SU1614765A3 - Способ получени рекомбинантной плазмидной ДНК pHTN 713, кодирующей фактор некроза опухоли человека - Google Patents

Способ получени рекомбинантной плазмидной ДНК pHTN 713, кодирующей фактор некроза опухоли человека Download PDF

Info

Publication number
SU1614765A3
SU1614765A3 SU853869300A SU3869300A SU1614765A3 SU 1614765 A3 SU1614765 A3 SU 1614765A3 SU 853869300 A SU853869300 A SU 853869300A SU 3869300 A SU3869300 A SU 3869300A SU 1614765 A3 SU1614765 A3 SU 1614765A3
Authority
SU
USSR - Soviet Union
Prior art keywords
dna
plasmid
tnf
human
polypeptide
Prior art date
Application number
SU853869300A
Other languages
English (en)
Russian (ru)
Inventor
Ямада Масааки
Фурутани Ясуджи
Нотаке Мицие
Ямагиси Юнити
Original Assignee
Дайниппон Фармасьютикал Ко., Лтд (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дайниппон Фармасьютикал Ко., Лтд (Фирма) filed Critical Дайниппон Фармасьютикал Ко., Лтд (Фирма)
Application granted granted Critical
Publication of SU1614765A3 publication Critical patent/SU1614765A3/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/525Tumour necrosis factor [TNF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SU853869300A 1984-03-06 1985-03-05 Способ получени рекомбинантной плазмидной ДНК pHTN 713, кодирующей фактор некроза опухоли человека SU1614765A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59043617A JPS60185799A (ja) 1984-03-06 1984-03-06 ヒト癌壊死因子

Publications (1)

Publication Number Publication Date
SU1614765A3 true SU1614765A3 (ru) 1990-12-15

Family

ID=12668798

Family Applications (1)

Application Number Title Priority Date Filing Date
SU853869300A SU1614765A3 (ru) 1984-03-06 1985-03-05 Способ получени рекомбинантной плазмидной ДНК pHTN 713, кодирующей фактор некроза опухоли человека

Country Status (2)

Country Link
JP (1) JPS60185799A (enrdf_load_stackoverflow)
SU (1) SU1614765A3 (enrdf_load_stackoverflow)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
GR851626B (enrdf_load_stackoverflow) * 1984-07-05 1985-11-26 Genentech Inc
JP2675294B2 (ja) * 1984-10-15 1997-11-12 カイロン コーポレイション ヒト腫瘍壊死因子
JP2557053B2 (ja) * 1984-12-21 1996-11-27 バイオジェン インコーポレイテッド 腫瘍壊死因子の精製、製造および使用法
EP0437610B1 (en) * 1988-09-22 1996-06-12 Teijin Limited Novel physiologically active polypeptide, recombinant plasmid, recombinant microbial cells, medicinal composition, and process for recovering purified polypeptide
JPH0242986A (ja) * 1989-06-28 1990-02-13 Asahi Chem Ind Co Ltd 新規なヒト生理活性ポリペプチドをコードするdna
JPH07101993A (ja) * 1993-10-01 1995-04-18 Akira Kaji 新規抗腫瘍性ペプチド
JP6173915B2 (ja) * 2010-11-25 2017-08-02 イムナテ・ソシエテ・ア・レスポンサビリテ・リミテImnate Sarl 感染症、自己免疫疾患、同種因子に対する免疫応答、アレルギー性疾患、腫瘍、移植片拒絶反応、および、遺伝子療法または遺伝子ワクチン接種のために使用されるウイルスベクターに対する免疫応答の予防および/または治療における使用のための免疫原性ペプチド

Also Published As

Publication number Publication date
JPH0157955B2 (enrdf_load_stackoverflow) 1989-12-08
JPS60185799A (ja) 1985-09-21

Similar Documents

Publication Publication Date Title
EP0155549B1 (en) Dna encoding human tumor necrosis factor and human tumor necrosis factor polypeptide
US5288852A (en) Human tumor necrosis factor polypeptides
JP2740417B2 (ja) ヒト神経成長因子の遺伝子組換えによる調製法
JP2766621B2 (ja) 組み換えg−csf
TW458984B (en) Novel mutant hIL-4 proteins as antagonists or partial agonists of human interleukin 4
SU1762761A3 (ru) Способ получени полипептида со свойствами фактора некроза опухоли
JPS63251095A (ja) 新規融合蛋白質およびその精製方法
JPH01501283A (ja) 新規な型のコロニー刺激因子―1
JPH07501447A (ja) Mgfおよびil−3を含む融合タンパク質
JPH06505631A (ja) 巨核球刺激因子
EP0146026B1 (en) Dna encoding rabbit tnf, vector having said dna inserted thereinto, host transformed with said vector, rabbit tnf polypeptide, and process for production thereof
SU1614765A3 (ru) Способ получени рекомбинантной плазмидной ДНК pHTN 713, кодирующей фактор некроза опухоли человека
US5496713A (en) Process for producing 20 kD human growth hormone
AU607930B2 (en) Homogeneous recombinant immune interferon fragments
US4828988A (en) Hybrid polypeptides comprising somatocrinine and alpha1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine
CN104725485B (zh) 一种重组活性肽及其同步制备方法
JP2862870B2 (ja) 新規ペプチド
SU1607690A3 (ru) Способ стабилизации рекомбинантного фактора некроза опухоли
JP2675294B2 (ja) ヒト腫瘍壊死因子
JPH03297388A (ja) 新規なtnf変異体、その製造法及びそれを有効成分とする抗腫瘍剤
US6018037A (en) DNA coding for (Leu13) motilin
US5695952A (en) Method for producing Leu13 !motilin
SU1739855A3 (ru) Способ получени полипептида, обладающего активностью фактора некроза опухоли человека
US5359036A (en) Growth hormone-like glycoproteins
RU1825376C (ru) Способ получени ДНК, кодирующей гормон роста лосос , способ конст-ни промежуточной рекомбинантной плазмидной ДНК, содержащей ДНК-фрагмент, кодирующий гормон роста лосос , дл получени плазмид pS GH1, pS GH3, pS GH9, pS GH10, pS GH14 и pS GH17, способ получени реком-ной плазмидной ДНК pS GH1B2, кодирующей гормон роста лосос , способ получени реком-ной плазмидной ДНК pSGH II С2, кодирующей гормон роста лосос , способ получени реком-ного гормона роста лосос