SU1431680A3 - Способ получени 4,1,6-трихлор-4,1,6-тридеоксигалактосахарозы - Google Patents
Способ получени 4,1,6-трихлор-4,1,6-тридеоксигалактосахарозы Download PDFInfo
- Publication number
- SU1431680A3 SU1431680A3 SU813338232A SU3338232A SU1431680A3 SU 1431680 A3 SU1431680 A3 SU 1431680A3 SU 813338232 A SU813338232 A SU 813338232A SU 3338232 A SU3338232 A SU 3338232A SU 1431680 A3 SU1431680 A3 SU 1431680A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- sucrose
- solution
- hydroxyl groups
- prime
- tgs
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 14
- 239000005720 sucrose Substances 0.000 claims abstract description 30
- 229930006000 Sucrose Natural products 0.000 claims abstract description 29
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 29
- 239000000203 mixture Substances 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 4
- 239000012320 chlorinating reagent Substances 0.000 claims abstract 5
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 36
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 36
- 239000000243 solution Substances 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims description 21
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 10
- 239000013078 crystal Substances 0.000 claims description 10
- 238000005660 chlorination reaction Methods 0.000 claims description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 6
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 claims description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 5
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- -1 benzoyl halide Chemical class 0.000 claims description 2
- 238000005516 engineering process Methods 0.000 claims description 2
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 230000020176 deacylation Effects 0.000 claims 2
- 238000005947 deacylation reaction Methods 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 239000003729 cation exchange resin Substances 0.000 claims 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims 1
- 229910052753 mercury Inorganic materials 0.000 claims 1
- AGDRDFJCYMPNFZ-UHFFFAOYSA-N methane;methanol Chemical compound C.OC AGDRDFJCYMPNFZ-UHFFFAOYSA-N 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 2
- 235000019408 sucralose Nutrition 0.000 abstract 3
- 150000003445 sucroses Chemical class 0.000 abstract 3
- BAQAVOSOZGMPRM-UHFFFAOYSA-N sucralose Chemical compound OC1C(O)C(Cl)C(CO)OC1OC1(CCl)C(O)C(O)C(CCl)O1 BAQAVOSOZGMPRM-UHFFFAOYSA-N 0.000 abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 19
- 239000011347 resin Substances 0.000 description 15
- 229920005989 resin Polymers 0.000 description 15
- 239000006188 syrup Substances 0.000 description 15
- 235000020357 syrup Nutrition 0.000 description 15
- 239000000047 product Substances 0.000 description 8
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000011541 reaction mixture Substances 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000000741 silica gel Substances 0.000 description 4
- 229910002027 silica gel Inorganic materials 0.000 description 4
- 235000011114 ammonium hydroxide Nutrition 0.000 description 3
- 239000003610 charcoal Substances 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000000908 ammonium hydroxide Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 238000010908 decantation Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000002024 ethyl acetate extract Substances 0.000 description 2
- SPVRWVNZBKXMQW-UHFFFAOYSA-N ethyl acetate;propan-2-one;hydrate Chemical compound O.CC(C)=O.CCOC(C)=O SPVRWVNZBKXMQW-UHFFFAOYSA-N 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- DWLRXXHSVZDNAZ-UHFFFAOYSA-N [Na].C[Na] Chemical compound [Na].C[Na] DWLRXXHSVZDNAZ-UHFFFAOYSA-N 0.000 description 1
