SU1482509A3 - Способ стабилизации пироксикама - Google Patents
Способ стабилизации пироксикама Download PDFInfo
- Publication number
- SU1482509A3 SU1482509A3 SU853966192A SU3966192A SU1482509A3 SU 1482509 A3 SU1482509 A3 SU 1482509A3 SU 853966192 A SU853966192 A SU 853966192A SU 3966192 A SU3966192 A SU 3966192A SU 1482509 A3 SU1482509 A3 SU 1482509A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- piroxicam
- methylglucamine
- volume
- solution
- ethanol
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 9
- 230000000087 stabilizing effect Effects 0.000 title abstract 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 21
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229960002702 piroxicam Drugs 0.000 claims abstract description 20
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 5
- 230000006641 stabilisation Effects 0.000 claims description 2
- 238000011105 stabilization Methods 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 abstract description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 5
- 229910001873 dinitrogen Inorganic materials 0.000 abstract description 3
- LVXHNCUCBXIIPE-UHFFFAOYSA-L disodium;hydrogen phosphate;hydrate Chemical compound O.[Na+].[Na+].OP([O-])([O-])=O LVXHNCUCBXIIPE-UHFFFAOYSA-L 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 18
- 239000007864 aqueous solution Substances 0.000 description 8
- 238000002347 injection Methods 0.000 description 8
- 239000007924 injection Substances 0.000 description 8
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 description 6
- 239000000126 substance Substances 0.000 description 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 239000002152 aqueous-organic solution Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- YNIRKEZIDLCCMC-UHFFFAOYSA-K trisodium;phosphate;hydrate Chemical compound [OH-].[Na+].[Na+].[Na+].OP([O-])([O-])=O YNIRKEZIDLCCMC-UHFFFAOYSA-K 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- CRKADHVTAQCXRA-UHFFFAOYSA-K trisodium;phosphate;dihydrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]P([O-])([O-])=O CRKADHVTAQCXRA-UHFFFAOYSA-K 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Finger-Pressure Massage (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843437232 DE3437232A1 (de) | 1984-10-10 | 1984-10-10 | Stabilisierte injektionsloesungen von piroxicam |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1482509A3 true SU1482509A3 (ru) | 1989-05-23 |
Family
ID=6247603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU853966192A SU1482509A3 (ru) | 1984-10-10 | 1985-10-09 | Способ стабилизации пироксикама |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4628053A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0177870B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPS6191116A (cg-RX-API-DMAC10.html) |
| KR (1) | KR890001001B1 (cg-RX-API-DMAC10.html) |
| CN (1) | CN85107838B (cg-RX-API-DMAC10.html) |
| AT (1) | ATE62416T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU557184B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA1251734A (cg-RX-API-DMAC10.html) |
| DD (1) | DD238329A5 (cg-RX-API-DMAC10.html) |
| DE (2) | DE3437232A1 (cg-RX-API-DMAC10.html) |
| DK (1) | DK165901C (cg-RX-API-DMAC10.html) |
| FI (1) | FI84315C (cg-RX-API-DMAC10.html) |
| GR (1) | GR852439B (cg-RX-API-DMAC10.html) |
| HU (1) | HU195111B (cg-RX-API-DMAC10.html) |
| IE (1) | IE58267B1 (cg-RX-API-DMAC10.html) |
| IL (1) | IL76624A0 (cg-RX-API-DMAC10.html) |
