PE20001332A1 - Derivados n-fenil-n`-fenilpropilpiperazina y un metodo para su produccion - Google Patents

Derivados n-fenil-n`-fenilpropilpiperazina y un metodo para su produccion

Info

Publication number
PE20001332A1
PE20001332A1 PE1999001244A PE00124499A PE20001332A1 PE 20001332 A1 PE20001332 A1 PE 20001332A1 PE 1999001244 A PE1999001244 A PE 1999001244A PE 00124499 A PE00124499 A PE 00124499A PE 20001332 A1 PE20001332 A1 PE 20001332A1
Authority
PE
Peru
Prior art keywords
phenylpropylpiperazine
phenyl
derivatives
production
refers
Prior art date
Application number
PE1999001244A
Other languages
English (en)
Inventor
Hiroki Sato
Eiichi Nagano
Jun Chikazawa
Mineo Takei
Raita Higashino
Original Assignee
Zeria Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeria Pharm Co Ltd filed Critical Zeria Pharm Co Ltd
Publication of PE20001332A1 publication Critical patent/PE20001332A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN DERIVADO N-FENIL-N`-FENILPROPILPIPERAZINA DE FORMULA I, DONDE: R1 ES ALQUILO, R2 ES ALCOXI, R3 ES CIANO, CARBOXILO, INDOLCARBONILO. TAMBIEN SE REFIERE A PROCEDIMIENTOS PARA LA PREPARACION. EL COMPUESTO I ES UN AGENTE BLOQUEANTE DE O1-ADRENERGICOS POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE LA HIPERTENSION, FALLO CARDIACO CONGESTIVO, ISQUEMIA MIOCARDICA, ARRITMIA, ANGINA DE PECHO, DISURIA
PE1999001244A 1998-06-30 1999-12-14 Derivados n-fenil-n`-fenilpropilpiperazina y un metodo para su produccion PE20001332A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19814898 1998-06-30

Publications (1)

Publication Number Publication Date
PE20001332A1 true PE20001332A1 (es) 2000-12-19

Family

ID=16386265

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001244A PE20001332A1 (es) 1998-06-30 1999-12-14 Derivados n-fenil-n`-fenilpropilpiperazina y un metodo para su produccion

Country Status (14)

Country Link
US (1) US6395739B1 (es)
EP (1) EP1090913A4 (es)
KR (1) KR20010053010A (es)
CN (1) CN1307563A (es)
AU (1) AU742720B2 (es)
BR (1) BR9911992A (es)
CA (1) CA2336083A1 (es)
HU (1) HUP0102609A3 (es)
NO (1) NO20006542L (es)
PE (1) PE20001332A1 (es)
PL (1) PL345166A1 (es)
TR (1) TR200003884T2 (es)
WO (1) WO2000000471A1 (es)
ZA (1) ZA200007636B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4117417A1 (de) * 1991-05-28 1992-12-03 Herberts Gmbh Waessrige dispersion eines kathodisch abscheidbaren bindemittels, verfahren zu deren herstellung und deren verwendung
CN1172919C (zh) * 2002-06-03 2004-10-27 上海医药工业研究院 芳烷醇哌嗪衍生物及其在制备抗抑郁症药物中的应用
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US20090076043A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched alfuzosin
EA023972B1 (ru) * 2008-02-21 2016-08-31 Рихтер Гедеон Нирт. Стабильный твёрдый препарат карипразина для перорального введения и способ его получения
PL2317852T3 (pl) 2008-07-16 2015-05-29 Richter Gedeon Nyrt Preparaty farmaceutyczne zawierające ligandy receptora dopaminy
JP2017214342A (ja) * 2016-06-02 2017-12-07 日清オイリオグループ株式会社 排尿障害の予防用又は改善用組成物
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH446348A (de) 1963-01-23 1967-11-15 Ciba Geigy Verfahren zur Herstellung von Piperazinverbindungen
GB9021535D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
EP0576766A1 (en) * 1992-06-29 1994-01-05 Novo Nordisk A/S Propanolamine derivatives, their preparation and use
DK0753511T3 (da) * 1994-03-30 2001-09-24 Zeria Pharm Co Ltd 4-indol-1-ylsmørsyrederivater, deres fremstilling og deres anvendelse som inhibitorer af alfa 1-adrenerge receptorer og testosteron-5alfa-reduktaser

