TR199900191T2 - (S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses. - Google Patents
(S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses.Info
- Publication number
- TR199900191T2 TR199900191T2 TR1999/00191T TR9900191T TR199900191T2 TR 199900191 T2 TR199900191 T2 TR 199900191T2 TR 1999/00191 T TR1999/00191 T TR 1999/00191T TR 9900191 T TR9900191 T TR 9900191T TR 199900191 T2 TR199900191 T2 TR 199900191T2
- Authority
- TR
- Turkey
- Prior art keywords
- improved process
- synthesis
- dihydroxybutyric acid
- esters
- protected esters
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- DZAIOXUZHHTJKN-VKHMYHEASA-N 3S,4-dihydroxy-butyric acid Chemical compound OC[C@@H](O)CC(O)=O DZAIOXUZHHTJKN-VKHMYHEASA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- FUDDLSHBRSNCBV-VKHMYHEASA-N (4s)-4-hydroxyoxolan-2-one Chemical compound O[C@@H]1COC(=O)C1 FUDDLSHBRSNCBV-VKHMYHEASA-N 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 150000002905 orthoesters Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrane Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2236996P | 1996-07-29 | 1996-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199900191T2 true TR199900191T2 (xx) | 1999-04-21 |
Family
ID=21809241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1999/00191T TR199900191T2 (xx) | 1996-07-29 | 1997-07-01 | (S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5998633A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0915866B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2000515882A (cg-RX-API-DMAC7.html) |
| KR (1) | KR100447370B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1093126C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE215078T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU3515497A (cg-RX-API-DMAC7.html) |
| CO (1) | CO4950542A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69711391T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0915866T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2176756T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HU226465B1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL127058A (cg-RX-API-DMAC7.html) |
| PT (1) | PT915866E (cg-RX-API-DMAC7.html) |
| TR (1) | TR199900191T2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1998004543A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA976705B (cg-RX-API-DMAC7.html) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1093126C (zh) * | 1996-07-29 | 2002-10-23 | 沃尼尔·朗伯公司 | 合成被保护的(s)－3,4－二羟基丁酸酯的改进方法 |
| WO2000005400A1 (en) * | 1998-07-24 | 2000-02-03 | Samsung Fine Chemicals Co., Ltd. | Process for preparing optically pure (s)-3,4-dihydroxybutyric acid derivatives |
| US6713290B2 (en) | 1998-07-24 | 2004-03-30 | Samsung Fine Chemicals Co., Ltd. | Process for preparing optically pure (S)-3-hydroxy-γ-butyrolactone |
| KR100332703B1 (ko) * | 1998-07-24 | 2002-08-27 | 삼성정밀화학 주식회사 | 광학활성을갖는(s)-3,4-에폭시부티르산염의제조방법 |
| US6235930B1 (en) * | 1999-03-31 | 2001-05-22 | Board Of Trustees Operating Michigan State University | Process for the preparation of 3,4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars |
| HU227840B1 (en) * | 1999-05-06 | 2012-05-02 | Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag | Intermediates of atorvastatin synthesis and process for producing them |
| ATE309985T1 (de) | 1999-12-17 | 2005-12-15 | Pfizer Science & Tech Ltd | Herstellungsverfahren auf industrieller basis von atorvastatin trihydrat hemi-kalziumsalz in kristalliner form |
