AR003128A1 - Derivados de bencimidazol 2-sustituidos y composicion farmaceutica que los comprende. - Google Patents

Derivados de bencimidazol 2-sustituidos y composicion farmaceutica que los comprende.

Info

Publication number
AR003128A1
AR003128A1 ARP960102801A AR10280196A AR003128A1 AR 003128 A1 AR003128 A1 AR 003128A1 AR P960102801 A ARP960102801 A AR P960102801A AR 10280196 A AR10280196 A AR 10280196A AR 003128 A1 AR003128 A1 AR 003128A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical composition
derivatives
alkyl
substituted
bencimidazole
Prior art date
Application number
ARP960102801A
Other languages
English (en)
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of AR003128A1 publication Critical patent/AR003128A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

En la presente se revelan compuestos de la fórmula (I), donde R1 es fenilo sustituido en el cual los sustituyentes son uno o dos halógeno, grupos alquilo,grupos carboxilo o grupos alquiloxicarbonilo; R2 es H o alquilo; R3 y R4 son independientemente H, alquilo, halógeno o nitro, y n es 1, 2 ó 3, o una salfarmacéuticamente aceptable del mismo, que son útiles como inhibidores de la proliferación de células del músculo liso. Además, se da a conocer unacomposición farmacéutica que comprende adichos derivados.
ARP960102801A 1995-06-07 1996-05-30 Derivados de bencimidazol 2-sustituidos y composicion farmaceutica que los comprende. AR003128A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/482,600 US5684030A (en) 1995-06-07 1995-06-07 2-substituted benzimidazole derivatives

Publications (1)

Publication Number Publication Date
AR003128A1 true AR003128A1 (es) 1998-07-08

Family

ID=23916709

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960102801A AR003128A1 (es) 1995-06-07 1996-05-30 Derivados de bencimidazol 2-sustituidos y composicion farmaceutica que los comprende.

Country Status (16)

Country Link
US (1) US5684030A (es)
EP (1) EP0830346A1 (es)
JP (1) JPH11506751A (es)
KR (1) KR19990022373A (es)
CN (1) CN1192207A (es)
AR (1) AR003128A1 (es)
AU (1) AU699503B2 (es)
BR (1) BR9609311A (es)
CA (1) CA2223939A1 (es)
HU (1) HUP9900642A3 (es)
IL (1) IL118411A0 (es)
MX (1) MX9709465A (es)
NZ (1) NZ309994A (es)
TW (1) TW411333B (es)
WO (1) WO1996040645A1 (es)
ZA (1) ZA964621B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997003970A1 (en) * 1995-07-17 1997-02-06 Fuji Photo Film Co., Ltd. Benzimidazole compounds
US5990146A (en) * 1997-08-20 1999-11-23 Warner-Lambert Company Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation
JP2007119478A (ja) * 1998-07-15 2007-05-17 Teijin Ltd チオベンズイミダゾール誘導体
US7395527B2 (en) 2003-09-30 2008-07-01 International Business Machines Corporation Method and apparatus for counting instruction execution and data accesses
US8381037B2 (en) 2003-10-09 2013-02-19 International Business Machines Corporation Method and system for autonomic execution path selection in an application
US7415705B2 (en) 2004-01-14 2008-08-19 International Business Machines Corporation Autonomic method and apparatus for hardware assist for patching code
US7895382B2 (en) 2004-01-14 2011-02-22 International Business Machines Corporation Method and apparatus for qualifying collection of performance monitoring events by types of interrupt when interrupt occurs

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2666764A (en) * 1951-07-14 1954-01-19 Ciba Pharm Prod Inc Process of splitting aralkylheterocyclic thioethers with aluminum bromide
US3341535A (en) * 1965-04-07 1967-09-12 Taisho Pharmaceutical Co Ltd Benzimidazole derivatives
FR1509192A (fr) * 1966-12-01 1968-01-12 Benzylthio-2 benzimidazoles
US3775426A (en) * 1971-03-17 1973-11-27 American Home Prod (benzimidazol-2-ylthio)-benzoyl-alkyl carboxylic acids and their alkyl esters
HU193951B (en) * 1985-03-11 1987-12-28 Richter Gedeon Vegyeszet Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them
US5128359A (en) * 1990-02-16 1992-07-07 Laboratoires Upsa Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation
GB9027200D0 (en) * 1990-12-14 1991-02-06 Smithkline Beecham Plc Medicaments
DE4212748A1 (de) * 1992-04-16 1993-10-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5387600A (en) * 1992-07-30 1995-02-07 Fuji Photo Film Co., Ltd. Treating arteriosclerosis using benzimidazole compositions
JP3668767B2 (ja) * 1993-02-18 2005-07-06 株式会社ムラタ はんだ、無電解はんだ、銀、ニッケル、亜鉛等の金属の表面 処理方法

Also Published As

Publication number Publication date
KR19990022373A (ko) 1999-03-25
US5684030A (en) 1997-11-04
ZA964621B (en) 1997-12-04
HUP9900642A3 (en) 2001-07-30
MX9709465A (es) 1998-02-28
AU6030396A (en) 1996-12-30
NZ309994A (en) 1999-10-28
WO1996040645A1 (en) 1996-12-19
AU699503B2 (en) 1998-12-03
BR9609311A (pt) 1999-07-06
CN1192207A (zh) 1998-09-02
EP0830346A1 (en) 1998-03-25
CA2223939A1 (en) 1996-12-19
TW411333B (en) 2000-11-11
JPH11506751A (ja) 1999-06-15
HUP9900642A2 (hu) 1999-09-28
IL118411A0 (en) 1996-09-12

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