TNSN97010A1 - Cyclopentanopyridyl-oxazolidinones contenant des heteroatomes. - Google Patents
Cyclopentanopyridyl-oxazolidinones contenant des heteroatomes.Info
- Publication number
- TNSN97010A1 TNSN97010A1 TNTNSN97010A TNSN97010A TNSN97010A1 TN SN97010 A1 TNSN97010 A1 TN SN97010A1 TN TNSN97010 A TNTNSN97010 A TN TNSN97010A TN SN97010 A TNSN97010 A TN SN97010A TN SN97010 A1 TNSN97010 A1 TN SN97010A1
- Authority
- TN
- Tunisia
- Prior art keywords
- cyclopentanopyridyl
- heteroatomes
- oxazolidinones containing
- oxazolidinones
- drugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
LA PRESENTE INVENTION CONCERNE DES CYCLOPENTANOPYRIDYL- OXAZOLIDINONES CONTENANT DES HETEROATOMES, DES PROCEDES POUR LEUR PREPARATION ET LEUR UTILISATION COMME MEDICAMENTS, EN PARTICULIER COMME MEDICAMENTS ANTIBACTERIENS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19601627A DE19601627A1 (de) | 1996-01-18 | 1996-01-18 | Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN97010A1 true TNSN97010A1 (fr) | 2005-03-15 |
Family
ID=7783042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNTNSN97010A TNSN97010A1 (fr) | 1996-01-18 | 1997-01-15 | Cyclopentanopyridyl-oxazolidinones contenant des heteroatomes. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5869659A (fr) |
EP (1) | EP0785201A1 (fr) |
JP (1) | JPH09202787A (fr) |
KR (1) | KR970059170A (fr) |
AU (1) | AU1012397A (fr) |
BG (1) | BG101139A (fr) |
BR (1) | BR9700716A (fr) |
CA (1) | CA2195177A1 (fr) |
CZ (1) | CZ15897A3 (fr) |
DE (1) | DE19601627A1 (fr) |
EE (1) | EE9700020A (fr) |
HU (1) | HU9700152D0 (fr) |
IL (1) | IL120016A0 (fr) |
MA (1) | MA24062A1 (fr) |
NO (1) | NO970210L (fr) |
PL (1) | PL317985A1 (fr) |
SG (1) | SG50001A1 (fr) |
SK (1) | SK6997A3 (fr) |
TN (1) | TNSN97010A1 (fr) |
TR (1) | TR199700039A2 (fr) |
ZA (1) | ZA97393B (fr) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU764184B2 (en) | 1998-01-23 | 2003-08-14 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
US7002020B1 (en) | 1998-01-23 | 2006-02-21 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
US6562844B2 (en) | 1998-01-23 | 2003-05-13 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
CN1311787A (zh) | 1998-06-05 | 2001-09-05 | 阿斯特拉曾尼卡有限公司 | 噁唑烷酮衍生物、其制备方法以及含有它们的药物组合物 |
KR20020022787A (ko) * | 1999-07-28 | 2002-03-27 | 로렌스 티. 마이젠헬더 | 옥사졸리디논 및 항감염제로서의 그의 용도 |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
MY127336A (en) | 2000-03-22 | 2006-11-30 | Upjohn Co | Container for linezolid iv solution |
US6514529B2 (en) | 2000-03-22 | 2003-02-04 | Pharmacia & Upjohn Company | Oxazolidinone tablet formulation |
GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
DK1301207T3 (da) | 2000-06-30 | 2005-10-10 | Pharmacia & Upjohn Co Llc | Sammensætninger til behandling af bakterieinfektioner indeholdende en oxazolidinonforbindelse, sulbactam og ampicillin |
US6423844B1 (en) | 2001-06-06 | 2002-07-23 | The United States Of America As Represented By The Secretary Of The Navy | Process for making 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-triamine |
US7141588B2 (en) * | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
AR038536A1 (es) * | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
CA2491287A1 (fr) * | 2002-08-12 | 2004-02-19 | Pharmacia & Upjohn Company | N-aryl-2-oxazolidinones et leurs derives |
ES2271660T3 (es) * | 2002-11-21 | 2007-04-16 | PHARMACIA & UPJOHN COMPANY LLC | Derivados de n-(4-piperazin-1-il)-fenil-2-oxazolidinona-5-carboxamida y compuestos relacionados como agentes antibacterianos. |
EP1594865A2 (fr) * | 2003-02-07 | 2005-11-16 | Warner-Lambert Company LLC | Agents antibacteriens |
WO2004069244A1 (fr) * | 2003-02-07 | 2004-08-19 | Warner-Lambert Company Llc | Derives d'oxazolidinone n-substitues par un noyau bicyclique, utilises comme agents antibacteriens |
US7012088B2 (en) * | 2003-02-24 | 2006-03-14 | Pharmacia & Upjohn Company | Indolone oxazolidinones and derivatives thereof |
US20040204463A1 (en) * | 2003-04-01 | 2004-10-14 | Harris Christina Renee | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
WO2005082900A2 (fr) * | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Amidoxines d'oxazolidinone utilisees en tant qu'agents antibacteriens |
JP2008509126A (ja) * | 2004-08-06 | 2008-03-27 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 抗菌剤としてオキシインドールを含有するオキサゾリジノン類 |
ZA200902382B (en) | 2006-10-19 | 2010-08-25 | Signal Pharm Llc | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors |
US8110578B2 (en) | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
ES2751705T3 (es) | 2009-10-26 | 2020-04-01 | Signal Pharm Llc | Métodos de síntesis y purificación de compuestos heteroarilo |
UA115319C2 (uk) | 2011-10-19 | 2017-10-25 | Сігнал Фармасьютікалз, Елелсі | Лікування злоякісної пухлини інгібітором тоr-кінази |
CA3125862A1 (fr) | 2011-12-02 | 2013-06-06 | Signal Pharmaceuticals, Llc | Compositions pharmaceutiques de 7-(6-(2-hydroxypropan-2-yl)pyridine-3-yl)-1-((trans)-4-methoxycyclohexyle)-3,4-dihydropyrazino [2,3-b]pyrazine-2(1h)-one, forme solide connexe et methodes d'utilisation |
US9375443B2 (en) | 2012-02-24 | 2016-06-28 | Signal Pharmaceuticals, Llc | Method for treating advanced non-small cell lung cancer (NSCLC) by administering a combination of a TOR kinase inhibitor and azacitidine or erlotinib |
AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
ES2638179T3 (es) | 2013-01-16 | 2017-10-19 | Signal Pharmaceuticals, Llc | Compuestos de pirrolopirimidina sustituidos, composiciones de los mismos, y métodos de tratamiento con los mismos |
EA030726B1 (ru) | 2013-04-17 | 2018-09-28 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | ФАРМАЦЕВТИЧЕСКИЕ СОСТАВЫ, СПОСОБЫ, ТВЕРДЫЕ ФОРМЫ И СПОСОБЫ ПРИМЕНЕНИЯ, ОТНОСЯЩИЕСЯ К 1-ЭТИЛ-7-(2-МЕТИЛ-6-(1H-1,2,4-ТРИАЗОЛ-3-ИЛ)ПИРИДИН-3-ИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1H)-ОНУ |
CN105339008A (zh) | 2013-04-17 | 2016-02-17 | 西格诺药品有限公司 | 用于治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯酰胺的组合疗法 |
MX2015014590A (es) | 2013-04-17 | 2016-03-03 | Signal Pharm Llc | Tratamiento de cancer con dihidropirazino-pirazinas. |
CA2908742C (fr) | 2013-04-17 | 2021-06-01 | Signal Pharmaceuticals, Llc | Polytherapie comprenant un inhibiteur de la kinase tor et un analogue de la cytidine pour le traitement du cancer |
EA030808B1 (ru) | 2013-04-17 | 2018-09-28 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | ПРИМЕНЕНИЕ 1-ЭТИЛ-7-(2-МЕТИЛ-6-(1Н-1,2,4-ТРИАЗОЛ-3-ИЛ)ПИРИДИН-3-ИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1Н)-ОНА В ЛЕЧЕНИИ МУЛЬТИФОРМНОЙ ГЛИОБЛАСТОМЫ |
US9937169B2 (en) | 2013-04-17 | 2018-04-10 | Signal Pharmaceuticals, Llc | Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy |
CA2909625C (fr) | 2013-04-17 | 2021-06-01 | Signal Pharmaceuticals, Llc | Polytherapie comprenant un inhibiteur de kinase tor et un compose de quinazolinone substitue en 5 pour le traitement du cancer |
MX2015015880A (es) | 2013-05-29 | 2016-05-31 | Signal Pharm Llc | Composiciones farmaceuticas de 7-(6-(2-hidroxipropan-2-il)piridin- 3-il)-1-((trans)-4-metoxiciclohexil)-3,4-dihidropirazino[2,3-b]pi razin-2(1h)-ona, una forma solida del mismo y metodos de su uso. |
NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
US9718824B2 (en) | 2014-04-16 | 2017-08-01 | Signal Pharmaceuticals, Llc | Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof |
EP3131552B1 (fr) | 2014-04-16 | 2020-07-15 | Signal Pharmaceuticals, LLC | Méthodes de traitement du cancer à l'aide d'une polythérapie avec des inhibiteurs de la kinase tor |
