SMT202500397T1 - Derivati bipirazolici come inibitori di jak - Google Patents
Derivati bipirazolici come inibitori di jakInfo
- Publication number
- SMT202500397T1 SMT202500397T1 SM20250397T SMT202500397T SMT202500397T1 SM T202500397 T1 SMT202500397 T1 SM T202500397T1 SM 20250397 T SM20250397 T SM 20250397T SM T202500397 T SMT202500397 T SM T202500397T SM T202500397 T1 SMT202500397 T1 SM T202500397T1
- Authority
- SM
- San Marino
- Prior art keywords
- jak inhibitors
- bipyrazole derivatives
- bipyrazole
- derivatives
- jak
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361824683P | 2013-05-17 | 2013-05-17 | |
| EP23185889.5A EP4275756B1 (en) | 2013-05-17 | 2014-05-16 | Bipyrazole derivatives as jak inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT202500397T1 true SMT202500397T1 (it) | 2025-11-10 |
Family
ID=50983151
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM20250397T SMT202500397T1 (it) | 2013-05-17 | 2014-05-16 | Derivati bipirazolici come inibitori di jak |
| SM20210040T SMT202100040T1 (it) | 2013-05-17 | 2014-05-16 | Derivati di bipirazolo come inibitori di jak |
| SM20230352T SMT202300352T1 (it) | 2013-05-17 | 2014-05-16 | Derivati bipirazolici come inibitori di jak |
| SM20190223T SMT201900223T1 (it) | 2013-05-17 | 2014-05-16 | Sale di bipirazolo come inibitore di jak |
| SM20170258T SMT201700258T1 (it) | 2013-05-17 | 2014-05-16 | Derivati di bipirazolo come inibitori di jak |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM20210040T SMT202100040T1 (it) | 2013-05-17 | 2014-05-16 | Derivati di bipirazolo come inibitori di jak |
| SM20230352T SMT202300352T1 (it) | 2013-05-17 | 2014-05-16 | Derivati bipirazolici come inibitori di jak |
| SM20190223T SMT201900223T1 (it) | 2013-05-17 | 2014-05-16 | Sale di bipirazolo come inibitore di jak |
| SM20170258T SMT201700258T1 (it) | 2013-05-17 | 2014-05-16 | Derivati di bipirazolo come inibitori di jak |
Country Status (36)
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA116187C2 (uk) | 2005-12-13 | 2018-02-26 | ÐÐœÑÐ°Ð¹Ñ Ð¥ÐŸÐ»ÐŽÑÐœÐ³Ñ ÐПÑпПÑейÑÐœ | ÐÐТÐÐ ÐÐÐ ÐÐÐÐÐÐЩÐÐÐ ÐÐÐ ÐÐÐ[2,3-b]ÐÐÐ ÐÐÐÐÐ Ð ÐÐÐ ÐÐÐ[2,3-b]ÐÐÐ ÐÐÐÐÐÐРЯРÐÐÐÐÐÐТÐРРЯÐУС-ÐÐÐÐÐÐ |
| WO2008157208A2 (en) | 2007-06-13 | 2008-12-24 | Incyte Corporation | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| PE20120371A1 (es) | 2009-05-22 | 2012-05-17 | Incyte Corp | 3-[4-(7h-pirrolo[2,3-d]pirimidin-4il)-1h-pirazol-1-il]octano o heptano-nitrilo como inhibidores de jak |
| EP2432555B1 (en) | 2009-05-22 | 2014-04-30 | Incyte Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| PL2448938T3 (pl) | 2009-06-29 | 2014-11-28 | Incyte Holdings Corp | Pirymidynony jako inhibitory PI3K |
| TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| DK3354652T3 (da) | 2010-03-10 | 2020-05-18 | Incyte Holdings Corp | Piperidin-4-yl azetidinderivativer som jak1-inhibitorer |
| PE20130216A1 (es) | 2010-05-21 | 2013-02-27 | Incyte Corp | Formulacion topica para un inhibidor de jak |
| PH12013501001A1 (en) | 2010-11-19 | 2019-09-02 | Incyte Holdings Corp | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| CA2822070C (en) | 2010-12-20 | 2019-09-17 | Incyte Corporation | N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors |
| AR086983A1 (es) | 2011-06-20 | 2014-02-05 | Incyte Corp | Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | äœçºïœïœïœæå¶åä¹ç°å·±åºæ°®éç°äžç·è¡çç© |
| PH12021552978A1 (en) | 2011-09-02 | 2022-08-22 | Incyte Holdings Corp | Heterocyclylamines as pi3k inhibitors |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | ÐÐœÑÐ°Ð¹Ñ Ð¥ÐŸÐ»ÐŽÑÐœÐ³Ñ ÐПÑпПÑейÑÐœ | СпПÑПбО Ñ Ð¿ÑПЌÑÐ¶ÐœÑ ÑпПлÑкО ÐŽÐ»Ñ ÐŸÑÑÐžÐŒÐ°ÐœÐœÑ ÑМгÑбÑÑПÑÑв jak |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| AR091079A1 (es) | 2012-05-18 | 2014-12-30 | Incyte Corp | Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak |
| AR093308A1 (es) | 2012-11-01 | 2015-05-27 | Incyte Corp | Derivados triciclicos fusionados de tiofeno como inhibidores de jak |
| NZ708157A (en) | 2012-11-15 | 2019-07-26 | Incyte Holdings Corp | Sustained-release dosage forms of ruxolitinib |
| SMT201900081T1 (it) | 2013-03-06 | 2019-05-10 | Incyte Holdings Corp | Procedimenti e intermedi per produrre un inibitore di jak |
| PE20200527A1 (es) | 2013-05-17 | 2020-03-09 | Incyte Corp | Derivados del bipirazol como inhibidores jak |
| HRP20200955T1 (hr) | 2013-08-07 | 2020-10-02 | Incyte Corporation | Dozni oblici s produÅŸenim oslobaÄanjem za jak1 inhibitor |
| KR20160136323A (ko) * | 2014-02-28 | 2016-11-29 | ìžì¬ìŽíž ìœí¬ë ìŽì | 곚ìíì±ìŽììŠíêµ° ì¹ë£ì© jak1 ìµì ì |
| NZ763326A (en) | 2014-04-08 | 2023-04-28 | Incyte Holdings Corp | Treatment of b-cell malignancies by a combination jak and pi3k inhibitor |
| PE20170300A1 (es) | 2014-04-30 | 2017-04-19 | Incyte Corp | Procesos para preparar un inhibidor de jak 1 y nuevas formas de este |
| WO2015184305A1 (en) * | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| WO2016172712A2 (en) | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| WO2016130501A1 (en) | 2015-02-09 | 2016-08-18 | Incyte Corporation | Aza-heteroaryl compounds as pi3k-gamma inhibitors |
| LT3262046T (lt) | 2015-02-27 | 2021-01-11 | Incyte Corporation | Pi3k inhibitoriaus druskos ir jų gamybos būdai |
| US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
| WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| US11052094B2 (en) * | 2015-05-29 | 2021-07-06 | Sydnexis, Inc. | D2O stabilized pharmaceutical formulations |
| PT3371190T (pt) | 2015-11-06 | 2022-07-08 | Incyte Corp | Compostos heterocÃclicos como inibidores de pi3k-gamma |
| US20170190689A1 (en) | 2016-01-05 | 2017-07-06 | Incyte Corporation | Pyridine and pyridimine compounds as pi3k-gamma inhibitors |
| TW201803871A (zh) | 2016-06-24 | 2018-02-01 | è±å¡ç¹å ¬åž | äœçºïŒ°ïŒ©ïŒïŒ«-γæå¶åä¹éç°ååç© |
| CN107759623B (zh) * | 2016-08-23 | 2020-08-14 | èå·æºå±±æºæ°Žçç©å»è¯æéå ¬åž | Jakæå¶åçäžéŽäœåå ¶å¶å€æ¹æ³ |
| EP3510030B1 (en) * | 2016-09-06 | 2023-03-22 | F. Hoffmann-La Roche AG | 8-(azetidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridinyl compounds, compositions and methods of use thereof |
| CN118063470A (zh) | 2017-10-18 | 2024-05-24 | å èµç¹å ¬åž | äœäžºPI3K-γæå¶åçç±åçŸåºå代ç猩ååªåè¡çç© |
| AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
| IL276302B2 (en) | 2018-01-30 | 2023-11-01 | Incyte Corp | Procedures for preparing [1-(3-fluoro-2-(trifluoromethyl(isonicotinyl}piperidine-4-one) |
| KR20240157777A (ko) | 2018-02-16 | 2024-11-01 | ìžì¬ìŽíž ìœí¬ë ìŽì | ì¬ìŽí 칎ìž-êŽë š ì¥ì ì ì¹ë£ë¥Œ ìí jak1 ê²œë¡ ìµì ì |
| WO2019191679A1 (en) | 2018-03-30 | 2019-10-03 | Incyte Corporation | Biomarkers for inflammatory skin disease |
| EP4424328A3 (en) * | 2018-03-30 | 2024-12-04 | Incyte Corporation | Treatment of hidradenitis suppurativa using jak inhibitors |
| CN112567247A (zh) | 2018-04-13 | 2021-03-26 | å èµç¹å ¬åž | çšäºç§»æ€ç©æ宿䞻ç ççç©æ å¿ç© |
| CN108484468A (zh) * | 2018-05-11 | 2018-09-04 | åäº¬å€§åŠ | è³åºæ°®æç¯äžç·ç±»ååç©çå¶å€æ¹æ³ |
| CA3101323A1 (en) | 2018-06-01 | 2019-12-05 | Incyte Corporation | Dosing regimen for the treatment of pi3k related disorders |
| CR20250050A (es) | 2018-09-05 | 2025-03-19 | Incyte Corp | Formas cristalinas de un inhibidor de fosfoinositida 3âquinasa (pi3k) (divisional 2021-0165) |
| EA202191170A1 (ru) | 2018-10-31 | 2021-07-27 | ÐÐœÑÐ°Ð¹Ñ ÐПÑпПÑейÑÐœ | ÐПЌбОМОÑÐŸÐ²Ð°ÐœÐœÐ°Ñ ÑеÑÐ°Ð¿ÐžÑ ÐŽÐ»Ñ Ð»ÐµÑÐµÐœÐžÑ Ð³ÐµÐŒÐ°ÑПлПгОÑеÑÐºÐžÑ Ð·Ð°Ð±ÐŸÐ»ÐµÐ²Ð°ÐœÐžÐ¹ |
| MX2021007260A (es) | 2018-12-19 | 2021-09-08 | Incyte Corp | Inhibidores de la vÃa de cinasa janus 1 (jak1) para el tratamiento de enfermedades gastrointestinales. |
| IL285999B1 (en) | 2019-03-05 | 2025-09-01 | Incyte Corp | JAK1 inhibitor pathway for the treatment of chronic lung allograft dysfunction |
| TW202102222A (zh) | 2019-03-19 | 2021-01-16 | çŸåè±å¡ç¹å ¬åž | çœæç ä¹çç©æšèšç© |
| CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧æ©ç§æ¯æ¬§å ¬åž | çšäºæ²»ççççDbaitååäžæ¿é ¶æå¶åçç»å |
| AU2020356575A1 (en) | 2019-09-27 | 2022-04-14 | Disc Medicine, Inc. | Methods for treating myelofibrosis and related conditions |
