TR200002756T2 - Hücresel kurtarma maddeleri olarak alifatik amino karboksilik ve amino fosfonik asitler, amino nitriller ve amino tetrazoller. - Google Patents

Hücresel kurtarma maddeleri olarak alifatik amino karboksilik ve amino fosfonik asitler, amino nitriller ve amino tetrazoller.

Info

Publication number
TR200002756T2
TR200002756T2 TR2000/02756T TR200002756T TR200002756T2 TR 200002756 T2 TR200002756 T2 TR 200002756T2 TR 2000/02756 T TR2000/02756 T TR 2000/02756T TR 200002756 T TR200002756 T TR 200002756T TR 200002756 T2 TR200002756 T2 TR 200002756T2
Authority
TR
Turkey
Prior art keywords
amino
tetrazoles
nitriles
phosphonic acids
carbon atoms
Prior art date
Application number
TR2000/02756T
Other languages
English (en)
Inventor
E. Dyck Lilian
A. Davis Bruce
Liu Ya-Dong
A. Durden David
A. Boulton Alan
Alick Paterson I. (�Ld�)
Original Assignee
University Of Saskatchewan Technologies Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Saskatchewan Technologies Inc. filed Critical University Of Saskatchewan Technologies Inc.
Publication of TR200002756T2 publication Critical patent/TR200002756T2/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/25—Aminoacetonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

Formül I'in yeni bilesimleri verilmis olup burada: m'nin 0 veya 1 ve 16 arasinda bir tam sayi veya 2 ila 17 karbon atomuna sahip alkenil, alkinil, alkoksi, alkilthio veya alkil sülfinil grup oldugu R1=(CH2)mCH3; R2=H, CH3 veya CH2CH3; R3=H veya CH3; R4=H veya CH3; R5= 1 ila 5 karbon atomuna sahip düsük alkil; n, 1 ve 3 arasinda bir tam sayi ve X, karboksil (COOH) veya karboksi (COOR5), siyano (C=N), fosfonik asit (PO3H2), fosfat ester (PO3[R5]2) veya 5-tetrazol ve farmasötik açidan uygun bilesimin tuzlari. Tercihen bilesimler R3=R4=R5=H, R2=CH3 ve R1'in bir ila bes karbon aromunun doymus alifatik zinciri oldugu R- ve S- konfigürasyonunun optik açidan saf enantiomerleridir. Bilesimler hücresel kurtarma maddeleri gibi yararlidir.
TR2000/02756T 1998-03-26 1999-03-25 Hücresel kurtarma maddeleri olarak alifatik amino karboksilik ve amino fosfonik asitler, amino nitriller ve amino tetrazoller. TR200002756T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7948998P 1998-03-26 1998-03-26
US7948898P 1998-03-26 1998-03-26

Publications (1)

Publication Number Publication Date
TR200002756T2 true TR200002756T2 (tr) 2000-12-21

Family

ID=26762066

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02756T TR200002756T2 (tr) 1998-03-26 1999-03-25 Hücresel kurtarma maddeleri olarak alifatik amino karboksilik ve amino fosfonik asitler, amino nitriller ve amino tetrazoller.

Country Status (15)

Country Link
EP (1) EP1064254B1 (tr)
JP (1) JP2002507591A (tr)
CN (1) CN1213999C (tr)
AT (1) ATE375975T1 (tr)
AU (1) AU767098B2 (tr)
BR (1) BR9909103A (tr)
CA (1) CA2325943A1 (tr)
DE (1) DE69937340T2 (tr)
EA (1) EA003677B1 (tr)
ES (1) ES2296383T3 (tr)
NO (1) NO20004774L (tr)
PL (1) PL343531A1 (tr)
SK (1) SK16662000A3 (tr)
TR (1) TR200002756T2 (tr)
WO (1) WO1999048858A2 (tr)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3113026A (en) * 1959-01-19 1963-12-03 Gen Aniline & Film Corp Polyvinyl alcohol photographic silver halide emulsions
DE1567221A1 (de) * 1965-06-01 1970-04-16 Berlin Chemie Veb Systemische Fungizide
BE758165A (fr) * 1969-10-28 1971-04-28 Cilag Chemie Adamantylurees et procedes pour les preparer
IL45563A0 (en) * 1973-09-05 1974-11-29 Sumitomo Chemical Co N-substituted aminonitrile derivatives,their preparation and their use as fungicides
US3991208A (en) * 1973-12-28 1976-11-09 Millmaster Onyx Corporation Amphoteric surface-active agents
DE2555769C3 (de) * 1975-12-11 1980-01-03 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von an der Aminogruppe aliphatisch substituierten Glycinnitrilen
DE3050800C2 (tr) * 1979-03-22 1989-06-22 Continental Pharma Inc., Bruessel/Bruxelles, Be
US4548726A (en) * 1984-11-16 1985-10-22 Texaco Inc. Water base hydraulic fluid
KR930005009B1 (ko) * 1990-03-27 1993-06-11 한국과학기술연구원 N-알킬치환아미노메틸포스폰산 유도체의 제조방법
US5169868A (en) * 1991-03-01 1992-12-08 University Of Saskatchewan Aliphatic propargylamines as specific mao-b inhibitors
JPH0856655A (ja) * 1994-08-16 1996-03-05 Frontier:Kk 細胞致死剤および細胞死抑制剤
ATE334668T1 (de) * 1996-05-31 2006-08-15 Allelix Neuroscience Inc Pharmazeutische zusammensetzung zur behandlung von neurologischen und neuropsychiatrischen erkrankungen

Also Published As

Publication number Publication date
AU767098B2 (en) 2003-10-30
EA200000987A1 (ru) 2001-06-25
NO20004774D0 (no) 2000-09-25
CA2325943A1 (en) 1999-09-30
PL343531A1 (en) 2001-08-27
ATE375975T1 (de) 2007-11-15
CN1213999C (zh) 2005-08-10
WO1999048858A3 (en) 2000-01-20
EP1064254B1 (en) 2007-10-17
JP2002507591A (ja) 2002-03-12
NO20004774L (no) 2000-09-25
EA003677B1 (ru) 2003-08-28
ES2296383T3 (es) 2008-04-16
AU2824099A (en) 1999-10-18
WO1999048858A2 (en) 1999-09-30
DE69937340T2 (de) 2008-07-17
DE69937340D1 (de) 2007-11-29
SK16662000A3 (sk) 2001-05-10
CN1299342A (zh) 2001-06-13
BR9909103A (pt) 2001-10-16
EP1064254A2 (en) 2001-01-03

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