BRPI1012205A2 - compostos com duas porções heteroarila bicíclica fundidas como moduladores de leucotrieno a4 hidrolase - Google Patents

compostos com duas porções heteroarila bicíclica fundidas como moduladores de leucotrieno a4 hidrolase

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Publication number
BRPI1012205A2
BRPI1012205A2 BRPI1012205-2A BRPI1012205A BRPI1012205A2 BR PI1012205 A2 BRPI1012205 A2 BR PI1012205A2 BR PI1012205 A BRPI1012205 A BR PI1012205A BR PI1012205 A2 BRPI1012205 A2 BR PI1012205A2
Authority
BR
Brazil
Prior art keywords
hydrolase
modulators
compounds
heteroaryl moieties
leukotriene
Prior art date
Application number
BRPI1012205-2A
Other languages
English (en)
Inventor
M. Bacani Genesis
C. Chrovian Christ
Eccles Wendy
M. Fourier Anne
Gomez Laurent
A. Grice Cheryl
M. Kearny Aaron
Landry-Bayle Adrienne
Lee Dutra Alice
Alejandro Santillan, Jr.
M. Tanis Virginia
M. Wiener John
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI1012205A2 publication Critical patent/BRPI1012205A2/pt

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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Abstract

compostos com duas porções heteroarila blcíclica. fundidas como moduladores--de leugotrieno a4 hidrolase, composição que os compreende e uso dos mesmos a presente invenção refere-se aos compostos com duas porções heteroarila bicíclia fundidas de fórmula i e suas composições farmacêuticas, e métodos de uso dos mesmos como moduladores de leucotrieno a4 hidrolase (l ta4h) e para o tratamento de doenças, distúrbios e condições mediadas por lta4h.
BRPI1012205-2A 2009-05-14 2010-05-12 compostos com duas porções heteroarila bicíclica fundidas como moduladores de leucotrieno a4 hidrolase BRPI1012205A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17816909P 2009-05-14 2009-05-14
US61/178,169 2009-05-14
US25277409P 2009-10-19 2009-10-19
US61/252,774 2009-10-19
PCT/US2010/034597 WO2010132599A1 (en) 2009-05-14 2010-05-12 Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase

Publications (1)

Publication Number Publication Date
BRPI1012205A2 true BRPI1012205A2 (pt) 2019-04-02

Family

ID=42334002

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1012205-2A BRPI1012205A2 (pt) 2009-05-14 2010-05-12 compostos com duas porções heteroarila bicíclica fundidas como moduladores de leucotrieno a4 hidrolase

Country Status (15)

Country Link
US (1) US8399465B2 (pt)
EP (1) EP2430019B1 (pt)
JP (1) JP5746685B2 (pt)
KR (1) KR101727650B1 (pt)
CN (1) CN102459251B (pt)
AR (1) AR080539A1 (pt)
AU (1) AU2010249041B2 (pt)
BR (1) BRPI1012205A2 (pt)
CA (1) CA2761881C (pt)
HK (1) HK1167859A1 (pt)
MX (1) MX2011012190A (pt)
NZ (1) NZ596137A (pt)
TW (1) TW201102396A (pt)
UY (1) UY32641A (pt)
WO (1) WO2010132599A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2761881C (en) 2009-05-14 2017-04-04 Janssen Pharmaceutica Nv Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase
EP3022194B1 (en) * 2013-07-15 2017-05-17 Boehringer Ingelheim International GmbH Inhibitors of leukotriene production
MD3448859T2 (ro) 2017-03-20 2020-03-31 Forma Therapeutics Inc Compoziții de pirolopirol în calitate de activatori ai piruvatkinazei (PKR)
BR112021005188A2 (pt) 2018-09-19 2021-06-08 Forma Therapeutics, Inc. tratamento de anemia falciforme com um composto de ativação de piruvato cinase r
JP7450610B2 (ja) 2018-09-19 2024-03-15 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー ピルビン酸キナーゼｒの活性化
EP4353727A1 (en) * 2022-10-13 2024-04-17 Masarykova Univerzita Substituted furopyridines for therapeutic use

