TR200000578T2 - Heparanas aktiviteye sahip olan bir polipeptit deşifre eden polinükleotit ve çevrilmiş hücrelerde aynısını izahı. - Google Patents
Heparanas aktiviteye sahip olan bir polipeptit deşifre eden polinükleotit ve çevrilmiş hücrelerde aynısını izahı.Info
- Publication number
- TR200000578T2 TR200000578T2 TR2000/00578T TR200000578T TR200000578T2 TR 200000578 T2 TR200000578 T2 TR 200000578T2 TR 2000/00578 T TR2000/00578 T TR 2000/00578T TR 200000578 T TR200000578 T TR 200000578T TR 200000578 T2 TR200000578 T2 TR 200000578T2
- Authority
- TR
- Turkey
- Prior art keywords
- polypeptide
- activity
- heparanas
- same
- polynucleotide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01166—Heparanase (3.2.1.166)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, e.g. Konjac gum, Locust bean gum, Guar gum
- G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
Abstract
Heparanez aktivitesine sahip olan bir polipeptiti desifre eden polinükleotit (hpa), heparanaz aktiviteye sahip olan rekombinant bir protein ve heparanaz ifade eden ayni dönüsük hücrelerle birlikte vektörlesir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/922,170 US5968822A (en) | 1997-09-02 | 1997-09-02 | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells |
US10938698A | 1998-07-02 | 1998-07-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200000578T2 true TR200000578T2 (tr) | 2000-07-21 |
Family
ID=25446621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/00578T TR200000578T2 (tr) | 1997-09-02 | 1998-08-31 | Heparanas aktiviteye sahip olan bir polipeptit deşifre eden polinükleotit ve çevrilmiş hücrelerde aynısını izahı. |
Country Status (12)
Country | Link |
---|---|
US (2) | US5968822A (tr) |
EP (5) | EP1439193B1 (tr) |
JP (1) | JP4187408B2 (tr) |
CN (1) | CN1272886A (tr) |
AT (1) | ATE318912T1 (tr) |
AU (1) | AU735116B2 (tr) |
CA (1) | CA2296758A1 (tr) |
DE (1) | DE69833667T2 (tr) |
ES (1) | ES2259816T3 (tr) |
PL (1) | PL338949A1 (tr) |
TR (1) | TR200000578T2 (tr) |
WO (1) | WO1999011798A1 (tr) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010006630A1 (en) * | 1997-09-02 | 2001-07-05 | Oron Yacoby-Zeevi | Introducing a biological material into a patient |
US6177545B1 (en) | 1997-09-02 | 2001-01-23 | Insight Strategy & Marketing Ltd. | Heparanase specific molecular probes and their use in research and medical applications |
US20040213789A1 (en) * | 1997-09-02 | 2004-10-28 | Oron Yacoby-Zeevi | Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies |
US6348344B1 (en) * | 1997-09-02 | 2002-02-19 | Insight Strategy & Marketing Ltd. | Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same |
US20030161823A1 (en) * | 1998-08-31 | 2003-08-28 | Neta Ilan | Therapeutic and cosmetic uses of heparanases |
US5968822A (en) * | 1997-09-02 | 1999-10-19 | Pecker; Iris | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells |
US20020088019A1 (en) * | 1997-09-02 | 2002-07-04 | Oron Yacoby-Zeevi | Methods of and pharmaceutical compositions for improving implantation of embryos |
US6699672B1 (en) | 1997-09-02 | 2004-03-02 | Insight Biopharmaceuticals Ltd. | Heparanase specific molecular probes and their use research and medical applications |
CN1280613A (zh) * | 1997-10-28 | 2001-01-17 | 澳大利亚国立大学 | 编码哺乳动物内切葡糖醛酸糖苷酶的分离的核酸分子及其应用 |
GB9802725D0 (en) * | 1998-02-09 | 1998-04-08 | Ciba Geigy Ag | Organic compounds |
EP1060252A2 (en) * | 1998-02-24 | 2000-12-20 | PHARMACIA & UPJOHN COMPANY | Human platelet heparanase polypeptides, polynucleotide molecules that encode them, and methods for the identification of compounds that alter heparanase activity |
WO2000012726A2 (en) * | 1998-08-27 | 2000-03-09 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase i and ii |
US7056504B1 (en) | 1998-08-27 | 2006-06-06 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase I and II |