| NO (1) | NO166687C (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ213758A (cg-RX-API-DMAC10.html) |
| PH (1) | PH23058A (cg-RX-API-DMAC10.html) |
| PT (1) | PT81264B (cg-RX-API-DMAC10.html) |
| SU (1) | SU1482509A3 (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA857783B (cg-RX-API-DMAC10.html) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2545910B1 (fr) * | 1983-05-11 | 1988-07-22 | Valeo | Dispositif pour ameliorer l'efficacite d'un echangeur de chaleur dans un boitier d'une installation de climatisation, et boitier de cette installation |
| IT1196307B (it) * | 1984-10-22 | 1988-11-16 | Chiesi Farma Spa | Formulazioni farmaceutiche acquose di piroxicam monoidrato |
| US5807568A (en) * | 1994-12-27 | 1998-09-15 | Mcneil-Ppc, Inc. | Enhanced delivery of topical compositions containing flurbiprofen |
| IT1283252B1 (it) * | 1996-03-15 | 1998-04-16 | Pulitzer Italiana | Soluzioni di piroxicam iniettabili per via parenterale |
| WO1998001138A1 (fr) * | 1996-07-04 | 1998-01-15 | Nippon Kayaku Kabushiki Kaisha | Injections de succinate sodique de methylprednisolone |
| US6136799A (en) * | 1998-04-08 | 2000-10-24 | Abbott Laboratories | Cosolvent formulations |
| DE10030345A1 (de) * | 2000-06-20 | 2002-01-10 | Boehringer Ingelheim Vetmed | Hochkonzentrierte stabile Meloxicamlösungen |
| US20020035107A1 (en) | 2000-06-20 | 2002-03-21 | Stefan Henke | Highly concentrated stable meloxicam solutions |
| DE10161077A1 (de) | 2001-12-12 | 2003-06-18 | Boehringer Ingelheim Vetmed | Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion |
| US8992980B2 (en) | 2002-10-25 | 2015-03-31 | Boehringer Ingelheim Vetmedica Gmbh | Water-soluble meloxicam granules |
| US8314124B2 (en) | 2004-02-06 | 2012-11-20 | Active Biotech Ab | Crystalline salts of quinoline compounds and methods for preparing them |
| EP1568369A1 (en) | 2004-02-23 | 2005-08-31 | Boehringer Ingelheim Vetmedica Gmbh | Use of meloxicam for the treatment of respiratory diseases in pigs |
| DE102004021281A1 (de) * | 2004-04-29 | 2005-11-24 | Boehringer Ingelheim Vetmedica Gmbh | Verwendung von Meloxicam-Formulierungen in der Veterinärmedizin |
| DE102004030409A1 (de) * | 2004-06-23 | 2006-01-26 | Boehringer Ingelheim Vetmedica Gmbh | Neue Verwendung von Meloxicam in der Veterinärmedizin |
| NZ567627A (en) * | 2005-09-30 | 2011-08-26 | Boehringer Ingelheim Vetmed | Granulation process for making a divisible tablet containing meloxicam |
| PT1937642E (pt) * | 2005-10-19 | 2014-11-25 | Teva Pharma | Cristais de sódio de laquinimod, e processos para o fabrico dos mesmos |
| KR20140091778A (ko) * | 2006-06-12 | 2014-07-22 | 테바 파마슈티컬 인더스트리즈 리미티드 | 안정한 라퀴니모드 제제 |
| PL2234485T3 (pl) | 2007-12-20 | 2014-06-30 | Teva Pharma | Stabilne preparaty lakwinimodu |
| KR20110048571A (ko) * | 2008-09-03 | 2011-05-11 | 테바 파마슈티컬 인더스트리즈 리미티드 | 면역 기능을 지닌 ２―옥소―１,２―다이하이드로―퀴놀린 조절제 |
| JP5359333B2 (ja) * | 2009-02-05 | 2013-12-04 | ゼリア新薬工業株式会社 | コロソリン酸含有水性液剤 |
| KR20160148050A (ko) * | 2009-07-30 | 2016-12-23 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 크론병의 치료 |
| US9585878B2 (en) * | 2009-08-10 | 2017-03-07 | Teva Pharmaceutical Industries, Ltd. | Treatment of BDNF-related disorders using laquinimod |
| ES3037313T3 (en) | 2009-10-12 | 2025-09-30 | Boehringer Ingelheim Vetmedica Gmbh | Containers for compositions comprising meloxicam |
| MX2012010077A (es) | 2010-03-03 | 2012-09-12 | Boehringer Ingelheim Vetmed | Uso de meloxicam para el tratamiento a largo plazo de trastornos musculoesqueleticos en gatos. |
