TN2010000304A1 - New processes - Google Patents
New processesInfo
- Publication number
- TN2010000304A1 TN2010000304A1 TN2010000304A TN2010000304A TN2010000304A1 TN 2010000304 A1 TN2010000304 A1 TN 2010000304A1 TN 2010000304 A TN2010000304 A TN 2010000304A TN 2010000304 A TN2010000304 A TN 2010000304A TN 2010000304 A1 TN2010000304 A1 TN 2010000304A1
- Authority
- TN
- Tunisia
- Prior art keywords
- nep inhibitors
- new processes
- ester
- group
- carboxyl group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08150353 | 2008-01-17 | ||
PCT/EP2009/050510 WO2009090251A2 (fr) | 2008-01-17 | 2009-01-16 | Nouveaux procédés |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2010000304A1 true TN2010000304A1 (en) | 2011-11-11 |
Family
ID=40758693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TN2010000304A TN2010000304A1 (en) | 2008-01-17 | 2010-06-30 | New processes |
Country Status (29)
Country | Link |
---|---|
US (4) | US8580974B2 (fr) |
EP (1) | EP2245009B1 (fr) |
JP (2) | JP5739667B2 (fr) |
KR (1) | KR101587668B1 (fr) |
CN (2) | CN101952249B (fr) |
AR (1) | AR070176A1 (fr) |
AU (1) | AU2009204759B2 (fr) |
BR (1) | BRPI0906764A2 (fr) |
CA (1) | CA2711529C (fr) |
CL (1) | CL2009000089A1 (fr) |
CO (1) | CO6290677A2 (fr) |
EC (1) | ECSP10010405A (fr) |
ES (1) | ES2602564T3 (fr) |
GT (1) | GT201000211A (fr) |
HU (1) | HUE030606T2 (fr) |
IL (1) | IL206664A0 (fr) |
MA (1) | MA31951B1 (fr) |
MX (1) | MX2010007842A (fr) |
MY (1) | MY169425A (fr) |
NZ (2) | NZ600119A (fr) |
PE (1) | PE20091364A1 (fr) |
PL (1) | PL2245009T3 (fr) |
PT (1) | PT2245009T (fr) |
RU (2) | RU2513521C2 (fr) |
SG (1) | SG187491A1 (fr) |
SI (1) | SI2245009T1 (fr) |
TN (1) | TN2010000304A1 (fr) |
TW (1) | TWI422370B (fr) |
WO (1) | WO2009090251A2 (fr) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20091364A1 (es) * | 2008-01-17 | 2009-10-13 | Novartis Ag | Proceso para la preparacion de inhibidores de nep |
US8450496B2 (en) * | 2009-03-24 | 2013-05-28 | Hoffman-La Roche Inc. | Process for the preparation of propionic acid derivatives |
PT2435409E (pt) | 2009-05-28 | 2014-11-05 | Novartis Ag | Derivados aminopropiónicos substituídos como inibidores de neprilisina |
JP5466759B2 (ja) | 2009-05-28 | 2014-04-09 | ノバルティス アーゲー | ネプリライシン阻害剤としての置換アミノ酪酸誘導体 |
CA2772681C (fr) | 2009-09-23 | 2017-01-03 | Zhejiang Jiuzhou Pharmaceutical Co., Ltd. | Procede pour la fabrication de n-acylbphenylalanine |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
PL2526088T3 (pl) * | 2010-01-22 | 2016-01-29 | Novartis Ag | Produkty pośrednie inhibitorów obojętnej endopeptydazy oraz sposób ich wytwarzania |
AU2011295170B2 (en) * | 2010-08-23 | 2014-12-18 | Novartis Ag | Process for the preparation of intermediates for the manufacture of NEP inhibitors |
CN103080077B (zh) * | 2010-08-23 | 2015-06-10 | 诺华股份有限公司 | 用于制造nep抑制剂的中间体的制备工艺 |
ES2608780T3 (es) * | 2010-08-23 | 2017-04-17 | Novartis Ag | Nuevo proceso para la preparación de intermediarios útiles para la elaboración de inhibidores de NEP |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
PT2651896E (pt) | 2010-12-15 | 2015-11-03 | Theravance Biopharma R&D Ip Llc | Inibidores de neprilisina |
CA2819153A1 (fr) | 2010-12-15 | 2012-06-21 | Theravance, Inc. | Inhibiteurs de neprilysine |
EP2675792B1 (fr) | 2011-02-17 | 2016-01-06 | Theravance Biopharma R&D IP, LLC | Dérivés aminobutyriques substitués utilisés en tant qu'inhibiteurs de néprilysine |
EP2675795B1 (fr) | 2011-02-17 | 2016-04-20 | Theravance Biopharma R&D IP, LLC | Dérivés aminobutyriques substitués en tant qu'inhibiteurs de néprilysine |
CA2835216A1 (fr) | 2011-05-31 | 2012-12-06 | Theravance, Inc. | Inhibiteurs de neprilysine |
CA2835281A1 (fr) | 2011-05-31 | 2012-12-06 | Theravance, Inc. | Inhibiteurs de neprilysine |
