PA8653401A1 - Nuevos inhibidores de hmg-co-a reductasa basados en pirazol - Google Patents
Nuevos inhibidores de hmg-co-a reductasa basados en pirazolInfo
- Publication number
- PA8653401A1 PA8653401A1 PA20058653401A PA8653401A PA8653401A1 PA 8653401 A1 PA8653401 A1 PA 8653401A1 PA 20058653401 A PA20058653401 A PA 20058653401A PA 8653401 A PA8653401 A PA 8653401A PA 8653401 A1 PA8653401 A1 PA 8653401A1
- Authority
- PA
- Panama
- Prior art keywords
- reductasa
- hmg
- pirazol
- disease
- compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
SE DESCRIBEN NUEVOS COMPUESTOS Y COMPOSICIONES FARMACEUTICAS UTILES COMO AGENTES HIPOCOLESTEROLEMICOS E HIPOLIPIDEMICOS. MAS ESPECIFICAMENTE, SE DESCRIBEN POTENTES INHIBIDORES DE LA ENZIMA 3-HIDROXI-3-METILGLUTARIL-COENZIMA A REDUCTASA ("HMG COA REDUCTASA"). SE DESCRIBEN TAMBIEN PROCEDIMIENTOS DE USO DE TALES COMPUESTOS Y COMPOSICIONES PARA TRATAR SUJETOS, INCLUYENDO SERES HUMANOS, QUE SUFREN HIPERLIPIDEMIA, HIPERCOLESTEROLEMIA, HIPERTRIGLICERIDEMIA, ATEROSCLEROSIS, ENFERMEDAD DE ALZHEIMER, HIPERTROFIA PROSTATICA BENIGNA (HPB), DIABETES Y OSTEOPOROSIS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63048104P | 2004-11-23 | 2004-11-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8653401A1 true PA8653401A1 (es) | 2006-09-08 |
Family
ID=35708411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20058653401A PA8653401A1 (es) | 2004-11-23 | 2005-11-23 | Nuevos inhibidores de hmg-co-a reductasa basados en pirazol |
Country Status (25)
Country | Link |
---|---|
US (2) | US7446121B2 (es) |
EP (1) | EP1819681B1 (es) |
JP (1) | JP2008520642A (es) |
KR (1) | KR20070084455A (es) |
AP (1) | AP2007003979A0 (es) |
AR (1) | AR052244A1 (es) |
AT (1) | ATE439347T1 (es) |
AU (1) | AU2005308575A1 (es) |
BR (1) | BRPI0518300A2 (es) |
CA (1) | CA2590533C (es) |
CR (1) | CR9102A (es) |
DE (1) | DE602005016009D1 (es) |
EA (1) | EA200700875A1 (es) |
ES (1) | ES2328384T3 (es) |
GT (1) | GT200500338A (es) |
IL (1) | IL182569A0 (es) |
MA (1) | MA30108B1 (es) |
MX (1) | MX2007005137A (es) |
NL (1) | NL1030487C2 (es) |
PA (1) | PA8653401A1 (es) |
PE (1) | PE20061057A1 (es) |
TN (1) | TNSN07202A1 (es) |
TW (1) | TW200626556A (es) |
UY (1) | UY29220A1 (es) |
WO (1) | WO2006056845A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20070084455A (ko) * | 2004-11-23 | 2007-08-24 | 워너-램버트 캄파니 엘엘씨 | 지질혈증 치료용 hmg co-a 환원효소 억제제로서의7-(2h-피라졸-3-일)-3,5-디히드록시-헵탄산 유도체 |
WO2006087630A2 (en) * | 2005-02-16 | 2006-08-24 | Warner-Lambert Company Llc | OXYPYRAZOLE HMG Co-A REDUCTASE INHIBITORS |
WO2007107843A1 (en) * | 2006-03-22 | 2007-09-27 | Pfizer Products Inc. | Methods of treatment with cetp inhibitors |
US7834050B2 (en) * | 2006-03-29 | 2010-11-16 | Duke University | Small molecule insulin mimetics absent quinones |
WO2008059372A2 (en) * | 2006-11-17 | 2008-05-22 | Pfizer Products Inc. | Crystal form of (3r,5r)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-metyl-benzylcarbamoyl)-2h-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid sodium salt |
CN103313977B (zh) * | 2010-10-21 | 2015-06-03 | 拜耳知识产权有限责任公司 | 1-(杂环羰基)哌啶 |
AR087701A1 (es) | 2011-08-31 | 2014-04-09 | Japan Tobacco Inc | Derivados de pirazol con actividad inhibidora de sglt1 |
CA3085086C (en) | 2011-12-06 | 2023-08-08 | Delta Faucet Company | Ozone distribution in a faucet |