- 230000000397 acetylating effect Effects 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000005341 cation exchange Methods 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- OAIVIYSBZFEOIU-UHFFFAOYSA-N chloroform;propan-2-one Chemical compound CC(C)=O.ClC(Cl)Cl OAIVIYSBZFEOIU-UHFFFAOYSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 239000011491 glass wool Substances 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 229920000172 poly(styrenesulfonic acid) Polymers 0.000 description 1
- 229940005642 polystyrene sulfonic acid Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000006884 silylation reaction Methods 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Glass Compositions (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LV920524A LV5134A3 (lv) | 1980-07-08 | 1992-12-29 | 4,1',6'-trihlor-4,1',6'-tridezoksigalaktosaharozes iegusanas panemiens |
| LTRP674A LT2148B (lt) | 1980-07-08 | 1993-06-22 | 4,1',6'-trichlor-4,1',6'-trideoksigalaktosacharozes gavimo budas |
| MD94-0108A MD125C2 (ro) | 1980-07-08 | 1994-03-16 | Procedeu de obţinere a 4,1',6'-tricolor-4,1',6'-trideoxigalactozaharozei |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8022320 | 1980-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1431680A3 true SU1431680A3 (ru) | 1988-10-15 |
Family
ID=10514604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU813338232A SU1431680A3 (ru) | 1980-07-08 | 1981-07-07 | Способ получени 4,1,6-трихлор-4,1,6-тридеоксигалактосахарозы |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4380476A (enExample) |
| EP (1) | EP0043649B1 (enExample) |
| JP (1) | JPS5746995A (enExample) |
| AT (1) | ATE9355T1 (enExample) |
| CA (1) | CA1171852A (enExample) |
| DE (1) | DE3165986D1 (enExample) |
| DK (1) | DK155087C (enExample) |
| GR (1) | GR74583B (enExample) |
| IE (1) | IE51370B1 (enExample) |
| SU (1) | SU1431680A3 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2633698C1 (ru) * | 2016-12-21 | 2017-10-17 | Общество с ограниченной ответственностью "Сахар Плюс" | Способ получения сукралозы |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0103479B1 (en) * | 1982-09-13 | 1986-02-05 | TATE & LYLE PUBLIC LIMITED COMPANY | Sucrose derivatives |
| GB8316790D0 (en) * | 1983-06-21 | 1983-07-27 | Tate & Lyle Plc | Chemical process |
| GB8525871D0 (en) * | 1985-10-21 | 1985-11-27 | Tate & Lyle Plc | Chemical compound |
| GB8525953D0 (en) * | 1985-10-21 | 1985-11-27 | Mcneilab Inc | Preparation of galactopyranoside |
| GB8622345D0 (en) * | 1986-09-17 | 1986-10-22 | Tate & Lyle Plc | Sucrose derivatives |
| US4986991A (en) * | 1987-05-15 | 1991-01-22 | Wm Wrigley, Jr., Company | Chewing gum having an extended sweetness |
| US4950746A (en) * | 1988-07-18 | 1990-08-21 | Noramco, Inc. | Process for synthesizing sucrose derivatives by regioselective reaction |
| GB8818430D0 (en) * | 1988-08-03 | 1988-09-07 | Tate & Lyle Plc | Process |
| FR2635326B1 (fr) * | 1988-08-10 | 1992-05-15 | Beghin Say Sa | Procede pour la preparation de 4,1(prime),6(prime)-trichloro-4,1(prime),6(prime)-tridesoxy-galactosaccharose |
| GB8822673D0 (en) * | 1988-09-27 | 1988-11-02 | Tate & Lyle Plc | Selective acylation of sugars |
| DE68903624T2 (de) * | 1988-09-16 | 1993-05-13 | Tate & Lyle Plc | Verfahren zur chlorierung von zucker. |
| MD31C2 (ro) * | 1988-09-16 | 1995-01-31 | Tate & Lyle Public Limited Company | Procedeu de obţinere a zaharolozei |
| US4980463A (en) * | 1989-07-18 | 1990-12-25 | Noramco, Inc. | Sucrose-6-ester chlorination |
| US5089608A (en) * | 1990-03-23 | 1992-02-18 | Mcneil-Ppc, Inc. | Selective 6-acylation of sucrose mediated by cyclic adducts of dialkyltin oxides and diols |
| US5023329A (en) * | 1990-04-23 | 1991-06-11 | Noramco, Inc. | Sucrose-6-ester production process |
| US5136031A (en) * | 1990-07-09 | 1992-08-04 | Tate & Lyle Public Limited Company | Chlorination of sugars |
| US5298611A (en) * | 1993-03-12 | 1994-03-29 | Mcneil-Ppc, Inc. | Sucralose pentaester production |
