TR200102434T2 - 8-Siyano-1-siklopropil-7- (1S,6S-2,8-diazabisiklo-[4,3.0]nonan-8-il) -6-floro-1.4-dihidro-4-okso-3-kinolinkarbokslik asidin C kristal deĞiçikliĞi - Google Patents

8-Siyano-1-siklopropil-7- (1S,6S-2,8-diazabisiklo-[4,3.0]nonan-8-il) -6-floro-1.4-dihidro-4-okso-3-kinolinkarbokslik asidin C kristal deĞiçikliĞi

Info

Publication number
TR200102434T2
TR200102434T2 TR2001/02434T TR200102434T TR200102434T2 TR 200102434 T2 TR200102434 T2 TR 200102434T2 TR 2001/02434 T TR2001/02434 T TR 2001/02434T TR 200102434 T TR200102434 T TR 200102434T TR 200102434 T2 TR200102434 T2 TR 200102434T2
Authority
TR
Turkey
Prior art keywords
nonan
diazabicyclo
cyclopropyl
dihydro
oxo
Prior art date
Application number
TR2001/02434T
Other languages
English (en)
Inventor
Rast Hubert
Himmler Thomas
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of TR200102434T2 publication Critical patent/TR200102434T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Bu buluç, 8-Siyano-1-siklopropil-7- (1S,6S-2,8-diazabisiklo-[4,3.0]nonan-8-il) -6-flüoro-1.4-dihidro-4-okso-3-kinolinkarbokslik asidin tan mlanm ç bir kristal deGiçikliGine, bunun haz rlanmas na mahsus yöntemlere ve eczac l k ile ilgili preparasyonlar içinde kullan m na iliçkindir. Kristal deGiçikliGi formül (I) 'in 8-Siyano-1-siklopropil-7- (1S,6S-2,8-diazabisiklo-[4,3.0]nonan-8-il) -6-flüoro-1.4-dihidro-4-okso-3-kinolinkarbokslik asidinin diGer kristal deGiçikliklerinden kendisine ait kendine has X- ç n toz difraktogram ve kendisine ait farkl l k termik çemas (tarife bak n z) ile ay rt edilmektedir.
TR2001/02434T 1999-02-26 2000-02-14 8-Siyano-1-siklopropil-7- (1S,6S-2,8-diazabisiklo-[4,3.0]nonan-8-il) -6-floro-1.4-dihidro-4-okso-3-kinolinkarbokslik asidin C kristal deĞiçikliĞi TR200102434T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19908449A DE19908449A1 (de) 1999-02-26 1999-02-26 Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure

Publications (1)

Publication Number Publication Date
TR200102434T2 true TR200102434T2 (tr) 2002-03-21

Family

ID=7899027

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02434T TR200102434T2 (tr) 1999-02-26 2000-02-14 8-Siyano-1-siklopropil-7- (1S,6S-2,8-diazabisiklo-[4,3.0]nonan-8-il) -6-floro-1.4-dihidro-4-okso-3-kinolinkarbokslik asidin C kristal deĞiçikliĞi

Country Status (26)

Country Link
US (1) US6649762B1 (tr)
EP (1) EP1155018B1 (tr)
JP (1) JP2002538158A (tr)
KR (1) KR100756471B1 (tr)
CN (1) CN1191253C (tr)
AT (1) ATE226952T1 (tr)
AU (1) AU763003B2 (tr)
BR (1) BR0008493A (tr)
CA (1) CA2362801A1 (tr)
CZ (1) CZ299700B6 (tr)
DE (2) DE19908449A1 (tr)
DK (1) DK1155018T3 (tr)
ES (1) ES2181644T3 (tr)
HK (1) HK1044948B (tr)
HU (1) HUP0200006A3 (tr)
IL (2) IL144702A0 (tr)
NO (1) NO320191B1 (tr)
NZ (1) NZ513750A (tr)
PL (1) PL349368A1 (tr)
PT (1) PT1155018E (tr)
RU (1) RU2248356C2 (tr)
SK (1) SK285562B6 (tr)
TR (1) TR200102434T2 (tr)
UA (1) UA70356C2 (tr)
WO (1) WO2000052009A1 (tr)
ZA (1) ZA200106289B (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19854355A1 (de) 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854356A1 (de) 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908449A1 (de) * 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
DE19908448A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation D von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo[4.3.0)nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino incarbonsäure
DE102004015981A1 (de) * 2004-04-01 2005-10-20 Bayer Healthcare Ag Neue kirstalline Form von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE102006049520A1 (de) * 2006-10-20 2008-04-24 Bayer Healthcare Ag Verfahren zur Herstellung von Pradofloxacin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2676521B2 (ja) 1988-03-22 1997-11-17 北陸製薬株式会社 キノロンカルボン酸化合物ｉ型結晶の製造法
CZ138297A3 (en) 1994-11-18 1997-10-15 Pharmacia & Upjohn Novel physically stable form of solid fluoroquinolone
DE19546249A1 (de) 1995-12-12 1997-06-19 Bayer Ag Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE19633805A1 (de) * 1996-02-23 1997-08-28 Bayer Ag Gegenenenfalls substituierte 8-Cyan-l-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäuren und ihre Derivate
RU2173318C2 (ru) 1996-02-23 2001-09-10 Байер Акциенгезелльшафт 8-циан-1-циклопропил-7-(2,8-диазабицикло(4.3.0)-нонан-8-ил)-6-фтор-1,4-дигидро-4-оксо-3-хинолинкарбоновые кислоты, их производные и фармацевтическая композиция, обладающая антибактериальной активностью
DE19854355A1 (de) 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854356A1 (de) 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908449A1 (de) * 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
DE19908448A1 (de) 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation D von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo[4.3.0)nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino incarbonsäure

Also Published As

Publication number Publication date
ZA200106289B (en) 2002-07-31
CA2362801A1 (en) 2000-09-08
CN1191253C (zh) 2005-03-02
PT1155018E (pt) 2003-02-28
BR0008493A (pt) 2002-02-05
NZ513750A (en) 2001-09-28
CN1342160A (zh) 2002-03-27
ATE226952T1 (de) 2002-11-15
IL144702A0 (en) 2002-06-30
DK1155018T3 (da) 2003-02-17
SK11952001A3 (sk) 2001-12-03
RU2248356C2 (ru) 2005-03-20
SK285562B6 (sk) 2007-03-01
EP1155018A1 (de) 2001-11-21
AU763003B2 (en) 2003-07-10
CZ299700B6 (cs) 2008-10-22
CZ20013064A3 (cs) 2002-01-16
AU3154300A (en) 2000-09-21
PL349368A1 (en) 2002-07-15
HUP0200006A3 (en) 2002-08-28
US6649762B1 (en) 2003-11-18
EP1155018B1 (de) 2002-10-30
HK1044948B (zh) 2005-10-14
KR20010089630A (ko) 2001-10-06
HUP0200006A2 (en) 2002-06-29
JP2002538158A (ja) 2002-11-12
DE50000700D1 (de) 2002-12-05
KR100756471B1 (ko) 2007-09-07
HK1044948A1 (en) 2002-11-08
UA70356C2 (uk) 2004-10-15
ES2181644T3 (es) 2003-03-01
DE19908449A1 (de) 2000-08-31
NO20014061L (no) 2001-08-21
WO2000052009A1 (de) 2000-09-08
IL144702A (en) 2006-07-05
NO320191B1 (no) 2005-11-07
NO20014061D0 (no) 2001-08-21

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