Also Published As

Publication number Publication date
EP1090913A1 (en) 2001-04-11
HUP0102609A2 (hu) 2001-12-28
CA2336083A1 (en) 2000-01-06
PL345166A1 (en) 2001-12-03
BR9911992A (pt) 2001-03-27
CN1307563A (zh) 2001-08-08
US6395739B1 (en) 2002-05-28
NO20006542L (no) 2001-02-28
AU742720B2 (en) 2002-01-10
AU4290399A (en) 2000-01-17
HUP0102609A3 (en) 2002-12-28
TR200003884T2 (tr) 2001-05-21
KR20010053010A (ko) 2001-06-25
WO2000000471A1 (fr) 2000-01-06
EP1090913A4 (en) 2001-11-07
NO20006542D0 (no) 2000-12-21
ZA200007636B (en) 2001-07-09

Similar Documents

Publication Publication Date Title
KR960704854A (ko) 축합 피리다진계 화합물 (fused pyridazine compound)
PE20001562A1 (es) Derivados de benzamida como inhibidores de la produccion hepatica de la apo proteina b-100
PE20001332A1 (es) Derivados n-fenil-n`-fenilpropilpiperazina y un metodo para su produccion
PE20001330A1 (es) Derivados de fenilglicina
PL173023B1 (pl) Sposób wytwarzania pochodnych imidazolu
KR960031462A (ko) 복소환식 화합물
ATE266636T1 (de) Benzimidazolinone, benzoxazolinone, benzopiperazinone, indanone und deren derivate als faktor xa inhibitoren
NZ513449A (en) Oxamic acids and derivatives as thyroid receptor ligands
CA2269053A1 (en) Crystals of benzimidazole derivatives and their production
DE60020873D1 (de) Nervonsäurederivate,ihre herstellung und anwendung
YU52000A (sh) Jedinjenja meta-azaciklične amino benzojeve kiseline i njihovi derivati, koji su antagonisti integrina
PE10299A1 (es) Procedimiento para sintetizar piridinas sustituidas
MC1706A1 (fr) Dérivés de tétrahydronaphtalène
PE20011078A1 (es) PROCEDIMIENTO DE OBTENCION DE LOS DERIVADOS DE DIBENZO [b, f] AZEPINA
EA200200973A1 (ru) Пиридазинилфенилгидразоны, применяемые при застойной сердечной недостаточности
KR940005615A (ko) 시클로헵트이미다졸 유도체, 그의 제조방법 및 이 화합물을 함유하는 치료제
DE60009287D1 (de) Neuartige isoquinolin-derivate oder salze davon
AR029452A1 (es) Compuestos de 4-amino-3-alcoxiiminapirrolidina, utilizables en la preparacion de derivados de acidos quinolincarboxilicos y de sales e hidratos farmaceuticamente aceptables de los mismos y procedimiento de preparacion de dicho compuesto, respectivamente de dichos derivados
AR248394A1 (es) Procedimiento para obtener nuevos derivados de la n-bencilpiridina.
AR021678A1 (es) Derivados n-fenil-n'-fenilpropilpiperazina y un metodo para su produccion
ECSP993269A (es) Derivados n-fenil- n' fenilpropilpiperazina y un metodo para su produccion
KR890009879A (ko) 5- 아미노-1- 페닐-4-니트로피라졸의 제조방법
AR003129A1 (es) Derivados de bencimidazol 2-sustituidos y composiciones farmaceuticas que los comprenden
TR200100082T2 (tr) Klavulanik asit tuz ve esterlerinin hazırlanması için geliştirilmiş yöntem
PE20000479A1 (es) Eteres de morfolino

Legal Events

Date Code Title Description
FD Application declared void or lapsed