| US5498709A (en) * | 1994-10-17 | 1996-03-12 | Mcneil-Ppc, Inc. | Production of sucralose without intermediate isolation of crystalline sucralose-6-ester |
| ZA958724B (en) * | 1994-10-17 | 1997-04-16 | Mcnell Ppc Inc | Production of sucralose without intermediate isolation of crystalline sucralose-6-ester |
| US6075139A (en) | 1996-07-24 | 2000-06-13 | Iowa State University Research Foundation, Inc. | Linear and cyclic sucrose reaction products, their preparation and their use |
| WO1998035974A1 (en) * | 1997-02-13 | 1998-08-20 | Mcneil-Ppc Inc. | Chromatographic purification of chlorinated sucrose |
| US5900478A (en) * | 1997-06-20 | 1999-05-04 | Iowa State University Research Foundation, Inc. | Activated mono-, di-, and polysaccharides reaction products thereof, their preparation and uses |
| RU2217435C2 (ru) * | 1998-05-15 | 2003-11-27 | Ростислав Георгиевич Жбанков | Способ получения 4,1'6'-трихлор-4,1',6'-тридезоксигалактосахарозы |
| WO2002040495A2 (en) * | 2000-11-17 | 2002-05-23 | Mcneil-Ppc, Inc. | Improved sucralose composition and process for the crystallization thereof |
| US7049435B2 (en) * | 2002-03-08 | 2006-05-23 | Tate & Lyle Public Limited Company | Extractive methods for purifying sucralose |
| US6998480B2 (en) * | 2002-03-08 | 2006-02-14 | Tate & Lyle Public Limited Company | Process for improving sucralose purity and yield |
| US20040170735A2 (en) * | 2002-04-05 | 2004-09-02 | Mcneil-Ppc, Inc. | Methods and compositions for altering the sweetness delivery profile of sucralose |
| US6890581B2 (en) * | 2002-04-05 | 2005-05-10 | Tate & Lyle Public Limited Company | Methods for buffer stabilized aqueous deacylation |
| CN1176094C (zh) * | 2003-05-23 | 2004-11-17 | 广东省食品工业研究所 | 一种三氯蔗糖的合成方法 |
| DE602004032578D1 (de) | 2004-03-19 | 2011-06-16 | Vb Medicare Pvt Ltd | Verbessertes verfahren zur herstellung von chlorierter saccharose |
| CN101098970B (zh) * | 2004-12-10 | 2010-05-12 | V.B.医疗保险私人有限公司 | 通过在6-乙酰基-4,1',6'三氯半乳蔗糖和4,1',6'三氯半乳蔗糖的有机溶剂提取物的浓缩过程中直接加入碳酸盐和碳酸氢盐来调节pH的方法 |
| US20080125584A1 (en) * | 2004-12-10 | 2008-05-29 | Rakesh Ratnam | Salts Assisted Selective Extraction Of 6-Acetyl- 4,1' , 6' Trichlorogalactosucrose And 4,1', 6' Trichlorogalactosucrosse From Aqueous Reaction Mixture |
| CN101175762A (zh) * | 2005-01-03 | 2008-05-07 | 法马德医疗保险私人有限公司 | 通过氯化试剂的共-加入进行蔗糖-6-酯的氯化 |
| US7750146B2 (en) | 2005-03-18 | 2010-07-06 | Tate & Lyle Plc | Granular sucralose |
| US20060247180A1 (en) * | 2005-04-29 | 2006-11-02 | Bergey James L | Purgative composition and uses thereof |
| GB2442619B (en) * | 2005-05-04 | 2010-05-26 | Pharmed Medicare Pvt Ltd | Chlorination of sucrose acylates using triphosgene |
| US20060276639A1 (en) * | 2005-06-01 | 2006-12-07 | Healthy Brands, Llc | Conversion of sucralose-6-ester to sucralose |
| CA2620869A1 (en) * | 2005-08-30 | 2007-05-10 | Pharmed Medicare Pvt. Ltd. | Process for production of chlorinated sucrose based on hydrophobic affinity chromatography |
| CN101253187A (zh) * | 2005-08-30 | 2008-08-27 | 法马德医疗保险私人有限公司 | 含有蔗糖酯的反应物中吡啶及其类似物的除去方法 |
| CN101268091A (zh) * | 2005-09-22 | 2008-09-17 | 法马德医疗保险私人有限公司 | 从无水氯化反应物料制备6-o-酰基氯化蔗糖的新型方法 |
| US20070100139A1 (en) * | 2005-10-31 | 2007-05-03 | Healthy Brands, Llc | Methods for chlorinating sucrose-6-ester |
| US7741477B2 (en) * | 2006-01-10 | 2010-06-22 | Alembic Limited | Process for purification of sucralose |
| MX2008010982A (es) * | 2006-02-28 | 2008-10-21 | V B Medicare Private Ltd | Reactivo novedosos de cloracion y proceso novedoso para la cloracion de azucares que usa cloruro de tionilo. |
| CN1814609B (zh) | 2006-03-06 | 2010-11-10 | 盐城捷康三氯蔗糖制造有限公司 | 一种提高三氯蔗糖合成收率的方法 |
| CN100418976C (zh) * | 2006-04-03 | 2008-09-17 | 广州科宏食品添加物有限公司 | 一种三氯蔗糖的制备方法 |
| CN100420697C (zh) * | 2006-08-30 | 2008-09-24 | 河北苏科瑞科技有限公司 | 一种制备蔗糖-6-有机酸酯的方法 |
