TW200517374A - Cyclohexanecarboxylic acids - Google Patents
Cyclohexanecarboxylic acidsInfo
- Publication number
- TW200517374A TW200517374A TW093122176A TW93122176A TW200517374A TW 200517374 A TW200517374 A TW 200517374A TW 093122176 A TW093122176 A TW 093122176A TW 93122176 A TW93122176 A TW 93122176A TW 200517374 A TW200517374 A TW 200517374A
- Authority
- TW
- Taiwan
- Prior art keywords
- cyclohexanecarboxylic acids
- pyrrolidinylmethoxy
- indolylcarbonyl
- cyclohexanecarboxylate
- vla
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003201062 | 2003-07-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
TW200517374A true TW200517374A (en) | 2005-06-01 |
TWI340134B TWI340134B (en) | 2011-04-11 |
Family
ID=34100472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW093122176A TWI340134B (en) | 2003-07-24 | 2004-07-23 | Cyclohexanecarboxylic acids |
Country Status (13)
Country | Link |
---|---|
US (2) | US7691894B2 (zh) |
EP (1) | EP1650205B1 (zh) |
JP (1) | JP4676884B2 (zh) |
KR (1) | KR101051842B1 (zh) |
CN (1) | CN1826336B (zh) |
AT (1) | ATE555106T1 (zh) |
CA (2) | CA2528586A1 (zh) |
ES (1) | ES2382806T3 (zh) |
HK (1) | HK1091484A1 (zh) |
IL (1) | IL172443A0 (zh) |
MX (1) | MXPA06000850A (zh) |
TW (1) | TWI340134B (zh) |
WO (1) | WO2005009992A1 (zh) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7691894B2 (en) * | 2003-07-24 | 2010-04-06 | Daiichi Pharmaceutical Co., Ltd. | Cyclohexanecarboxylic acid compound |
US8129366B2 (en) | 2005-12-13 | 2012-03-06 | Daiichi Sankyo Company, Limited | VLA-4 inhibitory drug |
US20090177254A1 (en) * | 2007-08-17 | 2009-07-09 | Searete Llc, A Limited Liability Of The State Of The State Of Delaware | System, devices, and methods including actively-controllable electrostatic and electromagnetic sterilizing excitation delivery system |
US8647292B2 (en) * | 2007-08-17 | 2014-02-11 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having components that are actively controllable between two or more wettability states |
US8702640B2 (en) * | 2007-08-17 | 2014-04-22 | The Invention Science Fund I, Llc | System, devices, and methods including catheters configured to monitor and inhibit biofilm formation |
US8162924B2 (en) | 2007-08-17 | 2012-04-24 | The Invention Science Fund I, Llc | System, devices, and methods including actively-controllable superoxide water generating systems |
US8366652B2 (en) | 2007-08-17 | 2013-02-05 | The Invention Science Fund I, Llc | Systems, devices, and methods including infection-fighting and monitoring shunts |
US8706211B2 (en) * | 2007-08-17 | 2014-04-22 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having self-cleaning surfaces |
US20090163964A1 (en) * | 2007-08-17 | 2009-06-25 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System, devices, and methods including sterilizing excitation delivery implants with general controllers and onboard power |
US8753304B2 (en) * | 2007-08-17 | 2014-06-17 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having acoustically actuatable waveguide components for delivering a sterilizing stimulus to a region proximate a surface of the catheter |
US20110160644A1 (en) * | 2007-08-17 | 2011-06-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including catheters configured to release ultraviolet energy absorbing agents |
US20090048648A1 (en) * | 2007-08-17 | 2009-02-19 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Self-sterilizing device |
US8460229B2 (en) | 2007-08-17 | 2013-06-11 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having components that are actively controllable between transmissive and reflective states |
