TR200100274T2 - Metabolik bozuklukların tedavisi için glikokortikoit ve tiroit hormon reseptörü ligandları. - Google Patents
Metabolik bozuklukların tedavisi için glikokortikoit ve tiroit hormon reseptörü ligandları.Info
- Publication number
- TR200100274T2 TR200100274T2 TR2001/00274T TR200100274T TR200100274T2 TR 200100274 T2 TR200100274 T2 TR 200100274T2 TR 2001/00274 T TR2001/00274 T TR 2001/00274T TR 200100274 T TR200100274 T TR 200100274T TR 200100274 T2 TR200100274 T2 TR 200100274T2
- Authority
- TR
- Turkey
- Prior art keywords
- receptor ligands
- glucocorticoid
- treatment
- hormone receptor
- metabolic disorders
- Prior art date
Links
- 108090000079 Glucocorticoid Receptors Proteins 0.000 title abstract 2
- 102100033417 Glucocorticoid receptor Human genes 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 102000004217 thyroid hormone receptors Human genes 0.000 title abstract 2
- 108090000721 thyroid hormone receptors Proteins 0.000 title abstract 2
- 208000030159 metabolic disease Diseases 0.000 title 1
- -1 alkenyl carboxylic acid Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003862 glucocorticoid Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/90—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. amino-diphenylethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
- C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9816935.2A GB9816935D0 (en) | 1998-08-05 | 1998-08-05 | Novel glucocortoid and thyroid receptor ligands for the treatment of metabolic disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200100274T2 true TR200100274T2 (tr) | 2001-09-21 |
Family
ID=10836671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2001/00274T TR200100274T2 (tr) | 1998-08-05 | 1999-08-04 | Metabolik bozuklukların tedavisi için glikokortikoit ve tiroit hormon reseptörü ligandları. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6492424B1 (enExample) |
| EP (1) | EP1102739B1 (enExample) |
| JP (1) | JP2002522407A (enExample) |
| KR (1) | KR20010072113A (enExample) |
| CN (1) | CN1311767A (enExample) |
| AT (1) | ATE238267T1 (enExample) |
| AU (1) | AU753376B2 (enExample) |
| BG (1) | BG105214A (enExample) |
| BR (1) | BR9912742A (enExample) |
| CA (1) | CA2339194A1 (enExample) |
| DE (1) | DE69907210T2 (enExample) |
| DK (1) | DK1102739T3 (enExample) |
| ES (1) | ES2193730T3 (enExample) |
| GB (1) | GB9816935D0 (enExample) |
| HU (1) | HUP0103222A3 (enExample) |
| ID (1) | ID28805A (enExample) |
| IL (1) | IL141106A0 (enExample) |
| MX (1) | MXPA01001047A (enExample) |
| NO (1) | NO20010610L (enExample) |
| PL (1) | PL345824A1 (enExample) |
| SE (1) | SE1102739T5 (enExample) |
| SI (1) | SI20579A (enExample) |
| SK (1) | SK942001A3 (enExample) |
| TR (1) | TR200100274T2 (enExample) |
| WO (1) | WO2000007972A1 (enExample) |
| ZA (1) | ZA200100832B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ513449A (en) * | 1999-03-01 | 2004-02-27 | Pfizer Prod Inc | Oxamic acids and derivatives as thyroid receptor ligands |
| US6599942B1 (en) | 1999-03-29 | 2003-07-29 | Novartis Ag | Thyromimetic organic compounds |
| US6790978B2 (en) | 1999-03-29 | 2004-09-14 | Novartis Ag | Thyromimetic organic compounds |
| GB9928805D0 (en) * | 1999-12-07 | 2000-02-02 | Karobio Ab | Compounds active at the Glucocorticoid and Thyroid Hormone Receptors |
| US6664291B2 (en) | 2000-03-31 | 2003-12-16 | Pfizer, Inc. | Malonamic acids and derivatives thereof as thyroid receptor ligands |
| DE10038007A1 (de) * | 2000-08-04 | 2002-02-14 | Bayer Ag | Neue Amino-und Amido-Diphenylether für Arzneimittel |
| ES2246292T3 (es) | 2000-10-30 | 2006-02-16 | Pfizer Products Inc. | Moduladores de receptor glucocorticoide. |
| AU2001216038A1 (en) * | 2000-11-14 | 2002-05-27 | Alcon Laboratories Inc. | Treatment of glaucoma and ocular hypertension |
| GB0029102D0 (en) * | 2000-11-29 | 2001-01-10 | Karobio Ab | Compounds active at the glucocorticoid receptor |
| GB0029100D0 (en) * | 2000-11-29 | 2001-01-10 | Karobio Ab | Compounds active at the glucocorticoid receptor |
