TR201900227T4 - İnsan tümör nekroz faktörü alfa için özgünlüğü olan antikor molekülleri ve bunların kullanımı. - Google Patents

İnsan tümör nekroz faktörü alfa için özgünlüğü olan antikor molekülleri ve bunların kullanımı. Download PDF

Info

Publication number
TR201900227T4
TR201900227T4 TR2019/00227T TR201900227T TR201900227T4 TR 201900227 T4 TR201900227 T4 TR 201900227T4 TR 2019/00227 T TR2019/00227 T TR 2019/00227T TR 201900227 T TR201900227 T TR 201900227T TR 201900227 T4 TR201900227 T4 TR 201900227T4
Authority
TR
Turkey
Prior art keywords
specificity
necrosis factor
tumor necrosis
antibody molecules
human tumor
Prior art date
Application number
TR2019/00227T
Other languages
English (en)
Turkish (tr)
Inventor
Singh Athwal Diljeet
Thomas Brown Derek
Neil Charles Weir Andrew
George Popplewell Andrew
Paul Chapman Andrew
John King David
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9893121&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR201900227(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Publication of TR201900227T4 publication Critical patent/TR201900227T4/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compression Of Band Width Or Redundancy In Fax (AREA)
TR2019/00227T 2000-06-06 2001-06-05 İnsan tümör nekroz faktörü alfa için özgünlüğü olan antikor molekülleri ve bunların kullanımı. TR201900227T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0013810.7A GB0013810D0 (en) 2000-06-06 2000-06-06 Biological products

Publications (1)

Publication Number Publication Date
TR201900227T4 true TR201900227T4 (tr) 2019-02-21

Family

ID=9893121

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/00227T TR201900227T4 (tr) 2000-06-06 2001-06-05 İnsan tümör nekroz faktörü alfa için özgünlüğü olan antikor molekülleri ve bunların kullanımı.

Country Status (42)

