TW200711660A - Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development - Google Patents
Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug developmentInfo
- Publication number
- TW200711660A TW200711660A TW095120699A TW95120699A TW200711660A TW 200711660 A TW200711660 A TW 200711660A TW 095120699 A TW095120699 A TW 095120699A TW 95120699 A TW95120699 A TW 95120699A TW 200711660 A TW200711660 A TW 200711660A
- Authority
- TW
- Taiwan
- Prior art keywords
- progression
- agents
- monitoring
- candidate
- clinical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68961205P | 2005-06-10 | 2005-06-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200711660A true TW200711660A (en) | 2007-04-01 |
Family
ID=37532890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW095120699A TW200711660A (en) | 2005-06-10 | 2006-06-09 | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
Country Status (8)
Country | Link |
---|---|
US (1) | US8741589B2 (zh) |
EP (1) | EP1907018B1 (zh) |
JP (1) | JP2008543787A (zh) |
AU (1) | AU2006257821A1 (zh) |
CA (1) | CA2611033A1 (zh) |
IL (1) | IL187859A0 (zh) |
TW (1) | TW200711660A (zh) |
WO (1) | WO2006135879A2 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111655298A (zh) * | 2017-11-21 | 2020-09-11 | 索尔维克斯有限公司 | 包含氘代3-o-甲基葡萄糖用于肿瘤疾病磁共振的诊断制剂以及使用所述制剂的诊断方法 |
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US7001587B2 (en) * | 2001-10-24 | 2006-02-21 | The Regents Of The University Of California | Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water |
AU2003217385B2 (en) | 2002-02-12 | 2008-09-11 | The Regents Of The University Of California | Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation |
WO2004011426A2 (en) | 2002-07-30 | 2004-02-05 | The Regents Of The University Of California | Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry |
DE20211783U1 (de) * | 2002-07-31 | 2002-11-07 | Fa. Hermann Heye i.Ins., 31683 Obernkirchen | Pressstempelmechanismus einer Glasformmaschine |
US20060105339A1 (en) * | 2002-09-04 | 2006-05-18 | Marc Hellerstein | Methods for measuring the rates of replication and death of microbial infectious agents in an infected |
DE60324950D1 (de) | 2002-09-13 | 2009-01-08 | Univ California | Verfahren zur messung der geschwindigkeiten des cholesterinrückwärtstransports in vivo als index für anti-artherogenese |
US20070248540A1 (en) * | 2002-09-16 | 2007-10-25 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
CA2504313C (en) | 2002-11-04 | 2012-01-17 | Marc K. Hellerstein | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
US7262020B2 (en) * | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
US20050202406A1 (en) * | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
CA2559095A1 (en) * | 2004-03-11 | 2005-09-22 | The Regents Of The University Of California | Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients |
US20050238577A1 (en) * | 2004-03-29 | 2005-10-27 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
JP4118918B2 (ja) * | 2005-02-28 | 2008-07-16 | シャープ株式会社 | 信号品質評価装置、情報記録再生装置、信号品質評価方法、記録条件決定方法、信号品質評価プログラム、信号品質評価プログラムを記録したコンピュータ読み取り可能な記録媒体 |
US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
TW200711660A (en) | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
US10646594B2 (en) * | 2009-06-19 | 2020-05-12 | Case Western Reserve University | Deuterated metabolic water precursor for detecting and treating diseased tissue |
WO2012147978A1 (ja) * | 2011-04-28 | 2012-11-01 | 株式会社アウレオサイエンス | 安定同位体2Hおよび/または安定同位体13Cで標識されたβ-1,3-1,6グルカン、これを用いたプローブ、ならびにその製造方法 |
JP2014526685A (ja) | 2011-09-08 | 2014-10-06 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 代謝流量測定、画像化、および顕微鏡法 |
ES2668678T3 (es) | 2011-12-07 | 2018-05-21 | Glaxosmithkline Llc | Procedimiento de determinación de la masa muscular esquelética corporal total |
EP2817621A4 (en) * | 2012-02-21 | 2016-02-24 | Univ Northwestern | DETECTION OF ANTI-MULLERIAN HORMONE IN WHOLE BLOOD |
WO2014030650A1 (ja) | 2012-08-20 | 2014-02-27 | 大塚製薬株式会社 | 糖代謝能の測定方法及びそれに使用する組成物 |
US9134319B2 (en) | 2013-03-15 | 2015-09-15 | The Regents Of The University Of California | Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo |
KR20150132301A (ko) | 2013-03-15 | 2015-11-25 | 오츠카 세이야쿠 가부시키가이샤 | 지방산 연소에 의한 인슐린 저항성의 측정 방법, 및 그에 사용하는 조성물 |
RU2613272C1 (ru) * | 2015-10-07 | 2017-03-15 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский институт акушерства и педиатрии" Министерства здравоохранения Российской Федерации | Способ определения компенсации сахарного диабета 1 типа у подростков |
CN108827750B (zh) * | 2018-07-27 | 2020-10-09 | 西北核技术研究所 | 一种同位素稀释定量检测方法 |
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JP5116662B2 (ja) | 2005-04-06 | 2013-01-09 | ワシントン ユニバーシティ イン セント ルイス | インビボにおける神経系由来生体分子の代謝測定方法 |
US20060251576A1 (en) | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
TW200711660A (en) | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
-
2006
- 2006-06-09 TW TW095120699A patent/TW200711660A/zh unknown
- 2006-06-12 WO PCT/US2006/022915 patent/WO2006135879A2/en active Application Filing
- 2006-06-12 CA CA002611033A patent/CA2611033A1/en not_active Abandoned
- 2006-06-12 EP EP06784805.1A patent/EP1907018B1/en not_active Not-in-force
- 2006-06-12 AU AU2006257821A patent/AU2006257821A1/en not_active Abandoned
- 2006-06-12 US US11/451,735 patent/US8741589B2/en not_active Expired - Fee Related
- 2006-06-12 JP JP2008516033A patent/JP2008543787A/ja not_active Withdrawn
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2007
- 2007-12-03 IL IL187859A patent/IL187859A0/en unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111655298A (zh) * | 2017-11-21 | 2020-09-11 | 索尔维克斯有限公司 | 包含氘代3-o-甲基葡萄糖用于肿瘤疾病磁共振的诊断制剂以及使用所述制剂的诊断方法 |
CN111655298B (zh) * | 2017-11-21 | 2023-02-03 | 索尔维克斯有限公司 | 包含氘代3-o-甲基葡萄糖用于肿瘤疾病磁共振的诊断制剂以及使用所述制剂的诊断方法 |
Also Published As
Publication number | Publication date |
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CA2611033A1 (en) | 2006-12-21 |
US8741589B2 (en) | 2014-06-03 |
WO2006135879A3 (en) | 2007-10-04 |
JP2008543787A (ja) | 2008-12-04 |
AU2006257821A1 (en) | 2006-12-21 |
EP1907018B1 (en) | 2014-04-02 |
US20060280682A1 (en) | 2006-12-14 |
EP1907018A2 (en) | 2008-04-09 |
EP1907018A4 (en) | 2011-04-20 |
WO2006135879A2 (en) | 2006-12-21 |
IL187859A0 (en) | 2008-03-20 |
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