SU833166A3 - "Способ получени агликона антибиотческого а-35512 фактора в4 - Google Patents
"Способ получени агликона антибиотческого а-35512 фактора в4 Download PDFInfo
- Publication number
- SU833166A3 SU833166A3 SU782610502A SU2610502A SU833166A3 SU 833166 A3 SU833166 A3 SU 833166A3 SU 782610502 A SU782610502 A SU 782610502A SU 2610502 A SU2610502 A SU 2610502A SU 833166 A3 SU833166 A3 SU 833166A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- factor
- aglycone
- methanol
- water
- solution
- Prior art date
Links
- 108010025808 A35512 antibiotic complex Proteins 0.000 title claims abstract 10
- HGPIFQIEQCQPPE-UHFFFAOYSA-N antibiotic a 35512 Chemical compound C=1C2=CC=C(OC3C(C(O)C(O)C(CO)O3)O)C=1C1=C(O)C=C(O)C=C1C(C(=O)OC)NC(=O)C(C(C1=CC=C(C=C1)OC=1C=C3C=C(C=1OC1C(C(OC4C(C(O)C(O)C(C)O4)O)C(O)C(CO)O1)O)OC1=CC=C(C=C1)C1O)OC4OC(C)C(O)C(C)(N)C4)NC(=O)C2NC(=O)C3NC(=O)C(C(C=2Cl)=C3)NC(=O)C1NC(=O)C(N)C1=CC=CC(O)=C1OC3=CC=2OC1OC(C)C(O)C(O)C1O HGPIFQIEQCQPPE-UHFFFAOYSA-N 0.000 title claims abstract 10
- 238000000034 method Methods 0.000 title claims description 7
- 102000003712 Complement factor B Human genes 0.000 claims abstract description 38
- 108090000056 Complement factor B Proteins 0.000 claims abstract description 38
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 claims abstract description 24
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 claims abstract description 24
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims abstract description 17
- 230000003115 biocidal effect Effects 0.000 claims abstract description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 7
- 229940088710 antibiotic agent Drugs 0.000 claims abstract description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 45
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000007864 aqueous solution Substances 0.000 claims description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 6
- 238000010521 absorption reaction Methods 0.000 claims description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 6
- 238000004587 chromatography analysis Methods 0.000 claims description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- 238000000862 absorption spectrum Methods 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 239000002609 medium Substances 0.000 claims description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 239000012531 culture fluid Substances 0.000 claims description 3
- 238000000855 fermentation Methods 0.000 claims description 3
- 230000004151 fermentation Effects 0.000 claims description 3
- 239000001963 growth medium Substances 0.000 claims description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
- 239000011707 mineral Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000004448 titration Methods 0.000 claims description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 108010081391 Ristocetin Proteins 0.000 claims description 2
- 230000002378 acidificating effect Effects 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- BGTFCAQCKWKTRL-YDEUACAXSA-N chembl1095986 Chemical compound C1[C@@H](N)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]([C@H]1C(N[C@H](C2=CC(O)=CC(O[C@@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=C2C=2C(O)=CC=C(C=2)[C@@H](NC(=O)[C@@H]2NC(=O)[C@@H]3C=4C=C(C(=C(O)C=4)C)OC=4C(O)=CC=C(C=4)[C@@H](N)C(=O)N[C@@H](C(=O)N3)[C@H](O)C=3C=CC(O4)=CC=3)C(=O)N1)C(O)=O)=O)C(C=C1)=CC=C1OC1=C(O[C@@H]3[C@H]([C@H](O)[C@@H](O)[C@H](CO[C@@H]5[C@H]([C@@H](O)[C@H](O)[C@@H](C)O5)O)O3)O[C@@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@@H]3[C@H]([C@H](O)[C@@H](CO)O3)O)C4=CC2=C1 BGTFCAQCKWKTRL-YDEUACAXSA-N 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 208000002925 dental caries Diseases 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 230000007935 neutral effect Effects 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims 12
- 239000012458 free base Substances 0.000 claims 8
- 238000004809 thin layer chromatography Methods 0.000 claims 7
- 229920001817 Agar Polymers 0.000 claims 5
- 239000008272 agar Substances 0.000 claims 5
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 3
- 238000004458 analytical method Methods 0.000 claims 3
- 239000000706 filtrate Substances 0.000 claims 3
- 239000004375 Dextrin Substances 0.000 claims 2
- 229920001353 Dextrin Polymers 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
- 240000003183 Manihot esculenta Species 0.000 claims 2
