TR199900191T2 - (S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses. - Google Patents
(S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses.Info
- Publication number
- TR199900191T2 TR199900191T2 TR1999/00191T TR9900191T TR199900191T2 TR 199900191 T2 TR199900191 T2 TR 199900191T2 TR 1999/00191 T TR1999/00191 T TR 1999/00191T TR 9900191 T TR9900191 T TR 9900191T TR 199900191 T2 TR199900191 T2 TR 199900191T2
- Authority
- TR
- Turkey
- Prior art keywords
- improved process
- synthesis
- dihydroxybutyric acid
- esters
- protected esters
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- DZAIOXUZHHTJKN-VKHMYHEASA-N 3S,4-dihydroxy-butyric acid Chemical compound OC[C@@H](O)CC(O)=O DZAIOXUZHHTJKN-VKHMYHEASA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- FUDDLSHBRSNCBV-VKHMYHEASA-N (4s)-4-hydroxyoxolan-2-one Chemical compound O[C@@H]1COC(=O)C1 FUDDLSHBRSNCBV-VKHMYHEASA-N 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 150000002905 orthoesters Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrane Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2236996P | 1996-07-29 | 1996-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199900191T2 true TR199900191T2 (xx) | 1999-04-21 |
Family
ID=21809241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1999/00191T TR199900191T2 (xx) | 1996-07-29 | 1997-07-01 | (S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5998633A (enExample) |
| EP (1) | EP0915866B1 (enExample) |
| JP (1) | JP2000515882A (enExample) |
| KR (1) | KR100447370B1 (enExample) |
| CN (1) | CN1093126C (enExample) |
| AT (1) | ATE215078T1 (enExample) |
| AU (1) | AU3515497A (enExample) |
| CO (1) | CO4950542A1 (enExample) |
| DE (1) | DE69711391T2 (enExample) |
| DK (1) | DK0915866T3 (enExample) |
| ES (1) | ES2176756T3 (enExample) |
| HU (1) | HU226465B1 (enExample) |
| IL (1) | IL127058A (enExample) |
| PT (1) | PT915866E (enExample) |
| TR (1) | TR199900191T2 (enExample) |
| WO (1) | WO1998004543A1 (enExample) |
| ZA (1) | ZA976705B (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2176756T3 (es) * | 1996-07-29 | 2002-12-01 | Warner Lambert Co | Proceso perfeccionado para la sintesis de los esteres protegidos del acido (s)-3,4-dihidroxibutirico. |
| US6713290B2 (en) | 1998-07-24 | 2004-03-30 | Samsung Fine Chemicals Co., Ltd. | Process for preparing optically pure (S)-3-hydroxy-γ-butyrolactone |
| ES2183584T3 (es) * | 1998-07-24 | 2003-03-16 | Samsung Fine Chemicals Co Ltd | Procedimiento para la preparacion de (s) -3-hidroxi-gamma-butirolactona opticamente pura. |
| KR100332703B1 (ko) * | 1998-07-24 | 2002-08-27 | 삼성정밀화학 주식회사 | 광학활성을갖는(s)-3,4-에폭시부티르산염의제조방법 |
| US6235930B1 (en) * | 1999-03-31 | 2001-05-22 | Board Of Trustees Operating Michigan State University | Process for the preparation of 3,4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars |
| HU227840B1 (en) * | 1999-05-06 | 2012-05-02 | Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag | Intermediates of atorvastatin synthesis and process for producing them |
| CA2388226A1 (en) | 1999-12-17 | 2001-06-21 | William Tully | A factory scale process for producing crystalline atorvastatin trihydrate hemi calcium salt |
| EP1242373B1 (en) | 1999-12-17 | 2006-03-15 | Pfizer Science and Technology Ireland Limited | A process for producing crystalline atorvastatin calcium |
| JP4598917B2 (ja) * | 2000-04-28 | 2010-12-15 | ダイセル化学工業株式会社 | ラクトンの製造方法 |
| KR100645665B1 (ko) | 2000-07-27 | 2006-11-13 | 에스케이 주식회사 | (ｓ)-베타-하이드록시-감마-부티로락톤의 연속 제조방법 |
| US6476235B2 (en) * | 2001-01-09 | 2002-11-05 | Warner-Lambert Company | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide |
| EP1728785A1 (en) | 2001-01-09 | 2006-12-06 | Warner-Lambert Company LLC | 7-[(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-heptanoic acid ester 3,5-dioxo-acetal |