| US8258291B2 (en) * | 2006-10-25 | 2012-09-04 | Mamtek International Limited | Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC) |
| US20080103295A1 (en) * | 2006-10-25 | 2008-05-01 | David Losan Ho | Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst |
| MX2009005889A (es) * | 2006-12-05 | 2009-08-12 | Tate & Lyle Technology Ltd | Recuperacion de cloruro de tritilo. |
| CN100591684C (zh) * | 2006-12-27 | 2010-02-24 | 盐城捷康三氯蔗糖制造有限公司 | 三氯蔗糖结晶方法 |
| CN101260126B (zh) * | 2007-03-06 | 2010-12-22 | 盐城捷康三氯蔗糖制造有限公司 | 三氯蔗糖的结晶方法 |
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| US8884004B2 (en) | 2011-09-02 | 2014-11-11 | Divi's Laboratories, Ltd. | Process for the preparation of sucralose |
| ES2574261T3 (es) | 2011-10-14 | 2016-06-16 | Lexington Pharmaceuticals Laboratories, Llc | Cloración de carbohidratos y derivados de carbohidratos |
| CN103113426B (zh) * | 2013-03-19 | 2015-01-21 | 新发药业有限公司 | 一锅法制备甜味剂三氯蔗糖的方法 |
| US10227367B2 (en) | 2013-12-16 | 2019-03-12 | Tate & Lyle Technology Limited | Chlorination of sucrose-6-esters |
| CN103936799B (zh) * | 2014-04-24 | 2016-04-20 | 南京工业大学 | 一种蔗糖-6-乙酸酯的合成方法 |
| GB2544217B (en) | 2014-08-08 | 2020-03-25 | Tate & Lyle Tech Ltd | Chlorination of sucrose-6-esters |
| GB2536480B (en) | 2015-03-17 | 2019-09-04 | Tate & Lyle Tech Ltd | DMF Distillation |
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| CN108315372A (zh) * | 2018-01-26 | 2018-07-24 | 东南大学 | 一种酶法脱除三氯蔗糖-6-乙酯乙酰基的方法 |
| CN109897075B (zh) * | 2019-04-24 | 2023-12-05 | 盐城捷康三氯蔗糖制造有限公司 | 一种三氯蔗糖-6-乙酸酯的绿色合成方法 |
| CN114052236B (zh) * | 2020-07-29 | 2023-08-22 | 盐城捷康三氯蔗糖制造有限公司 | 高甜度、低热量的复合甜味剂晶体及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117224A (en) * | 1974-10-15 | 1978-09-26 | Tate & Lyle Limited | Preparation of sucrose 6,6'-dichloro hexa-acetate |
| GB1543167A (en) * | 1976-01-08 | 1979-03-28 | Tate & Lyle Ltd | Sweeteners |
| DE2962239D1 (en) * | 1978-10-18 | 1982-04-01 | Tate & Lyle Patent Holdings | A method for the preparation of 2-chloro-2-deoxy saccharides and some 2-chloro-2-deoxy saccharides |
| JPS5522700A (en) * | 1979-08-13 | 1980-02-18 | Rikagaku Kenkyusho | Preparation of sugar ester |
| GB2065648B (en) | 1979-12-20 | 1983-08-17 | Tate & Lyle Ltd | Preparation of 4,1',6'-trichloro-4,1',6'-trideoxgalactosucrose |
-
1981
- 1981-06-09 EP EP81302563A patent/EP0043649B1/en not_active Expired
- 1981-06-09 AT AT81302563T patent/ATE9355T1/de not_active IP Right Cessation
- 1981-06-09 DE DE8181302563T patent/DE3165986D1/de not_active Expired
- 1981-06-10 CA CA000379457A patent/CA1171852A/en not_active Expired
- 1981-06-15 DK DK262281A patent/DK155087C/da active
- 1981-06-18 GR GR65273A patent/GR74583B/el unknown
- 1981-06-19 US US06/275,593 patent/US4380476A/en not_active Expired - Lifetime
- 1981-07-07 SU SU813338232A patent/SU1431680A3/ru active
- 1981-07-07 JP JP56106170A patent/JPS5746995A/ja active Granted
- 1981-07-07 IE IE1517/81A patent/IE51370B1/en not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| Патент GB № 1543167, кл. С 07 Н, 1977. Фаэркют. Carbohydrate Reseach, . 40, 1975, 285-298, * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2633698C1 (ru) * | 2016-12-21 | 2017-10-17 | Общество с ограниченной ответственностью "Сахар Плюс" | Способ получения сукралозы |
Also Published As
| Publication number | Publication date |
|---|---|
| US4380476A (en) | 1983-04-19 |
| JPS6261597B2 (enExample) | 1987-12-22 |
| DK155087B (da) | 1989-02-06 |
| DK262281A (da) | 1982-01-09 |
| IE51370B1 (en) | 1986-12-10 |
| EP0043649A1 (en) | 1982-01-13 |
| IE811517L (en) | 1982-01-08 |
| CA1171852A (en) | 1984-07-31 |
| DE3165986D1 (en) | 1984-10-18 |
| ATE9355T1 (de) | 1984-09-15 |
| EP0043649B1 (en) | 1984-09-12 |
| DK155087C (da) | 1989-06-26 |
| JPS5746995A (en) | 1982-03-17 |
| GR74583B (enExample) | 1984-06-29 |
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