TNSN96153A1 - Procedes et intermediaires pour la preparation de 1-benzyl-4 ((5,6 -dimethoxy-1-indanone)-2- yl) methylpiperidine. - Google Patents

Procedes et intermediaires pour la preparation de 1-benzyl-4 ((5,6 -dimethoxy-1-indanone)-2- yl) methylpiperidine.

Info

Publication number
TNSN96153A1
TNSN96153A1 TNTNSN96153A TNSN96153A TNSN96153A1 TN SN96153 A1 TNSN96153 A1 TN SN96153A1 TN TNSN96153 A TNTNSN96153 A TN TNSN96153A TN SN96153 A TNSN96153 A TN SN96153A TN SN96153 A1 TNSN96153 A1 TN SN96153A1
Authority
TN
Tunisia
Prior art keywords
preparation
indanone
methylpiperidine
dimethoxy
benzyl
Prior art date
Application number
TNTNSN96153A
Other languages
English (en)
French (fr)
Inventor
M Devries Keith
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN96153A1 publication Critical patent/TNSN96153A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
TNTNSN96153A 1995-12-15 1996-12-11 Procedes et intermediaires pour la preparation de 1-benzyl-4 ((5,6 -dimethoxy-1-indanone)-2- yl) methylpiperidine. TNSN96153A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US875395P 1995-12-15 1995-12-15

Publications (1)

Publication Number Publication Date
TNSN96153A1 true TNSN96153A1 (fr) 2005-03-15

Family

ID=21733469

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN96153A TNSN96153A1 (fr) 1995-12-15 1996-12-11 Procedes et intermediaires pour la preparation de 1-benzyl-4 ((5,6 -dimethoxy-1-indanone)-2- yl) methylpiperidine.

Country Status (33)

Country Link
EP (1) EP0883607A1 (ro)
JP (1) JP3066083B2 (ro)
KR (1) KR20000064387A (ro)
AP (1) AP708A (ro)
AR (1) AR004368A1 (ro)
AU (1) AU716462B2 (ro)
BG (1) BG102525A (ro)
BR (1) BR9612018A (ro)
CA (1) CA2237647A1 (ro)
CO (1) CO4750831A1 (ro)
CZ (1) CZ180898A3 (ro)
DZ (1) DZ2141A1 (ro)
GT (1) GT199600092A (ro)
HN (1) HN1996000065A (ro)
HR (1) HRP960592A2 (ro)
HU (1) HUP9904275A3 (ro)
IL (3) IL136421A0 (ro)
IS (1) IS4752A (ro)
MA (1) MA24032A1 (ro)
NO (1) NO982712L (ro)
NZ (1) NZ318843A (ro)
OA (1) OA10694A (ro)
PE (1) PE25698A1 (ro)
PL (1) PL197306B1 (ro)
RO (1) RO121382B1 (ro)
RU (1) RU2160731C2 (ro)
SK (1) SK75498A3 (ro)
TN (1) TNSN96153A1 (ro)
TW (1) TW414787B (ro)
UY (1) UY24401A1 (ro)
WO (1) WO1997022584A1 (ro)
YU (1) YU49486B (ro)
ZA (1) ZA9610533B (ro)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1047674B1 (en) 1998-01-16 2005-03-30 Eisai Co., Ltd. Process for production of donepezil derivatives
IL125809A (en) 1998-08-17 2005-08-31 Finetech Lab Ltd Process and intermediates for production of donepezil and related compounds
US7148354B2 (en) * 2002-07-24 2006-12-12 Dr. Reddy's Laboratories Limited Process for preparation of donepezil
IL150982A (en) 2002-07-30 2007-02-11 Ori Lerman Process for making Donafzil
IL151253A0 (en) * 2002-08-14 2003-04-10 Finetech Lab Ltd Process for production of highly pure donepezil hydrochloride
US6953856B2 (en) 2003-02-12 2005-10-11 Usv, Limited Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI)
US6649765B1 (en) 2003-02-12 2003-11-18 Usv Limited, Bsd Marg. Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL)
WO2004082685A1 (en) * 2003-03-21 2004-09-30 Ranbaxy Laboratories Limited Process for the preparation of donepezil and derivatives thereof
WO2004099142A1 (en) * 2003-05-05 2004-11-18 Ranbaxy Laboratories Limited Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs
AU2003247158A1 (en) 2003-07-01 2005-01-21 Hetero Drugs Limited Preparation of intermediates for acetyl cholinesterase inhibitors
CN1280273C (zh) * 2003-11-05 2006-10-18 天津和美生物技术有限公司 合成多奈哌齐及其衍生物的方法
CA2581926A1 (en) 2004-09-29 2006-04-06 Chemagis Ltd. Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride
CN100436416C (zh) * 2005-07-29 2008-11-26 西南合成制药股份有限公司 盐酸多奈哌齐合成工艺
GB0515803D0 (en) * 2005-07-30 2005-09-07 Pliva Hrvatska D O O Intermediate compounds
AR057910A1 (es) 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar donepezilo
EP1973878B1 (en) 2006-01-04 2010-11-24 Cipla Limited Process and intermediate for preparation of donepezil
CN101626688A (zh) * 2006-12-11 2010-01-13 雷维瓦药品公司 茚满酮基胆碱酯酶抑制剂的组合物、合成和使用方法
WO2013078608A1 (en) 2011-11-29 2013-06-06 Ziqiang Gu Donepezil pamoate and methods of making and using the same
EP3033082B1 (en) 2013-08-16 2021-06-16 Universiteit Maastricht Treatment of cognitive impairment with pde4 inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2642069B1 (fr) * 1989-01-20 1991-04-12 Rhone Poulenc Sante Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent
DE4439822A1 (de) * 1994-11-08 1996-08-29 Bayer Ag Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen

Also Published As

Publication number Publication date
AU7092596A (en) 1997-07-14
PL327512A1 (en) 1998-12-21
CO4750831A1 (es) 1999-03-31
BG102525A (en) 1999-05-31
AP9600892A0 (en) 1997-01-31
KR20000064387A (ko) 2000-11-06
IS4752A (is) 1998-05-22
UY24401A1 (es) 1997-06-09
CA2237647A1 (en) 1997-06-26
RO121382B1 (ro) 2007-04-30
EP0883607A1 (en) 1998-12-16
AP708A (en) 1998-12-04
MA24032A1 (fr) 1997-07-01
YU49486B (sh) 2006-08-17
AU716462B2 (en) 2000-02-24
GT199600092A (es) 1998-05-12
PL197306B1 (pl) 2008-03-31
RU2160731C2 (ru) 2000-12-20
MX9804820A (es) 1998-10-31
AR004368A1 (es) 1998-11-04
JP3066083B2 (ja) 2000-07-17
SK75498A3 (en) 1999-08-06
DZ2141A1 (fr) 2002-07-23
HUP9904275A3 (en) 2001-05-28
NO982712D0 (no) 1998-06-12
PE25698A1 (es) 1998-05-21
HUP9904275A2 (hu) 2000-05-28
CZ180898A3 (cs) 1999-05-12
TW414787B (en) 2000-12-11
JPH11500756A (ja) 1999-01-19
YU66096A (en) 1999-11-22
IL124452A0 (en) 1998-12-06
IL136421A0 (en) 2001-06-14
HN1996000065A (es) 1997-06-26
BR9612018A (pt) 1999-02-17
WO1997022584A1 (en) 1997-06-26
IL136420A0 (en) 2001-06-14
HRP960592A2 (en) 1998-06-30
NO982712L (no) 1998-06-12
NZ318843A (en) 2000-01-28
ZA9610533B (en) 1998-06-15
OA10694A (en) 2001-05-04

Similar Documents

Publication Publication Date Title
TNSN96153A1 (fr) Procedes et intermediaires pour la preparation de 1-benzyl-4 ((5,6 -dimethoxy-1-indanone)-2- yl) methylpiperidine.
TNSN98025A1 (fr) Derives d'acide arylsulfonylhydroxamique, procede pour leur preparation et compositions les contenant.
TNSN98150A1 (fr) Derives d'acides aryloxyarylsulfonylaminohydroxamiques ; procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN98019A1 (fr) Derives d'acide arylsulfonylaminohydroxamique, procede pour leur preparation et compositions pharmaceutiques les contenant.
TNSN98022A1 (fr) DERIVES DE N-HYDROXY-β-SULFONYLPROPIONAMIDE, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT.
TNSN98156A1 (fr) Associations pharmaceutiques d'amlodipine et d'atorvastatine et procede pour leur preparation
TNSN01016A1 (fr) Procede pour la synthese asymetrique de pregabaline
MA26723A1 (fr) Acides oxamiques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN98017A1 (fr) Derives de sulfonyluree, procede pour leur preparation et compositions pharmaceutiques les contenant.
TNSN98155A1 (fr) Associations de compositions pharmaceutiques d'atorvastatine et d'agents antihypertensifs, et procede pour leur preparation
TNSN97078A1 (fr) Derives d'indole nouveaux, procede pour leur preparation et formulations pharmaceutiques les contenant
TNSN99156A1 (fr) Derives d'acide hydroxypipecolate-hydroxamique nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN98127A1 (fr) Derives d'azetidinylpropylpiperidine , procede pour leur preparation et compositions pharmaceutiques les contenant.
TNSN97087A1 (fr) 4(3h)-quinazolinones 2,3-disubstituees nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN99055A1 (fr) Derives bicycliques d'acide hydroxamique nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2780403B3 (fr) Nouvelle forme de l'irbesartan, procedes pour obtenir ladite forme et compositions pharmaceutiques en contenant
TNSN98035A1 (fr) Atropisomeres de 3-aryl-4(3h)-quinazolinones, procede pour leur preparation et compositions les contenant
TNSN98158A1 (fr) Associations pharmaceutiques d'amlodipine et d'une statine, et procede pour leur preparation
MA27676A1 (fr) 2-amino-6-(2-substitue-4-phenoxy)-substitue-pyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26608A1 (fr) Procede de preparation d'une composition pharmaceutique destinee au traitement de l'insuffisance cardiaque.
DE69325393D1 (de) Pharmazeutische zusammensetzungen und verfahren unter verwendung von isobutyramid zur behandlung von betaglobinerkrankungen
FR2600891B1 (fr) Produit pharmaceutique pour la stimulation de l'apprentissage et l'amelioration de la memoire contenant comme principe actif, le chlorhydrate de 9-amino-2,3, 5,6,7,8,-hexahydro-14-cyclopenta(b)quinoline monohydrate
ATE217191T1 (de) Verwendung von phanquinon zur behandlung von alzheimer's krankheit
MA24704A1 (fr) Formulations nouvelles de paroxetine et procede pour leur preparation
TNSN00034A1 (fr) Derives de 2-aminopyridine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant