JPS5746995A - Manufacture of 4,1',6'-trichloro-4,1',6'- trideoxygalactosucrose - Google Patents

Manufacture of 4,1',6'-trichloro-4,1',6'- trideoxygalactosucrose

Info

Publication number
JPS5746995A
JPS5746995A JP56106170A JP10617081A JPS5746995A JP S5746995 A JPS5746995 A JP S5746995A JP 56106170 A JP56106170 A JP 56106170A JP 10617081 A JP10617081 A JP 10617081A JP S5746995 A JPS5746995 A JP S5746995A
Authority
JP
Japan
Prior art keywords
sucrose
trideoxygalactosucrose
trichloro
monoacylated
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56106170A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6261597B2 (enExample
Inventor
Sarutan Mafutei Kuizaa
Aametsudo Kaan Riazu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TALRES DEV
TARURESU DEV ENU EI NV
Original Assignee
TALRES DEV
TARURESU DEV ENU EI NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TALRES DEV, TARURESU DEV ENU EI NV filed Critical TALRES DEV
Publication of JPS5746995A publication Critical patent/JPS5746995A/ja
Publication of JPS6261597B2 publication Critical patent/JPS6261597B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Glass Compositions (AREA)
JP56106170A 1980-07-08 1981-07-07 Manufacture of 4,1',6'-trichloro-4,1',6'- trideoxygalactosucrose Granted JPS5746995A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8022320 1980-07-08

Publications (2)

Publication Number Publication Date
JPS5746995A true JPS5746995A (en) 1982-03-17
JPS6261597B2 JPS6261597B2 (enExample) 1987-12-22

Family

ID=10514604

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56106170A Granted JPS5746995A (en) 1980-07-08 1981-07-07 Manufacture of 4,1',6'-trichloro-4,1',6'- trideoxygalactosucrose

Country Status (10)

Country Link
US (1) US4380476A (enExample)
EP (1) EP0043649B1 (enExample)
JP (1) JPS5746995A (enExample)
AT (1) ATE9355T1 (enExample)
CA (1) CA1171852A (enExample)
DE (1) DE3165986D1 (enExample)
DK (1) DK155087C (enExample)
GR (1) GR74583B (enExample)
IE (1) IE51370B1 (enExample)
SU (1) SU1431680A3 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005526767A (ja) * 2002-03-08 2005-09-08 テート アンド ライル パブリック リミテッド カンパニー スクラロースの純度および収率を改善するためのプロセス
JP2009528342A (ja) * 2006-02-28 2009-08-06 ヴイ ビー メディケア プライヴェート リミテッド 塩化チオニルを使用する糖類を塩素化するための新規塩素化試薬及び新規方法
JP2009298803A (ja) * 2000-11-17 2009-12-24 Tate & Lyle Plc 改良されたスクラロース組成物およびその結晶化の方法
JP2010511705A (ja) * 2006-12-05 2010-04-15 テート アンド ライル テクノロジー リミテッド トリチルクロライド回収
US7838642B2 (en) 2007-03-06 2010-11-23 Jk Sucralose Inc. Process for the preparation of sucralose by the deacylation of trichlorosucrose-6-ethyl ester

Families Citing this family (80)