US20020068054A1 (en) * | 2000-09-11 | 2002-06-06 | Insight Strategy & Marketing Ltd. And Hadasit Medical Research Services And Development Ltd. | Therapeutic and cosmetic uses of heparanases |
US20030217375A1 (en) * | 1998-08-31 | 2003-11-20 | Eyal Zcharia | Transgenic animals expressing heparanase and uses thereof |
AU2878600A (en) * | 1999-03-01 | 2000-09-21 | Hadasit Medical Research Services & Development Company Ltd | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells |
US6597996B1 (en) | 1999-04-23 | 2003-07-22 | Massachusetts Institute Of Technology | Method for indentifying or characterizing properties of polymeric units |
US20040224922A1 (en) * | 1999-08-26 | 2004-11-11 | Malcolm King | Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto |
JP2003510053A (ja) * | 1999-09-23 | 2003-03-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ヘパラナーゼ蛋白質ファミリーの1種、ヘパラナーゼ−2 |
DE60029624T2 (de) * | 1999-12-22 | 2007-08-09 | Ucb S.A. | Homologe enzyme der humanen heparanase sowie alternative spleissformen davon |
ES2527853T3 (es) * | 2000-03-08 | 2015-01-30 | Massachusetts Institute Of Technology | Heparinasa III y sus usos |
EP1319183B1 (en) | 2000-09-12 | 2009-03-25 | Massachusetts Institute Of Technology | Methods and products related to low molecular weight heparin |
MXPA03002243A (es) | 2000-09-15 | 2004-12-03 | Reddy Therapeutics Inc | Metodos y composiciones para ensayos de glucosidasa. |
WO2002032283A2 (en) * | 2000-10-17 | 2002-04-25 | Insight Strategy And Marketing Ltd. | Methods of and pharmaceutical compositions for improving implantation of embryos |
EP1328260A2 (en) | 2000-10-18 | 2003-07-23 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
AU2002241532A1 (en) * | 2000-11-30 | 2002-06-11 | Sangamo Biosciences, Inc. | Human heparanase gene regulatory sequences |
FR2818131B1 (fr) * | 2000-12-14 | 2005-02-11 | Oreal | Composition cosmetique comprenant de l'heparanase |
US20040033218A1 (en) * | 2000-12-19 | 2004-02-19 | Oron Yacoby-Zeevi | Use of ecm degrading enzymes for the improvement of cell transplantation |
EP1353556A4 (en) * | 2001-01-23 | 2009-09-09 | Massachusetts Inst Technology | SYNTHESIS OF HEPARIN AND OTHER GLYCOSAMINOGLYCANS IN SOLID PHASE AND SOLUTION PHASE |
EP1417304A4 (en) * | 2001-07-13 | 2005-11-23 | Imclone Systems Inc | METHOD AND COMPOSITION FOR INHIBITING HEPARANASE ACTIVITY |
US6671189B2 (en) * | 2001-11-09 | 2003-12-30 | Minebea Co., Ltd. | Power converter having primary and secondary side switches |
CH696701A5 (de) | 2001-12-18 | 2007-10-15 | Hoffmann La Roche | Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen. |
EP1532241B1 (en) * | 2002-06-03 | 2010-09-15 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from chondroitinase b |
EP1382574A3 (en) * | 2002-06-21 | 2004-05-26 | Sanden Corporation | Mineral water making apparatus |
AU2003295411A1 (en) * | 2002-11-07 | 2004-06-03 | Celltech R & D | Human monoclonal antibodies to heparanase |
US7259140B2 (en) | 2003-03-28 | 2007-08-21 | Thomas Jefferson University | Heparin-binding peptides and uses thereof |
US20060269552A1 (en) * | 2003-06-09 | 2006-11-30 | Oron Yacoby-Zeevi | Heparanase activity neutralizing anti-heparanase monclonal antibody and other anti-heparanase antibodies |
JP2007506416A (ja) * | 2003-09-26 | 2007-03-22 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | 合成ヘパラナーゼ分子及びその使用 |
WO2007034480A2 (en) * | 2005-09-20 | 2007-03-29 | Carmel-Haifa University Economic Corp. Ltd | Heparanases and splice variants thereof, ponucleotides encoding them and uses thereof |
WO2008057265A2 (en) * | 2006-10-27 | 2008-05-15 | University Of Maryland | Single nucleotide polymorphisms and the identification of lactose intolerance |
CN102711463B (zh) * | 2009-12-03 | 2015-05-13 | Opko健康公司 | 超硫酸化双糖制剂 |
AU2014225708B2 (en) * | 2013-03-05 | 2018-10-18 | Baylor College Of Medicine | Heparanase expression in human T lymphocytes |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5061689A (en) * | 1986-12-24 | 1991-10-29 | Bioderm, Inc. | Zinc bacitracin containing wound dressing |