| HUP0203798A3 (en) | 1999-12-17 | 2008-10-28 | Warner Lambert Res & Dev Ie | A process for producing crystalline atorvastatin calcium |
| JP4598917B2 (ja) * | 2000-04-28 | 2010-12-15 | ダイセル化学工業株式会社 | ラクトンの製造方法 |
| KR100645665B1 (ko) | 2000-07-27 | 2006-11-13 | 에스케이 주식회사 | (ｓ)-베타-하이드록시-감마-부티로락톤의 연속 제조방법 |
| US6476235B2 (en) | 2001-01-09 | 2002-11-05 | Warner-Lambert Company | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide |
| EP1734034A3 (en) | 2001-01-09 | 2007-01-03 | Warner-Lambert Company LLC | Carboxylic acid salts of beta-alanine esters or -amides |
| WO2002057229A1 (en) * | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN) |
| JP3965155B2 (ja) | 2001-06-29 | 2007-08-29 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 結晶型［Ｒ−（Ｒ＊，Ｒ＊）］−２−（４−フルオロフェニル）−β，δ−ジヒドロキシ−５−（１−メチルエチル）−３−フェニル−４−［（フェニルアミノ）カルボニル］−１Ｈ−ピロール−１−ヘプタン酸カルシウム塩（２：１）（アトロバスタチン） |
| PL366610A1 (en) * | 2001-07-06 | 2005-02-07 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives |
| KR100598079B1 (ko) * | 2002-02-25 | 2006-07-07 | 바이오콘 리미티드 | 신규의 보로네이트 에스테르 |
| GB0211716D0 (en) | 2002-05-22 | 2002-07-03 | Phoenix Chemicals Ltd | Process |
| RU2279430C2 (ru) | 2002-08-06 | 2006-07-10 | Уорнер-Ламберт Компани Ллс | Способ получения фениламида 5-(4-фторфенил)-1-[2-(2r,4r)-4-гидрокси-6-оксотетрагидропиран-2-ил)этил]-2-изопропил-4-фенил-1h-пиррол-3-карбоновой кислоты |
| CA2499655A1 (en) * | 2002-09-18 | 2004-04-01 | Sk Corporation | Continuous process for the production of optically pure (s)-.beta.-hydroxy-.gamma.-butyrolactone |
| EP1625223A4 (en) * | 2002-09-20 | 2009-11-11 | Verenium Corp | CHEMOENZYMATIC PROCEDURES FOR SYNTHESIS OF STATINES AND STATIN INTERCONNECTIONS |
| US6713639B1 (en) | 2002-10-28 | 2004-03-30 | Council Of Scientific And Industrial Research | Process for preparing enantiomerically pure (S)-3-hydroxy-gamma-butyrolactone |
| KR100780984B1 (ko) * | 2003-04-14 | 2007-11-29 | 워너-램버트 캄파니 엘엘씨 | 5-(4-플루오로페닐)-1-[2-((2ｒ,4ｒ)-4-히드록시-6-옥소-테트라히드로-피란-2-일)에틸]-2-이소프로필-4-페닐-1ｈ-피롤-3-카르복실산 페닐아미드의 제조 방법 |
| ATE425132T1 (de) * | 2003-04-22 | 2009-03-15 | Biocon Ltd | Neues verfahren zur stereoselektiven reduktion von beta-ketoestern |
| US7790197B2 (en) * | 2003-06-09 | 2010-09-07 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
| US20040253305A1 (en) * | 2003-06-12 | 2004-12-16 | Luner Paul E. | Pharmaceutical compositions of atorvastatin |
| US7655692B2 (en) * | 2003-06-12 | 2010-02-02 | Pfizer Inc. | Process for forming amorphous atorvastatin |
| US20050271717A1 (en) | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
| CA2539158A1 (en) * | 2003-09-17 | 2005-03-24 | Warner-Lambert Company Llc | Crystalline forms of ['r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid |
| WO2005068642A2 (en) | 2003-10-01 | 2005-07-28 | Board Of Trustees Operating Michigan State University | Bacterial synthesis of 1,2,4-butanetriol enantiomers |
| KR100829268B1 (ko) * | 2004-04-16 | 2008-05-13 | 화이자 프로덕츠 인코포레이티드 | 비정질 아토바스타틴 칼슘의 제조 방법 |
| US7875731B2 (en) | 2004-05-05 | 2011-01-25 | Pfizer Inc. | Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)Carbonyl]-1H-pyrrole-1-heptanoic acid |
| EP1771412A2 (en) | 2004-07-20 | 2007-04-11 | Warner-Lambert Company LLC | Crystalline forms of [r-(r*)]-2-(4-fluorophenyl)-bet a,gamma-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-hept anoic acid calcium salt (2:1) |
| AU2005298383A1 (en) * | 2004-10-28 | 2006-05-04 | Warner-Lambert Company Llc | Process for forming amorphous atorvastatin |