| US6583180B2 (en) | 2001-02-14 | 2003-06-24 | Abbott Laboratories | Glucocorticoid receptor modulators |
| US6777442B2 (en) * | 2001-03-12 | 2004-08-17 | Bayer Aktiengesellschaft | Diphenyl derivatives |
| GB0111861D0 (en) | 2001-05-15 | 2001-07-04 | Karobio Ab | Novel compounds |
| AU2002331145B2 (en) * | 2001-08-24 | 2008-07-10 | Karo Bio Ab | Prime ring substituted thyroid receptor antagonists for the treatment of cardiac and metabolic disorders |
| GB0120691D0 (en) * | 2001-08-24 | 2001-10-17 | Karobio Ab | Novel Compounds |
| ES2253495T3 (es) | 2001-09-26 | 2006-06-01 | Pfizer Products Inc. | Acidos indol carboxilicos como ligandos de receptores tiroideos. |
| AU2002334675A1 (en) | 2001-09-26 | 2003-04-07 | Theravance, Inc. | Substituted phenol compounds useful for anesthesia and sedation |
| CA2473886C (en) | 2002-01-22 | 2012-08-21 | The Regents Of The University Of California | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof |
| CA2473162A1 (en) * | 2002-01-30 | 2003-08-07 | Kissei Pharmaceutical Co., Ltd. | Novel thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof |
| GB0215978D0 (en) * | 2002-07-10 | 2002-08-21 | Karobio Ab | Novel compounds |
| AU2002951977A0 (en) | 2002-10-10 | 2002-10-24 | Leo Engineering Pty Ltd | Improvements to two-part vessels |
| WO2005051298A2 (en) | 2003-11-19 | 2005-06-09 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
| WO2006128058A2 (en) * | 2005-05-26 | 2006-11-30 | Metabasis Therapeutics, Inc. | Thyromimetics for the treatment of fatty liver diseases |
| GB0406378D0 (en) * | 2004-03-22 | 2004-04-21 | Karobio Ab | Novel pharmaceutical compositions |
| WO2006128056A2 (en) * | 2005-05-26 | 2006-11-30 | Metabasis Therapeutics, Inc. | Novel phosphinic acid-containing thyromimetics |
| EP2273881A1 (en) * | 2008-04-15 | 2011-01-19 | Osteogenex, Inc. | Compounds and methods for altering bone growth |
| AU2017363206A1 (en) | 2016-11-21 | 2019-06-13 | Viking Therapeutics, Inc. | Method of treating glycogen storage disease |
| EP3634426A4 (en) | 2017-06-05 | 2021-04-07 | Viking Therapeutics, Inc. | COMPOSITIONS FOR TREATMENT OF FIBROSE |
| MX2020009843A (es) | 2018-03-22 | 2020-12-11 | Viking Therapeutics Inc | Formas cristalinas y metodos de produccion de formas cristalinas de un compuesto. |
| WO2020117962A1 (en) | 2018-12-05 | 2020-06-11 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0580550T3 (da) * | 1992-07-21 | 1998-02-02 | Ciba Geigy Ag | Oxamidsyrederivater som hypercholesterolæmiske midler |
| JP2002527355A (ja) * | 1998-06-08 | 2002-08-27 | カロ バイオ アクチェブラーグ | 糖尿病の治療 |
-
1998
- 1998-08-05 GB GBGB9816935.2A patent/GB9816935D0/en not_active Ceased
-
1999
- 1999-08-04 DE DE69907210T patent/DE69907210T2/de not_active Expired - Fee Related
- 1999-08-04 CA CA002339194A patent/CA2339194A1/en not_active Abandoned
- 1999-08-04 MX MXPA01001047A patent/MXPA01001047A/es not_active IP Right Cessation
- 1999-08-04 WO PCT/IB1999/001447 patent/WO2000007972A1/en not_active Ceased
- 1999-08-04 US US09/744,865 patent/US6492424B1/en not_active Expired - Fee Related
- 1999-08-04 BR BR9912742-3A patent/BR9912742A/pt not_active Application Discontinuation
- 1999-08-04 AT AT99936913T patent/ATE238267T1/de not_active IP Right Cessation
- 1999-08-04 TR TR2001/00274T patent/TR200100274T2/xx unknown
- 1999-08-04 JP JP2000563607A patent/JP2002522407A/ja active Pending
- 1999-08-04 PL PL99345824A patent/PL345824A1/xx not_active Application Discontinuation
- 1999-08-04 CN CN99809310A patent/CN1311767A/zh active Pending
- 1999-08-04 ES ES99936913T patent/ES2193730T3/es not_active Expired - Lifetime
- 1999-08-04 IL IL14110699A patent/IL141106A0/xx unknown
- 1999-08-04 EP EP99936913A patent/EP1102739B1/en not_active Expired - Lifetime
- 1999-08-04 DK DK99936913T patent/DK1102739T3/da active
- 1999-08-04 ID IDW20010257A patent/ID28805A/id unknown
- 1999-08-04 HU HU0103222A patent/HUP0103222A3/hu unknown
- 1999-08-04 AU AU51881/99A patent/AU753376B2/en not_active Ceased
- 1999-08-04 KR KR1020017001279A patent/KR20010072113A/ko not_active Withdrawn
