TR199800543A2 - Benziloksi ikame edilen, aniliye edilmis N-heterosiklik bilesikler. - Google Patents
Benziloksi ikame edilen, aniliye edilmis N-heterosiklik bilesikler.Info
- Publication number
- TR199800543A2 TR199800543A2 TR1998/00543A TR9800543A TR199800543A2 TR 199800543 A2 TR199800543 A2 TR 199800543A2 TR 1998/00543 A TR1998/00543 A TR 1998/00543A TR 9800543 A TR9800543 A TR 9800543A TR 199800543 A2 TR199800543 A2 TR 199800543A2
- Authority
- TR
- Turkey
- Prior art keywords
- anilylated
- heterocyclic compounds
- benzyloxy substituted
- benzyloxy
- substituted
- Prior art date
Links
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Bulusun konusu, asagidaki formül (I)'e sahip olan Formül (I) ve semboller B, D, R1 ve R2'nin patent istemlerinde belirtilen anlamlara geldigi bilesikler, bunlarin üretimine yönelik bir yöntem ve bunlarin karaciger sirozu ve Alzheimer hastaliginin tedavisine yönelik ilaçlar olarak kullanimi ile ilgilidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19712960A DE19712960A1 (de) | 1997-03-27 | 1997-03-27 | Benzyloxy-substituierte, anellierte N-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Bradykininrezeptorantagonisten |
Publications (1)
Publication Number | Publication Date |
---|---|
TR199800543A2 true TR199800543A2 (tr) | 1998-10-21 |
Family
ID=7824838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR1998/00543A TR199800543A2 (tr) | 1997-03-27 | 1998-03-25 | Benziloksi ikame edilen, aniliye edilmis N-heterosiklik bilesikler. |
Country Status (16)
Country | Link |
---|---|
US (1) | US6211196B1 (tr) |
EP (1) | EP0867432B1 (tr) |
JP (1) | JPH10279563A (tr) |
KR (1) | KR19980080757A (tr) |
CN (1) | CN1194978A (tr) |
AT (1) | ATE268759T1 (tr) |
AU (1) | AU5965298A (tr) |
BR (1) | BR9801132A (tr) |
CA (1) | CA2232499A1 (tr) |
CZ (1) | CZ91498A3 (tr) |
DE (2) | DE19712960A1 (tr) |
ES (1) | ES2223090T3 (tr) |
HU (1) | HUP9800649A3 (tr) |
NO (1) | NO981383L (tr) |
PL (1) | PL325597A1 (tr) |
TR (1) | TR199800543A2 (tr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10134721A1 (de) * | 2001-07-17 | 2003-02-06 | Bayer Ag | Tetrahydrochinoxaline |
US6492517B1 (en) | 2001-07-19 | 2002-12-10 | Air Products And Chemicals, Inc. | Method for preparing halomethyl heterocyclic compounds |
US6958349B2 (en) * | 2002-04-10 | 2005-10-25 | Ortho-Mcneil Pharmaceuticals, Inc. | Heteroaryl alkylamide derivatives useful as bradykinin receptor modulators |
WO2003093245A1 (en) * | 2002-05-03 | 2003-11-13 | Elan Pharmaceuticals, Inc. | Sulfonylquinoxalone acetamide derivatives and related compounds as bradykinin antagonists |
ITMI20021247A1 (it) * | 2002-06-07 | 2003-12-09 | Menarini Ricerche Spa | Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche |
MX2007010572A (es) | 2005-03-01 | 2007-10-04 | Wyeth Corp | Compuestos de cinolina y su uso como moduladores de receptor x de higado. |
TWI407960B (zh) | 2007-03-23 | 2013-09-11 | Jerini Ag | 小分子緩激肽b2受體調節劑 |
JP6479854B2 (ja) | 2014-05-07 | 2019-03-06 | エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングEvotec International GmbH | 医薬組成物のためのスルホキシイミン置換キナゾリン |
WO2019101906A1 (en) | 2017-11-24 | 2019-05-31 | Pharvaris B.V. | Novel bradykinin b2 receptor antagonists |
AR118982A1 (es) | 2019-05-23 | 2021-11-17 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
AR118983A1 (es) | 2019-05-23 | 2021-11-17 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
PT4203919T (pt) | 2021-08-05 | 2024-04-23 | Pharvaris Gmbh | Composição à base de lípidos para administração oral de antagonistas do recetor b2 da bradicinina |
WO2023180577A1 (en) | 2022-03-25 | 2023-09-28 | Pharvaris Gmbh | Therapeutic uses of bradykinin b2-receptor antagonists |
WO2023180575A1 (en) | 2022-03-25 | 2023-09-28 | Pharvaris Gmbh | Solid composition comprising solubilised bradykinin b2-receptor antagonists |
TW202345810A (zh) | 2022-03-25 | 2023-12-01 | 瑞士商帕法瑞斯有限責任公司 | 包含緩激肽b2受體拮抗劑之固態延長釋放組成物 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5202336A (en) * | 1986-09-24 | 1993-04-13 | Bayer Aktiengesellschaft | Antiflammatory quinolin methoxy phenylsulphonamides |
AU680870B2 (en) * | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
CN1168667A (zh) * | 1994-10-27 | 1997-12-24 | 藤沢药品工业株式会社 | 用作缓激肽拮抗剂的吡啶并嘧啶酮,喹啉和稠合的n-杂环化合物 |
FR2735128B1 (fr) * | 1995-06-07 | 1997-07-25 | Fournier Ind & Sante | Nouveaux composes de benzenesulfonamide, leur procede de preparation et utilisation en therapeutique. |
FR2737892B1 (fr) * | 1995-08-17 | 1997-10-24 | Fournier Ind & Sante | Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique |
GB9519077D0 (en) * | 1995-09-18 | 1995-11-15 | Fujisawa Pharmaceutical Co | New heterocyclic compounds |
DE19610784A1 (de) * | 1996-03-19 | 1997-09-25 | Hoechst Ag | Fluoralkyl- und Fluoralkoxysubstituierte heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung |
EP0808627A2 (de) * | 1996-05-22 | 1997-11-26 | Hoechst Aktiengesellschaft | Verwendung nicht-peptidischer Bradykinin-Antagonisten zur Behandlung und Prävention von chronisch-fibrogenetischen Lebererkrankungen, akuten Lebererkrankungen und den damit verbundenen Komplikationen |
DK0835659T3 (da) * | 1996-10-14 | 2005-04-18 | Aventis Pharma Gmbh | Anvendelse af ikke-peptidiske antagonister for bradykinin til fremstilling af lægemidler til behandling og forebyggelse af Alzheimer's sygdom |
-
1997
- 1997-03-27 DE DE19712960A patent/DE19712960A1/de not_active Withdrawn
-
1998
- 1998-03-18 CA CA002232499A patent/CA2232499A1/en not_active Abandoned
- 1998-03-23 DE DE59811526T patent/DE59811526D1/de not_active Expired - Lifetime
- 1998-03-23 AT AT98105200T patent/ATE268759T1/de not_active IP Right Cessation
- 1998-03-23 EP EP98105200A patent/EP0867432B1/de not_active Expired - Lifetime
- 1998-03-23 ES ES98105200T patent/ES2223090T3/es not_active Expired - Lifetime
- 1998-03-25 TR TR1998/00543A patent/TR199800543A2/tr unknown
- 1998-03-25 HU HU9800649A patent/HUP9800649A3/hu unknown
- 1998-03-25 CZ CZ98914A patent/CZ91498A3/cs unknown
- 1998-03-26 NO NO981383A patent/NO981383L/no unknown
- 1998-03-26 CN CN98105890A patent/CN1194978A/zh active Pending
- 1998-03-26 JP JP10079423A patent/JPH10279563A/ja not_active Ceased
- 1998-03-26 AU AU59652/98A patent/AU5965298A/en not_active Abandoned
- 1998-03-26 BR BR9801132A patent/BR9801132A/pt not_active Application Discontinuation
- 1998-03-26 US US09/048,305 patent/US6211196B1/en not_active Expired - Fee Related
- 1998-03-27 PL PL98325597A patent/PL325597A1/xx unknown
- 1998-03-27 KR KR1019980010670A patent/KR19980080757A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US6211196B1 (en) | 2001-04-03 |
ATE268759T1 (de) | 2004-06-15 |
DE59811526D1 (de) | 2004-07-15 |
ES2223090T3 (es) | 2005-02-16 |
PL325597A1 (en) | 1998-09-28 |
EP0867432A3 (de) | 1998-10-14 |
CN1194978A (zh) | 1998-10-07 |
EP0867432A2 (de) | 1998-09-30 |
MX9802372A (es) | 1998-09-30 |
HUP9800649A2 (hu) | 1998-12-28 |
JPH10279563A (ja) | 1998-10-20 |
AU5965298A (en) | 1998-10-01 |
CZ91498A3 (cs) | 1998-10-14 |
NO981383D0 (no) | 1998-03-26 |
EP0867432B1 (de) | 2004-06-09 |
HU9800649D0 (en) | 1998-05-28 |
KR19980080757A (ko) | 1998-11-25 |
NO981383L (no) | 1998-09-28 |
BR9801132A (pt) | 2000-03-21 |
CA2232499A1 (en) | 1998-09-27 |
DE19712960A1 (de) | 1998-10-01 |
HUP9800649A3 (en) | 1999-01-28 |
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