| US20090088465A1 (en) * | 2004-12-02 | 2009-04-02 | Stephen Craig Dyar | Pharmaceutical Compositions of Amorphous Atorvastatin and Process for Preparing Same |
| US7714141B2 (en) * | 2005-05-31 | 2010-05-11 | Kowa Co., Ltd. | Processes for production of optically active PPAR-activating compounds and intermediates for production thereof |
| CA2547216A1 (en) | 2005-09-21 | 2007-03-21 | Renuka D. Reddy | Process for annealing amorphous atorvastatin |
| US8084488B2 (en) * | 2005-11-21 | 2011-12-27 | Pfizer Inc. | Forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid magnesium |
| US20110165641A1 (en) * | 2006-03-31 | 2011-07-07 | The Board Of Trustees Of Michigan State University | Synthesis of 1,2,4-Butanetriol Enantiomers from Carbohydrates |
| EP2054518A2 (en) * | 2006-07-19 | 2009-05-06 | Board of Trustees of Michigan State University | Microbial synthesis of d-1,2,4-butanetriol |
| KR100850558B1 (ko) | 2008-01-02 | 2008-08-06 | 조동옥 | 아토르바스타틴의 효율적인 제조방법 |
| JP2009256316A (ja) | 2008-03-28 | 2009-11-05 | Daicel Chem Ind Ltd | β−ヒドロキシ−γ−ブチロラクトンの製造方法 |
| CN101337906B (zh) * | 2008-08-15 | 2012-06-27 | 河南豫辰精细化工有限公司 | 一种4-甲基-3-氧代-n-苯基戊酰胺的制备方法 |
| SI2373609T1 (sl) | 2008-12-19 | 2013-12-31 | Krka, D.D., Novo Mesto | Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov |
| EP2327682A1 (en) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
| MX2013015272A (es) | 2011-07-01 | 2014-04-14 | Dsm Sinochem Pharm Nl Bv | Cristales micronizados. |
| CN106397241A (zh) * | 2016-08-23 | 2017-02-15 | 杨锋 | 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法 |
| CN106588689A (zh) * | 2016-12-15 | 2017-04-26 | 河南豫辰药业股份有限公司 | 一种从结晶母液废液中回收阿托伐他汀中间体m4的方法 |
| CN112939901B (zh) * | 2021-02-09 | 2023-05-09 | 中国科学院福建物质结构研究所 | 一种α-羟基-γ-丁内酯的制备方法 |
| CN114195670B (zh) * | 2021-12-31 | 2024-03-15 | 河南豫辰药业股份有限公司 | 一种阿托伐他汀母核m4的精制方法 |
| CN117447350A (zh) * | 2023-10-26 | 2024-01-26 | 河南豫辰药业股份有限公司 | 一种阿托伐他汀m4有机废物综合再利用方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2710688B2 (ja) * | 1990-10-09 | 1998-02-10 | 鐘淵化学工業株式会社 | ４―ブロモ―３―ヒドロキシ酪酸エステル誘導体の製造法 |
| CA2049536C (en) * | 1991-05-13 | 1999-07-06 | Rawle I. Hollingsworth | Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof |
| JP3351563B2 (ja) * | 1992-12-03 | 2002-11-25 | 鐘淵化学工業株式会社 | ３−ヒドロキシ酪酸誘導体の製造法 |
| CN1093126C (zh) * | 1996-07-29 | 2002-10-23 | 沃尼尔·朗伯公司 | 合成被保护的(s)－3,4－二羟基丁酸酯的改进方法 |
-
1997
- 1997-07-01 CN CN97195996A patent/CN1093126C/zh not_active Expired - Fee Related
- 1997-07-01 AT AT97931557T patent/ATE215078T1/de not_active IP Right Cessation
- 1997-07-01 US US09/230,397 patent/US5998633A/en not_active Expired - Fee Related
- 1997-07-01 DE DE69711391T patent/DE69711391T2/de not_active Expired - Fee Related
- 1997-07-01 JP JP10508813A patent/JP2000515882A/ja not_active Ceased
- 1997-07-01 ES ES97931557T patent/ES2176756T3/es not_active Expired - Lifetime
- 1997-07-01 HU HU9904348A patent/HU226465B1/hu not_active IP Right Cessation
- 1997-07-01 DK DK97931557T patent/DK0915866T3/da active
- 1997-07-01 TR TR1999/00191T patent/TR199900191T2/xx unknown
- 1997-07-01 AU AU35154/97A patent/AU3515497A/en not_active Abandoned
- 1997-07-01 PT PT97931557T patent/PT915866E/pt unknown
- 1997-07-01 EP EP97931557A patent/EP0915866B1/en not_active Expired - Lifetime
- 1997-07-01 IL IL12705897A patent/IL127058A/en not_active IP Right Cessation
- 1997-07-01 WO PCT/US1997/011654 patent/WO1998004543A1/en not_active Ceased
- 1997-07-01 KR KR10-1999-7000721A patent/KR100447370B1/ko not_active Expired - Fee Related
- 1997-07-28 CO CO97042973A patent/CO4950542A1/es unknown
