TW200904442A - Pyrrolopyrimidine derivatives - Google Patents
Pyrrolopyrimidine derivatives Download PDFInfo
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- TW200904442A TW200904442A TW097111869A TW97111869A TW200904442A TW 200904442 A TW200904442 A TW 200904442A TW 097111869 A TW097111869 A TW 097111869A TW 97111869 A TW97111869 A TW 97111869A TW 200904442 A TW200904442 A TW 200904442A
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- Prior art keywords
- alkyl
- group
- optionally substituted
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- 150000004944 pyrrolopyrimidines Chemical class 0.000 title abstract description 12
- 150000001875 compounds Chemical class 0.000 claims abstract description 325
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- -1 Cm alkane Oxyl group Chemical group 0.000 claims description 192
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 107
- 238000000034 method Methods 0.000 claims description 88
- 125000004432 carbon atom Chemical group C* 0.000 claims description 82
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- 229910052736 halogen Inorganic materials 0.000 claims description 56
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 54
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- 125000004434 sulfur atom Chemical group 0.000 claims description 48
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 41
- 125000005842 heteroatom Chemical group 0.000 claims description 40
- 201000010099 disease Diseases 0.000 claims description 39
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- 125000005843 halogen group Chemical group 0.000 claims description 30
- 125000002950 monocyclic group Chemical group 0.000 claims description 28
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Landscapes
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| TWI583681B (zh) * | 2014-08-21 | 2017-05-21 | 輝瑞大藥廠 | 胺基嘧啶基化合物 |
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| US7705004B2 (en) | 2007-08-17 | 2010-04-27 | Portola Pharmaceuticals, Inc. | Protein kinase inhibitors |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| MX2010011463A (es) | 2008-04-16 | 2011-06-03 | Portola Pharm Inc | 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas. |
| JP2011518219A (ja) * | 2008-04-22 | 2011-06-23 | ポートラ ファーマシューティカルズ， インコーポレイテッド | タンパク質キナーゼの阻害剤 |
| WO2010034740A1 (en) * | 2008-09-23 | 2010-04-01 | Palau Pharma, S.A. | (r)-3-(n,n-dimethylamino)pyrrolidine derivatives |
| JP5431495B2 (ja) | 2008-12-05 | 2014-03-05 | エフ．ホフマン−ラ ロシュ アーゲー | ピロロピラジニル尿素キナーゼ阻害薬 |
| CN102459267B (zh) * | 2009-06-08 | 2014-11-26 | 武田药品工业株式会社 | 用作jak抑制剂的二氢吡咯并萘啶酮化合物 |
| PL2493895T3 (pl) * | 2009-10-29 | 2017-10-31 | Vectura Ltd | Zawierające azot (N) heteroarylowe pochodne jako inhibitory kinazy JAK3 |
| TW201204732A (en) | 2010-07-09 | 2012-02-01 | Leo Pharma As | Novel homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof |
| MX2013001970A (es) * | 2010-08-20 | 2013-08-09 | Hutchison Medipharma Ltd | Compuestos de pirrolopirimidina y usos de los mismos. |
| WO2012030924A1 (en) * | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Azolopyridine and azolopyrimidine compounds and methods of use thereof |
| WO2012030912A1 (en) * | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | 7-cyclylquinazoline derivatives and methods of use thereof |
| SG11201402570QA (en) | 2011-11-23 | 2014-06-27 | Portola Pharm Inc | Pyrazine kinase inhibitors |
| WO2014013014A1 (en) | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Jak inhibitors for activation of epidermal stem cell populations |
| JP6321039B2 (ja) * | 2013-01-18 | 2018-05-09 | グアンヂョウ マキシノヴェル ファーマシューティカル カンパニー リミテッド | 五員かつ六員複素環式化合物並びにその製造方法、医薬品組成物及びその使用 |
| KR101657616B1 (ko) * | 2013-05-24 | 2016-09-19 | 주식회사유한양행 | 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법 |
| CN106458914B (zh) * | 2014-03-28 | 2020-01-14 | 常州捷凯医药科技有限公司 | 作为axl抑制剂的杂环化合物 |
| CN105315285B (zh) * | 2014-07-25 | 2017-12-08 | 上海海雁医药科技有限公司 | 2,4‑二取代7H‑吡咯并[2,3‑d]嘧啶衍生物、其制法与医药上的用途 |
| CN105732636B (zh) * | 2014-12-30 | 2020-04-21 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
| WO2016130920A2 (en) | 2015-02-13 | 2016-08-18 | Dana-Farber Cancer Institute, Inc. | Lrrk2 inhibitors and methods of making and using the same |
| CN104876934B (zh) * | 2015-05-12 | 2017-08-11 | 山东大学 | 一种含氮杂环苯基哌啶类化合物及其制备方法与应用 |
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| KR20250010141A (ko) | 2015-10-16 | 2025-01-20 | 애브비 인코포레이티드 | (3S,4R)-3-에틸-4-(3H-이미다조[1,2-a]피롤로[2,3-e]-피라진-8-일)-N-(2,2,2-트리플루오로에틸)피롤리딘-1-카복스아미드및 이의 고체상 형태의 제조 방법 |
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| US20220242870A1 (en) * | 2019-05-17 | 2022-08-04 | Voronoi Inc. | Heterocycle-fused pyrimidine derivative and use thereof |
| CN110183471B (zh) * | 2019-05-21 | 2022-02-15 | 江苏大学 | 一种哌嗪类衍生物及制备方法及应用 |
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| CN116528869A (zh) * | 2020-11-27 | 2023-08-01 | 安锐生物医药科技(广州)有限公司 | 氨基杂芳基激酶抑制剂 |
| WO2022117012A1 (zh) * | 2020-12-02 | 2022-06-09 | 百极弘烨（广东）医药科技有限公司 | 螺环jak抑制剂、含其的药物组合物及其应用 |
| WO2022216098A1 (ko) * | 2021-04-08 | 2022-10-13 | 주식회사 스탠다임 | 신규한 lrrk2 억제제 |
| US20250283174A1 (en) | 2022-05-16 | 2025-09-11 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stem cells induced by chronic inflammation |
| AU2023298142A1 (en) * | 2022-06-29 | 2025-01-09 | Alcon Inc. | Azetidinyl pyrimidines and uses thereof as jak inhibitors |
| CN118005609B (zh) * | 2022-11-09 | 2025-06-17 | 沈阳药科大学 | 2-氨基嘧啶类化合物及其用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW505646B (en) * | 1998-06-19 | 2002-10-11 | Pfizer Prod Inc | Pyrrolo [2,3-d] pyrimidine compounds |
| PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| RU2434871C2 (ru) * | 2005-02-03 | 2011-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Пирролопиримидины, применимые в качестве ингибиторов протеинкиназы |
| GB0526246D0 (en) * | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
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- 2008-03-31 KR KR1020097020666A patent/KR20100015353A/ko not_active Withdrawn
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- 2008-03-31 MX MX2009010595A patent/MX2009010595A/es not_active Application Discontinuation
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| TWI583681B (zh) * | 2014-08-21 | 2017-05-21 | 輝瑞大藥廠 | 胺基嘧啶基化合物 |
Also Published As
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| MX2009010595A (es) | 2009-10-22 |
| EP2142550A1 (en) | 2010-01-13 |
| CA2682646A1 (en) | 2008-10-09 |
| US20100113420A1 (en) | 2010-05-06 |
| IL201073A0 (en) | 2010-05-17 |
| AU2008234822A1 (en) | 2008-10-09 |
| WO2008119792A1 (en) | 2008-10-09 |
| CL2008000946A1 (es) | 2008-10-10 |
| PE20090996A1 (es) | 2009-07-15 |
| KR20100015353A (ko) | 2010-02-12 |
| US20110160185A9 (en) | 2011-06-30 |
| BRPI0809992A2 (pt) | 2014-10-14 |
| RU2009140319A (ru) | 2011-05-10 |
| CN101679440A (zh) | 2010-03-24 |
| JP2010523522A (ja) | 2010-07-15 |
| AR065901A1 (es) | 2009-07-08 |
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