US20090163977A1 (en) * | 2007-08-17 | 2009-06-25 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System, devices, and methods including sterilizing excitation delivery implants with cryptographic logic components |
US8734718B2 (en) * | 2007-08-17 | 2014-05-27 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component |
US20110295088A1 (en) | 2008-12-04 | 2011-12-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including implantable devices with anti-microbial properties |
EP2384168B1 (en) * | 2008-12-04 | 2014-10-08 | Searete LLC | Actively-controllable sterilizing excitation delivery implants |
US8585627B2 (en) * | 2008-12-04 | 2013-11-19 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters configured to monitor biofilm formation having biofilm spectral information configured as a data structure |
US20110152751A1 (en) * | 2008-12-04 | 2011-06-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including catheters having UV-Energy emitting coatings |
EP3873884A1 (en) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Quinoline derivatives as alpha4beta7 integrin inhibitors |
KR102641718B1 (ko) | 2018-10-30 | 2024-02-29 | 길리애드 사이언시즈, 인코포레이티드 | 알파4베타7 인테그린 억제제로서의 이미다조피리딘 유도체 |
WO2020092401A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN |
JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4ベータ7インテグリンの阻害のための化合物 |
KR20220047323A (ko) | 2019-08-14 | 2022-04-15 | 길리애드 사이언시즈, 인코포레이티드 | 알파 4 베타 7 인테그린의 저해용 화합물 |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
DE2500157C2 (de) | 1975-01-03 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung |
DE2706977A1 (de) * | 1977-02-18 | 1978-08-24 | Hoechst Ag | Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung |
DE3063878D1 (en) | 1979-07-13 | 1983-07-28 | Thomae Gmbh Dr K | Derivatives of carboxylic acids, their preparation and medicaments containing them |
JPS60181081A (ja) | 1984-02-29 | 1985-09-14 | Kaken Pharmaceut Co Ltd | 新規ビスベンゾフラニルケトン誘導体 |
JPH04112868A (ja) | 1990-09-03 | 1992-04-14 | Otsuka Pharmaceut Co Ltd | 置換ヘテロ環を有するフェニルカルボン酸誘導体 |
JPH0543574A (ja) | 1991-08-13 | 1993-02-23 | Wakamoto Pharmaceut Co Ltd | ヘテロ環置換テトラゾール−1−酢酸誘導体 |
FR2694295B1 (fr) | 1992-07-28 | 1994-09-02 | Adir | Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent. |
ES2103181B1 (es) | 1994-08-01 | 1998-04-01 | Menarini Lab | Amidas naftalenicas con accion antagonista de los leucotrienos. |
GB9408936D0 (en) | 1994-05-05 | 1994-06-22 | Cancer Res Inst | Anti-cancer compounds |
US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
EP0835104A4 (en) | 1995-06-30 | 1999-10-20 | Smithkline Beecham Corp | USE OF STAT 5 SH2 DOMAINE SPECIFIC COMPOUNDS TO PROMOTE ERYTHROPOSIS |
US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
DE69736669T2 (de) | 1996-07-25 | 2007-09-13 | Biogen Idec Ma Inc., Cambridge | Zelladhäsionsinhibitoren |
WO1998008818A1 (en) | 1996-08-26 | 1998-03-05 | Genetics Institute, Inc. | Inhibitors of phospholipase enzymes |
DE19647381A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Ag | Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
AU739035B2 (en) | 1996-11-22 | 2001-10-04 | Elan Pharmaceuticals, Inc. | N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds |
US6117901A (en) * | 1996-11-22 | 2000-09-12 | Athena Neurosciences, Inc. | N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for use |
CA2316235A1 (en) | 1997-12-23 | 1999-07-08 | Aventis Pharma Limited | Substituted .beta.-alanines |
IL137540A0 (en) | 1998-02-25 | 2001-07-24 | Genetics Inst | Inhibitors of phospholipase a2 |
YU75500A (sh) | 1998-05-28 | 2002-12-10 | Biogen Inc. | NOVI VLA-4 INHIBITORI oMePUPA-V |