US11458214B2 (en) | 2015-12-21 | 2022-10-04 | Delta Faucet Company | Fluid delivery system including a disinfectant device |
SG11202009179TA (en) * | 2018-04-04 | 2020-10-29 | Japan Tobacco Inc | Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof |
CN114425329B (zh) * | 2022-03-10 | 2024-04-19 | 西安凯立新材料股份有限公司 | 孕烯醇酮醋酸酯合成用催化剂及其制备方法和应用 |
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-
2005
- 2005-11-14 KR KR1020077011587A patent/KR20070084455A/ko not_active Application Discontinuation
- 2005-11-14 EP EP05801166A patent/EP1819681B1/en active Active
- 2005-11-14 MX MX2007005137A patent/MX2007005137A/es not_active Application Discontinuation
- 2005-11-14 ES ES05801166T patent/ES2328384T3/es active Active
- 2005-11-14 AT AT05801166T patent/ATE439347T1/de not_active IP Right Cessation
- 2005-11-14 BR BRPI0518300-6A patent/BRPI0518300A2/pt not_active Application Discontinuation
- 2005-11-14 AP AP2007003979A patent/AP2007003979A0/xx unknown
- 2005-11-14 WO PCT/IB2005/003461 patent/WO2006056845A1/en active Application Filing
- 2005-11-14 JP JP2007542152A patent/JP2008520642A/ja active Pending
- 2005-11-14 CA CA2590533A patent/CA2590533C/en not_active Expired - Fee Related
- 2005-11-14 DE DE602005016009T patent/DE602005016009D1/de active Active
- 2005-11-14 EA EA200700875A patent/EA200700875A1/ru unknown
- 2005-11-14 AU AU2005308575A patent/AU2005308575A1/en not_active Abandoned
- 2005-11-18 US US11/283,264 patent/US7446121B2/en not_active Expired - Fee Related
- 2005-11-21 PE PE2005001361A patent/PE20061057A1/es not_active Application Discontinuation
- 2005-11-21 UY UY29220A patent/UY29220A1/es not_active Application Discontinuation
- 2005-11-21 AR ARP050104871A patent/AR052244A1/es unknown
- 2005-11-22 GT GT200500338A patent/GT200500338A/es unknown
- 2005-11-22 TW TW094140920A patent/TW200626556A/zh unknown
- 2005-11-22 NL NL1030487A patent/NL1030487C2/nl not_active IP Right Cessation
- 2005-11-23 PA PA20058653401A patent/PA8653401A1/es unknown
-
2007
- 2007-04-16 IL IL182569A patent/IL182569A0/en unknown
- 2007-05-03 CR CR9102A patent/CR9102A/es not_active Application Discontinuation
- 2007-05-22 TN TNP2007000202A patent/TNSN07202A1/fr unknown
- 2007-05-23 MA MA29934A patent/MA30108B1/fr unknown
-
2008
- 2008-10-08 US US12/247,434 patent/US20090170852A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2008520642A (ja) | 2008-06-19 |
KR20070084455A (ko) | 2007-08-24 |
EP1819681A1 (en) | 2007-08-22 |
MX2007005137A (es) | 2007-06-22 |
MA30108B1 (fr) | 2009-01-02 |
ES2328384T3 (es) | 2009-11-12 |
US20060111422A1 (en) | 2006-05-25 |
TNSN07202A1 (fr) | 2008-11-21 |
GT200500338A (es) | 2006-06-22 |
TW200626556A (en) | 2006-08-01 |
EA200700875A1 (ru) | 2007-12-28 |
NL1030487C2 (nl) | 2007-01-08 |
US20090170852A1 (en) | 2009-07-02 |
IL182569A0 (en) | 2007-07-24 |
CA2590533A1 (en) | 2006-06-01 |
WO2006056845A1 (en) | 2006-06-01 |
NL1030487A1 (nl) | 2006-05-24 |
CR9102A (es) | 2007-05-30 |
ATE439347T1 (de) | 2009-08-15 |
DE602005016009D1 (de) | 2009-09-24 |
US7446121B2 (en) | 2008-11-04 |
BRPI0518300A2 (pt) | 2008-11-11 |
AR052244A1 (es) | 2007-03-07 |
CA2590533C (en) | 2010-09-07 |
UY29220A1 (es) | 2006-06-30 |
PE20061057A1 (es) | 2006-11-09 |
AP2007003979A0 (en) | 2007-06-30 |
EP1819681B1 (en) | 2009-08-12 |
AU2005308575A1 (en) | 2006-06-01 |
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