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US4612373A (en) * 1982-09-13 1986-09-16 Tate & Lyle Public Limited Co. Trichloro, 6-substituted sucrose compounds, compositions and uses therefor
GB8316790D0 (en) * 1983-06-21 1983-07-27 Tate & Lyle Plc Chemical process
GB8525871D0 (en) * 1985-10-21 1985-11-27 Tate & Lyle Plc Chemical compound
GB8525953D0 (en) * 1985-10-21 1985-11-27 Mcneilab Inc Preparation of galactopyranoside
GB8622345D0 (en) * 1986-09-17 1986-10-22 Tate & Lyle Plc Sucrose derivatives
US4986991A (en) * 1987-05-15 1991-01-22 Wm Wrigley, Jr., Company Chewing gum having an extended sweetness
US4950746A (en) * 1988-07-18 1990-08-21 Noramco, Inc. Process for synthesizing sucrose derivatives by regioselective reaction
GB8818430D0 (en) * 1988-08-03 1988-09-07 Tate & Lyle Plc Process
FR2635326B1 (fr) * 1988-08-10 1992-05-15 Beghin Say Sa Procede pour la preparation de 4,1(prime),6(prime)-trichloro-4,1(prime),6(prime)-tridesoxy-galactosaccharose
EP0364100B1 (en) * 1988-09-16 1992-11-25 TATE & LYLE PUBLIC LIMITED COMPANY Process for the chlorination of sugars
GB8822673D0 (en) * 1988-09-27 1988-11-02 Tate & Lyle Plc Selective acylation of sugars
MD31C2 (ro) * 1988-09-16 1995-01-31 Tate & Lyle Public Limited Company Procedeu de obţinere a zaharolozei
US4980463A (en) * 1989-07-18 1990-12-25 Noramco, Inc. Sucrose-6-ester chlorination
US5089608A (en) * 1990-03-23 1992-02-18 Mcneil-Ppc, Inc. Selective 6-acylation of sucrose mediated by cyclic adducts of dialkyltin oxides and diols
US5023329A (en) * 1990-04-23 1991-06-11 Noramco, Inc. Sucrose-6-ester production process
US5136031A (en) * 1990-07-09 1992-08-04 Tate & Lyle Public Limited Company Chlorination of sugars
US5298611A (en) * 1993-03-12 1994-03-29 Mcneil-Ppc, Inc. Sucralose pentaester production
ZA958724B (en) * 1994-10-17 1997-04-16 Mcnell Ppc Inc Production of sucralose without intermediate isolation of crystalline sucralose-6-ester
US5498709A (en) * 1994-10-17 1996-03-12 Mcneil-Ppc, Inc. Production of sucralose without intermediate isolation of crystalline sucralose-6-ester
US6075139A (en) * 1996-07-24 2000-06-13 Iowa State University Research Foundation, Inc. Linear and cyclic sucrose reaction products, their preparation and their use
US5977349A (en) * 1997-02-13 1999-11-02 Mcneil-Ppc, Inc. Chromatographic purification of chlorinated sucrose
US5900478A (en) * 1997-06-20 1999-05-04 Iowa State University Research Foundation, Inc. Activated mono-, di-, and polysaccharides reaction products thereof, their preparation and uses
EP1076661A1 (en) * 1998-05-15 2001-02-21 Rostislav G. Zhbankov Method of preparation of 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose
US7049435B2 (en) 2002-03-08 2006-05-23 Tate & Lyle Public Limited Company Extractive methods for purifying sucralose
US20040170735A2 (en) * 2002-04-05 2004-09-02 Mcneil-Ppc, Inc. Methods and compositions for altering the sweetness delivery profile of sucralose
US6890581B2 (en) * 2002-04-05 2005-05-10 Tate & Lyle Public Limited Company Methods for buffer stabilized aqueous deacylation
CN1176094C (zh) * 2003-05-23 2004-11-17 广东省食品工业研究所 一种三氯蔗糖的合成方法
DE602004032578D1 (de) 2004-03-19 2011-06-16 Vb Medicare Pvt Ltd Verbessertes verfahren zur herstellung von chlorierter saccharose
WO2006061855A2 (en) * 2004-12-10 2006-06-15 Pharmed Medicare Private Limited Salts assisted selective extraction of 6-acetyl-4.1', 6' trichlorogalactosucrose and 4, 1 ', 6' trichlorogalactosucrose from aqueous reaction mixture
WO2006061854A2 (en) * 2004-12-10 2006-06-15 Pharmed Medicare Private Limited CONTROL OF pH BY DIRECT ADDITION OF CARBONATES AND BICARBONATES DURING CONCENTRATION OF ORGANIC SOLVENT EXTRACTS OF 6- ACETYL- 4,1 ‘, 6' TRICHLOROGALACTOSUCROSE AND 4,1 ‘, 6' TRICHLOROGALACTOSUCROSE
KR20070113194A (ko) * 2005-01-03 2007-11-28 팜드 메디케어 프리베이트 리미티드 염소화 시약의 동시 첨가에 의한 수크로스-6-에스테르염소화
US7750146B2 (en) 2005-03-18 2010-07-06 Tate & Lyle Plc Granular sucralose
US20060247180A1 (en) * 2005-04-29 2006-11-02 Bergey James L Purgative composition and uses thereof
GB2442619B (en) * 2005-05-04 2010-05-26 Pharmed Medicare Pvt Ltd Chlorination of sucrose acylates using triphosgene
US20060276639A1 (en) * 2005-06-01 2006-12-07 Healthy Brands, Llc Conversion of sucralose-6-ester to sucralose
CA2620869A1 (en) * 2005-08-30 2007-05-10 Pharmed Medicare Pvt. Ltd. Process for production of chlorinated sucrose based on hydrophobic affinity chromatography