WO1999064392A1 (fr) | 1998-06-08 | 1999-12-16 | Ajinomoto Co., Inc. | Derive de benzamidine |
DE69928667T2 (de) | 1998-06-30 | 2006-08-10 | Pfizer Products Inc., Groton | Nicht-peptidische Inhibitoren von VLA-4-abhängiger Zellbindung für die Behandlung von entzündlichen, autoimmun-und respiratorischen Krankheiten und Atemstörungen |
AU5052199A (en) | 1998-07-23 | 2000-02-14 | Astrazeneca Ab | Chemical compounds |
GB9916374D0 (en) | 1998-07-23 | 1999-09-15 | Zeneca Ltd | Chemical compounds |
NZ509781A (en) | 1998-08-26 | 2003-05-30 | Aventis Pharma Ltd | Quinoline or indolyl derivativees useful for modulating the inhibition of cell adhesion |
GB9821199D0 (en) | 1998-09-30 | 1998-11-25 | Glaxo Group Ltd | Chemical compounds |
US6429132B1 (en) | 1998-12-23 | 2002-08-06 | Aurora Systems, Inc. | Combination CMP-etch method for forming a thin planar layer over the surface of a device |
US6207700B1 (en) | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
DK1153017T3 (da) | 1999-02-16 | 2006-07-17 | Aventis Pharma Ltd | Bicykliske forbindelser og deres anvendelse som integrinreceptorligander |
JP2000344666A (ja) | 1999-04-01 | 2000-12-12 | Sankyo Co Ltd | 糖及び脂質代謝改善剤 |
CN1350534A (zh) | 1999-04-12 | 2002-05-22 | 阿文蒂斯药物有限公司 | 作为整联蛋白拮抗剂的取代双环杂芳基化合物 |
ES2321055T3 (es) | 1999-05-05 | 2009-06-02 | Aventis Pharma Limited | Compuestos biblicos sustituidos. |
AU769652B2 (en) | 1999-05-05 | 2004-01-29 | Cubist Pharmaceuticals, Inc. | Novel prolines as antimicrobial agents |
WO2000068195A2 (en) | 1999-05-05 | 2000-11-16 | Aventis Pharma Limited | Substituted pyrrolidines as cell adhesion inhibitors |
MXPA01013406A (es) | 1999-06-30 | 2003-09-04 | Daiichi Seiyaku Co | Compuestos inhibidores de vla-4. |
KR100720907B1 (ko) | 1999-08-13 | 2007-05-25 | 바이오겐 아이덱 엠에이 인코포레이티드 | 세포 유착 억제제 |
EP1263726B1 (en) | 1999-11-10 | 2007-09-26 | Sanofi-Aventis Deutschland GmbH | N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor xa |
HUP0203897A3 (en) | 1999-12-28 | 2005-06-28 | Pfizer Prod Inc | Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
GB0001346D0 (en) | 2000-01-21 | 2000-03-08 | Astrazeneca Uk Ltd | Chemical compounds |
DE10006453A1 (de) | 2000-02-14 | 2001-08-16 | Bayer Ag | Piperidylcarbonsäuren als Integrinantagonisten |
GB0004686D0 (en) | 2000-02-28 | 2000-04-19 | Aventis Pharma Ltd | Chemical compounds |
WO2001064640A1 (en) | 2000-03-01 | 2001-09-07 | Aventis Pharma Limited | 2,3-dihydro-1h-indolinyl-alkanoic acids as cell adhesion inhibitors |
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
EP1303485A1 (en) | 2000-07-19 | 2003-04-23 | F. Hoffmann-La Roche Ag | Pyrrolidine derivatives as inhibitors of endothelin-converting enzyme |
ATE524441T1 (de) * | 2000-12-28 | 2011-09-15 | Daiichi Seiyaku Co | Vla-4-inhibitoren |
GB2377933A (en) | 2001-07-06 | 2003-01-29 | Bayer Ag | Succinic acid derivatives useful as integrin antagonists |
WO2004099136A1 (ja) * | 2003-05-09 | 2004-11-18 | Daiichi Pharmaceutical Co., Ltd. | ピロリジン誘導体の製造方法 |
US7691894B2 (en) * | 2003-07-24 | 2010-04-06 | Daiichi Pharmaceutical Co., Ltd. | Cyclohexanecarboxylic acid compound |
-
2004
- 2004-07-23 US US10/562,122 patent/US7691894B2/en not_active Expired - Fee Related
- 2004-07-23 EP EP04747846A patent/EP1650205B1/en not_active Not-in-force
- 2004-07-23 WO PCT/JP2004/010457 patent/WO2005009992A1/ja active Application Filing
- 2004-07-23 KR KR1020067001503A patent/KR101051842B1/ko not_active IP Right Cessation
- 2004-07-23 MX MXPA06000850A patent/MXPA06000850A/es unknown
- 2004-07-23 AT AT04747846T patent/ATE555106T1/de active
- 2004-07-23 CA CA002528586A patent/CA2528586A1/en not_active Abandoned