Country Link
US (4) US7012135B2 (enExample)
EP (4) EP2230308B1 (enExample)
JP (3) JP4064812B2 (enExample)
KR (1) KR20020047097A (enExample)
CN (1) CN1289671C (enExample)
AP (1) AP2092A (enExample)
AR (1) AR033978A1 (enExample)
AT (1) ATE451460T1 (enExample)
AU (1) AU783756B2 (enExample)
BE (1) BE2010C019I2 (enExample)
BG (1) BG66072B1 (enExample)
BR (2) BR0106682A (enExample)
CA (2) CA2707766C (enExample)
CY (6) CY1109889T1 (enExample)
CZ (1) CZ300737B6 (enExample)
DE (3) DE10192353T1 (enExample)
DK (4) DK2230308T3 (enExample)
EC (1) ECSP024210A (enExample)
ES (5) ES2403217T3 (enExample)
FR (1) FR10C0015I2 (enExample)
GB (2) GB0013810D0 (enExample)
HU (4) HU230553B1 (enExample)
IL (3) IL147992A0 (enExample)
IS (2) IS2808B (enExample)
LT (1) LT2308975T (enExample)
LU (1) LU91674I2 (enExample)
MX (1) MXPA01013440A (enExample)
MY (1) MY136603A (enExample)
NL (1) NL300982I9 (enExample)
NO (4) NO334808B1 (enExample)
NZ (1) NZ516596A (enExample)
OA (1) OA12282A (enExample)
PE (1) PE20020292A1 (enExample)
PL (2) PL212738B1 (enExample)
PT (4) PT2230308E (enExample)
RU (1) RU2303604C2 (enExample)
SI (3) SI2308975T1 (enExample)
SK (1) SK288343B6 (enExample)
TR (1) TR201900227T4 (enExample)
TW (2) TWI316088B (enExample)
WO (1) WO2001094585A1 (enExample)
ZA (1) ZA200200097B (enExample)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
CA2385745C (en) 2001-06-08 2015-02-17 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
US20060073141A1 (en) * 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
GB0129105D0 (en) * 2001-12-05 2002-01-23 Celltech R&D Ltd Expression control using variable intergenic sequences
DK1495056T3 (da) * 2002-03-20 2011-05-02 Ucb Pharma Sa Fremgangsmåde til analyse af antistofdisulfidisomere
US20040009172A1 (en) * 2002-04-26 2004-01-15 Steven Fischkoff Use of anti-TNFalpha antibodies and another drug
PT2371392E (pt) 2002-05-02 2015-10-07 Wyeth Holdings Llc Conjugados de derivado da caliqueamicina - transportador
GB0210121D0 (en) * 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
WO2003099226A2 (en) * 2002-05-28 2003-12-04 Celltech R & D Limited Antibody peg positional isomers, compositions comprising same, and use thereof
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
US20040151722A1 (en) * 2002-07-19 2004-08-05 Abbott Biotechnology Ltd. Treatment of metabolic disorders using TNFalpha inhibitors
AU2003276844A1 (en) * 2002-08-28 2004-03-19 Pharmacia Corporation Formulations of modified antibodies and methods of making the same
US20040091490A1 (en) * 2002-08-28 2004-05-13 Robert Johnson Stable pH optimized formulation of a modified antibody
US20040105858A1 (en) * 2002-08-29 2004-06-03 Kim Joanne Young Hee Kwak Diagnosis and treatment of infertility
MY150740A (en) 2002-10-24 2014-02-28 Abbvie Biotechnology Ltd Low dose methods for treating disorders in which tnf? activity is detrimental
AU2003277828B2 (en) 2002-10-29 2009-06-04 Anaphore, Inc. Trimeric binding proteins for trimeric cytokines
US7285269B2 (en) 2002-12-02 2007-10-23 Amgen Fremont, Inc. Antibodies directed to tumor necrosis factor
US7101978B2 (en) 2003-01-08 2006-09-05 Applied Molecular Evolution TNF-α binding molecules
US7575893B2 (en) * 2003-01-23 2009-08-18 Genentech, Inc. Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
GB0303337D0 (en) * 2003-02-13 2003-03-19 Celltech R&D Ltd Biological products
MXPA05008785A (es) * 2003-02-19 2005-10-18 Pharmacia Corp Esteres de polietilen glicol activados.
WO2004098578A2 (en) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprising a pde4 inhibitor and a tnf-alfa antagonist selected from infliximab, adalimumab, cdp870 and cdp517
EP1639011B1 (en) * 2003-06-30 2008-11-12 Domantis Limited Pegylated single domain antibodies (dAb)
WO2005014649A2 (en) * 2003-08-08 2005-02-17 Pharmacia Corporation Method for the preparation of molecules having antibody activity
WO2005017174A2 (en) * 2003-08-13 2005-02-24 Sandoz Ag Process for the purification of recombinant polypeptides
DE602004004796T2 (de) * 2003-08-13 2007-12-06 Sandoz Ag Expressionsvektoren, transformierte wirtszellen und fermentationsverfahren zur herstellung rekombinanter polypeptide
GB0319601D0 (en) * 2003-08-20 2003-09-24 Sandoz Ag Production process
