BR9913507A - Piperidinas delta3 tricìclicas como antagonistas alfa2 - Google Patents
Piperidinas delta3 tricìclicas como antagonistas alfa2Info
- Publication number
- BR9913507A BR9913507A BR9913507-8A BR9913507A BR9913507A BR 9913507 A BR9913507 A BR 9913507A BR 9913507 A BR9913507 A BR 9913507A BR 9913507 A BR9913507 A BR 9913507A
- Authority
- BR
- Brazil
- Prior art keywords
- piperidines
- tricyclic
- delta3
- compounds
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Patente de Invenção: <B>"PIPERIDINAS DELTA3 TRICìCLICAS COMO ANTAGONISTAS ALFA~ 2~"<D>. A presente invenção refere-se aos compostos de fórmula (I), as formas N-óxido, aos sais de adição farmaceuticamente aceitáveis e às formas estereoquimicamente isoméricas dos compostos, onde Alk é C~ 1-6~alcanodiíla; n é 1 ou 2; X~ 1~ é -O-, -S-, -S(=O)- ou -S(=O)~ 2~-; cada R¹ é independentemente hidrogênio, halogênio, C~ 1-6~alquila, nitro, hidróxi ou C~ 1-4~alquilóxi; D é um heterociclo que contém nitrogênio mono, bi ou tricíclico opcionalmente substituído, uma 2H-benzopiranona, uma benzamida, uma benzofenona ou uma fenoxifenila que apresenta atividade central antagonista e adrenoceptores <244>~ 2~. A presente invenção refere-se adicionalmente à sua preparação, uso farmacêutico e composições.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98203370 | 1998-10-06 | ||
| PCT/EP1999/007419 WO2000020421A2 (en) | 1998-10-06 | 1999-10-01 | TRICYCLIC Δ3-PIPERIDINES AS α2-ANTAGONISTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9913507A true BR9913507A (pt) | 2001-06-05 |
Family
ID=8234191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9913507-8A BR9913507A (pt) | 1998-10-06 | 1999-10-01 | Piperidinas delta3 tricìclicas como antagonistas alfa2 |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6495555B1 (pt) |
| EP (1) | EP1119571B1 (pt) |
| JP (1) | JP4590101B2 (pt) |
| KR (1) | KR20010071843A (pt) |
| CN (1) | CN1131230C (pt) |
| AR (1) | AR024216A1 (pt) |
| AT (1) | ATE232869T1 (pt) |
| AU (1) | AU760502B2 (pt) |
| BG (1) | BG64872B1 (pt) |
| BR (1) | BR9913507A (pt) |
| CA (1) | CA2345622C (pt) |
| CZ (1) | CZ20011104A3 (pt) |
| DE (1) | DE69905478T2 (pt) |
| DK (1) | DK1119571T3 (pt) |
| EE (1) | EE04770B1 (pt) |
| ES (1) | ES2193751T3 (pt) |
| HK (1) | HK1038010A1 (pt) |
| HU (1) | HUP0104002A3 (pt) |
| ID (1) | ID28032A (pt) |
| IL (1) | IL142443A0 (pt) |
| NO (1) | NO20011270L (pt) |
| NZ (1) | NZ510115A (pt) |
| PL (1) | PL347894A1 (pt) |
| PT (1) | PT1119571E (pt) |
| RU (1) | RU2230744C2 (pt) |
| SI (1) | SI1119571T1 (pt) |
| SK (1) | SK285585B6 (pt) |
| TR (1) | TR200100952T2 (pt) |
| TW (1) | TWI248441B (pt) |
| UA (1) | UA69420C2 (pt) |
| WO (1) | WO2000020421A2 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20011105A3 (cs) * | 1998-10-06 | 2001-12-12 | Janssen Pharmaceutica N. V. | Tricyklické delta3-piperidiny jako farmaceutika |
| CA2480266C (en) * | 2002-04-03 | 2011-07-12 | Orion Corporation | Use of an alpha2-adrenoreceptor antagonist for cns-related diseases |
| CA2562406C (en) | 2004-04-12 | 2013-03-19 | Taisho Pharmaceutical Co., Ltd. | Cyclic amine compound |
| US20060035939A1 (en) * | 2004-07-14 | 2006-02-16 | Japan Tobacco Inc. | 3-Aminobenzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity |
| RU2392278C2 (ru) * | 2004-07-15 | 2010-06-20 | Джапан Тобакко Инк. | Конденсированное производное бензамида и ингибитор активности подтипа 1 рецептора ваниллоида (vr1) |
| US7906508B2 (en) * | 2005-12-28 | 2011-03-15 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity |
| US8399465B2 (en) | 2009-05-14 | 2013-03-19 | Janssen Pharmaceutica Nv | Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase |
| JOP20200052A1 (ar) * | 2013-12-19 | 2017-06-16 | Bayer Pharma AG | بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c |
| US9624199B2 (en) | 2013-12-19 | 2017-04-18 | Bayer Pharma Aktiengesellschaft | Substituted bipiperidinyl derivatives |
| CA2934133A1 (en) * | 2013-12-19 | 2015-06-25 | Bayer Pharma Aktiengesellschaft | Substituted piperidinyl-tetrahydroquinolines |
| CN114276359B (zh) * | 2022-01-05 | 2023-05-05 | 浙江大学 | 一种1,2,3,4-四氢苯并[4,5]呋喃[2,3-c]吡啶衍生物的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3522959A1 (de) | 1985-06-27 | 1987-01-08 | Merck Patent Gmbh | Indolderivate |
| US4673680A (en) * | 1985-09-18 | 1987-06-16 | Pendleton Robert G | α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility |
| US4985422A (en) * | 1988-04-27 | 1991-01-15 | Glaxo Group Limited | Lactam derivatives |
| US4971974A (en) * | 1988-06-16 | 1990-11-20 | Neurex Corporation | Benzothiophenes as appetite suppressants |
| US5100891A (en) * | 1991-01-18 | 1992-03-31 | Hoechst-Roussel Pharmaceuticals Inc. | Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds |
| PT942911E (pt) * | 1996-12-06 | 2002-04-29 | Abbott Lab | Compostos alfa 1 adrenergicos de benzopiranopirrolo e benzopiranopiridina |
| CN1129578C (zh) * | 1997-12-25 | 2003-12-03 | 明治制果株式会社 | 四氢苯并吲哚衍生物 |
| CZ20011105A3 (cs) * | 1998-10-06 | 2001-12-12 | Janssen Pharmaceutica N. V. | Tricyklické delta3-piperidiny jako farmaceutika |
-
1999
- 1999-01-10 UA UA2001031999A patent/UA69420C2/uk unknown
- 1999-10-01 CA CA002345622A patent/CA2345622C/en not_active Expired - Fee Related
- 1999-10-01 SI SI9930264T patent/SI1119571T1/xx unknown
- 1999-10-01 DK DK99950627T patent/DK1119571T3/da active
- 1999-10-01 WO PCT/EP1999/007419 patent/WO2000020421A2/en not_active Application Discontinuation
- 1999-10-01 US US09/806,547 patent/US6495555B1/en not_active Expired - Lifetime
- 1999-10-01 ES ES99950627T patent/ES2193751T3/es not_active Expired - Lifetime
- 1999-10-01 CZ CZ20011104A patent/CZ20011104A3/cs unknown
- 1999-10-01 AT AT99950627T patent/ATE232869T1/de not_active IP Right Cessation
- 1999-10-01 HU HU0104002A patent/HUP0104002A3/hu unknown
- 1999-10-01 PT PT99950627T patent/PT1119571E/pt unknown
- 1999-10-01 BR BR9913507-8A patent/BR9913507A/pt not_active IP Right Cessation
- 1999-10-01 EP EP99950627A patent/EP1119571B1/en not_active Expired - Lifetime
- 1999-10-01 TW TW088116898A patent/TWI248441B/zh not_active IP Right Cessation
- 1999-10-01 EE EEP200100209A patent/EE04770B1/xx not_active IP Right Cessation
- 1999-10-01 DE DE69905478T patent/DE69905478T2/de not_active Expired - Lifetime
- 1999-10-01 RU RU2001111812/04A patent/RU2230744C2/ru not_active IP Right Cessation
- 1999-10-01 KR KR1020017000442A patent/KR20010071843A/ko active Search and Examination
- 1999-10-01 ID IDW20010780A patent/ID28032A/id unknown
- 1999-10-01 TR TR2001/00952T patent/TR200100952T2/xx unknown
- 1999-10-01 PL PL99347894A patent/PL347894A1/xx not_active Application Discontinuation
- 1999-10-01 JP JP2000574533A patent/JP4590101B2/ja not_active Expired - Fee Related
- 1999-10-01 IL IL14244399A patent/IL142443A0/xx not_active IP Right Cessation
- 1999-10-01 SK SK432-2001A patent/SK285585B6/sk unknown
- 1999-10-01 AU AU63341/99A patent/AU760502B2/en not_active Ceased
- 1999-10-01 NZ NZ510115A patent/NZ510115A/xx unknown
- 1999-10-01 CN CN99811682A patent/CN1131230C/zh not_active Expired - Fee Related
- 1999-10-05 AR ARP990105038A patent/AR024216A1/es not_active Application Discontinuation
-
2001
- 2001-03-12 BG BG105332A patent/BG64872B1/bg unknown
- 2001-03-13 NO NO20011270A patent/NO20011270L/no not_active Application Discontinuation
- 2001-12-10 HK HK01108631A patent/HK1038010A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1976 DE18/11/2008. |