SU493067A3 - Способ получени фенилимидазолидинонов - Google Patents
Способ получени фенилимидазолидиноновInfo
- Publication number
- SU493067A3 SU493067A3 SU1970169A SU1970169A SU493067A3 SU 493067 A3 SU493067 A3 SU 493067A3 SU 1970169 A SU1970169 A SU 1970169A SU 1970169 A SU1970169 A SU 1970169A SU 493067 A3 SU493067 A3 SU 493067A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- group
- alkyl
- obtaining
- radical
- phenylimidazolidinone
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 7
- QKKGTRSHKSWYAK-UHFFFAOYSA-N 1-phenylimidazolidin-2-one Chemical compound O=C1NCCN1C1=CC=CC=C1 QKKGTRSHKSWYAK-UHFFFAOYSA-N 0.000 title description 3
- 125000000217 alkyl group Chemical group 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 125000003545 alkoxy group Chemical group 0.000 description 7
- 125000005843 halogen group Chemical group 0.000 description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 7
- 125000003118 aryl group Chemical group 0.000 description 6
- 238000000354 decomposition reaction Methods 0.000 description 6
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 6
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 5
- -1 1-phenethyl-4- (2 methylphenyl) -piperazine Chemical compound 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- WICKLEOONJPMEQ-UHFFFAOYSA-N 1-(2-methylphenyl)piperazine Chemical compound CC1=CC=CC=C1N1CCNCC1 WICKLEOONJPMEQ-UHFFFAOYSA-N 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 125000004663 dialkyl amino group Chemical group 0.000 description 2
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000005429 oxyalkyl group Chemical group 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 235000009518 sodium iodide Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 2
- 125000003006 2-dimethylaminoethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 102000001839 Neurturin Human genes 0.000 description 1
- 108010015406 Neurturin Proteins 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 description 1
- YAMHXTCMCPHKLN-UHFFFAOYSA-N imidazolidin-2-one Chemical compound O=C1NCCN1 YAMHXTCMCPHKLN-UHFFFAOYSA-N 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT492071A AT311956B (de) | 1971-06-07 | 1971-06-07 | Verfahren zur Herstellung neuer Phenylimidazolidinonderivate und ihrer Salze |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU493067A3 true SU493067A3 (ru) | 1975-11-25 |
Family
ID=3569889
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1970169A SU493067A3 (ru) | 1971-06-07 | 1972-05-31 | Способ получени фенилимидазолидинонов |
| SU1791532A SU453839A3 (ru) | 1971-06-07 | 1972-05-31 | Способ получения фенилимидазолидинонов |
| SU1970168A SU503516A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
| SU1970167A SU505358A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
| SU1970164A SU499806A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
| SU1970171A SU492085A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени фенилимидазолидинонов |
| SU1970242A SU509228A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производныхпиперазина |
| SU1970170A SU498907A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени фенилимидазолидинонов |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1791532A SU453839A3 (ru) | 1971-06-07 | 1972-05-31 | Способ получения фенилимидазолидинонов |
| SU1970168A SU503516A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
| SU1970167A SU505358A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
| SU1970164A SU499806A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производных пиперазина |
| SU1970171A SU492085A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени фенилимидазолидинонов |
| SU1970242A SU509228A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени производныхпиперазина |
| SU1970170A SU498907A3 (ru) | 1971-06-07 | 1973-11-14 | Способ получени фенилимидазолидинонов |
Country Status (20)
| Country | Link |
|---|---|
| AR (7) | AR200112A1 (enExample) |
| AT (1) | AT311956B (enExample) |
| AU (1) | AU473287B2 (enExample) |
| BE (1) | BE784475A (enExample) |
| BG (1) | BG22822A3 (enExample) |
| CA (1) | CA1011336A (enExample) |
| CH (7) | CH573425A5 (enExample) |