CN101253187A (zh) * 2005-08-30 2008-08-27 法马德医疗保险私人有限公司 含有蔗糖酯的反应物中吡啶及其类似物的除去方法
WO2007057920A2 (en) * 2005-09-22 2007-05-24 Pharmed Medicare Pvt. Ltd. Novel preparation of 6-o-acyl chlorosucrose from anhydrous chlorinated reaction mass
US20070100139A1 (en) * 2005-10-31 2007-05-03 Healthy Brands, Llc Methods for chlorinating sucrose-6-ester
US7741477B2 (en) * 2006-01-10 2010-06-22 Alembic Limited Process for purification of sucralose
CN1814609B (zh) 2006-03-06 2010-11-10 盐城捷康三氯蔗糖制造有限公司 一种提高三氯蔗糖合成收率的方法
CN100418976C (zh) * 2006-04-03 2008-09-17 广州科宏食品添加物有限公司 一种三氯蔗糖的制备方法
CN100420697C (zh) * 2006-08-30 2008-09-24 河北苏科瑞科技有限公司 一种制备蔗糖-6-有机酸酯的方法
US20080103295A1 (en) * 2006-10-25 2008-05-01 David Losan Ho Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst
US8258291B2 (en) * 2006-10-25 2012-09-04 Mamtek International Limited Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC)
CN100591684C (zh) * 2006-12-27 2010-02-24 盐城捷康三氯蔗糖制造有限公司 三氯蔗糖结晶方法
CN101260126B (zh) * 2007-03-06 2010-12-22 盐城捷康三氯蔗糖制造有限公司 三氯蔗糖的结晶方法
US20080300401A1 (en) * 2007-06-04 2008-12-04 Polymed Therapeutics, Inc. Novel chlorination process for preparing sucralose
US20080300392A1 (en) * 2007-06-04 2008-12-04 Polymed Therapeutics, Inc. Novel chlorination process for preparing sucralose
CN101177437B (zh) * 2007-12-07 2010-10-27 浙江普洛医药科技有限公司 一种环保的三氯蔗糖的合成方法
CN101245085B (zh) * 2007-12-19 2012-02-01 上海同辰生物科技有限公司 一种三氯蔗糖的合成及纯化工艺
AR070082A1 (es) 2008-01-04 2010-03-10 Tate & Lyle Technology Ltd Metodo para la produccion de sucralosa
US7932380B2 (en) 2008-03-06 2011-04-26 Wanhe International (Group) Co. Ltd. Process for the preparation of sucralose
WO2009117317A1 (en) 2008-03-20 2009-09-24 Tate & Lyle Technology Ltd Removal of acids from tertiary amide solvents
US8436157B2 (en) 2008-03-26 2013-05-07 Tate & Lyle Technology Limited Method for the production of sucralose
US8497367B2 (en) 2008-04-03 2013-07-30 Tate & Lyle Technology Limited Sucralose purification process
US8212022B2 (en) 2008-04-03 2012-07-03 Tate & Lyle Technology Limited Effect of carbohydrate concentration on sucralose extraction efficiency
AR071134A1 (es) * 2008-04-03 2010-05-26 Tate & Lyle Technology Ltd Cristalizacion de sucralosa a partir de chorros que contienen sucralosa
US20090259036A1 (en) * 2008-04-03 2009-10-15 Tate & Lyle Technology Limited Extraction of less polar impurities from sucralose containing aqueous feed streams
US20090299055A1 (en) * 2008-04-03 2009-12-03 Tate & Lyle Technology Limited Purification of Sucralose Containing Feed Streams for Sucralose Crystallization
CN101260128B (zh) * 2008-04-11 2011-04-27 中国计量学院 一种三氯蔗糖五乙酸酯的合成方法
GB2468936B (en) 2009-03-27 2011-09-07 Mohamad Rami Radwan Jaber Chlorination of sucrose-6-esters
GB2469157B (en) * 2009-03-30 2011-07-06 John Kerr Process for removing dimethylamine during sucralose production
GB2471348B (en) 2009-06-22 2011-12-14 Tate & Lyle Technology Ltd A method for producing sucralose-6-acylate
GB2474310B (en) 2009-10-12 2012-02-29 Tate & Lyle Technology Ltd Process for the production of sucrose-6-ester
GB2474311B (en) 2009-10-12 2012-10-17 Tate & Lyle Technology Ltd Low temperature, single solvent process for the production of sucrose-6-ester
CA2817630C (en) * 2010-11-23 2019-09-03 Lexington Pharmaceuticals Laboratories, Llc Low temperature chlorination of carbohydrates
US8884004B2 (en) 2011-09-02 2014-11-11 Divi's Laboratories, Ltd. Process for the preparation of sucralose
HUE027876T2 (en) 2011-10-14 2016-10-28 Lexington Pharmaceuticals Laboratories Llc Carbohydrate chlorination and carbohydrate derivatives
CN103113426B (zh) * 2013-03-19 2015-01-21 新发药业有限公司 一锅法制备甜味剂三氯蔗糖的方法
CN105829332B (zh) 2013-12-16 2018-10-02 塔特和莱利技术有限公司 蔗糖-6-酯的氯化
CN103936799B (zh) * 2014-04-24 2016-04-20 南京工业大学 一种蔗糖-6-乙酸酯的合成方法
WO2016020635A1 (en) 2014-08-08 2016-02-11 Tate & Lyle Technology Limited Chlorination of sucrose-6-esters
GB2536480B (en) 2015-03-17 2019-09-04 Tate & Lyle Tech Ltd DMF Distillation
GB2551591B (en) 2016-06-23 2019-08-07 Tate & Lyle Tech Ltd Liquid-liquid extraction of DMF
RU2633698C1 (ru) * 2016-12-21 2017-10-17 Общество с ограниченной ответственностью "Сахар Плюс" Способ получения сукралозы
CN108315372A (zh) * 2018-01-26 2018-07-24 东南大学 一种酶法脱除三氯蔗糖-6-乙酯乙酰基的方法
CN109897075B (zh) * 2019-04-24 2023-12-05 盐城捷康三氯蔗糖制造有限公司 一种三氯蔗糖-6-乙酸酯的绿色合成方法
CN114052236B (zh) * 2020-07-29 2023-08-22 盐城捷康三氯蔗糖制造有限公司 高甜度、低热量的复合甜味剂晶体及其制备方法
CN112384522A (zh) * 2020-09-21 2021-02-19 安徽金禾实业股份有限公司 一种蔗糖-6-羧酸酯的制备方法