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- RHGKLRLOHDJJDR-UHFFFAOYSA-N citrulline Chemical compound OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 2
- 235000019425 dextrin Nutrition 0.000 claims 2
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 claims 2
- 238000004816 paper chromatography Methods 0.000 claims 2
- 239000002244 precipitate Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 1
- 244000045195 Cicer arietinum Species 0.000 claims 1
- 235000010523 Cicer arietinum Nutrition 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 239000005909 Kieselgur Substances 0.000 claims 1
- 241000191938 Micrococcus luteus Species 0.000 claims 1
- 229920001007 Nylon 4 Polymers 0.000 claims 1
- 239000001888 Peptone Substances 0.000 claims 1
- 108010080698 Peptones Proteins 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 239000003463 adsorbent Substances 0.000 claims 1
- 150000001345 alkine derivatives Chemical class 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000000908 ammonium hydroxide Substances 0.000 claims 1
- 239000007900 aqueous suspension Substances 0.000 claims 1
- 230000000975 bioactive effect Effects 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- SAKUKAQFBMDKGX-UHFFFAOYSA-N butan-1-ol;2-pyridin-2-ylacetic acid;hydrate Chemical compound O.CCCCO.OC(=O)CC1=CC=CC=N1 SAKUKAQFBMDKGX-UHFFFAOYSA-N 0.000 claims 1
- 239000008367 deionised water Substances 0.000 claims 1
- 229910021641 deionized water Inorganic materials 0.000 claims 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 231100000676 disease causative agent Toxicity 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 230000032050 esterification Effects 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 229960002989 glutamic acid Drugs 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000002054 inoculum Substances 0.000 claims 1
- 239000003456 ion exchange resin Substances 0.000 claims 1
- 229920003303 ion-exchange polymer Polymers 0.000 claims 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims 1
- 239000008459 masheri Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 235000013372 meat Nutrition 0.000 claims 1
- 235000010755 mineral Nutrition 0.000 claims 1
- 239000011259 mixed solution Substances 0.000 claims 1
- 235000013379 molasses Nutrition 0.000 claims 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 claims 1
- 235000019319 peptone Nutrition 0.000 claims 1
- 239000003495 polar organic solvent Substances 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000012264 purified product Substances 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 238000005070 sampling Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000000741 silica gel Substances 0.000 claims 1
- 229910002027 silica gel Inorganic materials 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
- 235000017550 sodium carbonate Nutrition 0.000 claims 1
- 239000008223 sterile water Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 244000005700 microbiome Species 0.000 abstract description 4
- 241000958233 Streptomyces candidus Species 0.000 abstract description 2
- 150000001720 carbohydrates Chemical class 0.000 abstract description 2
- 235000014633 carbohydrates Nutrition 0.000 abstract description 2
- 150000003839 salts Chemical class 0.000 abstract description 2
- 102000016550 Complement Factor H Human genes 0.000 abstract 1
- 108010053085 Complement Factor H Proteins 0.000 abstract 1
- 241000282849 Ruminantia Species 0.000 abstract 1
- 238000010564 aerobic fermentation Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 244000144977 poultry Species 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical class NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 241000187747 Streptomyces Species 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- -1 methanol and ethanol Chemical class 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229950004257 ristocetin Drugs 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Fodder In General (AREA)
- Compounds Of Unknown Constitution (AREA)
- Feed For Specific Animals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68927476A | 1976-05-24 | 1976-05-24 | |
| US05/689,273 US4029769A (en) | 1976-05-24 | 1976-05-24 | Antibiotic A-35512B aglycone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU833166A3 true SU833166A3 (ru) | 1981-05-23 |
Family