- 2004-07-23 JP JP2005512024A patent/JP4676884B2/ja not_active Expired - Fee Related
- 2004-07-23 CN CN2004800212300A patent/CN1826336B/zh not_active Expired - Fee Related
- 2004-07-23 CA CA2770493A patent/CA2770493A1/en not_active Abandoned
- 2004-07-23 ES ES04747846T patent/ES2382806T3/es active Active
- 2004-07-23 TW TW093122176A patent/TWI340134B/zh not_active IP Right Cessation
-
2005
- 2005-12-07 IL IL172443A patent/IL172443A0/en unknown
-
2006
- 2006-11-01 HK HK06112004.3A patent/HK1091484A1/xx unknown
-
2009
- 2009-10-07 US US12/574,907 patent/US7893279B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1650205A4 (en) | 2010-04-28 |
CA2770493A1 (en) | 2005-02-03 |
JP4676884B2 (ja) | 2011-04-27 |
MXPA06000850A (es) | 2006-03-30 |
EP1650205B1 (en) | 2012-04-25 |
TWI340134B (en) | 2011-04-11 |
HK1091484A1 (en) | 2007-01-19 |
US20070105936A1 (en) | 2007-05-10 |
WO2005009992A1 (ja) | 2005-02-03 |
CN1826336B (zh) | 2010-06-02 |
EP1650205A1 (en) | 2006-04-26 |
KR20060037394A (ko) | 2006-05-03 |
IL172443A0 (en) | 2006-04-10 |
JPWO2005009992A1 (ja) | 2006-09-07 |
US7893279B2 (en) | 2011-02-22 |
ATE555106T1 (de) | 2012-05-15 |
US7691894B2 (en) | 2010-04-06 |
CA2528586A1 (en) | 2005-02-03 |
CN1826336A (zh) | 2006-08-30 |
ES2382806T3 (es) | 2012-06-13 |
KR101051842B1 (ko) | 2011-07-25 |
US20100022783A1 (en) | 2010-01-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL172443A0 (en) | Cyclohexanecarboxylic acid compound | |
YU41801A (sh) | Derivati fenilglicina | |
RS93604A (en) | Substituted phenylacetamides and their use as glucokinase activators | |
RS51444B (sr) | JEDINJENJA KOJA SADRŽE LAKTAM I NJIHOVI DERIVATI KAO INHIBITORI FAKTORA Xa | |
NO20035603D0 (no) | Fluorpyrrolidiner som dipeptidyl peptidase inhibitorer | |
ES2291311T3 (es) | 3-cianoquinolinas, 3-ciano-1,6-naftiridinas y 3-ciano-1,7-naftiridinas como inhibidores de proteina quinasas. | |
MXPA06000725A (es) | Sal de acido (2s-4s)-4 -fluoro-1 -[4-fluoro- beta-(4- fluorofenil) -l-fenilalanil] -2-pirrolidincarbonitril p-toluenosulfonico y formas cristalinas anhidras del mismo. | |
BR0307529A (pt) | Derivados de n-fenil-2-pirimidina-amina | |
RS52283B (sr) | 3-z-[1-(4-(n-((4-metil-piperazin-1-il)-metilkarbonil)-n- metil-amino)-anilino)-1-fenil-metilen]-6-metoksikarbonil-2- indolinon-monoetansulfonat i njegova primena u farmaceutskoj kompoziciji | |
NO990405L (no) | Substituerte N-(indol-2-karbonyl)-glycinamider og derivater som antidiabetiske midler | |
GB0124627D0 (en) | Novel compounds | |
MXPA03009604A (es) | Compuestos de espiropirazol. | |
MXPA03009548A (es) | Arilsulfonamidas como agentes antivirales. | |
JO2369B1 (en) | New cyclohexyl sulfonate | |
HK1080077A1 (zh) | 非肽的brs-3激動劑 | |
IL146543A0 (en) | Inhibitors of metalloproteinases | |
BR0311267A (pt) | Sìntese de pirazóis | |
GEP20074257B (en) | Novel method for the synthesis of s-indoline-2-carboxylic acid and application thereof in the synthesis of perindopril | |
MXPA03008248A (es) | Agentes colorantes para fibras de queratina que contienen derivados de n-heteroarilmetil-m-fenilendiamina, asi como nuevos derivados de n-heteroarilmetil-m-fenilendiamina. | |
CY1106738T1 (el) | Διεργασια και ενδιαμεσα για την παρασκευη αναστολεων ρετροϊικης πρωτεασης | |
RS52014B (sr) | Nova so benzoilgvanidina | |
EA200400393A1 (ru) | Антитела против каспазы-8, их получение и применение | |
GB0113920D0 (en) | Composition | |
MXPA04003477A (es) | Sintesis de 4-(piperidil)-(2-piridil)metanona-(e)-o-metiloxima y sales. | |
DK1223350T3 (da) | Klemholder til pladeformede elementer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Annulment or lapse of patent due to non-payment of fees |