AR003129A1 - Derivados de bencimidazol 2-sustituidos y composiciones farmaceuticas que los comprenden - Google Patents

Derivados de bencimidazol 2-sustituidos y composiciones farmaceuticas que los comprenden

Info

Publication number
AR003129A1
AR003129A1 ARP960102802A AR10280296A AR003129A1 AR 003129 A1 AR003129 A1 AR 003129A1 AR P960102802 A ARP960102802 A AR P960102802A AR 10280296 A AR10280296 A AR 10280296A AR 003129 A1 AR003129 A1 AR 003129A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical compositions
alkyl
bencimidazole
substituted derivatives
substituted
Prior art date
Application number
ARP960102802A
Other languages
English (en)
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of AR003129A1 publication Critical patent/AR003129A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un derivado de bencimidazol 2-sustituido, caracterizado por tener la fórmula (I), en donde R1 es alquilo de 1 a 6 átomos de carbono, trifluormetiloo piridinilo; R2 es H, alquilo de 1 a 6 átomos de carbono o arilalquilo sustituido de 7a 10 átomos de carbono, en el que los sustituyentes son uno odos halógenos, grupos carboxilo o alcoxicarbonilo de 2 a 7 átomos de carbono; R3 y R4 son H, alquilo de 1 a 6 átomos de carbono, halógeno o nitro;o una salfarmacéuticamente aceptable delmismo. Estos derivados son útiles como inhibidores de la proliferación de células de músculo liso. Asimismo, se dana conocer composiciones farmacéuticas que los comprenden.
ARP960102802A 1995-06-07 1996-05-30 Derivados de bencimidazol 2-sustituidos y composiciones farmaceuticas que los comprenden AR003129A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/477,842 US5654436A (en) 1995-06-07 1995-06-07 2-substituted benzimidazole derivatives

Publications (1)

Publication Number Publication Date
AR003129A1 true AR003129A1 (es) 1998-07-08

Family

ID=23897571

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960102802A AR003129A1 (es) 1995-06-07 1996-05-30 Derivados de bencimidazol 2-sustituidos y composiciones farmaceuticas que los comprenden

Country Status (18)

Country Link
US (1) US5654436A (es)
EP (1) EP0830344B1 (es)
JP (1) JPH11506752A (es)
KR (1) KR19990022318A (es)
CN (1) CN1192204A (es)
AR (1) AR003129A1 (es)
AT (1) ATE209635T1 (es)
BR (1) BR9608557A (es)
CA (1) CA2223962A1 (es)
DE (1) DE69617420T2 (es)
ES (1) ES2165501T3 (es)
HU (1) HUP9900895A3 (es)
IL (1) IL118412A0 (es)
NZ (1) NZ309498A (es)
PT (1) PT830344E (es)
TW (1) TW322473B (es)
WO (1) WO1996040644A1 (es)
ZA (1) ZA964622B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990146A (en) * 1997-08-20 1999-11-23 Warner-Lambert Company Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation
US8163777B2 (en) 2006-03-23 2012-04-24 Synta Pharmaceuticals Corp. Benzimidazolyl-pyridine compounds for inflammation and immune-related uses
US8501957B2 (en) * 2008-12-10 2013-08-06 China Medical University Benzimidazole compounds and their use as anticancer agents
JP6212628B2 (ja) * 2013-04-29 2017-10-11 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ２−フェニル又は２−ヘタリールイミダゾール［１，２−ａ］ピリジン誘導体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2876233A (en) * 1956-10-29 1959-03-03 Gruenenthal Chemie 1-(p-halobenzyl)-2-methyl benzimidazoles and salts
FR1228524A (es) * 1958-05-23 1960-08-31
FR1530439A (fr) * 1966-05-16 1968-06-28 Pentachlorobenzyl-1 benzimidazoles
HU193951B (en) * 1985-03-11 1987-12-28 Richter Gedeon Vegyeszet Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
US5128359A (en) * 1990-02-16 1992-07-07 Laboratoires Upsa Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation
GB9027200D0 (en) * 1990-12-14 1991-02-06 Smithkline Beecham Plc Medicaments
DE4212748A1 (de) * 1992-04-16 1993-10-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5387600A (en) * 1992-07-30 1995-02-07 Fuji Photo Film Co., Ltd. Treating arteriosclerosis using benzimidazole compositions