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59004A0 (en) * 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
US4321378A (en) 1979-01-16 1982-03-23 Delalande S.A. 8-(5-Pyrimidinecarboxamide)nor-tropane derivatives
FR2446823A1 (fr) 1979-01-16 1980-08-14 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
US4424358A (en) * 1979-01-16 1984-01-03 Delalande S.A. β-3-Amino nor-tropane compounds
US4329466A (en) * 1979-01-16 1982-05-11 Delalande S.A. Certain nor-tropan-8-amine-3-aryl or heteroaryl derivatives
FR2476088A2 (fr) * 1979-01-16 1981-08-21 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
US4352802A (en) * 1980-06-10 1982-10-05 Beecham Group Limited Bicyclo[3.3.1]nonyl-benzamide
NZ199080A (en) * 1980-12-12 1984-07-31 Beecham Group Ltd 2-alkoxy-4-amino-5-alkylsulphonyl-n-(3beta-(8-hydrocarbyl-8-azabicyclo (3,2,1)octyl))benzamides
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPS63170356A (ja) 1986-12-30 1988-07-14 Yamanouchi Pharmaceut Co Ltd アニリン誘導体及びその製造法
US5070094A (en) 1989-09-05 1991-12-03 G. D. Searle & Co. N-benzyltropaneamides
US5187180A (en) 1990-07-26 1993-02-16 Merck Frosst Canada, Inc. (quinolin-2-ylmethoxy)heterotetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes
HUT69705A (en) * 1991-11-25 1995-09-28 Pfizer Indole derivatives
TW251287B (pt) 1993-04-30 1995-07-11 Nissei Co Ltd
US5585492A (en) 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
US6506876B1 (en) 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
US5700816A (en) 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
US5794887A (en) 1995-11-17 1998-08-18 Komerath; Narayanan M. Stagnation point vortex controller
AU1952597A (en) 1996-02-13 1997-09-02 G.D. Searle & Co. Combinations, having immunosuppressive effects, containing cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor
US6110994A (en) * 1996-06-14 2000-08-29 Cabot Corporation Polymeric products containing modified carbon products and methods of making and using the same
US6110944A (en) 1997-03-12 2000-08-29 G. D. Searle & Co. LTA4, hydrolase inhibitors
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
UA69420C2 (uk) 1998-10-06 2004-09-15 Янссен Фармацевтика Н.В. ТРИЦИКЛІЧНІ <font face="Symbol">D3</font>-ПІПЕРИДИНИ ЯК <font face="Symbol">a<sub></font>2</sub>-АНТАГОНІСТИ
EP1159263A1 (en) 1999-02-26 2001-12-05 Merck & Co., Inc. Novel sulfonamide compounds and uses thereof
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6559140B2 (en) 2000-03-09 2003-05-06 Abbott Laboratories Cyclic and bicyclic diamino histamine-3 receptor antagonists
MY145722A (en) 2000-04-27 2012-03-30 Abbott Lab Diazabicyclic central nervous system active agents
FR2814166B1 (fr) * 2000-09-21 2005-07-01 Innothera Lab Sa Derives 5-phenoxyindole et leurs applications therapeutiques
FR2831884B1 (fr) 2001-11-02 2003-12-26 Pf Medicament Nouveaux derives amides heteroaromatiques de 3 beta-amino azabicyclooctane, leur procede de preparation et leurs applications en therapeutique
US7152144B2 (en) 2002-05-29 2006-12-19 Hitachi, Ltd. Centralized storage management method
EP1636183A1 (en) 2003-05-16 2006-03-22 Ambit Biosciences Corporation Pyrrole compounds and uses thereof
EP1660491B1 (en) * 2003-07-28 2008-08-06 Janssen Pharmaceutica N.V. Benzimidazole, benzthiazole and benzoxazole derivatives and their use as lta4h modulators
CN101407471A (zh) * 2003-08-29 2009-04-15 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7750158B2 (en) 2004-06-22 2010-07-06 Schering Corporation Cannabinoid receptor ligands
GB2415818B (en) 2004-06-30 2008-12-31 Autoliv Dev Arrangement for triggering a vehicle safety device
TWI400232B (zh) 2004-09-13 2013-07-01 Ono Pharmaceutical Co 含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑
EP1868605A2 (en) * 2005-03-31 2007-12-26 Janssen Pharmaceutica, N.V. Phenyl and pyridyl lta4h modulators
ES2277745B1 (es) 2005-06-14 2008-06-01 Laboratorios Almirall S.A. Derivados n-amida de 8-azabiciclo /3.2.1/oct-3-ilo como antagonistas de ccr1.
GB0514018D0 (en) 2005-07-07 2005-08-17 Ionix Pharmaceuticals Ltd Chemical compounds
UA101943C2 (ru) * 2005-09-21 2013-05-27 Декод Дженетикс Ехф Биарилзамещенные гетероциклические ингибиторы lta4h для лечения воспаления
HUE031972T2 (en) 2005-12-29 2017-08-28 Celtaxsys Inc Diamin derivatives as leukotriene A4 hydrolase inhibitors
EP2044038B1 (en) 2006-06-06 2014-07-02 Cornerstone Therapeutics Inc. Novel piperazines, pharmaceutical compositions and methods of use thereof
WO2008016811A2 (en) 2006-07-31 2008-02-07 Neurogen Corporation Aminopiperidines and realted compounds
TW200906396A (en) * 2007-02-14 2009-02-16 Janssen Pharmaceutica Nv LTA4H modulators and uses thereof
US7935725B2 (en) * 2007-10-31 2011-05-03 Janssen Pharmaceutica Nv Aryl-substituted bridged or fused diamines as modulators of leukotriene A4 hydrolase
CA2761881C (en) 2009-05-14 2017-04-04 Janssen Pharmaceutica Nv Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase
WO2011050245A1 (en) 2009-10-23 2011-04-28 Yangbo Feng Bicyclic heteroaryls as kinase inhibitors

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US8399465B2 (en) 2013-03-19
KR101727650B1 (ko) 2017-04-17
TW201102396A (en) 2011-01-16
UY32641A (es) 2010-11-30
EP2430019A1 (en) 2012-03-21
CA2761881C (en) 2017-04-04
CA2761881A1 (en) 2010-11-18
CN102459251B (zh) 2015-05-20
AU2010249041B2 (en) 2014-11-13
US20100292208A1 (en) 2010-11-18
JP2012526837A (ja) 2012-11-01
HK1167859A1 (en) 2012-12-14
JP5746685B2 (ja) 2015-07-08
EP2430019B1 (en) 2013-09-18
KR20120060783A (ko) 2012-06-12
AR080539A1 (es) 2012-04-18
NZ596137A (en) 2013-08-30
MX2011012190A (es) 2011-12-08

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