| US20110218191A1 (en) * | 2010-03-03 | 2011-09-08 | Boehringer Ingelheim Vetmedica Gmbh | Use of meloxicam for the long term-treatment of kidney disorders in cats |
| DE102010014290A1 (de) * | 2010-04-08 | 2011-10-13 | Hans Otto Meyer zu Spelbrink | Mittel zur prophylaktischen und therapeutischen Behandlung von Herpes-Infektionen |
| US9795568B2 (en) | 2010-05-05 | 2017-10-24 | Boehringer Ingelheim Vetmedica Gmbh | Low concentration meloxicam tablets |
| WO2013055907A1 (en) | 2011-10-12 | 2013-04-18 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
| CN104093310A (zh) | 2012-02-03 | 2014-10-08 | 泰华制药工业有限公司 | 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 |
| TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| US8975279B2 (en) | 2012-11-07 | 2015-03-10 | Teva Pharmaceutical Industries, Ltd. | Amine salts of laquinimod |
| WO2014153145A2 (en) | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
| KR101749425B1 (ko) * | 2015-11-17 | 2017-06-22 | 연세대학교 산학협력단 | 난용성 약물의 서방형 제제 |
| US20190142789A1 (en) * | 2017-08-09 | 2019-05-16 | Piedmont Animal Health, Llc | Therapeutic formulations and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE629650A (cg-RX-API-DMAC10.html) * | 1967-05-18 | 1900-01-01 | ||
| US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
| DE2602363C2 (de) * | 1976-01-22 | 1984-04-12 | Bayer Ag, 5090 Leverkusen | Wäßrige, injizierbare Niclofolan- Formulierungen |
| DE2756113A1 (de) * | 1977-12-16 | 1979-06-21 | Thomae Gmbh Dr K | Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| DE3217315C2 (de) * | 1982-05-08 | 1986-05-22 | Gödecke AG, 1000 Berlin | Arzneimittelzubereitungen mit einem Gehalt an Oxicam-Derivaten |
| AT376879B (de) * | 1982-10-27 | 1985-01-10 | Gerot Pharmazeutika | Verfahren zur herstellung einer injektionsloesung |
-
1984
- 1984-10-10 DE DE19843437232 patent/DE3437232A1/de not_active Ceased
-
1985
- 1985-09-30 DE DE8585112378T patent/DE3582468D1/de not_active Expired - Fee Related
- 1985-09-30 EP EP85112378A patent/EP0177870B1/de not_active Expired - Lifetime
- 1985-09-30 AT AT85112378T patent/ATE62416T1/de not_active IP Right Cessation
- 1985-10-07 US US06/784,903 patent/US4628053A/en not_active Expired - Fee Related
- 1985-10-08 GR GR852439A patent/GR852439B/el unknown
- 1985-10-08 KR KR1019850007399A patent/KR890001001B1/ko not_active Expired
- 1985-10-08 JP JP60224617A patent/JPS6191116A/ja active Granted
- 1985-10-08 CA CA000492481A patent/CA1251734A/en not_active Expired
- 1985-10-08 PT PT81264A patent/PT81264B/pt not_active IP Right Cessation
- 1985-10-09 DK DK461385A patent/DK165901C/da not_active IP Right Cessation
- 1985-10-09 AU AU48421/85A patent/AU557184B2/en not_active Ceased
- 1985-10-09 IL IL76624A patent/IL76624A0/xx not_active IP Right Cessation
- 1985-10-09 ZA ZA857783A patent/ZA857783B/xx unknown
- 1985-10-09 NZ NZ213758A patent/NZ213758A/xx unknown
- 1985-10-09 NO NO854011A patent/NO166687C/no unknown
- 1985-10-09 DD DD85281570A patent/DD238329A5/de not_active IP Right Cessation
- 1985-10-09 SU SU853966192A patent/SU1482509A3/ru active
- 1985-10-09 CN CN85107838A patent/CN85107838B/zh not_active Expired
- 1985-10-09 HU HU853920A patent/HU195111B/hu not_active IP Right Cessation
- 1985-10-09 FI FI853926A patent/FI84315C/fi not_active IP Right Cessation
- 1985-10-09 PH PH32905A patent/PH23058A/en unknown
- 1985-10-09 IE IE248385A patent/IE58267B1/en not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| За вка DE № 3217315, кл. А 61 К 31/54, 198а. * |
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