- 1999-08-04 SI SI9920064A patent/SI20579A/sl unknown
- 1999-08-04 SK SK94-2001A patent/SK942001A3/sk unknown
- 1999-08-04 SE SE99936913T patent/SE1102739T5/xx unknown
-
2001
- 2001-01-30 ZA ZA200100832A patent/ZA200100832B/xx unknown
- 2001-02-02 BG BG105214A patent/BG105214A/xx unknown
- 2001-02-05 NO NO20010610A patent/NO20010610L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE1102739T3 (enExample) | 2003-08-12 |
| US6492424B1 (en) | 2002-12-10 |
| ID28805A (id) | 2001-07-05 |
| AU5188199A (en) | 2000-02-28 |
| BG105214A (en) | 2001-12-29 |
| ZA200100832B (en) | 2001-10-31 |
| CN1311767A (zh) | 2001-09-05 |
| DE69907210D1 (de) | 2003-05-28 |
| WO2000007972A1 (en) | 2000-02-17 |
| AU753376B2 (en) | 2002-10-17 |
| DK1102739T3 (da) | 2003-08-18 |
| HUP0103222A2 (hu) | 2002-01-28 |
| CA2339194A1 (en) | 2000-02-17 |
| DE69907210T2 (de) | 2004-02-19 |
| EP1102739B1 (en) | 2003-04-23 |
| ATE238267T1 (de) | 2003-05-15 |
| EP1102739A1 (en) | 2001-05-30 |
| MXPA01001047A (es) | 2002-09-02 |
| KR20010072113A (ko) | 2001-07-31 |
| SE1102739T5 (enExample) | 2003-09-16 |
| JP2002522407A (ja) | 2002-07-23 |
| NO20010610L (no) | 2001-04-04 |
| GB9816935D0 (en) | 1998-09-30 |
| HUP0103222A3 (en) | 2002-12-28 |
| PL345824A1 (en) | 2002-01-14 |
| IL141106A0 (en) | 2002-02-10 |
| ES2193730T3 (es) | 2003-11-01 |
| NO20010610D0 (no) | 2001-02-05 |
| BR9912742A (pt) | 2001-05-02 |
| SI20579A (sl) | 2001-12-31 |
| SK942001A3 (en) | 2001-12-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TR200100274T2 (tr) | Metabolik bozuklukların tedavisi için glikokortikoit ve tiroit hormon reseptörü ligandları. | |
| KR100258680B1 (en) | Novel potent inducers of terminal differentiation andmethods of use thereof. | |
| CA2190765A1 (en) | Novel potent inducers of terminal differentiation and methods of use thereof | |
| TR199801179T2 (xx) | Yeni taksoitler, bunlar�n haz�rlanmalar� ve ila� bile�imleri. | |
| CA2294098A1 (en) | Novel thyroid receptor ligands and method | |
| NZ312303A (en) | Novel nor-pregnanes for inducing hypothalamic effects | |
| EP0990650B8 (en) | Tricyclic pyrrole or pyrazole derivatives | |
| EP1484058A3 (en) | Pharmaceutical composition for inhibiting altering gene expression and for inducing differentiation in non-malignant cells | |
| DE60236456D1 (de) | Liposomale abgabe von verbindungen auf vitamin-e-basis | |
| HUP0203896A2 (hu) | Helyettesítet 8-arilkinolin-foszfodiészteráz-4-inhibitorok és alkalmazásuk | |
| DE69227088D1 (de) | Verwendung von 1-(aminoalkyl)-3-Quinoxalin-2-on Derivaten zur Herstellung von neuroprotektiven Mitteln | |
| ES8501410A1 (es) | Un procedimiento para la preparacion de nuevos derivados de fosfolipidos. | |
| ES2081777A6 (es) | Nuevos derivados de acido d,l-glutamico y acido d,l-aspartico | |
| TW328957B (en) | Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation | |
| WO1991008737A3 (en) | Pharmacologically active amide carboxylate derivatives | |
| RO115802B1 (ro) | Derivaţi ai acidului pirazol dihidrobenzofuranil propenoic, intermediar pentru prepararea acestora, compoziţii farmaceutice ale acestora şi metodă de tratament | |
| DE69714577D1 (de) | Neue steroidcarbamate als potenzierungsmittel | |
| ATE296115T1 (de) | Ortsspezifische arzneimittel verabreichung | |
| Louiset et al. | Effect of acetylcholine on the electrical and secretory activities of frog pituitary melanotrophs | |
| ES8500883A1 (es) | Procedimiento para preparar compuestos complejos de (1, 2-difeniletilendiamina)-platino (ii) | |
| DE68905361D1 (de) | Trienische derivate mit chromenischer struktur, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen. | |
| KR910020014A (ko) | α-옥소피롤로[2,3-b]인돌 아세트산, 에스테르, 아미드 및 관련 동족체, 이의 제조방법 및 약제로서의 이의 용도 | |
| WO2001044205A3 (en) | Phenanthryl piperazinyl dicarboxylic acids as selective nmda receptor modulating agents | |
| GB1322640A (en) | Selected 5-substituted-5-phenylalkyl barbituric acids analgetic compositions and method based thereon | |
| ES472208A1 (es) | Procedimiento para la obtencion de nuevos derivados de 2- bencimidazol. |