SU1395142A3 - Способ получени карбапенемов - Google Patents

Способ получени карбапенемов Download PDF

Info

Publication number
SU1395142A3
SU1395142A3 SU843789215A SU3789215A SU1395142A3 SU 1395142 A3 SU1395142 A3 SU 1395142A3 SU 843789215 A SU843789215 A SU 843789215A SU 3789215 A SU3789215 A SU 3789215A SU 1395142 A3 SU1395142 A3 SU 1395142A3
Authority
SU
USSR - Soviet Union
Prior art keywords
methyl
solution
mmol
dimethyl
mixture
Prior art date
Application number
SU843789215A
Other languages
English (en)
Russian (ru)
Inventor
Декстразе Пьер
Original Assignee
Бристоль-Мейерз Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристоль-Мейерз Компани filed Critical Бристоль-Мейерз Компани
Application granted granted Critical
Publication of SU1395142A3 publication Critical patent/SU1395142A3/ru

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H01L27/02—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having potential barriers; including integrated passive circuit elements having potential barriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Power Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SU843789215A 1983-09-09 1984-09-07 Способ получени карбапенемов SU1395142A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53001283A 1983-09-09 1983-09-09

Publications (1)

Publication Number Publication Date
SU1395142A3 true SU1395142A3 (ru) 1988-05-07

Family

ID=24112102

Family Applications (1)

Application Number Title Priority Date Filing Date
SU843789215A SU1395142A3 (ru) 1983-09-09 1984-09-07 Способ получени карбапенемов

Country Status (17)

Country Link
KR (1) KR870001743B1 (de)
AT (1) AT387387B (de)
CA (1) CA1273010A (de)
CS (1) CS248721B2 (de)
DD (1) DD232495A5 (de)
DK (1) DK429584A (de)
ES (1) ES8601218A1 (de)
FI (1) FI843466A (de)
GR (1) GR80297B (de)
HU (1) HU192431B (de)
LU (1) LU85535A1 (de)
NO (1) NO843541L (de)
OA (1) OA07808A (de)
PT (1) PT79184B (de)
SU (1) SU1395142A3 (de)
YU (1) YU154884A (de)
ZW (1) ZW15184A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2945534B1 (fr) 2009-05-12 2012-11-16 Sanofi Aventis DERIVES DE CYCLOPENTAL[c]PYRROLE-2-CARBOXYLATES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52147B1 (en) * 1980-03-27 1987-07-08 Merck & Co Inc 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation
EP0074599A1 (de) * 1981-09-09 1983-03-23 Takeda Chemical Industries, Ltd. 5,6-Cis-Carbapenem-Derivate, ihre Herstellung und Verwendung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Патент ClOA if 4350631, кл. 260-245.2. 1982. *

Also Published As

Publication number Publication date
PT79184B (en) 1986-11-24
ZW15184A1 (en) 1985-04-03
YU154884A (en) 1987-06-30
LU85535A1 (fr) 1985-04-29
DK429584A (da) 1985-03-10
KR850002099A (ko) 1985-05-06
ES535718A0 (es) 1985-11-01
FI843466A0 (fi) 1984-09-05
HUT34979A (en) 1985-05-28
FI843466A (fi) 1985-03-10
GR80297B (en) 1985-01-09
CS248721B2 (en) 1987-02-12
ATA289784A (de) 1988-06-15
DD232495A5 (de) 1986-01-29
ES8601218A1 (es) 1985-11-01
CA1273010A (en) 1990-08-21
KR870001743B1 (ko) 1987-09-26
DK429584D0 (da) 1984-09-07
AT387387B (de) 1989-01-10
NO843541L (no) 1985-03-11
PT79184A (en) 1984-10-01
HU192431B (en) 1987-06-29
OA07808A (fr) 1986-11-20

Similar Documents

Publication Publication Date Title
ES2939775T3 (es) Macrociclos como moduladores del regulador de la conductancia transmembrana de la fibrosis quística, composiciones farmacéuticas de los mismos, su uso en el tratamiento de la fibrosis quística, y procesos para elaborarlos
AU636913B2 (en) Tricyclic carbapenem compounds
NO167918B (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive karbapenemderivater
JP2018135384A (ja) １−シアノ−２−（４−シクロプロピル−ベンジル）−４−（β−Ｄ−グルコピラノース−１−イル）−ベンゼンの結晶性錯体、その調製方法及び薬物を調製するためのその使用
NO164980B (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive karbapenemderivater.
EA011161B1 (ru) 3- или 4-монозамещённые производные фенола и тиофенола, полезные в качестве h-лигандов
JPH0215552B2 (de)
HUT56095A (en) Process for producing benzopyrane derivatives and pharmaceutical compositions containing them
CA2118961A1 (en) Novel 2-thiosubstituted carbapenems
CA2028176A1 (en) Carbapenem compounds
CA1283659C (en) Carbapenem antibiotics
SU1395142A3 (ru) Способ получени карбапенемов
NO163957B (no) Analogifremgangsm te til fremstilling av terapeutisk aktive karbapenemforbindelser.
JPS61215367A (ja) カルバペネム中間体の製造方法
US5194624A (en) Intermediates for the preparation of compounds of antimicrobial activity
FR2533568A1 (fr) Nouveaux antibiotiques de la classe des carbapenems, et leur application pharmaceutique
FI81577C (fi) Foerfarande foer framstaellning av som laekemedel anvaendbara 2-(2-substituerad-2-iminoetyltio)-6-(1-hydroxietyl)- 1-karbapen -2-em-3-karboxylsyror.
WO2023154344A1 (en) 2-methyl-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran] derivatives as inhibitors of apol1 and methods of using same
NZ199487A (en) Azabicycloheptene derivatives,intermediates and pharmaceutical compositions
WO1997004770A1 (en) 2-(fluorenonyl)-carbapenems, compositions and methods of use
AU2020320890B2 (en) SGLT2/DPP4 inhibitor and application thereof
EP0321187A1 (de) 6-(Substituiertes Methylen)peneme
CA1273014A (en) Carbapenem process
JPH0310627B2 (de)
WO1987000178A1 (en) Novel antibiotic derivatives, process for their preparation, and use thereof