DE69833667D1 - Polynukleotid kodierend für ein polypeptid mit heparanase-aktivität und dessen expression in transduzierten zellen - Google Patents

Polynukleotid kodierend für ein polypeptid mit heparanase-aktivität und dessen expression in transduzierten zellen

Info

Publication number
DE69833667D1
DE69833667D1 DE69833667T DE69833667T DE69833667D1 DE 69833667 D1 DE69833667 D1 DE 69833667D1 DE 69833667 T DE69833667 T DE 69833667T DE 69833667 T DE69833667 T DE 69833667T DE 69833667 D1 DE69833667 D1 DE 69833667D1
Authority
DE
Germany
Prior art keywords
polypeptide
transduced cells
expression
heparanase activity
polynucleotide coding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69833667T
Other languages
English (en)
Other versions
DE69833667T2 (de
Inventor
Iris Pecker
Israel Vlodavsky
Elena Feinstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hadasit Medical Research Services and Development Co
Insight Biopharmaceuticals Ltd
Original Assignee
Hadasit Medical Research Services and Development Co
Insight Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25446621&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69833667(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hadasit Medical Research Services and Development Co, Insight Biopharmaceuticals Ltd filed Critical Hadasit Medical Research Services and Development Co
Application granted granted Critical
Publication of DE69833667D1 publication Critical patent/DE69833667D1/de
Publication of DE69833667T2 publication Critical patent/DE69833667T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01166—Heparanase (3.2.1.166)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, e.g. Konjac gum, Locust bean gum, Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
DE69833667T 1997-09-02 1998-08-31 Polynukleotid, kodierend für ein polypeptid mit heparanase-aktivität und dessen expression in transduzierten zellen Expired - Lifetime DE69833667T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/922,170 US5968822A (en) 1997-09-02 1997-09-02 Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells
US922170 1997-09-02
US10938698A 1998-07-02 1998-07-02
US109386 1998-07-02
PCT/US1998/017954 WO1999011798A1 (en) 1997-09-02 1998-08-31 Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells

Publications (2)

Publication Number Publication Date
DE69833667D1 true DE69833667D1 (de) 2006-04-27
DE69833667T2 DE69833667T2 (de) 2007-03-08

Family

ID=25446621

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69833667T Expired - Lifetime DE69833667T2 (de) 1997-09-02 1998-08-31 Polynukleotid, kodierend für ein polypeptid mit heparanase-aktivität und dessen expression in transduzierten zellen

Country Status (12)

Country Link
US (2) US5968822A (de)
EP (5) EP1439193B1 (de)
JP (1) JP4187408B2 (de)
CN (1) CN1272886A (de)
AT (1) ATE318912T1 (de)
AU (1) AU735116B2 (de)
CA (1) CA2296758A1 (de)
DE (1) DE69833667T2 (de)
ES (1) ES2259816T3 (de)
PL (1) PL338949A1 (de)
TR (1) TR200000578T2 (de)
WO (1) WO1999011798A1 (de)

