TR199902848T2 - Ergolin türevleri ve bunlarin somatostatin reseptör antagonist olarak kullanimlari - Google Patents

Ergolin türevleri ve bunlarin somatostatin reseptör antagonist olarak kullanimlari

Info

Publication number
TR199902848T2
TR199902848T2 TR1999/02848T TR9902848T TR199902848T2 TR 199902848 T2 TR199902848 T2 TR 199902848T2 TR 1999/02848 T TR1999/02848 T TR 1999/02848T TR 9902848 T TR9902848 T TR 9902848T TR 199902848 T2 TR199902848 T2 TR 199902848T2
Authority
TR
Turkey
Prior art keywords
receptor antagonists
somatostatin receptor
ergoline derivatives
ergoline
derivatives
Prior art date
Application number
TR1999/02848T
Other languages
English (en)
Inventor
Pfaeffli Paul
Neumann Peter
Swoboda Robert
St�Tz Peter
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TR199902848T2 publication Critical patent/TR199902848T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C07D457/08—Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Mevcut bulus R1-R6' nin tanimlanan sekilde oldugu formül I'deki karisimlari FORMÜL1 ve karisimlari hazirlama islemini sunar. Formül I' deki karisimlar ilaç olarak yararlidir.
TR1999/02848T 1997-05-29 1998-05-27 Ergolin türevleri ve bunlarin somatostatin reseptör antagonist olarak kullanimlari TR199902848T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9711043.1A GB9711043D0 (en) 1997-05-29 1997-05-29 Organic compounds

Publications (1)

Publication Number Publication Date
TR199902848T2 true TR199902848T2 (tr) 2000-02-21

Family

ID=10813201

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/02848T TR199902848T2 (tr) 1997-05-29 1998-05-27 Ergolin türevleri ve bunlarin somatostatin reseptör antagonist olarak kullanimlari

Country Status (24)

Country Link
US (1) US6221870B1 (tr)
EP (1) EP0986558A2 (tr)
JP (1) JP2001527580A (tr)
KR (1) KR20010013103A (tr)
CN (1) CN1259946A (tr)
AR (1) AR012870A1 (tr)
AU (1) AU727841B2 (tr)
BR (1) BR9809491A (tr)
CA (1) CA2288810A1 (tr)
CO (1) CO4950561A1 (tr)
CZ (1) CZ289466B6 (tr)
GB (1) GB9711043D0 (tr)
HU (1) HUP0002311A3 (tr)
ID (1) ID22916A (tr)
IL (1) IL132571A0 (tr)
NO (1) NO995482L (tr)
NZ (1) NZ500386A (tr)
PE (1) PE74899A1 (tr)
PL (1) PL336502A1 (tr)
RU (1) RU2191776C2 (tr)
SK (1) SK160899A3 (tr)
TR (1) TR199902848T2 (tr)
WO (1) WO1998054183A2 (tr)
ZA (1) ZA984560B (tr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10043321B4 (de) * 2000-08-24 2005-07-28 Neurobiotec Gmbh Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung
US20070243240A9 (en) * 2000-08-24 2007-10-18 Fred Windt-Hanke Transdermal therapeutic system
DE10053397A1 (de) * 2000-10-20 2002-05-02 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
DE10341317B4 (de) * 2003-09-03 2008-10-23 Axxonis Pharma Ag Transdermales therapeutisches System (TTS) zur Verabreichung von Ergolinverbindungen ausgenommen Pergolid
DK1401863T3 (da) * 2001-06-08 2009-05-25 Ipsen Pharma Kimære somatostatin-dopamin-analoge
FI20031454A0 (fi) 2003-10-06 2003-10-06 Juvantia Pharma Ltd Oy Selektiivisiä somatostatiinireseptori 1 ja/tai 4 -agonisteja ja -antagonisteja
KR101000923B1 (ko) * 2004-01-08 2010-12-13 삼성전자주식회사 원격 제어기의 매크로 설정 장치 및 방법
EP1885693A4 (en) * 2005-05-18 2010-09-15 Siegfried Wurster HIGH SELECTIVITY PEPTIDOMIMETICS FOR SOMATOSTATIN RECEPTOR 1 AND / OR 4 SUBTYPES
JP2007067096A (ja) * 2005-08-30 2007-03-15 Fujitsu Ltd 半導体装置
US8710092B2 (en) * 2009-12-23 2014-04-29 Map Pharmaceuticals, Inc. Substituted indolo 4,3 FG quinolines useful for treating migraine
BR112013033339A2 (pt) 2011-06-23 2016-08-16 Map Pharmaceuticals Inc análogos de fluorergolina
WO2013095707A1 (en) 2011-12-19 2013-06-27 Map Pharmaceuticals, Inc. Novel iso-ergoline derivatives
CA2859175A1 (en) 2011-12-21 2013-06-27 Map Pharmaceuticals, Inc. Novel neuromodulatory compounds
US9012640B2 (en) 2012-06-22 2015-04-21 Map Pharmaceuticals, Inc. Cabergoline derivatives
CN104768565B (zh) 2012-11-01 2017-04-26 益普生制药股份有限公司 促生长素抑制素类似物及其二聚体
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
EP3247357A4 (en) 2015-01-20 2018-07-11 Xoc Pharmaceuticals, Inc Isoergoline compounds and uses thereof
CN107428745A (zh) * 2015-01-20 2017-12-01 Xoc制药股份有限公司 麦角灵化合物及其用途
BR112019025420A2 (pt) 2017-06-01 2020-06-16 Xoc Pharmaceuticals, Inc. Compostos policíclicos e usos destes
JP7099717B2 (ja) 2019-09-30 2022-07-12 株式会社理研バイオ ソマトスタチン受容体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3592816A (en) 1966-02-08 1971-07-13 Sandoz Ltd N-substituted piperazides of lysergic acid
CH475252A (de) * 1966-02-08 1969-07-15 Sandoz Ag Verfahren zur Herstellung neuer Lysergsäure-Derivate
GB1188197A (en) 1967-10-11 1970-04-15 Sandoz Ltd Lysergic Acid Derivatives
NL6818658A (tr) * 1968-01-18 1969-07-22
GB1580448A (en) * 1976-12-06 1980-12-03 Farmaceutici Italia 8 -acetyl-6-methyl-ergoline i derivatives
GB8501078D0 (en) * 1985-01-16 1985-02-20 Erba Farmitalia Piperazin-1-yl-ergo-line derivatives
TW357143B (en) 1995-07-07 1999-05-01 Novartis Ag Benzo[g]quinoline derivatives

Also Published As

Publication number Publication date
CZ424599A3 (cs) 2000-03-15
IL132571A0 (en) 2001-03-19
NO995482D0 (no) 1999-11-09
AU8210898A (en) 1998-12-30
AR012870A1 (es) 2000-11-22
CN1259946A (zh) 2000-07-12
PL336502A1 (en) 2000-07-03
PE74899A1 (es) 1999-09-14
NO995482L (no) 1999-11-09
NZ500386A (en) 2002-05-31
CA2288810A1 (en) 1998-12-03
EP0986558A2 (en) 2000-03-22
CZ289466B6 (cs) 2002-01-16
AU727841B2 (en) 2001-01-04
BR9809491A (pt) 2000-10-17
GB9711043D0 (en) 1997-07-23
HUP0002311A2 (hu) 2000-12-28
CO4950561A1 (es) 2000-09-01
HUP0002311A3 (en) 2002-08-28
SK160899A3 (en) 2000-07-11
ID22916A (id) 1999-12-16
US6221870B1 (en) 2001-04-24
JP2001527580A (ja) 2001-12-25
RU2191776C2 (ru) 2002-10-27
KR20010013103A (ko) 2001-02-26
WO1998054183A2 (en) 1998-12-03
ZA984560B (en) 1998-11-30
WO1998054183A3 (en) 1999-03-04

Similar Documents

Publication Publication Date Title
TR199902848T2 (tr) Ergolin türevleri ve bunlarin somatostatin reseptör antagonist olarak kullanimlari
TR199801594A2 (tr) CCR-3 reseptör antagonistleri.
TR200101398T2 (tr) Pirolidin türevleri-CCR-3 reseptörü antagonistleri.
TR200101961T2 (tr) 1,2-halkalı kinolin türevleri
SE9702773D0 (sv) Novel compounds
ATE245636T1 (de) Benzofurylpiperazine: 5-ht2c serotoninrezeptor agonisten
EA200101177A1 (ru) Производные индола в качестве антагонистов прогестерона
EP1109542A4 (en) NITROSED AND NITROSYLATED ANTAGONISTS OF THE ALPHA ADRENERGIC RECEPTOR, COMPOSITIONS AND USES THEREOF
WO2000066581A8 (en) Cyanopyrroles as progesterone receptor agonists
ATE331726T1 (de) Adenine-derivate
WO1999064401A3 (en) Imidazolyl derivatives and their use as somatostatin receptor ligands
PT1274687E (pt) Derivados de 1,2,3,4-tetra-hidroisoquinolina
TR199900920T2 (tr) Nafthiridin türevleri.
DE69616480D1 (de) Piperidinderivate als neurokininantagonisten
TR199802284T2 (tr) Dopamin D3 reseptörlerinin modülatörleri olarak tetrahidroizokuinolin türevleri.
TR200101155T2 (tr) 4-Aroil Piperidin CCR-3 Reseptör Antagonistleri III
CY1108610T1 (el) Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
HK1043365A1 (en) N-(iminomethyl) amine derivatives, their preparation, their use as medicines and compositions containing them n-.
TR200102489T2 (tr) 3-Fenilpiridin Türevleri ve bunların NK-1 alıcı antagonistler olarak kullanılması
ATE230392T1 (de) Amidinophenyl-pyrrolidine, -pyrroline und - isoxazolidine und ihre derivate
ATE293448T1 (de) Benzo(d)azepin-derivative als 5-ht6-rezeptor- antagonisten
TR200002542T2 (tr) Meta-azasiklik amino benzoik asit bileşikleri ve bunların integrin antagonistleri olan türevleri
SE9300012D0 (sv) New peptides
MX9801890A (es) Nuevos compuestos antagonistas selectivos del receptor nk3 humano, procedimiento para su obtencion y composiciones farmaceuticas que los contienen.
HUP0103203A2 (hu) Azaadamantánszármazékok és ezeket tartalmazó gyógyszerkészítmények