WO2015160880A1 (fr) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | Formes solides comprenant 1-éthyl-7-(2-méthyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl)-3,4-dihydropyrazino(2,3-b)pyrazin-2(1h)-one, et co-formateur, compositions et procédés d'utilisation de ces dernières |
JP2017520603A (ja) | 2014-07-14 | 2017-07-27 | シグナル ファーマシューティカルズ,エルエルシー | 置換ピロロピリミジン化合物を使用するがんの治療方法及びその組成物 |
NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
CN110996955A (zh) | 2017-06-22 | 2020-04-10 | 细胞基因公司 | 以乙型肝炎病毒感染为特征的肝细胞癌的治疗 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4921869A (en) * | 1987-10-09 | 1990-05-01 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4985429A (en) * | 1987-10-09 | 1991-01-15 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4965268A (en) * | 1987-10-09 | 1990-10-23 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4942183A (en) * | 1987-10-16 | 1990-07-17 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents |
US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
ES2157934T3 (es) | 1988-09-15 | 2001-09-01 | Upjohn Co | Fenil-5-beta-amidometiloxazolidin-2-onas sustituidas con nitrogeno en la posicion 3. |
US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
JP2679745B2 (ja) * | 1989-06-29 | 1997-11-19 | 明治製菓株式会社 | アゾール誘導体及びそれらを有効成分とする抗潰瘍剤 |
JP2669579B2 (ja) * | 1991-10-23 | 1997-10-29 | エーザイ株式会社 | オキサゾリドン誘導体 |
DE4332384A1 (de) | 1993-09-23 | 1995-03-30 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten III |
TW286317B (fr) * | 1993-12-13 | 1996-09-21 | Hoffmann La Roche | |
DE4425612A1 (de) * | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
-
1996
- 1996-01-18 DE DE19601627A patent/DE19601627A1/de not_active Withdrawn
-
1997
- 1997-01-07 EP EP97100114A patent/EP0785201A1/fr not_active Withdrawn
- 1997-01-10 AU AU10123/97A patent/AU1012397A/en not_active Abandoned
- 1997-01-13 US US08/785,145 patent/US5869659A/en not_active Expired - Fee Related
- 1997-01-14 MA MA24463A patent/MA24062A1/fr unknown
- 1997-01-15 CA CA002195177A patent/CA2195177A1/fr not_active Abandoned
- 1997-01-15 TN TNTNSN97010A patent/TNSN97010A1/fr unknown
- 1997-01-15 SG SG1997000082A patent/SG50001A1/en unknown
- 1997-01-16 BG BG101139A patent/BG101139A/xx unknown
- 1997-01-16 PL PL97317985A patent/PL317985A1/xx unknown
- 1997-01-16 JP JP9017765A patent/JPH09202787A/ja active Pending
- 1997-01-16 IL IL12001697A patent/IL120016A0/xx unknown
- 1997-01-16 EE EE9700020A patent/EE9700020A/xx unknown
- 1997-01-17 NO NO970210A patent/NO970210L/no unknown
- 1997-01-17 ZA ZA97393A patent/ZA97393B/xx unknown
- 1997-01-17 SK SK69-97A patent/SK6997A3/sk unknown
- 1997-01-17 TR TR97/00039A patent/TR199700039A2/xx unknown
- 1997-01-17 BR BR9700716A patent/BR9700716A/pt unknown
- 1997-01-17 CZ CZ97158A patent/CZ15897A3/cs unknown
- 1997-01-17 KR KR1019970001266A patent/KR970059170A/ko not_active Application Discontinuation
- 1997-01-17 HU HU9700152A patent/HU9700152D0/hu unknown
Also Published As
Publication number | Publication date |
---|---|
ZA97393B (en) | 1997-07-17 |
PL317985A1 (en) | 1997-07-21 |
HU9700152D0 (en) | 1997-03-28 |
US5869659A (en) | 1999-02-09 |
DE19601627A1 (de) | 1997-07-24 |
EP0785201A1 (fr) | 1997-07-23 |
BG101139A (en) | 1998-04-30 |
EE9700020A (et) | 1997-08-15 |
MX9700388A (es) | 1997-07-31 |
BR9700716A (pt) | 1998-10-06 |
IL120016A0 (en) | 1997-04-15 |
JPH09202787A (ja) | 1997-08-05 |
SG50001A1 (en) | 1998-06-15 |
NO970210L (no) | 1997-07-21 |
TR199700039A2 (tr) | 1997-08-21 |
SK6997A3 (en) | 1997-09-10 |
KR970059170A (ko) | 1997-08-12 |
CA2195177A1 (fr) | 1997-07-19 |
MA24062A1 (fr) | 1997-10-01 |
NO970210D0 (no) | 1997-01-17 |
AU1012397A (en) | 1997-07-24 |
CZ15897A3 (en) | 1997-08-13 |
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