TR200100952T2 - alfa-2-antagonistler olarak üç halkalı delta3-piperidinler - Google Patents

alfa-2-antagonistler olarak üç halkalı delta3-piperidinler

Info

Publication number
TR200100952T2
TR200100952T2 TR2001/00952T TR200100952T TR200100952T2 TR 200100952 T2 TR200100952 T2 TR 200100952T2 TR 2001/00952 T TR2001/00952 T TR 2001/00952T TR 200100952 T TR200100952 T TR 200100952T TR 200100952 T2 TR200100952 T2 TR 200100952T2
Authority
TR
Turkey
Prior art keywords
alpha
delta3
piperidines
antagonists
ring
Prior art date
Application number
TR2001/00952T
Other languages
English (en)
Inventor
Edmond Josephine Kennis Ludo
Maria Alfons Van Den Keybus Frans
Carolus Mertens Josephus
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of TR200100952T2 publication Critical patent/TR200100952T2/tr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Mevcut bulus, formül (I)'in bilesikleri, N-oksit formlari, farmasötik açidan kabul edilen ekleme tuzlari ve bunlarin stereokimyasal izomerik formlari ile ilgili olup, özelligi, Alk'in C1-6 alkanediil; n'nin 1 veya 2 olmasi, X1'in -O-, -S-, -S(=O) veya -S(=O)2-; her R1'in bagimsiz olarak hidrojen, halojen, C1-6 alkil, nitro, hidroksi veya C1-4 alkiloksi olmasi, D'nin istege göre, merkezi alfa 2-adrenoseptör antagonist aktivitesi olan heterosiklik bir 2H-benzopiranon, bir benzamit, bir benzofenon veya bir fenoksifenil içeren ikameli bir tek, çift veya üç halkali azot olmasidir. Ayrica bunlarin hazirlanmasi, farmasötik olarak kullanilmasi ve bilesimleri ile de ilgilidir. (FORMÜL VAR)
TR2001/00952T 1998-10-06 1999-10-01 alfa-2-antagonistler olarak üç halkalı delta3-piperidinler TR200100952T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98203370 1998-10-06

Publications (1)

Publication Number Publication Date
TR200100952T2 true TR200100952T2 (tr) 2001-10-22

Family

ID=8234191

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00952T TR200100952T2 (tr) 1998-10-06 1999-10-01 alfa-2-antagonistler olarak üç halkalı delta3-piperidinler

Country Status (31)

