TW200524603A - 2-amino-pyridine derivatives useful for the treatment of diseases - Google Patents

Info

Publication number

TW200524603A

TW200524603A TW093115990A TW93115990A TW200524603A TW 200524603 A TW200524603 A TW 200524603A TW 093115990 A TW093115990 A TW 093115990A TW 93115990 A TW93115990 A TW 93115990A TW 200524603 A TW200524603 A TW 200524603A

Authority

TW

Taiwan

Prior art keywords

propyl

amino

phenyl

methyl

hydroxy

Prior art date

2003-06-04

Links

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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 36
• 201000010099 disease Diseases 0.000 title claims abstract description 24
• 238000011282 treatment Methods 0.000 title claims description 27
• 150000003930 2-aminopyridines Chemical class 0.000 title claims description 7
• 150000001875 compounds Chemical class 0.000 claims abstract description 290
• 238000000034 method Methods 0.000 claims abstract description 106
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• 208000027866 inflammatory disease Diseases 0.000 claims abstract description 3
• -1 hydroxy Chemical group 0.000 claims description 387
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 226
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 170
• 150000001412 amines Chemical class 0.000 claims description 79
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 74
• 125000000217 alkyl group Chemical group 0.000 claims description 58
• 239000002253 acid Substances 0.000 claims description 54
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 51
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 44
• 150000003839 salts Chemical class 0.000 claims description 43
• HFACYLZERDEVSX-UHFFFAOYSA-N benzidine Chemical compound C1=CC(N)=CC=C1C1=CC=C(N)C=C1 HFACYLZERDEVSX-UHFFFAOYSA-N 0.000 claims description 41
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• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 35
• ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 claims description 33
• 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 31
• UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 30
• QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims description 29
• 206010006451 bronchitis Diseases 0.000 claims description 27
• 229940067157 phenylhydrazine Drugs 0.000 claims description 23
• 125000003277 amino group Chemical group 0.000 claims description 20
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 20
• GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims description 19
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• 230000000694 effects Effects 0.000 claims description 19
• PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims description 18
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• ZENKESXKWBIZCV-UHFFFAOYSA-N 2,2,4,4-tetrafluoro-1,3-benzodioxin-6-amine Chemical group O1C(F)(F)OC(F)(F)C2=CC(N)=CC=C21 ZENKESXKWBIZCV-UHFFFAOYSA-N 0.000 claims description 16
• OQLZINXFSUDMHM-UHFFFAOYSA-N Acetamidine Chemical compound CC(N)=N OQLZINXFSUDMHM-UHFFFAOYSA-N 0.000 claims description 16
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• VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 claims description 5
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• PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical compound NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 claims description 4
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