US5571506A (en) * | 1989-08-14 | 1996-11-05 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aromatic oligomeric compounds useful as mimics of bioactive macromolecules |
EP0487627B1 (en) * | 1989-08-23 | 1998-06-10 | Hadassah Medical Organization | Wound healing preparations containing heparanase |
US5300059A (en) * | 1991-11-19 | 1994-04-05 | Hydro Slip Technologies Inc. | Bloodbag and method of making same |
WO1993018745A1 (en) * | 1992-03-23 | 1993-09-30 | Geda International S.A. | Use of antiviral coating for latex items such as condoms |
AU7368994A (en) * | 1993-07-29 | 1995-02-28 | Upjohn Company, The | Use of heparanase to identify and isolate anti-heparanase compound |
US5565193A (en) * | 1993-08-05 | 1996-10-15 | Procter & Gamble | Hair styling compositions containing a silicone grafted polymer and low level of a volatile hydrocarbon solvent |
ATE187501T1 (de) * | 1996-01-23 | 1999-12-15 | Rapigene Inc | Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit |
US5968822A (en) * | 1997-09-02 | 1999-10-19 | Pecker; Iris | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells |
US6177545B1 (en) * | 1997-09-02 | 2001-01-23 | Insight Strategy & Marketing Ltd. | Heparanase specific molecular probes and their use in research and medical applications |
US6348344B1 (en) * | 1997-09-02 | 2002-02-19 | Insight Strategy & Marketing Ltd. | Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same |
CN1280613A (zh) * | 1997-10-28 | 2001-01-17 | 澳大利亚国立大学 | 编码哺乳动物内切葡糖醛酸糖苷酶的分离的核酸分子及其应用 |
GB9802725D0 (en) * | 1998-02-09 | 1998-04-08 | Ciba Geigy Ag | Organic compounds |
-
1997
- 1997-09-02 US US08/922,170 patent/US5968822A/en not_active Expired - Lifetime
-
1998
- 1998-08-31 EP EP04001481.3A patent/EP1439193B1/en not_active Expired - Lifetime
- 1998-08-31 EP EP06004005A patent/EP1676912A3/en not_active Withdrawn
- 1998-08-31 CN CN98809759A patent/CN1272886A/zh active Pending
- 1998-08-31 PL PL98338949A patent/PL338949A1/xx unknown
- 1998-08-31 AT AT98943469T patent/ATE318912T1/de not_active IP Right Cessation
- 1998-08-31 JP JP2000508806A patent/JP4187408B2/ja not_active Expired - Lifetime
- 1998-08-31 EP EP98943469A patent/EP0998569B1/en not_active Expired - Lifetime
- 1998-08-31 AU AU91258/98A patent/AU735116B2/en not_active Ceased
- 1998-08-31 EP EP04001482A patent/EP1439226A3/en not_active Ceased
- 1998-08-31 WO PCT/US1998/017954 patent/WO1999011798A1/en active Application Filing
- 1998-08-31 TR TR2000/00578T patent/TR200000578T2/tr unknown
- 1998-08-31 DE DE69833667T patent/DE69833667T2/de not_active Expired - Lifetime
- 1998-08-31 CA CA002296758A patent/CA2296758A1/en not_active Abandoned
- 1998-08-31 ES ES98943469T patent/ES2259816T3/es not_active Expired - Lifetime
- 1998-08-31 EP EP04018465A patent/EP1489183B1/en not_active Expired - Lifetime
-
1999
- 1999-11-08 US US09/435,739 patent/US6664105B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2296758A1 (en) | 1999-03-11 |
EP1439193A3 (en) | 2004-10-06 |
EP0998569B1 (en) | 2006-03-01 |
EP1439193A2 (en) | 2004-07-21 |
EP0998569A4 (en) | 2000-08-16 |
ATE318912T1 (de) | 2006-03-15 |
EP1439193B1 (en) | 2013-08-28 |
AU735116B2 (en) | 2001-06-28 |
DE69833667T2 (de) | 2007-03-08 |
EP1489183B1 (en) | 2011-10-26 |
EP1676912A2 (en) | 2006-07-05 |
EP1489183A1 (en) | 2004-12-22 |
WO1999011798A1 (en) | 1999-03-11 |
US6664105B1 (en) | 2003-12-16 |
AU9125898A (en) | 1999-03-22 |
JP2001514855A (ja) | 2001-09-18 |
JP4187408B2 (ja) | 2008-11-26 |
CN1272886A (zh) | 2000-11-08 |
DE69833667D1 (de) | 2006-04-27 |
EP1439226A3 (en) | 2004-10-06 |
US5968822A (en) | 1999-10-19 |
EP0998569A1 (en) | 2000-05-10 |
EP1676912A3 (en) | 2008-12-31 |
EP1439226A2 (en) | 2004-07-21 |
ES2259816T3 (es) | 2006-10-16 |
PL338949A1 (en) | 2000-12-04 |
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