| WO2002057229A1 (en) * | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN) |
| HUP0400381A2 (hu) * | 2001-06-29 | 2004-09-28 | Warner-Lambert Company Llc | [R-(R*,R*)]-2-(4fluorfenil)-béta, delta-dihidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)karbonil]-1H-pirrol-1-heptánsav 2:1 arányú kalciumsójának (atorvasztatin) kristályos formái |
| HUP0401014A2 (hu) * | 2001-07-06 | 2004-08-30 | Teva Pharmaceutical Industries Ltd. | Eljárás 7-amino-szin-3,5-dihidroxi-heptánsavszármazékok előállítására, 6-ciano-szin-3,5-dihidroxi-hexánsav származékokon keresztül |
| EP1478650B1 (en) * | 2002-02-25 | 2009-09-30 | Biocon Limited | Novel boronate esters |
| GB0211716D0 (en) | 2002-05-22 | 2002-07-03 | Phoenix Chemicals Ltd | Process |
| AU2003247124A1 (en) * | 2002-08-06 | 2004-02-25 | Warner-Lambert Company Llc | Process for preparing 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide |
| AU2002329102A1 (en) * | 2002-09-18 | 2004-04-08 | Sk Corporation | CONTINUOUS PROCESS FOR THE PRODUCTION OF OPTICALLY PURE (S)-Beta HYDROXY-Gamma-BUTYROLACTONE |
| WO2004027075A2 (en) * | 2002-09-20 | 2004-04-01 | Diversa Corporation | Chemoenzymatic methods for the synthesis of statins and stain intermediates |
| US6713639B1 (en) | 2002-10-28 | 2004-03-30 | Council Of Scientific And Industrial Research | Process for preparing enantiomerically pure (S)-3-hydroxy-gamma-butyrolactone |
| JP2006523670A (ja) * | 2003-04-14 | 2006-10-19 | ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー | ５−（４−フルオロフェニル）−１−［２−（（２ｒ，４ｒ）−４−ヒドロキシ−６−オキソ−テトラヒドロ−ピラン−２−イル）エチル］−２−イソプロピル−４−フェニル−１ｈ−ピロール−３−カルボン酸フェニルアミドの調製方法 |
| ES2323366T3 (es) * | 2003-04-22 | 2009-07-14 | Biocon Limited | Procedimiento novedoso para la reduccion estereoselectiva de beta-cetoesteres. |
| US7790197B2 (en) * | 2003-06-09 | 2010-09-07 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
| US7655692B2 (en) * | 2003-06-12 | 2010-02-02 | Pfizer Inc. | Process for forming amorphous atorvastatin |
| US20050271717A1 (en) * | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
| US20040253305A1 (en) * | 2003-06-12 | 2004-12-16 | Luner Paul E. | Pharmaceutical compositions of atorvastatin |
| RU2315755C2 (ru) * | 2003-09-17 | 2008-01-27 | Уорнер-Ламберт Компани Ллс | Кристаллические формы [r-(r*,r*)]-2-(4-фторфенил)-бета, дельта-дигидрокси-5-(1-метилэтил)-3-фенил-4-[(фениламино)карбонил]-1н-пиррол-1-гептановой кислоты |
| WO2005068642A2 (en) | 2003-10-01 | 2005-07-28 | Board Of Trustees Operating Michigan State University | Bacterial synthesis of 1,2,4-butanetriol enantiomers |
| JP2007532622A (ja) * | 2004-04-16 | 2007-11-15 | ファイザー・プロダクツ・インク | 非晶質アトルバスタチン・カルシウムの形成方法 |
| EP3581564A1 (en) | 2004-05-05 | 2019-12-18 | Pfizer Products Inc. | Diethylamine salt forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid |
| CA2754932C (en) | 2004-07-20 | 2014-04-01 | Warner-Lambert Company Llc | Novel forms of [r-(r*,r*)]-2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) |
| MX2007004722A (es) * | 2004-10-28 | 2007-06-15 | Warner Lambert Co | Procedimiento para formar atorvastatina amorfa. |
| JP2008521878A (ja) * | 2004-12-02 | 2008-06-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 非晶質アトルバスタチンの医薬組成物及びその製造のための方法 |
| JP4926955B2 (ja) * | 2005-05-31 | 2012-05-09 | 興和株式会社 | 光学活性ｐｐａｒ活性化化合物及びその製造中間体の製造法 |
| CA2547216A1 (en) | 2005-09-21 | 2007-03-21 | Renuka D. Reddy | Process for annealing amorphous atorvastatin |
| ES2304335T3 (es) | 2005-11-21 | 2010-05-19 | Warner-Lambert Company Llc | Formas nuevas del acido (r-(r*,r*))-2-(4-fluorofenil)-b,b-dihidroxi-5-(1-metiletil)-3-fenil-4-((fenilamino)carbonil)1h-pirrol-1-heptanoico, de magnesio. |
| US20110165641A1 (en) * | 2006-03-31 | 2011-07-07 | The Board Of Trustees Of Michigan State University | Synthesis of 1,2,4-Butanetriol Enantiomers from Carbohydrates |