KR100570422B1 (ko) * 2003-10-16 2006-04-11 한미약품 주식회사 대장균 분비서열을 이용하여 항체 단편을 분비·생산하는 발현벡터 및 이를 이용하여 항체 단편을 대량 생산하는 방법
CN100393748C (zh) * 2003-11-06 2008-06-11 上海中信国健药业有限公司 全人源肿瘤坏死因子抗体，其制备方法以及药物组合物
KR100772800B1 (ko) * 2003-11-17 2007-11-01 주식회사유한양행 인간 종양괴사인자 α를 인식하는 단일클론항체의가변영역 및 이를 코딩하는 유전자
US7435799B2 (en) 2004-01-08 2008-10-14 Applied Molecular Evolution TNF-α binding molecules
CN100427504C (zh) * 2004-06-02 2008-10-22 北京天广实生物技术有限公司 TNFα高亲和力嵌合抗体及其用途
JP2008504356A (ja) * 2004-06-30 2008-02-14 ドマンティス リミテッド 炎症性疾患を治療するための組成物及び方法
GB0425972D0 (en) * 2004-11-25 2004-12-29 Celltech R&D Ltd Biological products
US8022040B2 (en) * 2004-11-29 2011-09-20 The Regents Of The University Of California Hydroxyapatite-binding peptides for bone growth and inhibition
KR100971497B1 (ko) * 2004-12-29 2010-07-21 주식회사유한양행 인간 종양괴사인자-알파에 특이적으로 결합하는 인간화항체
AU2006246721B2 (en) 2005-05-16 2012-12-13 Abbvie Biotechnology Ltd Use of TNF inhibitor for treatment of erosive polyarthritis
EP1888644A1 (en) * 2005-06-01 2008-02-20 Micromet AG Anti-il2 antibodies
BRPI0611765B1 (pt) 2005-06-07 2022-09-27 Esbatech Ag Anticorpo ou fragmento de anticorpo estável e solúvel que se liga especificamente ao tnf-alfa seus usos e composição diagnóstica ou terapêutica
GB0520169D0 (en) 2005-10-04 2005-11-09 Celltech R&D Ltd Biological products
US9101670B2 (en) 2006-04-07 2015-08-11 Nektar Therapeutics Conjugates of an anti-TNF-α antibody
EP2010214A4 (en) 2006-04-10 2010-06-16 Abbott Biotech Ltd USES AND COMPOSITIONS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
WO2008063213A2 (en) * 2006-04-10 2008-05-29 Abbott Biotechnology Ltd. Uses and compositions for treatment of psoriatic arthritis
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
US20080131374A1 (en) * 2006-04-19 2008-06-05 Medich John R Uses and compositions for treatment of rheumatoid arthritis
AU2007269714A1 (en) 2006-07-03 2008-01-10 Charles David Adair Composition for modulating the expression of cell adhesion molecules
EP1914242A1 (en) * 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
ATE476176T1 (de) * 2007-03-02 2010-08-15 Farnam Co Inc Wachsähnliches material enthaltende tabletten mit verzögerter freisetzung
CA2690858A1 (en) * 2007-06-07 2008-12-18 Surmodics Pharmaceuticals, Inc. Reduced-mass, long-acting dosage forms
WO2008154543A2 (en) 2007-06-11 2008-12-18 Abbott Biotechnology Ltd. Methods for treating juvenile idiopathic arthritis
EP2185188B1 (en) * 2007-08-22 2014-08-06 Medarex, L.L.C. Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions
AU2009212079B2 (en) * 2008-02-05 2012-08-30 Delenex Therapeutics Ag Antigen-binding polypeptides against cartilage degeneration
JP5766598B2 (ja) * 2008-05-07 2015-08-19 アーゴス セラピューティクス インコーポレイテッド ヒトインターフェロン−αに対するヒト化抗体
JP5956752B2 (ja) 2008-06-25 2016-07-27 エスバテック − ア ノバルティス カンパニー エルエルシー Ｖｅｇｆを阻害する安定かつ可溶性の抗体
ES2861592T3 (es) * 2008-06-25 2021-10-06 Novartis Ag Anticuerpos estables y solubles que inhiben el TNF
PL3628686T3 (pl) 2008-06-25 2022-02-28 Novartis Ag Humanizowanie przeciwciał króliczych z zastosowaniem uniwersalnego zrębu przeciwciała
KR101882352B1 (ko) 2008-06-25 2018-07-26 에스바테크 - 어 노바티스 컴파니 엘엘씨 보편적 항체 프레임워크를 사용한 래빗 항체의 인간화
CN101684156B (zh) * 2008-09-27 2011-12-28 苏州工业园区晨健抗体组药物开发有限公司 人TNFα单克隆抗体、其PEG化纳米颗粒及其应用
US20110165063A1 (en) * 2009-01-29 2011-07-07 Abbott Laboratories Il-1 binding proteins
AU2010208637A1 (en) * 2009-01-29 2011-08-04 Abbvie Inc. IL-1 binding proteins
ES2804450T3 (es) 2009-07-10 2021-02-08 Ablynx Nv Método para la producción de dominios variables
CA2774692C (en) 2009-09-24 2017-12-19 Ucb Pharma S.A. Bacterial strain for recombinant protein expression, having protease deficient degp retaining chaperone activity, and knocked out tsp and ptr genes
ES2788457T3 (es) 2009-10-23 2020-10-21 Millennium Pharm Inc Moléculas de anticuerpo anti-GCC y composiciones y métodos relacionados
GB201000587D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000591D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000588D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000590D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201001791D0 (en) 2010-02-03 2010-03-24 Ucb Pharma Sa Process for obtaining antibodies
EP2542258A4 (en) 2010-03-04 2013-08-21 Vet Therapeutics Inc MONOCLONAL ANTIBODIES DIRECTED AGAINST CD52
US9616120B2 (en) 2010-03-04 2017-04-11 Vet Therapeutics, Inc. Monoclonal antibodies directed to CD20
US9226983B2 (en) 2010-04-07 2016-01-05 Abbvie Inc. TNF-α binding proteins
GB201012603D0 (en) * 2010-07-27 2010-09-08 Ucb Pharma Sa Protein purification
GB201012599D0 (en) * 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
GB201012784D0 (en) * 2010-07-29 2010-09-15 Ucb Pharma Sa Method
TWI538918B (zh) 2010-10-20 2016-06-21 財團法人工業技術研究院 人源化之單株抗體、其核苷酸序列與其用途
AR083495A1 (es) 2010-10-22 2013-02-27 Esbatech Alcon Biomed Res Unit Anticuerpos estables y solubles
US9920324B2 (en) 2011-06-01 2018-03-20 Intrexon Actobiotics Nv Polycistronic expression system for bacteria
EP2546267A1 (en) 2011-07-13 2013-01-16 UCB Pharma S.A. Bacterial host strain expressing recombinant DsbC
LT2731973T (lt) 2011-07-13 2018-02-26 Ucb Biopharma Sprl Bakterijų padermė, ekspresuojanti rekombinantinį dsbc
JP6117212B2 (ja) 2011-09-23 2017-04-19 イントレクソン・アクトバイオテイクス・エヌブイＩｎｔｒｅｘｏｎ Ａｃｔｏｂｉｏｔｉｃｓ ＮＶ 改変されたグラム陽性菌及びその使用
CA3131722A1 (en) 2011-09-23 2013-03-28 Intrexon Actobiotics Nv Modified gram positive bacteria and uses thereof
EP2791172B1 (en) 2011-12-16 2017-07-19 Synthon Biopharmaceuticals B.V. Compounds and methods for treating inflammatory diseases
US9156915B2 (en) 2012-04-26 2015-10-13 Thomas Jefferson University Anti-GCC antibody molecules
GB201208367D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Biological product
JP6352264B2 (ja) 2012-08-13 2018-07-04 ジェネンテック， インコーポレイテッド 抗ｊａｇｇｅｄ抗体および使用方法
EP3134439B1 (en) 2014-04-21 2018-12-26 Millennium Pharmaceuticals, Inc. Anti-psyk antibody molecules and use of same for syk-targeted therapy
CA2964463C (en) 2014-10-22 2024-02-13 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
MX381459B (es) 2014-12-22 2025-03-12 Ucb Biopharma Sprl Metodo de manufactura de proteina.
US11091559B2 (en) 2015-08-27 2021-08-17 Celldex Therapeutics, Inc. Anti-ALK antibodies and methods for use thereof
GB201522394D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
US10905727B2 (en) 2016-01-14 2021-02-02 Intrexon Actobiotics N.V. Compositions and methods for the treatment of type 1 diabetes
RU2680011C2 (ru) * 2016-04-29 2019-02-14 Закрытое Акционерное Общество "Биокад" Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы
PT3464318T (pt) * 2016-06-02 2021-07-02 Abbvie Inc Agonista do receptor de glucocorticóide e imunoconjugados dos mesmos
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
PH12020550779A1 (en) 2017-12-01 2021-04-19 Abbvie Inc Glucocorticoid receptor agonist and immunoconjugates thereof
EP3917954A1 (en) 2019-01-31 2021-12-08 Numab Therapeutics AG Multispecific antibodies having specificity for tnfa and il-17a, antibodies targeting il-17a, and methods of use thereof
KR102323342B1 (ko) * 2019-04-26 2021-11-08 주식회사 와이바이오로직스 IL-17A 및 TNF-α에 특이적으로 결합하는 이중표적 항체
CN111909268B (zh) * 2019-05-07 2022-04-19 北京天成新脉生物技术有限公司 低免疫原性低ADCC/CDC功能抗TNF-α人源化单克隆抗体TCX060及其应用
TW202237638A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 烏苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法
TW202237639A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 鳥苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法
CA3208365A1 (en) 2021-02-15 2022-08-18 Chantal KUHN Cell therapy compositions and methods for modulating tgf-b signaling
JP2024531480A (ja) 2021-08-26 2024-08-29 デュアリティ バイオロジクス（スーチョウ）カンパニー，リミティド ステロイド化合物及びそのコンジュゲート
SE545694C2 (en) * 2021-09-24 2023-12-05 Xbrane Biopharma Ab Dna construct comprising nucleotide sequences encoding amino acid sequences of certolizumab and pelb signal peptides
SE545714C2 (en) * 2021-09-24 2023-12-19 Xbrane Biopharma Ab Dna contructs for producing a pelb signal peptide
WO2023046930A1 (en) 2021-09-24 2023-03-30 Xbrane Biopharma Ab Dna constructs and host cells for expressing recombinant protein
WO2023154799A1 (en) 2022-02-14 2023-08-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination immunotherapy for treating cancer
KR20250075704A (ko) 2022-09-30 2025-05-28 익스텐드 바이오사이언시즈, 인크. 장기-지속형 부갑상선 호르몬
WO2024180518A1 (en) * 2023-03-01 2024-09-06 Lupin Limited Process for manufacturing antibody fragment protein
TW202525846A (zh) 2023-08-25 2025-07-01 美商普羅特歐拉吉克適美國公司 抗ｉｌ—１３多特異性抗體構築體及其用途
WO2025099576A1 (en) 2023-11-06 2025-05-15 Momenta Pharmaceuticals, Inc. Compositions and methods for treating rheumatoid arthritis

