DE69617420D1 - 2-substituierte benzimidazolderivate als inhibitoren der glatten muskelzellenproliferation - Google Patents

2-substituierte benzimidazolderivate als inhibitoren der glatten muskelzellenproliferation

Info

Publication number
DE69617420D1
DE69617420D1 DE69617420T DE69617420T DE69617420D1 DE 69617420 D1 DE69617420 D1 DE 69617420D1 DE 69617420 T DE69617420 T DE 69617420T DE 69617420 T DE69617420 T DE 69617420T DE 69617420 D1 DE69617420 D1 DE 69617420D1
Authority
DE
Germany
Prior art keywords
protriferation
inhibitors
smooth muscle
muscle cell
benzimidazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69617420T
Other languages
English (en)
Other versions
DE69617420T2 (de
Inventor
Mahmoud Elokdah
Chai Sie-Yearl
Sylvester Sulkowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of DE69617420D1 publication Critical patent/DE69617420D1/de
Publication of DE69617420T2 publication Critical patent/DE69617420T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69617420T 1995-06-07 1996-06-03 2-substituierte benzimidazolderivate als inhibitoren der glatten muskelzellenproliferation Expired - Fee Related DE69617420T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/477,842 US5654436A (en) 1995-06-07 1995-06-07 2-substituted benzimidazole derivatives
PCT/US1996/008374 WO1996040644A1 (en) 1995-06-07 1996-06-03 2-substituted benzimidazole derivatives as smooth muscle cell proliferation inhibitors

Publications (2)

Publication Number Publication Date
DE69617420D1 true DE69617420D1 (de) 2002-01-10
DE69617420T2 DE69617420T2 (de) 2002-05-02

Family

ID=23897571

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69617420T Expired - Fee Related DE69617420T2 (de) 1995-06-07 1996-06-03 2-substituierte benzimidazolderivate als inhibitoren der glatten muskelzellenproliferation

Country Status (18)

Country Link
US (1) US5654436A (de)
EP (1) EP0830344B1 (de)
JP (1) JPH11506752A (de)
KR (1) KR19990022318A (de)
CN (1) CN1192204A (de)
AR (1) AR003129A1 (de)
AT (1) ATE209635T1 (de)
BR (1) BR9608557A (de)
CA (1) CA2223962A1 (de)
DE (1) DE69617420T2 (de)
ES (1) ES2165501T3 (de)
HU (1) HUP9900895A3 (de)
IL (1) IL118412A0 (de)
NZ (1) NZ309498A (de)
PT (1) PT830344E (de)
TW (1) TW322473B (de)
WO (1) WO1996040644A1 (de)
ZA (1) ZA964622B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990146A (en) 1997-08-20 1999-11-23 Warner-Lambert Company Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation
WO2007112093A2 (en) * 2006-03-23 2007-10-04 Synta Pharmaceuticals Corp. Benzimidazolyl-pyridine compounds for inflammation and immune-related uses
US8501957B2 (en) * 2008-12-10 2013-08-06 China Medical University Benzimidazole compounds and their use as anticancer agents
SI2991983T1 (sl) 2013-04-29 2017-06-30 F. Hoffmann-La Roche Ag DERIVATI 2-FENIL ALI 2-HETARIL IMIDAZOL(1,2-a)PIRIDINA

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2876233A (en) * 1956-10-29 1959-03-03 Gruenenthal Chemie 1-(p-halobenzyl)-2-methyl benzimidazoles and salts
FR1228524A (de) * 1958-05-23 1960-08-31
FR1530439A (fr) * 1966-05-16 1968-06-28 Pentachlorobenzyl-1 benzimidazoles
HU193951B (en) * 1985-03-11 1987-12-28 Richter Gedeon Vegyeszet Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
US5128359A (en) * 1990-02-16 1992-07-07 Laboratoires Upsa Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation
GB9027200D0 (en) * 1990-12-14 1991-02-06 Smithkline Beecham Plc Medicaments
DE4212748A1 (de) * 1992-04-16 1993-10-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5387600A (en) * 1992-07-30 1995-02-07 Fuji Photo Film Co., Ltd. Treating arteriosclerosis using benzimidazole compositions

Also Published As

Publication number Publication date
BR9608557A (pt) 1999-07-06
AU697295B2 (en) 1998-10-01
IL118412A0 (en) 1996-09-12
AR003129A1 (es) 1998-07-08
EP0830344B1 (de) 2001-11-28
CN1192204A (zh) 1998-09-02
MX9709650A (es) 1998-07-31
JPH11506752A (ja) 1999-06-15
CA2223962A1 (en) 1996-12-19
HUP9900895A2 (hu) 1999-07-28
DE69617420T2 (de) 2002-05-02
EP0830344A1 (de) 1998-03-25
ES2165501T3 (es) 2002-03-16
ATE209635T1 (de) 2001-12-15
PT830344E (pt) 2002-04-29
HUP9900895A3 (en) 2001-08-28
NZ309498A (en) 2000-09-29
US5654436A (en) 1997-08-05
KR19990022318A (ko) 1999-03-25
WO1996040644A1 (en) 1996-12-19
AU5968396A (en) 1996-12-30
ZA964622B (en) 1997-12-04
TW322473B (de) 1997-12-11

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: WYETH (N.D.GES.D. STAATES DELAWARE), MADISON, N.J.

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee