TN2013000471A1 - Cycloalkyl-fused tetrahydroquinolines as crth2 receptor modulators - Google Patents
Cycloalkyl-fused tetrahydroquinolines as crth2 receptor modulatorsInfo
- Publication number
- TN2013000471A1 TN2013000471A1 TNP2013000471A TN2013000471A TN2013000471A1 TN 2013000471 A1 TN2013000471 A1 TN 2013000471A1 TN P2013000471 A TNP2013000471 A TN P2013000471A TN 2013000471 A TN2013000471 A TN 2013000471A TN 2013000471 A1 TN2013000471 A1 TN 2013000471A1
- Authority
- TN
- Tunisia
- Prior art keywords
- cycloalkyl
- receptor modulators
- crth2 receptor
- tetrahydroquinolines
- fused
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161498345P | 2011-06-17 | 2011-06-17 | |
PCT/US2012/042336 WO2012174176A1 (fr) | 2011-06-17 | 2012-06-14 | Tétrahydroquinolines à fusion cycloalkyle en tant que modulateurs de l'activité du récepteur crth2 |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2013000471A1 true TN2013000471A1 (en) | 2015-03-30 |
Family
ID=47357455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2013000471A TN2013000471A1 (en) | 2011-06-17 | 2013-11-13 | Cycloalkyl-fused tetrahydroquinolines as crth2 receptor modulators |
Country Status (25)
Country | Link |
---|---|
US (2) | US8592383B2 (fr) |
EP (1) | EP2720545B1 (fr) |
JP (1) | JP5629403B2 (fr) |
KR (1) | KR101599157B1 (fr) |
CN (1) | CN103763924B (fr) |
AR (1) | AR086931A1 (fr) |
AU (1) | AU2012271661B8 (fr) |
BR (1) | BR112013032557A2 (fr) |
CA (1) | CA2838731C (fr) |
CL (1) | CL2013003625A1 (fr) |
CO (1) | CO6821958A2 (fr) |
CR (1) | CR20130670A (fr) |
DO (1) | DOP2013000306A (fr) |
EA (1) | EA025100B1 (fr) |
EC (1) | ECSP14013156A (fr) |
ES (1) | ES2613644T3 (fr) |
IL (1) | IL229508A0 (fr) |
MA (1) | MA35188B1 (fr) |
MX (1) | MX2013014900A (fr) |
NI (1) | NI201300133A (fr) |
PE (1) | PE20140788A1 (fr) |
TN (1) | TN2013000471A1 (fr) |
TW (1) | TW201302711A (fr) |
WO (1) | WO2012174176A1 (fr) |
ZA (1) | ZA201308942B (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5952829B2 (ja) | 2010-12-23 | 2016-07-13 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Crth2受容体調節剤としてのキノキサリン類およびアザ−キノキサリン類 |
US9290453B2 (en) | 2010-12-23 | 2016-03-22 | Merck Sharp & Dohme Corp. | Quinolines and aza-quinolines as CRTH2 receptor modulators |
EP2922539B1 (fr) | 2012-10-01 | 2020-01-15 | Merck Sharp & Dohme Corp. | Isoquinolines substituées utiles comme modulateurs du récepteur crth2 |
CN104761437B (zh) * | 2015-03-31 | 2018-06-19 | 上海康鹏化学有限公司 | 一种4-溴-2,6-二氟三氟甲氧基苯的制备方法 |
CN104829556B (zh) * | 2015-05-06 | 2018-01-23 | 南京信息工程大学 | 一种由固体光气和氨基硫脲反应制备2‑羟基‑5‑氨基‑1,3,4‑噻二唑的方法 |
EP3337803B1 (fr) | 2015-07-23 | 2022-08-17 | Merck Sharp & Dohme LLC | Marqueurs génétiques associés à la réponse aux antagonistes du récepteur crth2 |
JP7122499B2 (ja) * | 2016-06-03 | 2022-08-22 | 幸久 村田 | がん転移阻害剤 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU693143B2 (en) | 1993-12-06 | 1998-06-25 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
US5510332A (en) | 1994-07-07 | 1996-04-23 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor |
JPH10506608A (ja) | 1994-07-11 | 1998-06-30 | アセナ ニューロサイエンシーズ,インコーポレイテッド | 白血球接着のインヒビター |
US5811391A (en) | 1994-08-25 | 1998-09-22 | Cytel Corporation | Cyclic CS-1 peptidomimetics, compositions and methods of using same |
GB9524630D0 (en) | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
AU5259296A (en) | 1995-04-07 | 1996-10-23 | Warner-Lambert Company | Flavones and coumarins as agents for the treatment of athero sclerosis |
WO1996040781A1 (fr) | 1995-06-07 | 1996-12-19 | Tanabe Seiyaku Co., Ltd. | INHIBITEURS PEPTIDIQUES CYCLIQUES D'ADHERENCE CELLULAIRE INDUITE PAR INTEGRINE β1 ET β¿2? |
US6034057A (en) | 1995-07-06 | 2000-03-07 | Zeneca Limited | Peptide inhibitors of fibronectine |
US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
US5925527A (en) | 1997-02-04 | 1999-07-20 | Trega Biosciences, Inc. | Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries |
GT199900147A (es) | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
KR100731566B1 (ko) | 1999-10-14 | 2007-06-22 | 가켄 세야쿠 가부시키가이샤 | 테트라히드로퀴놀린 유도체 |
FR2825092B1 (fr) | 2001-05-23 | 2005-01-14 | Servier Lab | Nouveau derives trycicliques de dihydro-quinoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2827206B1 (fr) | 2001-07-10 | 2004-04-02 | Nature Bois Emballages | Procede et dispositif de formage de planchettes, et emballages comportant de telles planchettes |
US7534897B2 (en) * | 2002-05-16 | 2009-05-19 | Shionogi & Co., Ltd. | Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism |
PL376156A1 (en) | 2002-10-04 | 2005-12-27 | Millennium Pharmaceuticals, Inc. | Pgd2 receptor antagonists for the treatment of inflammatory diseases |
US7504508B2 (en) | 2002-10-04 | 2009-03-17 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
WO2004035541A1 (fr) | 2002-10-15 | 2004-04-29 | Janssen Pharmaceutica, N.V. | Derives (piperidine-4-yl)-aminobenzamido a substitution benzyl servant de modulateurs de recepteurs delta-opioides |
ES2263015T3 (es) | 2002-10-21 | 2006-12-01 | Warner-Lambert Company Llc | Derivados de tetrahidroquinolina como antagonistas de crth2. |
CA2528774A1 (fr) | 2003-06-20 | 2005-01-27 | Coley Pharmaceutical Gmbh | Antagonistes des recepteurs toll (tlr) pour petites molecules |
US20050038070A1 (en) | 2003-07-09 | 2005-02-17 | Amgen Inc. | Asthma and allergic inflammation modulators |
AR048528A1 (es) | 2004-04-07 | 2006-05-03 | Millennium Pharm Inc | Compuestos derivados de quinolina como antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias y composiciones farmacéuticas que los contienen. |
CA2594280C (fr) | 2004-12-27 | 2013-04-23 | Anja Fecher | Derives de 2,3,4,9-tetrahydro-1h-carbazole utilises en tant qu'antagonistes des recepteurs de crth2 |
UA90706C2 (ru) * | 2005-02-24 | 2010-05-25 | Милленниум Фармасьютикалз, Инк. | Антагонисты рецептора pgd2 для лечения воспалительных заболеваний |
EP1915372B1 (fr) | 2005-08-12 | 2013-11-20 | Merck Canada Inc. | Derives d'indole en tant qu'antagonistes du recepteur crth2 |
CA2737460C (fr) | 2008-09-22 | 2016-12-20 | Merck Frosst Canada Ltd. | Derives d'indole utilisables en tant qu'antagonistes du recepteur crth2 |
CA2737483A1 (fr) | 2008-09-22 | 2010-03-25 | Merck Frosst Canada Ltd. | Derives d'indole comme antagonistes du recepteur crth2 |
AU2009295231A1 (en) | 2008-09-22 | 2010-03-25 | Merck Canada Inc. | Azaindole derivatives as CRTH2 receptor antagonists |
UA105039C2 (uk) * | 2009-02-24 | 2014-04-10 | Мерк Шарп Енд Доме Корп. | Похідні індолу як антагоністи рецептора crth2 |
US8927559B2 (en) | 2010-10-11 | 2015-01-06 | Merck Sharp & Dohme Corp. | Quinazolinone-type compounds as CRTH2 antagonists |
JP5952829B2 (ja) | 2010-12-23 | 2016-07-13 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Crth2受容体調節剤としてのキノキサリン類およびアザ−キノキサリン類 |
US9290453B2 (en) | 2010-12-23 | 2016-03-22 | Merck Sharp & Dohme Corp. | Quinolines and aza-quinolines as CRTH2 receptor modulators |
-
2012
- 2012-06-14 MX MX2013014900A patent/MX2013014900A/es not_active Application Discontinuation
- 2012-06-14 AU AU2012271661A patent/AU2012271661B8/en not_active Ceased
- 2012-06-14 US US13/523,354 patent/US8592383B2/en active Active
- 2012-06-14 AR ARP120102111A patent/AR086931A1/es not_active Application Discontinuation
- 2012-06-14 BR BR112013032557-7A patent/BR112013032557A2/pt active Search and Examination
- 2012-06-14 WO PCT/US2012/042336 patent/WO2012174176A1/fr active Application Filing
- 2012-06-14 CA CA2838731A patent/CA2838731C/fr not_active Expired - Fee Related
- 2012-06-14 EP EP12799914.2A patent/EP2720545B1/fr active Active
- 2012-06-14 PE PE2013002820A patent/PE20140788A1/es not_active Application Discontinuation
- 2012-06-14 CN CN201280029736.0A patent/CN103763924B/zh not_active Expired - Fee Related
- 2012-06-14 JP JP2014515975A patent/JP5629403B2/ja not_active Expired - Fee Related
- 2012-06-14 US US14/126,579 patent/US20140128367A1/en not_active Abandoned
- 2012-06-14 ES ES12799914.2T patent/ES2613644T3/es active Active
- 2012-06-14 EA EA201490031A patent/EA025100B1/ru not_active IP Right Cessation
- 2012-06-14 KR KR1020147000987A patent/KR101599157B1/ko not_active IP Right Cessation
- 2012-06-15 TW TW101121657A patent/TW201302711A/zh unknown
-
2013
- 2013-11-13 TN TNP2013000471A patent/TN2013000471A1/fr unknown
- 2013-11-19 IL IL229508A patent/IL229508A0/en unknown
- 2013-11-27 ZA ZA2013/08942A patent/ZA201308942B/en unknown
- 2013-12-05 NI NI201300133A patent/NI201300133A/es unknown
- 2013-12-12 CO CO13291233A patent/CO6821958A2/es not_active Application Discontinuation
- 2013-12-17 CR CR20130670A patent/CR20130670A/es unknown
- 2013-12-17 CL CL2013003625A patent/CL2013003625A1/es unknown
- 2013-12-17 MA MA36577A patent/MA35188B1/fr unknown
- 2013-12-17 DO DO2013000306A patent/DOP2013000306A/es unknown
-
2014
- 2014-01-17 EC ECSP14013156 patent/ECSP14013156A/es unknown
Also Published As
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