TNSN07202A1 - Derives d'acide 7-(2h-pyrazole-3-yl)-3, 5-dihyroxy heptanoique servant d'inhibiteurs de hmg-co a reductase pour le traitement de la lipidemie - Google Patents

Derives d'acide 7-(2h-pyrazole-3-yl)-3, 5-dihyroxy heptanoique servant d'inhibiteurs de hmg-co a reductase pour le traitement de la lipidemie

Info

Publication number
TNSN07202A1
TNSN07202A1 TNP2007000202A TNSN07202A TNSN07202A1 TN SN07202 A1 TNSN07202 A1 TN SN07202A1 TN P2007000202 A TNP2007000202 A TN P2007000202A TN SN07202 A TNSN07202 A TN SN07202A TN SN07202 A1 TNSN07202 A1 TN SN07202A1
Authority
TN
Tunisia
Prior art keywords
cycloalkyl
specifically
heteroaryl
alkyl
aryl
Prior art date
Application number
TNP2007000202A
Other languages
English (en)
Inventor
Chulho Choi
Richard H Hutchings
Jeffrey A Pfefferkorn
Daniel Meritt Bowles
William Keun Chan Park
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35708411&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TNSN07202(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of TNSN07202A1 publication Critical patent/TNSN07202A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

La présente invention propose des composés de formules (I), (IV) et (V) et des intermédiaires de formules (VI) et (VII) : (I), (IV), (V), (VI), (VII), formules dans lesquelles : R1 représente un atome d'hydrogène, un atome d'halogène, un groupe alkyle en C1 à C7, cycloalkyle en C3 à C8, aryle, aralkyle, hétéroaryle ou hétéroaralkyle ; plus spécifiquement, R1 représente un groupe alkyle en C1 à C7 ou cycloalkyle en C3 à C8 ; encore plus spécifiquement, R1 représente un groupe isopropyle ; le groupe alkyle cycloalkyle, aryle aralkyle, hétéroaryle ou hétéroaralkyle de R1 étant facultativement substitué ; R2 représente un atome d'hydrogène, un atome d'halogène, un groupe alkyle en C1 à C7, cycloalkyle en C3 à C8, aryle aralkyle, hétéroaryle, hétéroaralkyle, NC-, R2bR2aNCO(CH2)n -, R2bR2aNS(O)n -, R2cS(O)n-, R2bR2aN(CH2)n -, R2b-J-C(O)NR2a(CH2)n -, R2b-J-SO2NR2a(CH2)n -, R2b-J-SONR2a(CH2)n, R7OOC(CH2)n – ou R7CO(CH2)n - ; plus spécifiquement, R2 représente un groupe R2bR2a NCO(CH2)n - ; encore plus spécifiquement, R2 représente un groupe R2bR2aNCO- ; le groupe alkyle, cycloalkyle, hétéroaryle ou hétéroaralkyle de R2 étant facultativement substitué ; R3 représente un atome d'hydrogène, un groupe alkyle en C1 à C6, cycloalkyle en C3 à C6, aryle, aralkyle, hétéroaryle ou hétéroaralkyle ; plus spécifiquement R3 représente un groupe aryle ; encore plus spécifiquement, R3 représente un groupe phényle ou p-fluorophényle ; le groupe alkyle, cycloalkyle, aryle aralkyle, hétéroaryle ou hétéroaralkyle de R3 étant facultativement substitué et représentant une liaison ou étant absent. Les autres substituants sont définis dans les revendications. La présente invention concerne des composés et compositions pharmaceutiques utiles comme agents hypocholestérolémiques et hypolipidémiques. Plus spécifiquement, la présente invention concerne certains puissants inhibiteurs de l'enzyme 3-hydroxy-3-méthylglutaryl-coenzyme-A-réductase (« HMG-CoA-réductase »). Les composés sont utiles pour le traitement de l'hyperlipidémie, l'hypercholestérolémie, de l'hypertriglycéridémie, de l'athérosclérose, de la maladie d'Alzheimer, de l'hypertrophie prostatique bénigne (BPH) du diabète et de l'ostéoporose.
TNP2007000202A 2004-11-23 2007-05-22 Derives d'acide 7-(2h-pyrazole-3-yl)-3, 5-dihyroxy heptanoique servant d'inhibiteurs de hmg-co a reductase pour le traitement de la lipidemie TNSN07202A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63048104P 2004-11-23 2004-11-23
PCT/IB2005/003461 WO2006056845A1 (fr) 2004-11-23 2005-11-14 Derives d'acide 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoique comme inhibiteurs de hmg co-a reductase pour le traitement de l'hyperlipidemie

Publications (1)

Publication Number Publication Date
TNSN07202A1 true TNSN07202A1 (fr) 2008-11-21

Family

ID=35708411

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2007000202A TNSN07202A1 (fr) 2004-11-23 2007-05-22 Derives d'acide 7-(2h-pyrazole-3-yl)-3, 5-dihyroxy heptanoique servant d'inhibiteurs de hmg-co a reductase pour le traitement de la lipidemie

Country Status (25)

Country Link
US (2) US7446121B2 (fr)
EP (1) EP1819681B1 (fr)
JP (1) JP2008520642A (fr)
KR (1) KR20070084455A (fr)
AP (1) AP2007003979A0 (fr)
AR (1) AR052244A1 (fr)
AT (1) ATE439347T1 (fr)
AU (1) AU2005308575A1 (fr)
BR (1) BRPI0518300A2 (fr)
CA (1) CA2590533C (fr)
CR (1) CR9102A (fr)
DE (1) DE602005016009D1 (fr)
EA (1) EA200700875A1 (fr)
ES (1) ES2328384T3 (fr)
GT (1) GT200500338A (fr)
IL (1) IL182569A0 (fr)
MA (1) MA30108B1 (fr)
MX (1) MX2007005137A (fr)
NL (1) NL1030487C2 (fr)
PA (1) PA8653401A1 (fr)
PE (1) PE20061057A1 (fr)
TN (1) TNSN07202A1 (fr)
TW (1) TW200626556A (fr)
UY (1) UY29220A1 (fr)
WO (1) WO2006056845A1 (fr)

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US20060111422A1 (en) 2006-05-25
NL1030487C2 (nl) 2007-01-08
NL1030487A1 (nl) 2006-05-24
US20090170852A1 (en) 2009-07-02
EA200700875A1 (ru) 2007-12-28
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CA2590533C (fr) 2010-09-07
UY29220A1 (es) 2006-06-30
ATE439347T1 (de) 2009-08-15
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AP2007003979A0 (en) 2007-06-30
IL182569A0 (en) 2007-07-24
DE602005016009D1 (de) 2009-09-24
BRPI0518300A2 (pt) 2008-11-11
MX2007005137A (es) 2007-06-22
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