SU638260A3 - Способ получени 6-хлор-2-(1"пиперазинил) пиразина - Google Patents

Способ получени 6-хлор-2-(1"пиперазинил) пиразина

Info

Publication number
SU638260A3
SU638260A3 SU762346054A SU2346054A SU638260A3 SU 638260 A3 SU638260 A3 SU 638260A3 SU 762346054 A SU762346054 A SU 762346054A SU 2346054 A SU2346054 A SU 2346054A SU 638260 A3 SU638260 A3 SU 638260A3
Authority
SU
USSR - Soviet Union
Prior art keywords
chlor
pyrazine
piperazinyl
obtaining
temperature
Prior art date
Application number
SU762346054A
Other languages
English (en)
Russian (ru)
Inventor
Спенсер Саари Уолфред
Карл Ламма Уильям (Младший)
Original Assignee
Мерк Энд Ко Инк (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко Инк (Фирма) filed Critical Мерк Энд Ко Инк (Фирма)
Application granted granted Critical
Publication of SU638260A3 publication Critical patent/SU638260A3/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SU762346054A 1975-04-21 1976-04-20 Способ получени 6-хлор-2-(1"пиперазинил) пиразина SU638260A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57005275A 1975-04-21 1975-04-21

Publications (1)

Publication Number Publication Date
SU638260A3 true SU638260A3 (ru) 1978-12-15

Family

ID=24277994

Family Applications (1)

Application Number Title Priority Date Filing Date
SU762346054A SU638260A3 (ru) 1975-04-21 1976-04-20 Способ получени 6-хлор-2-(1"пиперазинил) пиразина

Country Status (36)

Country Link
JP (1) JPS51136688A (es)
AR (1) AR210349A1 (es)
AT (1) AT353795B (es)
AU (1) AU496854B2 (es)
BE (1) BE840904A (es)
BG (1) BG34185A3 (es)
CA (1) CA1059128A (es)
CH (1) CH619462A5 (es)
CS (1) CS195726B2 (es)
CY (1) CY1090A (es)
DD (1) DD124599A5 (es)
DE (1) DE2617205C3 (es)
DK (1) DK143899C (es)
EG (1) EG12387A (es)
ES (4) ES447150A1 (es)
FI (1) FI62666C (es)
FR (1) FR2308367A1 (es)
GB (1) GB1492528A (es)
GR (1) GR59900B (es)
HK (1) HK60380A (es)
HU (1) HU172684B (es)
IE (1) IE42979B1 (es)
IL (1) IL49391A (es)
KE (1) KE3088A (es)
LU (1) LU74795A1 (es)
MY (1) MY8100225A (es)
NL (1) NL167692C (es)
NO (1) NO146599C (es)
PH (1) PH12274A (es)
PL (1) PL99664B1 (es)
PT (1) PT65027B (es)
RO (1) RO73278A (es)
SE (1) SE421695B (es)
SU (1) SU638260A3 (es)
YU (1) YU100676A (es)
ZA (1) ZA762320B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en) 1978-03-17 1979-08-07 Merck & Co., Inc. Piperazinylpyrazines
US4252816A (en) * 1979-12-03 1981-02-24 Merck & Co., Inc. Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en) 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) * 1982-05-06 1985-04-03 American Cyanamid Company Antiatherosclerotic 1-piperazine derivatives
US4547505A (en) * 1983-03-25 1985-10-15 Degussa Aktiengesellschaft N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
EP0580465A1 (fr) * 1992-06-25 1994-01-26 Sanofi Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
DE69842058D1 (de) * 1997-10-27 2011-01-27 Neurosearch As Heteroaryl Diazacycloalkane als cholinergische Ligande für Nikotin-Acetylcholin-Rezeptoren
JP2002543070A (ja) 1999-04-26 2002-12-17 ニューロサーチ、アクティーゼルスカブ ヘテロアリールジアザシクロアルカン類、その製造方法及びその使用方法
KR20030031886A (ko) * 2000-02-16 2003-04-23 뉴로젠 코포레이션 치환된 아릴피라진
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
SE0202287D0 (sv) * 2002-07-19 2002-07-19 Biovitrum Ab New compounds
DK1534391T3 (da) 2002-07-19 2007-06-11 Biovitrum Ab Nye piperazinyl-pyrazinonderivater til behandling af 5-HT2A-recptor-relaterede forstyrrelser

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2606906A (en) * 1948-10-14 1952-08-12 American Cyanamid Co 1-(2-pyridyl) piperazine and process of preparing same

Also Published As

Publication number Publication date
CH619462A5 (en) 1980-09-30
IL49391A0 (en) 1976-06-30
DE2617205A1 (de) 1976-10-28
AT353795B (de) 1979-12-10
IL49391A (en) 1979-09-30
LU74795A1 (es) 1977-02-07
BE840904A (fr) 1976-08-16
BG34185A3 (en) 1983-07-15
CY1090A (en) 1980-12-27
AU1296676A (en) 1977-10-20
SE7604093L (sv) 1976-10-22
FI62666C (fi) 1983-02-10
NL167692B (nl) 1981-08-17
SE421695B (sv) 1982-01-25
NO146599C (no) 1982-11-03
PT65027A (en) 1976-05-01
MY8100225A (en) 1981-12-31
DE2617205C3 (de) 1981-01-29
ES447150A1 (es) 1977-09-16
FI62666B (fi) 1982-10-29
DK164476A (da) 1976-10-22
PL99664B1 (pl) 1978-07-31
JPS5522475B2 (es) 1980-06-17
EG12387A (en) 1978-12-31
AR210349A1 (es) 1977-07-29
FR2308367B1 (es) 1979-09-21
DK143899C (da) 1982-04-13
NL7603800A (nl) 1976-10-25
RO73278A (ro) 1982-09-09
IE42979L (en) 1976-10-21
NO146599B (no) 1982-07-26
ES459405A1 (es) 1978-08-16
JPS51136688A (en) 1976-11-26
FR2308367A1 (fr) 1976-11-19
PH12274A (en) 1978-12-12
IE42979B1 (en) 1980-11-19
ES459406A1 (es) 1978-08-16
KE3088A (en) 1980-11-07
GB1492528A (en) 1977-11-23
NL167692C (nl) 1982-01-18
CA1059128A (en) 1979-07-24
ES459407A1 (es) 1978-08-16
DE2617205B2 (de) 1980-05-08
ATA288376A (de) 1979-05-15
NO761207L (es) 1976-10-22
PT65027B (en) 1978-04-03
YU100676A (en) 1982-08-31
HU172684B (hu) 1978-11-28
GR59900B (en) 1978-03-16
AU496854B2 (en) 1978-11-02
FI760978A (es) 1976-10-22
HK60380A (en) 1980-11-07
DK143899B (da) 1981-10-26
ZA762320B (en) 1977-11-30
CS195726B2 (en) 1980-02-29
DD124599A5 (es) 1977-03-02

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