BR9909103A - ácidos alifático amino carboxìlico e amino fosfÈnico, amino nitrilas e amino tetrazóis como agentes de resgate celular - Google Patents

ácidos alifático amino carboxìlico e amino fosfÈnico, amino nitrilas e amino tetrazóis como agentes de resgate celular

Info

Publication number
BR9909103A
BR9909103A BR9909103-8A BR9909103A BR9909103A BR 9909103 A BR9909103 A BR 9909103A BR 9909103 A BR9909103 A BR 9909103A BR 9909103 A BR9909103 A BR 9909103A
Authority
BR
Brazil
Prior art keywords
amino
phosphonic
tetrazoles
nitriles
carbon atoms
Prior art date
Application number
BR9909103-8A
Other languages
English (en)
Inventor
I Alick Paterson
Lilian E Dyck
Bruce A Davis
Ya-Dong Liu
David A Durden
Alan A Boulton
Original Assignee
Univ Saskatchewan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Saskatchewan filed Critical Univ Saskatchewan
Publication of BR9909103A publication Critical patent/BR9909103A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/25—Aminoacetonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Dental Preparations (AREA)
  • Materials For Medical Uses (AREA)

Abstract

"áCIDOS ALIFáTICO AMINO CARBOXìLICO E AMINO FOSFÈNICO, AMINO NITRILAS E AMINO TETRAZóIS COMO AGENTES DE RESGATE CELULAR". São descritos novos compostos da fórmula (I) onde: R~1~ é (CH~2~)~m~CH~3~ onde m é o ou um inteiro na faixa de 1 a 16, ou uma alquenila, alquinila, alcóxi, alquiltio ou grupo alquil sulfinila possuindo de 2 a 17 átomos de carbono; R~2~ = H, CH~3~ ou CH~2~CH~3~; R~3~ = H ou CH~3~; R~4~ = H ou CH~3~; R~5~ = alquila inferior possuindo 1 a 5 átomos de carbono; n é um inteiro na faixa de 1 a 3; e x é carboxila (COOH) ou carbalcóxi (COOR~5~), ciano (C<154>N), ácido fosfónico (PO~3~H~2~), éster de fosfonato (PO~3~[R~5~]~2~) ou 5-tetrazol, e sais farmaceuticamente aceitáveis dos mesmos. Preferivelmente, os compostos são enantiómeros opcionalmente puros de configuração R ou S, na qual R~3~=R~4~=R~5~=H, R~2~=CH~3~ e R~1~ é uma cadeia alifática saturada de um a cinco átomos de carbono. Os compostos são úteis como agentes de resgate celular.
BR9909103-8A 1998-03-26 1999-03-25 ácidos alifático amino carboxìlico e amino fosfÈnico, amino nitrilas e amino tetrazóis como agentes de resgate celular BR9909103A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7948998P 1998-03-26 1998-03-26
US7948898P 1998-03-26 1998-03-26
PCT/CA1999/000250 WO1999048858A2 (en) 1998-03-26 1999-03-25 Aliphatic amino carboxylic and amino phosphonic acids, amino nitriles and amino tetrazoles as cellular rescue agents

Publications (1)

Publication Number Publication Date
BR9909103A true BR9909103A (pt) 2001-10-16

Family

ID=26762066

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909103-8A BR9909103A (pt) 1998-03-26 1999-03-25 ácidos alifático amino carboxìlico e amino fosfÈnico, amino nitrilas e amino tetrazóis como agentes de resgate celular

Country Status (15)

Country Link
EP (1) EP1064254B1 (pt)
JP (1) JP2002507591A (pt)
CN (1) CN1213999C (pt)
AT (1) ATE375975T1 (pt)
AU (1) AU767098B2 (pt)
BR (1) BR9909103A (pt)
CA (1) CA2325943A1 (pt)
DE (1) DE69937340T2 (pt)
EA (1) EA003677B1 (pt)
ES (1) ES2296383T3 (pt)
NO (1) NO20004774L (pt)
PL (1) PL343531A1 (pt)
SK (1) SK16662000A3 (pt)
TR (1) TR200002756T2 (pt)
WO (1) WO1999048858A2 (pt)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3113026A (en) * 1959-01-19 1963-12-03 Gen Aniline & Film Corp Polyvinyl alcohol photographic silver halide emulsions
DE1567221A1 (de) * 1965-06-01 1970-04-16 Berlin Chemie Veb Systemische Fungizide
BE758165A (fr) * 1969-10-28 1971-04-28 Cilag Chemie Adamantylurees et procedes pour les preparer
IL45563A0 (en) * 1973-09-05 1974-11-29 Sumitomo Chemical Co N-substituted aminonitrile derivatives,their preparation and their use as fungicides
US3991208A (en) * 1973-12-28 1976-11-09 Millmaster Onyx Corporation Amphoteric surface-active agents
DE2555769C3 (de) * 1975-12-11 1980-01-03 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von an der Aminogruppe aliphatisch substituierten Glycinnitrilen
DE3010599A1 (de) * 1979-03-22 1980-10-09 Continental Pharma Derivate von glycinamid, deren herstellung und verwendung
US4548726A (en) * 1984-11-16 1985-10-22 Texaco Inc. Water base hydraulic fluid
KR930005009B1 (ko) * 1990-03-27 1993-06-11 한국과학기술연구원 N-알킬치환아미노메틸포스폰산 유도체의 제조방법
US5169868A (en) * 1991-03-01 1992-12-08 University Of Saskatchewan Aliphatic propargylamines as specific mao-b inhibitors
JPH0856655A (ja) * 1994-08-16 1996-03-05 Frontier:Kk 細胞致死剤および細胞死抑制剤
CA2619901A1 (en) * 1996-05-31 1997-12-04 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders

Also Published As

Publication number Publication date
ATE375975T1 (de) 2007-11-15
CN1213999C (zh) 2005-08-10
EA003677B1 (ru) 2003-08-28
AU2824099A (en) 1999-10-18
CN1299342A (zh) 2001-06-13
NO20004774D0 (no) 2000-09-25
DE69937340T2 (de) 2008-07-17
WO1999048858A2 (en) 1999-09-30
NO20004774L (no) 2000-09-25
PL343531A1 (en) 2001-08-27
CA2325943A1 (en) 1999-09-30
ES2296383T3 (es) 2008-04-16
TR200002756T2 (tr) 2000-12-21
EA200000987A1 (ru) 2001-06-25
WO1999048858A3 (en) 2000-01-20
JP2002507591A (ja) 2002-03-12
EP1064254A2 (en) 2001-01-03
AU767098B2 (en) 2003-10-30
EP1064254B1 (en) 2007-10-17
SK16662000A3 (sk) 2001-05-10
DE69937340D1 (de) 2007-11-29

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTA A 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.