| JP2022551649A (ja) | 2019-10-10 | 2022-12-12 | ã€ã³ãµã€ãã»ã³ãŒãã¬ã€ã·ã§ã³ | 移æ€ç察宿䞻ç ã®ãã€ãªããŒã«ãŒ |
| WO2021072098A1 (en) | 2019-10-10 | 2021-04-15 | Incyte Corporation | Biomarkers for graft-versus-host disease |
| JP7518900B2 (ja) * | 2019-10-16 | 2024-07-18 | ã€ã³ãµã€ãã»ã³ãŒãã¬ã€ã·ã§ã³ | ç®èãšãªããããŒãã¹åã³æå¹³èç¬ïŒïœïœïŒã®æ²»çã®ããã®ïœïœïœïŒé»å®³å€ã®äœ¿çš |
| US11992490B2 (en) | 2019-10-16 | 2024-05-28 | Incyte Corporation | Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP) |
| US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| EP4149548A4 (en) | 2020-05-13 | 2024-05-08 | Disc Medicine, Inc. | ANTI-HEMOJUVELIN ANTIBODIES (HJV) FOR THE TREATMENT OF MYELOFIBROSIS |
| BR112022024632A2 (pt) | 2020-06-02 | 2023-02-28 | Incyte Corp | Processos para preparar um inibidor de jak1 |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| CA3192055A1 (en) | 2020-08-18 | 2022-02-24 | Incyte Corporation | Process and intermediates for preparing a jak1 inhibitor |
| KR20230096973A (ko) | 2020-08-18 | 2023-06-30 | ìžì¬ìŽíž ìœí¬ë ìŽì | Jak ì íŽì 륌 ì ì¡°íêž° ìí ë°©ë² ë° ì€ê°ì²Ž |
| CN112159394B (zh) * | 2020-10-09 | 2021-10-22 | åå Žç¹ç§çœçç©ç§ææéå ¬åž | äžç§äœäžºjakæ¿é ¶æå¶åçå°ååååç©åå ¶çšé |
| ES3025481T3 (en) | 2020-12-04 | 2025-06-09 | Incyte Corp | Jak inhibitor with a vitamin d analog for treatment of skin diseases |
| US11957661B2 (en) * | 2020-12-08 | 2024-04-16 | Incyte Corporation | JAK1 pathway inhibitors for the treatment of vitiligo |
| CN114081889A (zh) * | 2020-12-29 | 2022-02-25 | äžæµ·å²žéå»è¯ç§ææéå ¬åž | é¢é²ææ²»çegfråèœåŒåžžçžå ³çå¯äœçšçæ¹æ³ |
| US11918581B2 (en) | 2021-01-11 | 2024-03-05 | Incyte Corporation | Combination therapy comprising JAK pathway inhibitor and rock inhibitor |
| CA3219092A1 (en) | 2021-05-03 | 2022-11-10 | Incyte Corporation | Jak1 pathway inhibitors for the treatment of prurigo nodularis |
| US12071439B2 (en) | 2021-07-12 | 2024-08-27 | Incyte Corporation | Process and intermediates for preparing a JAK inhibitor |
| EP4565229A1 (en) | 2022-08-05 | 2025-06-11 | Incyte Corporation | Treatment of urticaria using jak inhibitors |
| WO2024192350A1 (en) | 2023-03-16 | 2024-09-19 | Incyte Corporation | Jak1 pathway inhibitors for the treatment of asthma |
| CN117186078A (zh) * | 2023-11-06 | 2023-12-08 | è¯åº·äŒæ(å京)å»è¯ç§ææéå ¬åž | æ°ä»£æ°®æç¯äžç·ç±»jakæå¶åè¯ç©åçšé |
| WO2025226637A1 (en) | 2024-04-22 | 2025-10-30 | Incyte Corporation | Combination therapy with an anti-colony stimulating factor 1 receptor antibody and a jak inhibitor |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS60106847U (ja) | 1983-12-27 | 1985-07-20 | å¯å£«éå·¥æ¥æ ªåŒäŒç€Ÿ | 宀å€åŸåé¡ |
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