- 1997-07-28 ZA ZA9706705A patent/ZA976705B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0915866A1 (en) | 1999-05-19 |
| US5998633A (en) | 1999-12-07 |
| JP2000515882A (ja) | 2000-11-28 |
| ES2176756T3 (es) | 2002-12-01 |
| CO4950542A1 (es) | 2000-09-01 |
| ATE215078T1 (de) | 2002-04-15 |
| CN1093126C (zh) | 2002-10-23 |
| HK1020728A1 (en) | 2000-05-19 |
| DE69711391D1 (de) | 2002-05-02 |
| IL127058A (en) | 2001-07-24 |
| WO1998004543A1 (en) | 1998-02-05 |
| KR20000029648A (ko) | 2000-05-25 |
| DE69711391T2 (de) | 2002-11-07 |
| IL127058A0 (en) | 1999-09-22 |
| HUP9904348A3 (en) | 2004-03-01 |
| HUP9904348A2 (hu) | 2000-04-28 |
| PT915866E (pt) | 2002-07-31 |
| DK0915866T3 (da) | 2002-06-10 |
| CN1223647A (zh) | 1999-07-21 |
| ZA976705B (en) | 1998-02-10 |
| EP0915866B1 (en) | 2002-03-27 |
| HU226465B1 (en) | 2008-12-29 |
| KR100447370B1 (ko) | 2004-09-08 |
| AU3515497A (en) | 1998-02-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TR199900191T2 (xx) | (S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses. | |
| RU95114376A (ru) | Нитроэфиры, обладающие фармакологической активностью, и способ их получения | |
| HUP0100845A3 (en) | Hydroxamid acid derivatives as matrix metalloprotease(mmp) inhibitors, process for producing them and pharmaceutical compositions containing them | |
| ID19926A (id) | Proses untuk produksi asam tereftalat murni | |
| ID21654A (id) | Proses derivatisasi selektif taksana | |
| PL341054A1 (en) | Novel suppositiories containing an active compound being unstable in acid environments | |
| IT1226726B (it) | Composti attivi come inibitori della biosintesi del colesterolo. | |
| AU5130299A (en) | Wrist-mounted i.v. administration set | |
| TR199800077T1 (xx) | Kontroll� ��z�len paroksetin terkipleri. | |
| ID21393A (id) | Asam benzazepinon-n-asetat tersubstitusi-asam fosfonat, proses pembuatan dan obat-obat yang mengandung senyawa ini | |
| WO1995001168A3 (de) | Pharmazeutische zubereitungen, die einen wirkstoff mit modifizierten amidingruppen enthält | |
| DE69015939D1 (de) | Brennstoffzellengenerator. | |
| MX9800408A (es) | Sales de derivados de amidina y de inhibidor de ciclooxigenasa, su procedimiento de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen. | |
| HUP0002921A3 (en) | Cyanoguanidines as cell proliferation inhibitors, process for producing them and pharmaceutical compositions containing them | |
| HUP0002853A3 (en) | 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives, and pharmaceutical compositions containing them | |
| GEP20063972B (en) | Streptogramin derivatives, preparation and compositions containing them | |
| NZ325235A (en) | New phenylamidine derivatives, a process for preparing the same and their use as medicaments | |
| JPS5433634A (en) | Information read-in system | |
| NO960826L (no) | Anvendelse av enzymer fra krill i forstoffer | |
| TR200000624T2 (tr) | Bir enzimin etkinliğinin arttırılması ile ilgili bir yöntem. | |
| FI945328L (fi) | Laitos sähköenergian tuottamiseksi polttoaineista, erityisesti biogeenisistä polttoaineista | |
| ES542835A0 (es) | Procedimiento de preparar un antigeno relacionado con el ligamento glicosidico,derivado de celulas de cancer. | |
| CA2294158A1 (en) | Natural antitumor or antiviral substances and use of the same | |
| MY122830A (en) | Process for the preparation of (alpha)-(2-4-disulfophenyl)-n-tert-butylnitrone and pharmaceutically acceptable salts thereof | |
| IL148161A0 (en) | Process for the preparation of 2-cyanopyridines |