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
DK336987D0 (da) 1987-07-01 1987-07-01 Novo Industri As Immobiliseringsmetode
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
US5030570A (en) 1988-06-30 1991-07-09 The Eunice Kennedy Shriver Center For Mental Retardation DNA encoding and method of expressing human monoamine oxidase type A
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
PT92900A (pt) * 1989-01-24 1990-07-31 Sistema de vectores de expressao para a producao de anticorpos monoclonais quimericos
GB8907617D0 (en) 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
GB9109645D0 (en) * 1991-05-03 1991-06-26 Celltech Ltd Recombinant antibodies
US5919452A (en) 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
GB9112536D0 (en) 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
GB9120467D0 (en) 1991-09-26 1991-11-06 Celltech Ltd Anti-hmfg antibodies and process for their production
AU6852594A (en) * 1993-06-03 1995-01-03 Therapeutic Antibodies Inc. Production of antibody fragments
NO309690B1 (no) 1995-01-23 2001-03-12 Western Atlas Int Inc Detonasjonsanordning av type eksploderende brotråd for bruk med et perforeringsverktöy i en brönn
WO1996033204A1 (en) 1995-04-20 1996-10-24 The Kennedy Institute Of Rheumatology Multiple administrations of anti-tnf antibody
KR100317188B1 (ko) 1996-02-09 2002-02-19 스타르크, 카르크 사람TNFα와결합하는사람항체
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
GB9625640D0 (en) * 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
WO1999009055A2 (en) * 1997-08-18 1999-02-25 Innogenetics N.V. Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders
GB9720054D0 (en) * 1997-09-19 1997-11-19 Celltech Therapeutics Ltd Biological products
DE69939033D1 (de) 1998-03-12 2008-08-14 Nektar Therapeutics Al Corp Verfahren zur Herstellung von Polymerkonjugaten
GB9812545D0 (en) * 1998-06-10 1998-08-05 Celltech Therapeutics Ltd Biological products
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products