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US4117224A (en) * 1974-10-15 1978-09-26 Tate & Lyle Limited Preparation of sucrose 6,6'-dichloro hexa-acetate
GB1543167A (en) * 1976-01-08 1979-03-28 Tate & Lyle Ltd Sweeteners
ATE732T1 (de) * 1978-10-18 1982-03-15 Tate & Lyle Patent Holdings Limited Verfahren zur herstellung von 2-chlor-2-deoxy-sacchariden und einige 2-chlor-2-deoxy-saccharide.
JPS5522700A (en) * 1979-08-13 1980-02-18 Rikagaku Kenkyusho Preparation of sugar ester
GB2065648B (en) 1979-12-20 1983-08-17 Tate & Lyle Ltd Preparation of 4,1',6'-trichloro-4,1',6'-trideoxgalactosucrose

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009298803A (ja) * 2000-11-17 2009-12-24 Tate & Lyle Plc 改良されたスクラロース組成物およびその結晶化の方法
JP2005526767A (ja) * 2002-03-08 2005-09-08 テート アンド ライル パブリック リミテッド カンパニー スクラロースの純度および収率を改善するためのプロセス
JP4916089B2 (ja) * 2002-03-08 2012-04-11 テート アンド ライル テクノロジー リミテッド スクラロースの純度および収率を改善するためのプロセス
JP2009528342A (ja) * 2006-02-28 2009-08-06 ヴイ ビー メディケア プライヴェート リミテッド 塩化チオニルを使用する糖類を塩素化するための新規塩素化試薬及び新規方法
JP2010511705A (ja) * 2006-12-05 2010-04-15 テート アンド ライル テクノロジー リミテッド トリチルクロライド回収
US7838642B2 (en) 2007-03-06 2010-11-23 Jk Sucralose Inc. Process for the preparation of sucralose by the deacylation of trichlorosucrose-6-ethyl ester

Also Published As

Publication number Publication date
EP0043649B1 (en) 1984-09-12
ATE9355T1 (de) 1984-09-15
IE811517L (en) 1982-01-08
DK262281A (da) 1982-01-09
EP0043649A1 (en) 1982-01-13
DK155087C (da) 1989-06-26
DE3165986D1 (en) 1984-10-18
GR74583B (enExample) 1984-06-29
CA1171852A (en) 1984-07-31
DK155087B (da) 1989-02-06
US4380476A (en) 1983-04-19
JPS6261597B2 (enExample) 1987-12-22
IE51370B1 (en) 1986-12-10
SU1431680A3 (ru) 1988-10-15

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