DE69910799D1 - Als inhibitoren der aicarftnützliche verbindungen - Google Patents

Als inhibitoren der aicarftnützliche verbindungen

Info

Publication number
DE69910799D1
DE69910799D1 DE69910799T DE69910799T DE69910799D1 DE 69910799 D1 DE69910799 D1 DE 69910799D1 DE 69910799 T DE69910799 T DE 69910799T DE 69910799 T DE69910799 T DE 69910799T DE 69910799 D1 DE69910799 D1 DE 69910799D1
Authority
DE
Germany
Prior art keywords
inhibitors
aicar
useful links
useful
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69910799T
Other languages
English (en)
Other versions
DE69910799T2 (de
Inventor
Michael Bleckman
Louise Palmer
Henry Romines
David Varney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agouron Pharmaceuticals LLC
Original Assignee
Agouron Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals LLC filed Critical Agouron Pharmaceuticals LLC
Application granted granted Critical
Publication of DE69910799D1 publication Critical patent/DE69910799D1/de
Publication of DE69910799T2 publication Critical patent/DE69910799T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69910799T 1998-09-04 1999-09-03 Als inhibitoren der aicarftnützliche verbindungen Expired - Fee Related DE69910799T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9925998P 1998-09-04 1998-09-04
US99259P 1998-09-04
PCT/US1999/020331 WO2000013688A1 (en) 1998-09-04 1999-09-03 Compounds useful as aicarft inhibitors

Publications (2)

Publication Number Publication Date
DE69910799D1 true DE69910799D1 (de) 2003-10-02
DE69910799T2 DE69910799T2 (de) 2004-02-19

Family

ID=22273984

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69910799T Expired - Fee Related DE69910799T2 (de) 1998-09-04 1999-09-03 Als inhibitoren der aicarftnützliche verbindungen

Country Status (9)

Country Link
US (1) US6525050B1 (de)
EP (1) EP1109560B1 (de)
AT (1) ATE247964T1 (de)
AU (1) AU5705099A (de)
DE (1) DE69910799T2 (de)
DK (1) DK1109560T3 (de)
ES (1) ES2207277T3 (de)
PT (1) PT1109560E (de)
WO (1) WO2000013688A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495558B1 (en) 1999-01-22 2002-12-17 Amgen Inc. Kinase inhibitors
US7279160B2 (en) * 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
EP1601969A2 (de) 2003-03-08 2005-12-07 Auvation Ltd Marker für dickdarmkrebs
US8738693B2 (en) 2004-07-09 2014-05-27 Qualcomm Incorporated System and method for managing distribution of media files
US9077766B2 (en) 2004-07-09 2015-07-07 Qualcomm Incorporated System and method for combining memory resources for use on a personal network
US8195744B2 (en) 2004-07-09 2012-06-05 Orb Networks, Inc. File sharing system for use with a network
US8819140B2 (en) 2004-07-09 2014-08-26 Qualcomm Incorporated System and method for enabling the establishment and use of a personal network
US7937484B2 (en) 2004-07-09 2011-05-03 Orb Networks, Inc. System and method for remotely controlling network resources
WO2006031806A2 (en) * 2004-09-10 2006-03-23 Atherogenics, Inc. 2-thiopyrimidinones as therapeutic agents
WO2006084233A2 (en) * 2005-02-04 2006-08-10 Cytrx Corporation Modulation of endogenous aicar levels for the treatment of diabetes and obesity
US8973072B2 (en) 2006-10-19 2015-03-03 Qualcomm Connected Experiences, Inc. System and method for programmatic link generation with media delivery
US20110082158A1 (en) * 2008-10-01 2011-04-07 Aleem Gangjee Selective proton coupled folate transporter and folate receptor, and garftase and/or other folate metabolizing enzymes inhibitor compounds and methods of using the same
US8252804B2 (en) * 2008-10-01 2012-08-28 Duquesne University Of The Holy Spirit Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same
EP3227279B1 (de) * 2014-12-02 2019-02-13 Eli Lilly and Company 1-oxo-1,2-dihydroisochinolin-7-yl-(5-substituiertes-thiophen-2-yl)-sulfonamid-verbindungen, formulierungen mit diesen verbindungen und deren verwendung als aicarft-inhibitoren in der behandlung von krebsen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU203736B (en) 1989-04-06 1991-09-30 Gyogyszerkutato Intezet Process for producing new thiouracil-derivatives and pharmaceutical compositions containing them
DE69327796T2 (de) * 1992-12-16 2000-06-21 Agouron Pharmaceuticals , Inc. Antiproliferative substituierte 5-thiapyrimidinon- und 5-selenopyrimidinonverbindungen
JP3401597B2 (ja) * 1993-01-08 2003-04-28 株式会社マンダム 皮膚保護剤組成物

Also Published As

Publication number Publication date
EP1109560A1 (de) 2001-06-27
WO2000013688A1 (en) 2000-03-16
US6525050B1 (en) 2003-02-25
EP1109560A4 (de) 2002-04-17
PT1109560E (pt) 2004-01-30
AU5705099A (en) 2000-03-27
ATE247964T1 (de) 2003-09-15
DE69910799T2 (de) 2004-02-19
ES2207277T3 (es) 2004-05-16
EP1109560B1 (de) 2003-08-27
DK1109560T3 (da) 2003-11-03

Similar Documents

Publication Publication Date Title
TR200201505T2 (tr) Terapötik maddeler olarak pirazolopirimidinler
NO20061506L (no) Heterocykliske inhibitorer av MEK og fremgangsmater for anvendelse derav
UA84175C2 (ru) Гетероциклические ингибиторы мэк и их применение
EA200500018A1 (ru) Бензконденсированные гетероариламидные производные тиенопиридинов, применяемые в качестве терапевтических агентов, фармацевтические композиции, включающие их, и способы их применения
DE60030741D1 (de) Chinazoline verbindungen als heilmittel
MX9707453A (es) Derivados de quinazolina.
TR200001279T2 (tr) Poli (ADP-riboz) polimeraz ("PARP") inhibitörleri, nevral ve kardiyovasküler doku hasarının tedavisi için yöntemler ve farmasötik bileşimler.
CA2478374A1 (en) N3 alkylated benzimidazole derivatives as mek inhibitors
EE200200091A (et) N-heterotsüklilised derivaadid kui NOSi inhibiitorid
HN2004000232A (es) " derivados de pirrolo(3,4-c) pirazol activos como inhibidores de quinasa, proceso para su preparacion y composiciones farmaceuticas que los comprenden."
EA201000643A1 (ru) Замещенное производное этилендиамина для лечения микобактериальных заболеваний и фармацевтическая композиция на его основе
ATE266028T1 (de) 1,1-dioxoisothiazolidin-substituierte indazole als inhibitoren der zellproliferation
DE69910799D1 (de) Als inhibitoren der aicarftnützliche verbindungen
TR200103395T2 (tr) 13-metil eritromisin türevleri.
ATE300541T1 (de) Pyrazolopyridinderivate
SE9802208D0 (sv) Novel compounds
ATE233754T1 (de) Diphenyl-piperidin derivate
SE0302573D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0300908D0 (sv) Azaindole derivatives, preparations thereof, uses thereof and compositions containing them
ATE297904T1 (de) Halo-alkoxycarbonylverbindungen
SE0301699D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0302570D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
BR0309996A (pt) Composto, composição farmacêutica, método de tratar ou melhorar doenças ou condições proliferativas, uso de um composto, e, método de tratar ou melhorar doenças inflamatórias
SE9802209D0 (sv) Novel compounds
SE9504662D0 (sv) New compounds

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee