CA2336083A1 - N-phenyl-n'-phenylpropylpiperazine derivatives and process for the preparation thereof - Google Patents

N-phenyl-n'-phenylpropylpiperazine derivatives and process for the preparation thereof Download PDF

Info

Publication number
CA2336083A1
CA2336083A1 CA002336083A CA2336083A CA2336083A1 CA 2336083 A1 CA2336083 A1 CA 2336083A1 CA 002336083 A CA002336083 A CA 002336083A CA 2336083 A CA2336083 A CA 2336083A CA 2336083 A1 CA2336083 A1 CA 2336083A1
Authority
CA
Canada
Prior art keywords
compound
formula
phenylpropylpiperazine
phenyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002336083A
Other languages
English (en)
French (fr)
Inventor
Mineo Takei
Eiichi Nagano
Jun Chikazawa
Raita Higashino
Hiroki Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeria Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2336083A1 publication Critical patent/CA2336083A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002336083A 1998-06-30 1999-06-28 N-phenyl-n'-phenylpropylpiperazine derivatives and process for the preparation thereof Abandoned CA2336083A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10/198148 1998-06-30
JP19814898 1998-06-30
PCT/JP1999/003448 WO2000000471A1 (fr) 1998-06-30 1999-06-28 Derives de n-phenyle-n'-phenylpropilpiperazine et leur procede de preparation

Publications (1)

Publication Number Publication Date
CA2336083A1 true CA2336083A1 (en) 2000-01-06

Family

ID=16386265

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002336083A Abandoned CA2336083A1 (en) 1998-06-30 1999-06-28 N-phenyl-n'-phenylpropylpiperazine derivatives and process for the preparation thereof

Country Status (14)

Country Link
US (1) US6395739B1 (tr)
EP (1) EP1090913A4 (tr)
KR (1) KR20010053010A (tr)
CN (1) CN1307563A (tr)
AU (1) AU742720B2 (tr)
BR (1) BR9911992A (tr)
CA (1) CA2336083A1 (tr)
HU (1) HUP0102609A3 (tr)
NO (1) NO20006542L (tr)
PE (1) PE20001332A1 (tr)
PL (1) PL345166A1 (tr)
TR (1) TR200003884T2 (tr)
WO (1) WO2000000471A1 (tr)
ZA (1) ZA200007636B (tr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4117417A1 (de) * 1991-05-28 1992-12-03 Herberts Gmbh Waessrige dispersion eines kathodisch abscheidbaren bindemittels, verfahren zu deren herstellung und deren verwendung
CN1172919C (zh) * 2002-06-03 2004-10-27 上海医药工业研究院 芳烷醇哌嗪衍生物及其在制备抗抑郁症药物中的应用
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US20090076043A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched alfuzosin
US20110059980A1 (en) * 2008-02-21 2011-03-10 Yasuaki Oobayashi Solid preparation for oral administration
SI2317852T1 (sl) 2008-07-16 2015-04-30 Richter Gedeon Nyrt. Farmacevtske formulacije, ki vsebujejo ligande dopaminskega receptorja
JP2017214342A (ja) * 2016-06-02 2017-12-07 日清オイリオグループ株式会社 排尿障害の予防用又は改善用組成物
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH446346A (de) * 1963-01-23 1967-11-15 Ciba Geigy Verfahren zur Herstellung von Piperazinverbindungen
GB9021535D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
EP0576766A1 (en) 1992-06-29 1994-01-05 Novo Nordisk A/S Propanolamine derivatives, their preparation and use
ES2160158T3 (es) * 1994-03-30 2001-11-01 Zeria Pharm Co Ltd Derivados de 4-indol-1-il acido butirico, su preparacion y su utilizacion como inhibidores de receptores alfa1-adrenergicos y testosterona 5alfa-reductasas.

Also Published As

Publication number Publication date
NO20006542L (no) 2001-02-28
HUP0102609A2 (hu) 2001-12-28
EP1090913A1 (en) 2001-04-11
PL345166A1 (en) 2001-12-03
PE20001332A1 (es) 2000-12-19
KR20010053010A (ko) 2001-06-25
NO20006542D0 (no) 2000-12-21
HUP0102609A3 (en) 2002-12-28
AU4290399A (en) 2000-01-17
US6395739B1 (en) 2002-05-28
AU742720B2 (en) 2002-01-10
EP1090913A4 (en) 2001-11-07
ZA200007636B (en) 2001-07-09
WO2000000471A1 (fr) 2000-01-06
CN1307563A (zh) 2001-08-08
BR9911992A (pt) 2001-03-27
TR200003884T2 (tr) 2001-05-21

Similar Documents

Publication Publication Date Title
US4207324A (en) 1,2-Di-Substituted-4-haloimidazole-5-acetic acid derivatives and their use
CA2172513C (en) Aminocyclohexylesters and uses thereof
US7435729B2 (en) Compounds and methods for modulation of estrogen receptors
US3454554A (en) Aminoalkyliminodibenzyl compounds
US4234595A (en) 3-Indolyl-tertiary butylaminopropanols
US4562201A (en) Aminomethyl benzanilides
US5055473A (en) Quinolinyl sulfonamide anti-arrhythmic agents and use thereas
AU742720B2 (en) N-phenyl-N'-phenylpropylpiperazine derivatives and process for the preparation thereof
US4806547A (en) Isoquinoline derivatives, analgesic compounds thereof and method of treating pain
US5059620A (en) Aryl substituted aminomethyl benzene derivatives
JPH0283375A (ja) ２−置換ピペラジニル−２−（１，２−ベンズイソキサゾール−３−イル）酢酸誘導体
EP0306827B1 (en) Amide compounds, process for preparing the same, and composition for activating gastric motor function containing the same
US5232978A (en) 1-(2-arylethyl)-pyrrolidines
US6300499B1 (en) α1-adrenergic receptor antagonists
CA1294961C (en) Aminoalcohols, their preparation process and their applications, particularly in therapeutics
US4748184A (en) Aryl substituted aminomethyl benzene derivatives having antiarrhythmic utility
US4539318A (en) Tertiary aminohydroxypropoxy substituted thiadiazoles, pharmaceutical compositions and use
MXPA01000086A (en) N-phenyl-n'-phenylpropylpiperazine derivatives and process for the preparation thereof
US4474783A (en) Cyclopropylmethyl piperazines, the process for preparing the same and their use in therapeutics
US3594401A (en) Acetylenically unsaturated diaryl nitriles and derivatives thereof
NZ195688A (en) 1-(8-quinolyl)-2-pyrrolidinone and pharmaceutical compositions
US3732248A (en) 3-substituted-1-phenyl indolinones
US3316245A (en) Morphanthridine carboxylic acid and derivatives
CZ20004720A3 (cs) N-fenyl-N'-fenylpropylpiperazinový derivát a způsob jeho přípravy
NO862494L (no) Fremgangsmaate for fremstilling av nye aromatiske forbindelser.

Legal Events

Date Code Title Description
FZDE Discontinued