HK1205141A1 (en) | 2015-12-11 |
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