Also Published As

Publication number Publication date
IS6217A (is) 2002-01-03
PT1287140E (pt) 2010-03-08
DK1287140T3 (da) 2010-04-19
HU230669B1 (hu) 2017-07-28
US7402662B2 (en) 2008-07-22
ES2707714T3 (es) 2019-04-04
NL300982I1 (enExample) 2019-05-01
CA2707766C (en) 2013-05-21
HUP0202346A2 (en) 2002-10-28
HUP0202346A3 (en) 2004-11-29
NO339282B1 (no) 2016-11-21
DK2308975T3 (da) 2016-10-31
IL195085A0 (en) 2009-08-03
EP2308975B1 (en) 2016-08-10
FR10C0015I2 (fr) 2011-12-30
JP4064812B2 (ja) 2008-03-19
LU91674I2 (fr) 2010-05-31
PT2308975T (pt) 2016-11-14
SI2308975T1 (sl) 2016-11-30
CA2380298A1 (en) 2001-12-13
NO2014026I2 (no) 2018-02-14
NO20160694A1 (no) 2002-04-08
SK288343B6 (sk) 2016-04-01
OA12282A (en) 2006-05-11
CZ300737B6 (cs) 2009-07-29
NL300982I9 (nl) 2019-05-06
MXPA01013440A (es) 2003-09-04
EP1287140B1 (en) 2009-12-09
HK1148776A1 (en) 2011-09-16
BR0106682A (pt) 2002-05-14
CY1121173T1 (el) 2020-05-29
NO2014026I1 (no) 2014-10-23
DE10192353T1 (de) 2003-05-22
SK3152002A3 (en) 2002-07-02
IS3016B (is) 2019-10-15
ATE451460T1 (de) 2009-12-15
CY2010011I2 (el) 2012-01-25
FR10C0015I1 (enExample) 2010-04-16
NO334808B1 (no) 2014-06-02
ES2403217T3 (es) 2013-05-16
GB2366800B (en) 2005-01-19
HU230553B1 (hu) 2016-11-28
EP2308975A1 (en) 2011-04-13
HUS1700013I1 (hu) 2017-08-28
JP2003535591A (ja) 2003-12-02
ES2337763T3 (es) 2010-04-29
US20020151682A1 (en) 2002-10-17
GB2366800A (en) 2002-03-20
EP3059314A1 (en) 2016-08-24
ZA200200097B (en) 2003-01-06
AP2002002690A0 (en) 2002-12-31
IL147992A0 (en) 2002-09-12
PT3059314T (pt) 2019-02-01
EP1287140A1 (en) 2003-03-05
EP3059314B1 (en) 2018-10-24
PL353960A1 (en) 2003-12-15
DK2230308T3 (da) 2013-05-06
BE2010C019I2 (enExample) 2020-08-20
NO20020554D0 (no) 2002-02-04
MY136603A (en) 2008-10-31
DE122010000027I1 (de) 2010-08-12
NZ516596A (en) 2004-07-30
IS2808B (is) 2012-09-15
AP2092A (en) 2010-02-28
US20030026805A1 (en) 2003-02-06
CY2010011I1 (el) 2012-01-25
JP2007105043A (ja) 2007-04-26
US7012135B2 (en) 2006-03-14
CY1109889T1 (el) 2012-01-25
DE60140738D1 (de) 2010-01-21
NO20020554L (no) 2002-04-08
KR20020047097A (ko) 2002-06-21
AR033978A1 (es) 2004-01-21
BG106278A (bg) 2002-12-29
BRPI0106682B1 (pt) 2020-10-13
AU783756B2 (en) 2005-12-01
PL218516B1 (pl) 2014-12-31
PT2230308E (pt) 2013-05-03
BRPI0106682B8 (pt) 2021-05-25
BG66072B1 (bg) 2011-01-31
ES2600080T3 (es) 2017-02-07
CY2019018I2 (el) 2020-05-29
LU91674I9 (enExample) 2019-01-03
TW200817430A (en) 2008-04-16
JP4476989B2 (ja) 2010-06-09
EP2230308B1 (en) 2013-01-23
PE20020292A1 (es) 2002-05-08
CZ2002837A3 (cs) 2002-05-15
HU230561B1 (hu) 2016-12-28
HUP1600483A2 (enExample) 2002-10-28
CA2380298C (en) 2010-09-28
IL147992A (en) 2009-06-15
JP2009171966A (ja) 2009-08-06
ES2230975A1 (es) 2005-05-01
CY1114143T1 (el) 2016-07-27
DK3059314T3 (en) 2019-02-18
CN1383450A (zh) 2002-12-04
US20080269465A1 (en) 2008-10-30
TWI316088B (en) 2009-10-21
ES2230975B2 (es) 2007-04-16
GB0128386D0 (en) 2002-01-16
LT2308975T (lt) 2016-11-10
TWI353358B (en) 2011-12-01
US20060233800A1 (en) 2006-10-19
NO20131316L (no) 2002-04-08
HUP1600016A2 (en) 2002-10-28
AU6051101A (en) 2001-12-17
PL212738B1 (pl) 2012-11-30
GB0013810D0 (en) 2000-07-26
EP2230308A1 (en) 2010-09-22
US7186820B2 (en) 2007-03-06
RU2303604C2 (ru) 2007-07-27
SI1287140T1 (sl) 2010-04-30
CA2707766A1 (en) 2001-12-13
WO2001094585A1 (en) 2001-12-13
NO341218B1 (no) 2017-09-11
CY2019018I1 (el) 2020-05-29
JP5185143B2 (ja) 2013-04-17
SI2230308T1 (sl) 2013-06-28
US7977464B2 (en) 2011-07-12
CN1289671C (zh) 2006-12-13
ECSP024210A (es) 2002-05-23
CY1118220T1 (el) 2017-06-28
PL399351A1 (pl) 2012-12-17
HK1051385A1 (en) 2003-08-01