ID=27104372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU782610502A SU833166A3 (ru) | 1976-05-24 | 1978-04-27 | "Способ получени агликона антибиотческого а-35512 фактора в4 |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS532401A (enExample) |
| AR (1) | AR212651A1 (enExample) |
| AT (1) | AT350717B (enExample) |
| AU (1) | AU513827B2 (enExample) |
| BG (1) | BG28271A3 (enExample) |
| CH (1) | CH637159A5 (enExample) |
| CS (1) | CS207457B2 (enExample) |
| DD (1) | DD132503A5 (enExample) |
| DE (1) | DE2722645A1 (enExample) |
| DK (1) | DK225877A (enExample) |
| FR (1) | FR2352828A1 (enExample) |
| GR (1) | GR66427B (enExample) |
| HK (1) | HK27181A (enExample) |
| HU (1) | HU179013B (enExample) |
| IE (1) | IE45501B1 (enExample) |
| KE (1) | KE3132A (enExample) |
| MX (1) | MX4232E (enExample) |
| MY (1) | MY8200039A (enExample) |
| NL (1) | NL7705664A (enExample) |
| NZ (1) | NZ184142A (enExample) |
| PL (3) | PL128225B1 (enExample) |
| PT (1) | PT66567B (enExample) |
| SE (1) | SE7705855L (enExample) |
| SU (1) | SU833166A3 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5129884U (enExample) * | 1974-08-28 | 1976-03-04 | ||
| GR75473B (enExample) * | 1981-04-20 | 1984-07-23 | Lilly Co Eli | |
| GB2137087B (en) * | 1983-03-18 | 1987-02-18 | American Cyanamid Co | Improving milk production |
| GB8608798D0 (en) * | 1986-04-11 | 1986-05-14 | Lepetit Spa | Recovery of glycopeptide antibiotics from aqueous solutions |
| RU2771176C1 (ru) * | 2021-08-31 | 2022-04-28 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр "Красноярский научный центр Сибирского отделения Российской академии наук" | Способ приготовления биологически активной кормовой добавки для коров |
-
1977
- 1977-05-12 AU AU25110/77A patent/AU513827B2/en not_active Expired
- 1977-05-17 SE SE7705855A patent/SE7705855L/xx not_active Application Discontinuation
- 1977-05-18 FR FR7715272A patent/FR2352828A1/fr active Granted
- 1977-05-18 NZ NZ184142A patent/NZ184142A/xx unknown
- 1977-05-18 PT PT66567A patent/PT66567B/pt unknown
- 1977-05-18 DE DE19772722645 patent/DE2722645A1/de not_active Withdrawn
- 1977-05-18 GR GR53497A patent/GR66427B/el unknown
- 1977-05-20 IE IE1033/77A patent/IE45501B1/en unknown
- 1977-05-20 CH CH627277A patent/CH637159A5/de not_active IP Right Cessation
- 1977-05-20 HU HU77EI742A patent/HU179013B/hu unknown
- 1977-05-20 AR AR267724A patent/AR212651A1/es active
- 1977-05-23 CS CS773396A patent/CS207457B2/cs unknown
- 1977-05-23 DK DK225877A patent/DK225877A/da not_active Application Discontinuation
- 1977-05-23 BG BG036390A patent/BG28271A3/xx unknown
- 1977-05-23 PL PL1977216678A patent/PL128225B1/pl unknown
- 1977-05-23 NL NL7705664A patent/NL7705664A/xx not_active Application Discontinuation
- 1977-05-23 PL PL19384277A patent/PL193842A1/xx unknown
- 1977-05-23 AT AT366877A patent/AT350717B/de not_active IP Right Cessation
- 1977-05-23 JP JP5971177A patent/JPS532401A/ja active Pending
- 1977-05-23 DD DD7700199066A patent/DD132503A5/xx unknown
- 1977-05-23 PL PL1977198342A patent/PL108561B1/pl unknown
- 1977-05-30 MX MX775752U patent/MX4232E/es unknown
-
1978
- 1978-04-27 SU SU782610502A patent/SU833166A3/ru active
-
1981
- 1981-06-02 KE KE3132A patent/KE3132A/xx unknown
- 1981-06-18 HK HK271/81A patent/HK27181A/xx unknown
-
1982
- 1982-12-30 MY MY39/82A patent/MY8200039A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT66567B (en) | 1978-10-18 |
| DD132503A5 (de) | 1978-10-04 |
| AR212651A1 (es) | 1978-08-31 |
| PL108561B1 (en) | 1980-04-30 |
| CS207457B2 (en) | 1981-07-31 |
| AU2511077A (en) | 1978-11-16 |
| AT350717B (de) | 1979-06-11 |
| NL7705664A (nl) | 1977-11-28 |
| DK225877A (da) | 1977-11-25 |
| NZ184142A (en) | 1979-11-01 |
| IE45501L (en) | 1977-11-24 |
| SE7705855L (sv) | 1977-11-25 |
| IE45501B1 (en) | 1982-09-08 |
| FR2352828A1 (fr) | 1977-12-23 |
| AU513827B2 (en) | 1981-01-08 |
| KE3132A (en) | 1981-06-19 |
| HU179013B (en) | 1982-08-28 |
| PL128225B1 (en) | 1984-01-31 |
| GR66427B (enExample) | 1981-03-20 |
| CH637159A5 (en) | 1983-07-15 |
| MY8200039A (en) | 1982-12-31 |
| BG28271A3 (en) | 1980-03-25 |
| DE2722645A1 (de) | 1977-12-08 |
| HK27181A (en) | 1981-06-26 |
| PL193842A1 (pl) | 1978-02-27 |
| ATA366877A (de) | 1978-11-15 |
| PT66567A (en) | 1977-06-01 |
| MX4232E (es) | 1982-02-19 |
| JPS532401A (en) | 1978-01-11 |
| FR2352828B1 (enExample) | 1982-10-15 |
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