Country Link
US (1) US6495555B1 (tr)
EP (1) EP1119571B1 (tr)
JP (1) JP4590101B2 (tr)
KR (1) KR20010071843A (tr)
CN (1) CN1131230C (tr)
AR (1) AR024216A1 (tr)
AT (1) ATE232869T1 (tr)
AU (1) AU760502B2 (tr)
BG (1) BG64872B1 (tr)
BR (1) BR9913507A (tr)
CA (1) CA2345622C (tr)
CZ (1) CZ20011104A3 (tr)
DE (1) DE69905478T2 (tr)
DK (1) DK1119571T3 (tr)
EE (1) EE04770B1 (tr)
ES (1) ES2193751T3 (tr)
HK (1) HK1038010A1 (tr)
HU (1) HUP0104002A3 (tr)
ID (1) ID28032A (tr)
IL (1) IL142443A0 (tr)
NO (1) NO20011270D0 (tr)
NZ (1) NZ510115A (tr)
PL (1) PL347894A1 (tr)
PT (1) PT1119571E (tr)
RU (1) RU2230744C2 (tr)
SI (1) SI1119571T1 (tr)
SK (1) SK285585B6 (tr)
TR (1) TR200100952T2 (tr)
TW (1) TWI248441B (tr)
UA (1) UA69420C2 (tr)
WO (1) WO2000020421A2 (tr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010071844A (ko) * 1998-10-06 2001-07-31 디르크 반테 의약으로서의 트리사이클릭 δ3-피페리딘
ES2367481T3 (es) * 2002-04-03 2011-11-03 Orion Corporation Uso de un antagonista del adrenoreceptor alfa2 para enfermedades relacionadas con el snc.
MXPA06011777A (es) 2004-04-12 2007-01-16 Taisho Pharma Co Ltd Compuesto de amina ciclico.
EP1775283A4 (en) * 2004-07-14 2008-12-10 Japan Tobacco Inc 3-AMINOBENZAMIDE COMPOUND AND INHIBITORS OF THE ACTIVITY OF VANILLOID RECEPTOR 1 (VR1)
CA2571133C (en) * 2004-07-15 2011-04-19 Japan Tobacco Inc. Fused benzamide compound and vanilloid receptor 1 (vr1) activity inhibitor
US7906508B2 (en) * 2005-12-28 2011-03-15 Japan Tobacco Inc. 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity
BRPI1012205A2 (pt) 2009-05-14 2019-04-02 Janssen Pharmaceutica Nv compostos com duas porções heteroarila bicíclica fundidas como moduladores de leucotrieno a4 hidrolase
JOP20200052A1 (ar) 2013-12-19 2017-06-16 Bayer Pharma AG بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c
TN2016000249A1 (en) 2013-12-19 2017-10-06 Bayer Pharma AG Substituted piperidinyl-tetrahydroquinolines.
EP3083610A1 (de) 2013-12-19 2016-10-26 Bayer Pharma Aktiengesellschaft Substituierte bipiperidinyl-derivate als adrenrezeptor alpha 2c antagonisten
CN114276359B (zh) * 2022-01-05 2023-05-05 浙江大学 一种1,2,3,4-四氢苯并[4,5]呋喃[2,3-c]吡啶衍生物的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3522959A1 (de) * 1985-06-27 1987-01-08 Merck Patent Gmbh Indolderivate
US4673680A (en) * 1985-09-18 1987-06-16 Pendleton Robert G α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
EP0339959A3 (en) * 1988-04-27 1991-03-20 Glaxo Group Limited Lactam derivatives
US4971974A (en) 1988-06-16 1990-11-20 Neurex Corporation Benzothiophenes as appetite suppressants
US5100891A (en) * 1991-01-18 1992-03-31 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds
NZ335711A (en) * 1996-12-06 2000-10-27 Abbott Lab Substituted benzopyranopyrrole and benzopyranopyridine derivatives
ATE290527T1 (de) 1997-12-25 2005-03-15 Meiji Seika Kaisha Tetrahydrobenzindol-derivate
KR20010071844A (ko) * 1998-10-06 2001-07-31 디르크 반테 의약으로서의 트리사이클릭 δ3-피페리딘

Also Published As

Publication number Publication date
CZ20011104A3 (cs) 2001-12-12
IL142443A0 (en) 2002-03-10
TWI248441B (en) 2006-02-01
KR20010071843A (ko) 2001-07-31
BG64872B1 (bg) 2006-07-31
UA69420C2 (uk) 2004-09-15
JP2002526545A (ja) 2002-08-20
HK1038010A1 (en) 2002-03-01
WO2000020421A2 (en) 2000-04-13
CA2345622C (en) 2007-12-04
AU6334199A (en) 2000-04-26
JP4590101B2 (ja) 2010-12-01
SI1119571T1 (en) 2003-08-31
BG105332A (en) 2001-11-30
PL347894A1 (en) 2002-04-22
AU760502B2 (en) 2003-05-15
EP1119571B1 (en) 2003-02-19
CA2345622A1 (en) 2000-04-13
PT1119571E (pt) 2003-06-30
EE200100209A (et) 2002-06-17
ID28032A (id) 2001-05-03
AR024216A1 (es) 2002-09-25
DE69905478T2 (de) 2004-03-18
SK285585B6 (sk) 2007-04-05
CN1131230C (zh) 2003-12-17
DE69905478D1 (de) 2003-03-27
NO20011270L (no) 2001-03-13
RU2230744C2 (ru) 2004-06-20
HUP0104002A3 (en) 2003-12-29
EE04770B1 (et) 2007-02-15
DK1119571T3 (da) 2003-05-26
US6495555B1 (en) 2002-12-17
SK4322001A3 (en) 2002-01-07
ES2193751T3 (es) 2003-11-01
WO2000020421A3 (en) 2000-08-03
NZ510115A (en) 2002-11-26
CN1332744A (zh) 2002-01-23
EP1119571A2 (en) 2001-08-01
ATE232869T1 (de) 2003-03-15
HUP0104002A2 (hu) 2002-03-28
NO20011270D0 (no) 2001-03-13
BR9913507A (pt) 2001-06-05

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