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US20010006630A1 (en) * 1997-09-02 2001-07-05 Oron Yacoby-Zeevi Introducing a biological material into a patient
US6177545B1 (en) 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
US20040213789A1 (en) * 1997-09-02 2004-10-28 Oron Yacoby-Zeevi Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies
US6348344B1 (en) * 1997-09-02 2002-02-19 Insight Strategy & Marketing Ltd. Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same
US20030161823A1 (en) * 1998-08-31 2003-08-28 Neta Ilan Therapeutic and cosmetic uses of heparanases
US5968822A (en) * 1997-09-02 1999-10-19 Pecker; Iris Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells
US20020088019A1 (en) * 1997-09-02 2002-07-04 Oron Yacoby-Zeevi Methods of and pharmaceutical compositions for improving implantation of embryos
US6699672B1 (en) 1997-09-02 2004-03-02 Insight Biopharmaceuticals Ltd. Heparanase specific molecular probes and their use research and medical applications
CN1280613A (zh) * 1997-10-28 2001-01-17 澳大利亚国立大学 编码哺乳动物内切葡糖醛酸糖苷酶的分离的核酸分子及其应用
GB9802725D0 (en) * 1998-02-09 1998-04-08 Ciba Geigy Ag Organic compounds
EP1060252A2 (de) * 1998-02-24 2000-12-20 PHARMACIA & UPJOHN COMPANY Menschliche plättchen heparanase polypeptide, dafür kodierende polynukleotide, und verfahren zum nachweis von verbindungen die heparinase-aktivität ändern
WO2000012726A2 (en) * 1998-08-27 2000-03-09 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase i and ii
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
US20020068054A1 (en) * 2000-09-11 2002-06-06 Insight Strategy & Marketing Ltd. And Hadasit Medical Research Services And Development Ltd. Therapeutic and cosmetic uses of heparanases
US20030217375A1 (en) * 1998-08-31 2003-11-20 Eyal Zcharia Transgenic animals expressing heparanase and uses thereof
AU2878600A (en) * 1999-03-01 2000-09-21 Hadasit Medical Research Services & Development Company Ltd Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
US6597996B1 (en) 1999-04-23 2003-07-22 Massachusetts Institute Of Technology Method for indentifying or characterizing properties of polymeric units
US20040224922A1 (en) * 1999-08-26 2004-11-11 Malcolm King Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto
JP2003510053A (ja) * 1999-09-23 2003-03-18 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング ヘパラナーゼ蛋白質ファミリーの１種、ヘパラナーゼ−２
DE60029624T2 (de) * 1999-12-22 2007-08-09 Ucb S.A. Homologe enzyme der humanen heparanase sowie alternative spleissformen davon
ES2527853T3 (es) * 2000-03-08 2015-01-30 Massachusetts Institute Of Technology Heparinasa III y sus usos
EP1319183B1 (de) 2000-09-12 2009-03-25 Massachusetts Institute Of Technology Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind
MXPA03002243A (es) 2000-09-15 2004-12-03 Reddy Therapeutics Inc Metodos y composiciones para ensayos de glucosidasa.
WO2002032283A2 (en) * 2000-10-17 2002-04-25 Insight Strategy And Marketing Ltd. Methods of and pharmaceutical compositions for improving implantation of embryos
EP1328260A2 (de) 2000-10-18 2003-07-23 Massachusetts Institute Of Technology Verfahren und produkte zur pulmonalen verabreichung von polysacchariden
AU2002241532A1 (en) * 2000-11-30 2002-06-11 Sangamo Biosciences, Inc. Human heparanase gene regulatory sequences
FR2818131B1 (fr) * 2000-12-14 2005-02-11 Oreal Composition cosmetique comprenant de l'heparanase
US20040033218A1 (en) * 2000-12-19 2004-02-19 Oron Yacoby-Zeevi Use of ecm degrading enzymes for the improvement of cell transplantation
EP1353556A4 (de) * 2001-01-23 2009-09-09 Massachusetts Inst Technology Fest- und flüssigphasen-synthese von heparin und anderen glykosaminoglykanen
EP1417304A4 (de) * 2001-07-13 2005-11-23 Imclone Systems Inc Verfahren und zusammensetzung zur hemmung der heparanaseaktivität
US6671189B2 (en) * 2001-11-09 2003-12-30 Minebea Co., Ltd. Power converter having primary and secondary side switches
CH696701A5 (de) 2001-12-18 2007-10-15 Hoffmann La Roche Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen.
EP1532241B1 (de) * 2002-06-03 2010-09-15 Massachusetts Institute Of Technology Rationell konstruierte, von chondroitinase b abgeleitete lyasen
EP1382574A3 (de) * 2002-06-21 2004-05-26 Sanden Corporation Vorrichtung zur herstellung von mineralwasser
AU2003295411A1 (en) * 2002-11-07 2004-06-03 Celltech R & D Human monoclonal antibodies to heparanase
US7259140B2 (en) 2003-03-28 2007-08-21 Thomas Jefferson University Heparin-binding peptides and uses thereof
US20060269552A1 (en) * 2003-06-09 2006-11-30 Oron Yacoby-Zeevi Heparanase activity neutralizing anti-heparanase monclonal antibody and other anti-heparanase antibodies
JP2007506416A (ja) * 2003-09-26 2007-03-22 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー 合成ヘパラナーゼ分子及びその使用
WO2007034480A2 (en) * 2005-09-20 2007-03-29 Carmel-Haifa University Economic Corp. Ltd Heparanases and splice variants thereof, ponucleotides encoding them and uses thereof
WO2008057265A2 (en) * 2006-10-27 2008-05-15 University Of Maryland Single nucleotide polymorphisms and the identification of lactose intolerance
CN102711463B (zh) * 2009-12-03 2015-05-13 Opko健康公司 超硫酸化双糖制剂
AU2014225708B2 (en) * 2013-03-05 2018-10-18 Baylor College Of Medicine Heparanase expression in human T lymphocytes

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US5061689A (en) * 1986-12-24 1991-10-29 Bioderm, Inc. Zinc bacitracin containing wound dressing
US5571506A (en) * 1989-08-14 1996-11-05 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aromatic oligomeric compounds useful as mimics of bioactive macromolecules
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AU7368994A (en) * 1993-07-29 1995-02-28 Upjohn Company, The Use of heparanase to identify and isolate anti-heparanase compound
US5565193A (en) * 1993-08-05 1996-10-15 Procter & Gamble Hair styling compositions containing a silicone grafted polymer and low level of a volatile hydrocarbon solvent
ATE187501T1 (de) * 1996-01-23 1999-12-15 Rapigene Inc Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit
US5968822A (en) * 1997-09-02 1999-10-19 Pecker; Iris Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
US6348344B1 (en) * 1997-09-02 2002-02-19 Insight Strategy & Marketing Ltd. Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same
CN1280613A (zh) * 1997-10-28 2001-01-17 澳大利亚国立大学 编码哺乳动物内切葡糖醛酸糖苷酶的分离的核酸分子及其应用
GB9802725D0 (en) * 1998-02-09 1998-04-08 Ciba Geigy Ag Organic compounds

Also Published As

Publication number Publication date
CA2296758A1 (en) 1999-03-11
EP1439193A3 (de) 2004-10-06
EP0998569B1 (de) 2006-03-01
EP1439193A2 (de) 2004-07-21
EP0998569A4 (de) 2000-08-16
ATE318912T1 (de) 2006-03-15
EP1439193B1 (de) 2013-08-28
AU735116B2 (en) 2001-06-28
DE69833667T2 (de) 2007-03-08
EP1489183B1 (de) 2011-10-26
EP1676912A2 (de) 2006-07-05
EP1489183A1 (de) 2004-12-22
WO1999011798A1 (en) 1999-03-11
US6664105B1 (en) 2003-12-16
AU9125898A (en) 1999-03-22
JP2001514855A (ja) 2001-09-18
JP4187408B2 (ja) 2008-11-26
CN1272886A (zh) 2000-11-08
EP1439226A3 (de) 2004-10-06
US5968822A (en) 1999-10-19
EP0998569A1 (de) 2000-05-10
EP1676912A3 (de) 2008-12-31
TR200000578T2 (tr) 2000-07-21
EP1439226A2 (de) 2004-07-21
ES2259816T3 (es) 2006-10-16
PL338949A1 (en) 2000-12-04

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