| EP2054518A2 (en) * | 2006-07-19 | 2009-05-06 | Board of Trustees of Michigan State University | Microbial synthesis of d-1,2,4-butanetriol |
| KR100850558B1 (ko) | 2008-01-02 | 2008-08-06 | 조동옥 | 아토르바스타틴의 효율적인 제조방법 |
| JP2009256316A (ja) | 2008-03-28 | 2009-11-05 | Daicel Chem Ind Ltd | β−ヒドロキシ−γ−ブチロラクトンの製造方法 |
| CN101337906B (zh) * | 2008-08-15 | 2012-06-27 | 河南豫辰精细化工有限公司 | 一种4-甲基-3-氧代-n-苯基戊酰胺的制备方法 |
| EP2327682A1 (en) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
| WO2010069593A1 (en) | 2008-12-19 | 2010-06-24 | Krka, D. D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
| WO2013004591A1 (en) | 2011-07-01 | 2013-01-10 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Micronized crystals of atorvastatin hemicalcium |
| CN106397241A (zh) * | 2016-08-23 | 2017-02-15 | 杨锋 | 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法 |
| CN106588689A (zh) * | 2016-12-15 | 2017-04-26 | 河南豫辰药业股份有限公司 | 一种从结晶母液废液中回收阿托伐他汀中间体m4的方法 |
| CN112939901B (zh) * | 2021-02-09 | 2023-05-09 | 中国科学院福建物质结构研究所 | 一种α-羟基-γ-丁内酯的制备方法 |
| CN114195670B (zh) * | 2021-12-31 | 2024-03-15 | 河南豫辰药业股份有限公司 | 一种阿托伐他汀母核m4的精制方法 |
| CN117447350B (zh) * | 2023-10-26 | 2026-02-13 | 河南豫辰药业股份有限公司 | 一种阿托伐他汀m4有机废物综合再利用方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2710688B2 (ja) * | 1990-10-09 | 1998-02-10 | 鐘淵化学工業株式会社 | ４―ブロモ―３―ヒドロキシ酪酸エステル誘導体の製造法 |
| CA2049536C (en) * | 1991-05-13 | 1999-07-06 | Rawle I. Hollingsworth | Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof |
| JP3351563B2 (ja) * | 1992-12-03 | 2002-11-25 | 鐘淵化学工業株式会社 | ３−ヒドロキシ酪酸誘導体の製造法 |
| ES2176756T3 (es) * | 1996-07-29 | 2002-12-01 | Warner Lambert Co | Proceso perfeccionado para la sintesis de los esteres protegidos del acido (s)-3,4-dihidroxibutirico. |
-
1997
- 1997-07-01 ES ES97931557T patent/ES2176756T3/es not_active Expired - Lifetime
- 1997-07-01 HU HU9904348A patent/HU226465B1/hu not_active IP Right Cessation
- 1997-07-01 WO PCT/US1997/011654 patent/WO1998004543A1/en not_active Ceased
- 1997-07-01 CN CN97195996A patent/CN1093126C/zh not_active Expired - Fee Related
- 1997-07-01 JP JP10508813A patent/JP2000515882A/ja not_active Ceased
- 1997-07-01 PT PT97931557T patent/PT915866E/pt unknown
- 1997-07-01 DE DE69711391T patent/DE69711391T2/de not_active Expired - Fee Related
- 1997-07-01 TR TR1999/00191T patent/TR199900191T2/xx unknown
- 1997-07-01 AT AT97931557T patent/ATE215078T1/de not_active IP Right Cessation
- 1997-07-01 IL IL12705897A patent/IL127058A/en not_active IP Right Cessation
- 1997-07-01 US US09/230,397 patent/US5998633A/en not_active Expired - Fee Related
- 1997-07-01 AU AU35154/97A patent/AU3515497A/en not_active Abandoned
- 1997-07-01 EP EP97931557A patent/EP0915866B1/en not_active Expired - Lifetime
- 1997-07-01 KR KR10-1999-7000721A patent/KR100447370B1/ko not_active Expired - Fee Related
- 1997-07-01 DK DK97931557T patent/DK0915866T3/da active
- 1997-07-28 CO CO97042973A patent/CO4950542A1/es unknown
- 1997-07-28 ZA ZA9706705A patent/ZA976705B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA976705B (en) | 1998-02-10 |
| PT915866E (pt) | 2002-07-31 |
| ATE215078T1 (de) | 2002-04-15 |
| JP2000515882A (ja) | 2000-11-28 |
| AU3515497A (en) | 1998-02-20 |
| HU226465B1 (en) | 2008-12-29 |
| CN1093126C (zh) | 2002-10-23 |
| US5998633A (en) | 1999-12-07 |
| HK1020728A1 (en) | 2000-05-19 |
| WO1998004543A1 (en) | 1998-02-05 |
| CN1223647A (zh) | 1999-07-21 |
| HUP9904348A3 (en) | 2004-03-01 |
| EP0915866B1 (en) | 2002-03-27 |
| DK0915866T3 (da) | 2002-06-10 |
| IL127058A0 (en) | 1999-09-22 |
| ES2176756T3 (es) | 2002-12-01 |
| KR100447370B1 (ko) | 2004-09-08 |
| DE69711391D1 (de) | 2002-05-02 |
| KR20000029648A (ko) | 2000-05-25 |
| DE69711391T2 (de) | 2002-11-07 |
| CO4950542A1 (es) | 2000-09-01 |
| EP0915866A1 (en) | 1999-05-19 |
| IL127058A (en) | 2001-07-24 |
| HUP9904348A2 (hu) | 2000-04-28 |
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