Similar Documents

Publication Publication Date Title
TR201900227T4 (tr) İnsan tümör nekroz faktörü alfa için özgünlüğü olan antikor molekülleri ve bunların kullanımı.
TW200714081A (en) Encoding apparatus, encoding method and program thereof, and decoding apparatus, decoding method and program thereof
MX2024011078A (es) Metodo y aparato de prediccion de bloques de croma.
MX2016000943A (es) Aparato y método para codificar y decodificar una señal de audio con relleno inteligente de separaciones en el dominio espectral.
PH12015501078A1 (en) Method and apparatus for encoding video by using deblocking filtering, and method and apparatus for decoding video by using deblocking filtering
MY190750A (en) Mode dependent scanning of coefficients of a block of video data
MY154633A (en) Multi-resolution switched audio encoding/decoding scheme
UA114418C2 (uk) Визначення контекстів для кодування даних коефіцієнтів перетворення при кодуванні відео
MY179322A (en) Method and apparatus for encoding video, and method and apparatus for decoding video
TW200627962A (en) Video coding, decoding and hypothetical reference decoder
MX337935B (es) Sistema y metodo para implementar una administracion eficiente de memoria intermedia decodificada en codificacion de video de vistas multiples.
TW200723887A (en) Method and apparatus for weighted prediction for scalable video coding
EA201301072A1 (ru) Антитела против il-23p19 и их применение
TW200625970A (en) Color image encoding and decoding method and apparauts using a correlation between chrominance components
BR0305432A (pt) Método de codificação de imagem e método de decodificação de imagem
NO20070560L (no) Multikanalsynthesiser og fremgangsmate for a generere et flerkanalsutgangssignal.
MY180135A (en) Nested entropy encoding
AR069887A1 (es) Prediccion mejorada de los pixeles para la codificacion de video
MXPA06014105A (es) Metodo y aparato para codificacion y descodificacion sin perdida.
ATE441905T1 (de) Codierschema für einen ein zeitlich veraenderliches graphikmodell darstellenden datenstrom
WO2009037726A1 (ja) 動画像符号化装置および動画像復号装置
TW200714080A (en) Transcoder and transcoding method operating in a transform domain for video coding schemes possessing different transform kernels
PH12021550833A1 (en) Image coding/decoding method, coder, decoder, and storage medium
AR053164A1 (es) Codificacion mejorada de datos de multimedia
TW200612755A (en) System for enhancing compression ratio of scalable video coding and method thereof