TW201111373A - 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazine derivatives - Google Patents

3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazine derivatives Download PDF

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Publication number
TW201111373A
TW201111373A TW099127347A TW99127347A TW201111373A TW 201111373 A TW201111373 A TW 201111373A TW 099127347 A TW099127347 A TW 099127347A TW 99127347 A TW99127347 A TW 99127347A TW 201111373 A TW201111373 A TW 201111373A
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TW
Taiwan
Prior art keywords
amino
dihydro
group
fluorophenyl
carboxylic acid
Prior art date
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TW099127347A
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English (en)
Chinese (zh)
Inventor
Matteo Andreini
David Banner
Wolfgang Guba
Hans Hilpert
Harald Mauser
Alexander V Mayweg
Robert Narquizian
Eoin Power
Mark Rogers-Evans
Massimiliano Travagli
Michela Valacchi
Thomas Woltering
Wolfgang Wostl
Original Assignee
Hoffmann La Roche
Siena Biotech Spa
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Application filed by Hoffmann La Roche, Siena Biotech Spa filed Critical Hoffmann La Roche
Publication of TW201111373A publication Critical patent/TW201111373A/zh

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
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    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
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  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW099127347A 2009-08-19 2010-08-16 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazine derivatives TW201111373A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09168132 2009-08-19

Publications (1)

Publication Number Publication Date
TW201111373A true TW201111373A (en) 2011-04-01

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ID=42953737

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TW099127347A TW201111373A (en) 2009-08-19 2010-08-16 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazine derivatives

Country Status (15)

Country Link
US (3) US8188079B2 (https=)
EP (1) EP2467368A1 (https=)
JP (1) JP2013502393A (https=)
KR (1) KR20120068870A (https=)
CN (1) CN102639516A (https=)
AR (1) AR077935A1 (https=)
AU (1) AU2010285005A1 (https=)
BR (1) BR112012003704A2 (https=)
CA (1) CA2768341A1 (https=)
IL (1) IL217918A0 (https=)
IN (1) IN2012DN00766A (https=)
MX (1) MX2012001985A (https=)
SG (1) SG178442A1 (https=)
TW (1) TW201111373A (https=)
WO (1) WO2011020806A1 (https=)

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