TW201028431A - Novel tools for the production of glycosylated proteins in host cells - Google Patents
Novel tools for the production of glycosylated proteins in host cells Download PDFInfo
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- TW201028431A TW201028431A TW098136974A TW98136974A TW201028431A TW 201028431 A TW201028431 A TW 201028431A TW 098136974 A TW098136974 A TW 098136974A TW 98136974 A TW98136974 A TW 98136974A TW 201028431 A TW201028431 A TW 201028431A
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
- C12Y204/99018—Dolichyl-diphosphooligosaccharide—protein glycotransferase (2.4.99.18)
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- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
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- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US19802308P | 2008-10-31 | 2008-10-31 | |
| EP08400044 | 2008-10-31 |
Publications (1)
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|---|---|
| TW201028431A true TW201028431A (en) | 2010-08-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| TW098136974A TW201028431A (en) | 2008-10-31 | 2009-10-30 | Novel tools for the production of glycosylated proteins in host cells |
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| Country | Link |
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| US (1) | US20110207214A1 (enExample) |
| EP (1) | EP2350123A1 (enExample) |
| JP (1) | JP2012506710A (enExample) |
| CN (1) | CN102203123A (enExample) |
| AU (1) | AU2009309925A1 (enExample) |
| CA (1) | CA2741964A1 (enExample) |
| IL (1) | IL212580A0 (enExample) |
| TW (1) | TW201028431A (enExample) |
| WO (1) | WO2010049177A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100787073B1 (ko) * | 2000-06-28 | 2007-12-21 | 글리코파이, 인크. | 변형된 당단백질의 제조방법 |
| CN102858949B (zh) | 2010-02-24 | 2016-07-06 | 默沙东公司 | 用于增加在巴氏毕赤酵母中生产的治疗性糖蛋白上的n-糖基化位点占据的方法 |
| RU2013128619A (ru) * | 2010-11-24 | 2014-12-27 | Новартис Интернэшнл Фармасьютикал Лтд. | Слитные ферменты |
| WO2013123034A1 (en) * | 2012-02-16 | 2013-08-22 | Merck Sharp & Dohme Corp. | Methods for reducing mannosyltransferase activity in yeast |
| CN102586316B (zh) * | 2012-02-16 | 2013-08-07 | 中国科学院微生物研究所 | 人源糖基化改造的汉逊酵母 |
| CN102839157A (zh) * | 2012-07-12 | 2012-12-26 | 扬州大学 | 稳定共表达hST3GalIV和β1-4GalT1的MDCK细胞系及构建方法和应用 |
| JP6356229B2 (ja) * | 2013-06-04 | 2018-07-11 | アイコン ジェネティクス ゲーエムベーハー | 植物産生糖タンパク質及び組換え糖タンパク質のn−グリコシル化部位占有率を調節する方法 |
| PL3019621T3 (pl) * | 2013-07-10 | 2019-05-31 | Glykos Finland Oy | Wytwarzanie glikoprotein o zwiększonym zajmowaniu miejsca N-glikozylacji |
| BR112016017606A2 (pt) * | 2014-01-29 | 2017-10-10 | Amgen Inc | superexpressão de reguladores de via de n-glicosilação para modular a glicosilação de proteínas recombinantes |
| CA2954974A1 (en) | 2014-07-21 | 2016-01-28 | Glykos Finland Oy | Production of glycoproteins with mammalian-like n-glycans in filamentous fungi |
| CN105372214B (zh) * | 2014-08-18 | 2019-06-28 | 中国科学院上海有机化学研究所 | 一种鉴定新红细胞生成刺激蛋白的n-连接寡糖结构的方法 |
| CN104784754B (zh) * | 2015-03-04 | 2017-05-10 | 重庆市畜牧科学院 | 一种蚕丝人工血管及制备方法 |
| CN106867966B (zh) * | 2015-12-11 | 2020-11-24 | 复旦大学 | 稳定表达核心α(1,3)岩藻糖基转移酶的脊椎动物细胞系及其制备方法 |
| JP6757341B2 (ja) * | 2018-01-26 | 2020-09-16 | 東洋紡株式会社 | アスペルギルス属微生物が生産するタンパク質のn型糖鎖構造を改変する方法 |
| CN108179160B (zh) * | 2018-01-29 | 2021-05-11 | 江南大学 | 一种植烷醇连接的高甘露糖型寡糖的制备方法 |
| EP3788164A4 (en) * | 2018-05-01 | 2022-01-26 | Conagen Inc. | Recombinant organisms and methods for producing glycomolecules with high glycan occupancy |
| CN110687035A (zh) * | 2019-10-10 | 2020-01-14 | 沈阳万类生物科技有限公司 | Annexin V-Light 650凋亡检测试剂盒 |
| CN117377752A (zh) * | 2021-03-11 | 2024-01-09 | 二进国际(美国)有限公司 | 用于生产具有减少的或不含n-连接的糖基化的外源蛋白的遗传修饰的丝状真菌 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7507573B2 (en) * | 2003-11-14 | 2009-03-24 | Vib, Vzw | Modification of protein glycosylation in methylotrophic yeast |
| CA2573745A1 (en) * | 2004-07-21 | 2007-01-12 | Glycofi, Inc. | Immunoglobulins comprising predominantly a glcnac2man3glcnac2 glycoform |
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2009
- 2009-10-30 TW TW098136974A patent/TW201028431A/zh unknown
- 2009-10-31 WO PCT/EP2009/007816 patent/WO2010049177A1/en not_active Ceased
- 2009-10-31 AU AU2009309925A patent/AU2009309925A1/en not_active Abandoned
- 2009-10-31 JP JP2011533616A patent/JP2012506710A/ja not_active Withdrawn
- 2009-10-31 CA CA2741964A patent/CA2741964A1/en not_active Abandoned
- 2009-10-31 US US13/126,856 patent/US20110207214A1/en not_active Abandoned
- 2009-10-31 CN CN2009801439193A patent/CN102203123A/zh active Pending
- 2009-10-31 EP EP09744637A patent/EP2350123A1/en not_active Withdrawn
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2011
- 2011-04-28 IL IL212580A patent/IL212580A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2350123A1 (en) | 2011-08-03 |
| CN102203123A (zh) | 2011-09-28 |
| WO2010049177A1 (en) | 2010-05-06 |
| US20110207214A1 (en) | 2011-08-25 |
| JP2012506710A (ja) | 2012-03-22 |
| AU2009309925A1 (en) | 2010-05-06 |
| IL212580A0 (en) | 2011-07-31 |
| CA2741964A1 (en) | 2010-05-06 |
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