Also Published As

Publication number Publication date
BR9608557A (pt) 1999-07-06
KR19990022318A (ko) 1999-03-25
AU5968396A (en) 1996-12-30
NZ309498A (en) 2000-09-29
TW322473B (es) 1997-12-11
JPH11506752A (ja) 1999-06-15
DE69617420D1 (de) 2002-01-10
CA2223962A1 (en) 1996-12-19
HUP9900895A2 (hu) 1999-07-28
EP0830344B1 (en) 2001-11-28
WO1996040644A1 (en) 1996-12-19
IL118412A0 (en) 1996-09-12
EP0830344A1 (en) 1998-03-25
ES2165501T3 (es) 2002-03-16
AU697295B2 (en) 1998-10-01
CN1192204A (zh) 1998-09-02
MX9709650A (es) 1998-07-31
DE69617420T2 (de) 2002-05-02
ATE209635T1 (de) 2001-12-15
PT830344E (pt) 2002-04-29
ZA964622B (en) 1997-12-04
HUP9900895A3 (en) 2001-08-28
US5654436A (en) 1997-08-05

Similar Documents

Publication Publication Date Title
EA199900591A1 (ru) АЗОТСОДЕРЖАЩИЕ ГЕТЕРОАРОМАТИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Ха
CO5060482A1 (es) Derivados terapeuticos de biarilo
RU95108387A (ru) Дикетопиперазин, способ его получения, фармацевтическая композиция, применение дикетопиперазина
AR014110A1 (es) Compuestos de 2-aminopiridinas, composiciones farmaceuticas, procedimiento de tratamiento, prevencion e inhibicion
DK1485359T3 (da) Natriumkanalblokkere
ATE253545T1 (de) Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren
DK0753301T3 (da) Kombination af et benzimidazol med angiotensin-II-antagonistisk aktivitet med et diuretika
FI862757A (fi) Pyridonkarbonsyraderivat och foerfarande foer framstaellning av dessa.
EA200000804A1 (ru) Мета-азациклические соединения аминобензойной кислоты и их производные, являющиеся ингибиторами интегрина
PE20040698A1 (es) Derivados de isoindolina
RS51193B (sr) Hidantoinski derivati korisni kao inhibitori metaloproteinaza
ES2176719T3 (es) Derivados de benzopirano que tienen una accion antagonista de leucotrienos.
PE69398A1 (es) Antagonistas de receptor de benzoxazinona dopamina d4
ATE453389T1 (de) Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen
AR003137A1 (es) Una composicion farmaceutica para tratar la leucemia
DK1000034T3 (da) Substituerede 6-alkylphenanthridiner
EA199901096A1 (ru) Цианогуанидины в качестве ингибиторов пролиферации клеток
AR003129A1 (es) Derivados de bencimidazol 2-sustituidos y composiciones farmaceuticas que los comprenden
AR002749A1 (es) Derivados de estiril bencimidazol y composicion farmaceutica que los comprende.
AR003128A1 (es) Derivados de bencimidazol 2-sustituidos y composicion farmaceutica que los comprende.
EA200200749A1 (ru) Производные гетероциклического амида
EA199900460A1 (ru) Производные бензолсульфоамида и лекарственные средства, содержащие упомянутые производные
ES2140552T3 (es) Derivados indol como inhibidores de la 5-alfa-reductasa-1.
ATE222583T1 (de) Derivate substituierter amidinonaphthylester
FI822706A0 (fi) Foerfarande foer framstaellning av farmakologiskt aktiva heteroaryloxipropanolaminer

Legal Events

Date Code Title Description
FB Suspension of granting procedure