TR200003884T2 - N-Fenil-N'-Fenilpropilpiperazin türevleri ve bunların hazırlanma prosesi - Google Patents

N-Fenil-N'-Fenilpropilpiperazin türevleri ve bunların hazırlanma prosesi

Info

Publication number
TR200003884T2
TR200003884T2 TR2000/03884T TR200003884T TR200003884T2 TR 200003884 T2 TR200003884 T2 TR 200003884T2 TR 2000/03884 T TR2000/03884 T TR 2000/03884T TR 200003884 T TR200003884 T TR 200003884T TR 200003884 T2 TR200003884 T2 TR 200003884T2
Authority
TR
Turkey
Prior art keywords
phenylpropylpiperazine
phenyl
derivatives
preparation process
group
Prior art date
Application number
TR2000/03884T
Other languages
English (en)
Inventor
Sato Hiroki
Nagano Eiichi
Chikazawa Jun
Takei Mineo
Higashino Raita
Original Assignee
Zeria Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeria Pharmaceutical Co., Ltd. filed Critical Zeria Pharmaceutical Co., Ltd.
Publication of TR200003884T2 publication Critical patent/TR200003884T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Mevcut bulus, içerisinde R1'in düsük bir alkil grubunu, R2'nin düsük bir alkoksi grubunu ve R3'ün siyano, karboksil veya bir indolkarbonil grubunu temsil ettigi, genel formül (1) ile simgelenen bir N-fenil-N-'fenilpropilpiperazin türevleri, bunu içeren ilaçlar ve bunlarin hazirlanmasi için bir proses ile ilgilidir. Bu bilesikler tesirli bir alfa1-adrenerjik reseptör bloke edici aktiviteye sahiptirler ve hipertansiyon, kongestif kalp yetmezligi, miyokardial iskemi, aritmi, anjin pektorisi, üriner bozukluklar ve prostatik hipertrofi sebebiyle sik idrara çikma gibi düzensizliklerin önlenmesinde ve tedavisinde yararlidirlar.
TR2000/03884T 1998-06-30 1999-06-28 N-Fenil-N'-Fenilpropilpiperazin türevleri ve bunların hazırlanma prosesi TR200003884T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19814898 1998-06-30

Publications (1)

Publication Number Publication Date
TR200003884T2 true TR200003884T2 (tr) 2001-05-21

Family

ID=16386265

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03884T TR200003884T2 (tr) 1998-06-30 1999-06-28 N-Fenil-N'-Fenilpropilpiperazin türevleri ve bunların hazırlanma prosesi

Country Status (14)

Country Link
US (1) US6395739B1 (tr)
EP (1) EP1090913A4 (tr)
KR (1) KR20010053010A (tr)
CN (1) CN1307563A (tr)
AU (1) AU742720B2 (tr)
BR (1) BR9911992A (tr)
CA (1) CA2336083A1 (tr)
HU (1) HUP0102609A3 (tr)
NO (1) NO20006542L (tr)
PE (1) PE20001332A1 (tr)
PL (1) PL345166A1 (tr)
TR (1) TR200003884T2 (tr)
WO (1) WO2000000471A1 (tr)
ZA (1) ZA200007636B (tr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4117417A1 (de) * 1991-05-28 1992-12-03 Herberts Gmbh Waessrige dispersion eines kathodisch abscheidbaren bindemittels, verfahren zu deren herstellung und deren verwendung
CN1172919C (zh) * 2002-06-03 2004-10-27 上海医药工业研究院 芳烷醇哌嗪衍生物及其在制备抗抑郁症药物中的应用
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US20090076043A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched alfuzosin
CA2715760C (en) * 2008-02-21 2017-06-13 Mitsubishi Tanabe Pharma Corporation Solid preparation for oral administration of cariprazine hydrochloride
SG192507A1 (en) 2008-07-16 2013-08-30 Richter Gedeon Nyrt Pharmaceutical formulations containing dopamine receptor ligands
JP2017214342A (ja) * 2016-06-02 2017-12-07 日清オイリオグループ株式会社 排尿障害の予防用又は改善用組成物
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH446348A (de) 1963-01-23 1967-11-15 Ciba Geigy Verfahren zur Herstellung von Piperazinverbindungen
GB9021535D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
EP0576766A1 (en) * 1992-06-29 1994-01-05 Novo Nordisk A/S Propanolamine derivatives, their preparation and use
KR100349634B1 (ko) * 1994-03-30 2003-01-08 제리아 신야쿠 고교 가부시키 가이샤 인돌유도체및이를함유하는제제

Also Published As

Publication number Publication date
EP1090913A4 (en) 2001-11-07
ZA200007636B (en) 2001-07-09
KR20010053010A (ko) 2001-06-25
US6395739B1 (en) 2002-05-28
NO20006542L (no) 2001-02-28
PE20001332A1 (es) 2000-12-19
HUP0102609A2 (hu) 2001-12-28
AU742720B2 (en) 2002-01-10
PL345166A1 (en) 2001-12-03
CN1307563A (zh) 2001-08-08
EP1090913A1 (en) 2001-04-11
CA2336083A1 (en) 2000-01-06
WO2000000471A1 (fr) 2000-01-06
AU4290399A (en) 2000-01-17
NO20006542D0 (no) 2000-12-21
BR9911992A (pt) 2001-03-27
HUP0102609A3 (en) 2002-12-28

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