CA2835220A1 (fr) | 2011-05-31 | 2012-12-06 | Theravance, Inc. | Inhibiteurs de neprilysine |
TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
ES2609810T3 (es) | 2012-05-31 | 2017-04-24 | Theravance Biopharma R&D Ip, Llc | Inhibidores de neprilisina donadores de óxido nítrico |
CN104470521B (zh) | 2012-06-08 | 2017-04-12 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
NZ702749A (en) | 2012-06-08 | 2017-01-27 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
CA2879697C (fr) | 2012-08-08 | 2020-07-07 | Theravance Biopharma R&D Ip, Llc | Inhibiteurs de neprilysine |
KR20150119107A (ko) | 2013-02-14 | 2015-10-23 | 노파르티스 아게 | 개선된 생체내 효능을 갖는 nep 억제제로서의 치환된 비스페닐 부탄산 유도체 |
EA028583B1 (ru) | 2013-02-14 | 2017-12-29 | Новартис Аг | Замещенные бис-фенилбутановые производные фосфоновой кислоты в качестве ингибиторов nep (нейтральная эндопептидаза) |
JP2016512195A (ja) | 2013-03-05 | 2016-04-25 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | ネプリライシン阻害剤 |
HUE063095T2 (hu) * | 2013-11-15 | 2023-12-28 | Hoffmann La Roche | Eljárások pirimidinilciklopentán vegyületek elõállítására |
CA2934936A1 (fr) | 2014-01-30 | 2015-08-06 | Theravance Biopharma R&D Ip, Llc | Inhibiteurs de la neprilysine |
SG11201606057PA (en) | 2014-01-30 | 2016-08-30 | Theravance Biopharma R&D Ip Llc | 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors |
WO2016074651A1 (fr) | 2014-11-14 | 2016-05-19 | Zentiva, K.S. | Procédé de préparation, d'isolation et de purification de formes pharmaceutiquement applicables de ahu-377 |
EP3489213B1 (fr) * | 2014-12-19 | 2021-04-28 | Basf Se | Composition destinée à l'utilisation dans un procédé de production de composés carbonyles optiquement actifs |
WO2016130650A1 (fr) | 2015-02-11 | 2016-08-18 | Theravance Biopharma R&D Ip, Llc | Acide (2s, 4r)-5-(5'-chloro-2'-fluorobiphényl-4-yl)-2-éthoxyoxalkylamino)-2-hydroxyméthyl-2-méthylpentanoïque à titre d'inhibiteur de néprilysine |
TW201632493A (zh) | 2015-02-13 | 2016-09-16 | 諾華公司 | 新穎方法 |
ES2857101T3 (es) | 2015-02-19 | 2021-09-28 | Theravance Biopharma R&D Ip Llc | Acido (2R,4R)-5-(5-cloro-2-fluorobifenil-4-il)-2-hidroxi-4-[(5-metiloxazol-2-carbonil)amino]pentanoico |
CN106146351B (zh) * | 2015-04-03 | 2020-09-11 | 博瑞生物医药(苏州)股份有限公司 | 制备联芳基取代的4-氨基-丁酸或其衍生物的方法 |
CN105061263B (zh) * | 2015-08-11 | 2017-03-15 | 苏州楚凯药业有限公司 | 一种nep抑制剂中间体的制备方法 |
CN105152980B (zh) * | 2015-09-11 | 2017-03-29 | 浙江永宁药业股份有限公司 | N‑叔丁氧羰基‑(4s)‑(对苯基苯基甲基)‑4‑氨基‑(2r)‑甲基丁酸的手性制备方法 |
WO2017051326A1 (fr) | 2015-09-23 | 2017-03-30 | Novartis Ag | Nouveaux procédés et intermédiaires utiles dans la synthèse d'inhibiteurs d'endopeptidase neutre (nep) |
EP3386955B1 (fr) | 2015-12-10 | 2020-08-05 | Novartis AG | Intermédiaires pour la production de sacubitril et leurs preparation |
EP3386945A1 (fr) | 2015-12-11 | 2018-10-17 | Zentiva, K.S. | Formes solides d'ester éthylique d'acide (2r,4s)-5-(biphényl-4-yl)-4-[(3-carboxypropionyl)amino]-2-méthylpentanoïque, ses sels et son procédé de préparation |
SI3408260T1 (sl) | 2016-03-08 | 2021-08-31 | Theravance Biopharma R&D Ip, Llc | Kristalinična (2S,4R)-5-(5'-kloro-2-fluoro-(1,1'-bifenil)-4-il)-2- (etoksimetil)-4-(3-hidroksiizoksazol-5-karboksamido)-2-metilpentanojska kislina in uporaba le-te |
JP6944473B2 (ja) | 2016-07-05 | 2021-10-06 | ノバルティス アーゲー | 初期サクビトリル中間体のための新規な方法 |
EP3500549B1 (fr) | 2016-08-17 | 2020-12-16 | Novartis AG | Nouveaux procédés et intermédiaires pour la synthèse d'inhibiteurs de nep |
EP3558930B1 (fr) | 2016-12-23 | 2021-05-26 | Novartis AG | Nouveau procédé pour des intermédiaires de sacubitril précoces |
EP3421455B1 (fr) * | 2017-06-29 | 2019-03-27 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Procédé amélioré pour la préparation de3-amino-piperidins chiraux, des intermédiaires utiles pour la préparation de tofacitinib |
CN109912508B (zh) * | 2019-04-30 | 2022-08-12 | 上海天慈国际药业有限公司 | 一种右美托咪定及其盐酸盐的制备方法 |
CN110878039A (zh) * | 2019-12-18 | 2020-03-13 | 株洲千金药业股份有限公司 | 一种沙库巴曲缬沙坦钠杂质的制备方法 |
CN115611857A (zh) * | 2022-09-09 | 2023-01-17 | 上海伍夫科技有限公司 | 一种2-甲基-5-(1-甲基吡咯烷-2-基)吡啶的制备方法 |
CN115772088A (zh) * | 2022-12-28 | 2023-03-10 | 海门瑞一医药科技有限公司 | 一种叔丁氧基(双二甲胺基)甲烷的制备方法 |
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EP1903027A1 (fr) | 2006-09-13 | 2008-03-26 | Novartis AG | Procédé de préparation de l' acide amino-4 butyrique ou de ses derivés et leur utilisation pour la préparation des inhibiteurs NEP |
EP2121578B1 (fr) * | 2007-01-12 | 2016-08-10 | Novartis AG | Procédé pour la préparation d'acide 5-biphenyle-4-amino-2-methyle-pentanoique |
ES2463693T3 (es) | 2007-05-10 | 2014-05-29 | R & D Biopharmaceuticals Gmbh | Derivados de tubulisina |
PE20091364A1 (es) * | 2008-01-17 | 2009-10-13 | Novartis Ag | Proceso para la preparacion de inhibidores de nep |
PL2526088T3 (pl) * | 2010-01-22 | 2016-01-29 | Novartis Ag | Produkty pośrednie inhibitorów obojętnej endopeptydazy oraz sposób ich wytwarzania |
AU2011295170B2 (en) * | 2010-08-23 | 2014-12-18 | Novartis Ag | Process for the preparation of intermediates for the manufacture of NEP inhibitors |
ES2608780T3 (es) * | 2010-08-23 | 2017-04-17 | Novartis Ag | Nuevo proceso para la preparación de intermediarios útiles para la elaboración de inhibidores de NEP |
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2009
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- 2009-01-16 PT PT97020218T patent/PT2245009T/pt unknown
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- 2009-01-16 HU HUE09702021A patent/HUE030606T2/en unknown
- 2009-01-16 KR KR1020107018152A patent/KR101587668B1/ko not_active IP Right Cessation
- 2009-01-16 PL PL09702021T patent/PL2245009T3/pl unknown
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- 2009-01-16 SG SG2013004098A patent/SG187491A1/en unknown
- 2009-01-16 CN CN2009801061724A patent/CN101952249B/zh active Active
- 2009-01-16 EP EP09702021.8A patent/EP2245009B1/fr active Active
- 2009-01-16 TW TW098101721A patent/TWI422370B/zh not_active IP Right Cessation
- 2009-01-16 MY MYPI2010003112A patent/MY169425A/en unknown
- 2009-01-16 SI SI200931552A patent/SI2245009T1/sl unknown
- 2009-01-16 US US12/863,213 patent/US8580974B2/en active Active
- 2009-01-16 ES ES09702021.8T patent/ES2602564T3/es active Active
- 2009-01-16 AU AU2009204759A patent/AU2009204759B2/en not_active Ceased
- 2009-01-16 RU RU2010133903/04A patent/RU2513521C2/ru not_active IP Right Cessation
- 2009-01-16 CA CA2711529A patent/CA2711529C/fr not_active Expired - Fee Related
- 2009-01-16 JP JP2010544498A patent/JP5739667B2/ja active Active
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- 2009-01-16 WO PCT/EP2009/050510 patent/WO2009090251A2/fr active Application Filing
- 2009-01-16 CN CN201310143383.3A patent/CN103483236B/zh active Active
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2010
- 2010-06-28 IL IL206664A patent/IL206664A0/en unknown
- 2010-06-30 TN TN2010000304A patent/TN2010000304A1/fr unknown
- 2010-06-30 MA MA32970A patent/MA31951B1/fr unknown
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2013
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- 2013-11-06 JP JP2013230570A patent/JP5800882B2/ja active Active
- 2013-11-11 US US14/076,302 patent/US9061973B2/en active Active
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2015
- 2015-05-18 US US14/715,129 patent/US9227934B2/en active Active
- 2015-11-12 US US14/939,513 patent/US9403766B2/en active Active
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