| DD (1) | DD101403A5 (enExample) |
| DE (1) | DE2223751A1 (enExample) |
| ES (1) | ES403542A1 (enExample) |
| FR (1) | FR2140492B1 (enExample) |
| GB (1) | GB1391491A (enExample) |
| HU (1) | HU165493B (enExample) |
| IE (1) | IE37812B1 (enExample) |
| IL (1) | IL39620A (enExample) |
| NL (1) | NL7207701A (enExample) |
| NO (1) | NO136841C (enExample) |
| SE (1) | SE392902B (enExample) |
| SU (8) | SU493067A3 (enExample) |
| ZA (1) | ZA723840B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2497810C1 (ru) * | 2012-06-28 | 2013-11-10 | Общество с ограниченной ответственностью "Объединенный центр исследований и разработок" | Способ получения n,n-диарилзамещенных 2-трихлорометилимидазолидинов |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW279864B (enExample) * | 1993-02-19 | 1996-07-01 | Janssen Pharmaceutica Nv | |
| US5607932A (en) * | 1994-07-12 | 1997-03-04 | Janssen Pharmaceutica N.V. | Heterocyclic derivatives of azolones |
| DE19822678A1 (de) * | 1998-05-20 | 1999-11-25 | Bayer Ag | Substituierte 1,3-Diaza-2-(thi)oxo-cycloalkane |
| CA2568609A1 (en) * | 2003-05-28 | 2004-12-09 | Imotep Inc. | Haloethyl urea compounds and their use to attenuate, inhibit or prevent non-cancerous pathogenic cellular proliferation and diseases associated therewith |
| CA2568607A1 (en) * | 2003-05-28 | 2004-12-09 | Imotep Inc. | Haloethyl urea compounds and the use thereof to attenuate, inhibit or prevent cancer cell migration |
-
1971
- 1971-06-07 AT AT492071A patent/AT311956B/de not_active IP Right Cessation
-
1972
- 1972-05-16 DE DE19722223751 patent/DE2223751A1/de active Pending
- 1972-05-31 SU SU1970169A patent/SU493067A3/ru active
- 1972-05-31 SU SU1791532A patent/SU453839A3/ru active
- 1972-06-05 BG BG020655A patent/BG22822A3/xx unknown
- 1972-06-05 CA CA143,854A patent/CA1011336A/en not_active Expired
- 1972-06-06 CH CH840072A patent/CH573425A5/xx not_active IP Right Cessation
- 1972-06-06 FR FR7220319A patent/FR2140492B1/fr not_active Expired
- 1972-06-06 AU AU43129/72A patent/AU473287B2/en not_active Expired
- 1972-06-06 HU HUBO1379A patent/HU165493B/hu unknown
- 1972-06-06 IL IL39620A patent/IL39620A/en unknown
- 1972-06-06 CH CH1507375A patent/CH590269A5/xx not_active IP Right Cessation
- 1972-06-06 CH CH1507475A patent/CH589644A5/xx not_active IP Right Cessation
- 1972-06-06 CH CH1507175A patent/CH583729A5/xx not_active IP Right Cessation
- 1972-06-06 BE BE784475A patent/BE784475A/xx unknown
- 1972-06-06 ES ES403542A patent/ES403542A1/es not_active Expired
- 1972-06-06 NO NO2007/72A patent/NO136841C/no unknown
- 1972-06-06 CH CH1507275A patent/CH591475A5/xx not_active IP Right Cessation
- 1972-06-06 CH CH1507575A patent/CH589645A5/xx not_active IP Right Cessation
- 1972-06-06 ZA ZA723840A patent/ZA723840B/xx unknown
- 1972-06-06 CH CH1507675A patent/CH589646A5/xx not_active IP Right Cessation
- 1972-06-06 SE SE7207420A patent/SE392902B/xx unknown
- 1972-06-06 DD DD163478A patent/DD101403A5/xx unknown
- 1972-06-07 AR AR242433A patent/AR200112A1/es active
- 1972-06-07 IE IE791/72A patent/IE37812B1/xx unknown
- 1972-06-07 GB GB2662372A patent/GB1391491A/en not_active Expired
- 1972-06-07 NL NL7207701A patent/NL7207701A/xx unknown
-
1973
- 1973-01-01 AR AR249754A patent/AR207109A1/es active
- 1973-01-01 AR AR249758A patent/AR205522A1/es active
- 1973-08-24 AR AR249757A patent/AR200139A1/es active
- 1973-08-24 AR AR249755A patent/AR202904A1/es active
- 1973-08-24 AR AR249753A patent/AR203017A1/es active
- 1973-08-24 AR AR249752A patent/AR202903A1/es active
- 1973-11-14 SU SU1970168A patent/SU503516A3/ru active
- 1973-11-14 SU SU1970167A patent/SU505358A3/ru active
- 1973-11-14 SU SU1970164A patent/SU499806A3/ru active
- 1973-11-14 SU SU1970171A patent/SU492085A3/ru active
- 1973-11-14 SU SU1970242A patent/SU509228A3/ru active
- 1973-11-14 SU SU1970170A patent/SU498907A3/ru active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2497810C1 (ru) * | 2012-06-28 | 2013-11-10 | Общество с ограниченной ответственностью "Объединенный центр исследований и разработок" | Способ получения n,n-диарилзамещенных 2-трихлорометилимидазолидинов |
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